Real-world outcomes of a loading phase with intravitreal faricimab in refractory Neovascular Age-Related Macular Degeneration (nAMD) patients by Xu Yufeng, Hong Ningxi, Su Mingzhi, Zheng Weixin, Ye Panpan

“…Limitations include the single-arm design, small sample size, and lack of long-term durability assessment.…”
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The ARMADILLO text message intervention to improve the sexual and reproductive health knowledge of adolescents in Peru: Results of a randomized controlled trial. by Jose E Perez-Lu, Fiorella Guerrero, César P Cárcamo, Mónica Alburqueque, Marina Chiappe, Michelle J Hindin, Ndema Habib, Lale Say, Lianne Gonsalves, Angela M Bayer

“…The content exposure analysis saw significant reductions in myths believed for Arm 1 (estimated subject-specific mean difference of -9.47% [-14.83%, -4.11%], p = .001) and Arm 2 (-5.93% [-8.57%, -3.29%], p < .001) as compared with the control arm; however Arm 1's reduced sample size (n = 28) is a severe limitation.…”
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Unraveling the causal pathway between phosphatidylinositol, metabolites, and metabolic syndrome: a Mendelian randomization study by YueGuang Yang, YanLing Ma, Ming Li, YuBo Han, Li Liu

“…This study seeks to clarify the causal link between PI and MetS while investigating the role of mediating metabolites. Methods A two-sample Mendelian randomization (MR) analysis was performed to examine the association between PI and MetS, utilizing aggregated data from genome-wide association studies (GWAS). …”
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Few-shot crop disease recognition using sequence- weighted ensemble model-agnostic meta-learning by Junlong Li, Quan Feng, Junqi Yang, Jianhua Zhang, Jianhua Zhang, Sen Yang

“…Diseases pose significant threats to crop production, leading to substantial yield reductions and jeopardizing global food security. Timely and accurate detection of crop diseases is essential for ensuring sustainable agricultural development and effective crop management. …”
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Mindfulness-based interventions and their relationships with body image and eating behavior in adolescents: a scoping review by Silvia Patrícia de Oliveira Silva Bacalhau, Luciana Gonçalves de Orange, Marco Aurélio de Valois Correia Junior, Juliana Vieira Nunes, Carolina Larissa Alves Sales de Almeida, Maria Wanderleya de Lavor Coriolano-Marinus

“…Heterogeneity among the methodologies used was observed: variations in sample sizes, age groups and gender of participants, and protocols used, which prevents generalization of the results to adolescents and corroborates the need to create a protocol based on information already available in the literature.…”
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The effect of warm saltwater and warm water baths on pain, fatigue, sleep quality, and functional capacity in patients with rheumatoid arthritis: a randomized controlled study✰ by Okşan Aktaş, Ayşe Arikan Dönmez, Sevgisun Kapucu, Muhammet Çinar

“…Data were analyzed with chi-square test, one-way ANOVA, paired sample t-test, and two-way mixed ANOVA with Bonferroni’s test. …”
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Glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery by Mariel Molina-Castro, Blair Rowitz, Blair Rowitz, Blair Rowitz, Marta Yanina Pepino, Marta Yanina Pepino, Marta Yanina Pepino

“…However, the acute GLP-1 decrease and profound FGF21 increase following alcohol intake were not magnified in the postoperative period, nor did alcohol-induced reductions in glucose become more pronounced.DiscussionThese findings suggest that, despite substantial weight loss and improvements in insulin sensitivity, acute alcohol consumption in the fasted state elicits comparable effects on GLP-1, FGF21, and glycemia before and a few months after metabolic surgery. …”
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Reliability and responsiveness of a tissue hardness meter and algometer for measuring tissue hardness and pressure pain threshold in upper trapezius myofascial trigger points by Soukmisai Somphithak, Uraiwan Chatchawan, Atipong Pimdee, Wiraphong Sucharit

“…Following six physical therapy sessions, significant reductions in TH (mean: −7.86%; MCID: −7.43%; AUC: 0.97) and significant increases in PPT (mean: 0.20 kg/cm2; MCID: 0.21 kg/cm2; AUC: 0.86) were observed. …”
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Rehabilitation treatment of coxo-femoral osteo-arthritis - a usefull alternative by Sterian Apostol, Liliana-Elena Stanciu, Corneliu-Dan Blendea, Andreea-Dalila Nedelcu, Elena Apostol, Dimitri Apostol, Petru Bordei

“…Within-group changes were analysed with paired-samples t tests (VAS, SF-20) and Wilcoxon signed-rank tests (WOMAC). …”
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The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study by Zahra Mohammad Alipour, Farahnazsadat Ahmadi, Sina Mohajernoei, Roghaye Gharaei, Nazanin Hojjati, Elham Shirali, Firouzeh Akbari Asbagh

“…PRP administration led to significant reductions in FSH levels (P<0.001) and marked increases in AMH levels and antral follicle count (AFC) (P=0.001 and P<0.001, respectively). …”
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Immunological Responses to Tetanus and Influenza Vaccination in Donkeys by Maciej Perzyna, Jowita Grzędzicka, Dominika Milczek‐Haduch, Izabela Dąbrowska, Michał Trela, Bartosz Pawliński, Olga Witkowska‐Piłaszewicz

“…PanB/CD21+ cells decreased from 41.5% ± 1.8% to 29.0% ± 1.0%, with significant reductions in IL‐10+, IL‐17+, and Ki67+ subsets (p < 0.001). …”
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Validation of the biological function and prognostic significance of AURKA in neuroblastoma. by Jing Chu

“…The expression of AURKA in 77 NB samples was detected by immunohistochemistry (IHC) method. …”
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Impact of different exercise modalities on neuroendocrine well-being markers among university students: a study of renalase and catecholamine responses by Vedat Çınar, Mehmet Fırat Bağ, Mehdi Aslan, Fidan Çınar, Alessandro Gennaro, Taner Akbulut, Gian Mario Migliaccio

“…Norepinephrine levels showed a significant decrease only in the aerobic exercise group, while non-significant reductions were observed in the other exercise groups. …”
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Impact of Wetting-Drying Cycles on Soil Intra-Aggregate Pore Architecture Under Different Management Systems by Luiz F. Pires, Jocenei A. T. de Oliveira, José V. Gaspareto, Adolfo N. D. Posadas, André L. F. Lourenço

“…The imaged porosity showed reductions of approximately 50% after 12 W-D cycles for CT and NT. …”
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Predictors and Correlates of Depression and Anxiety Symptom Trajectories in a Large Digital Mental Health Provider: Retrospective Analysis of Data From Rula Health by Kelsey Lynn McAlister, Lara Baez, Douglas Newton, Sam Seiniger, Amy Pearlman, Allie Woodhouse, Jennifer Huberty

“…ResultsA total of 365,741 adults (mean age 37.03, SD 11.81 years; 238,839/360,388, 66.27% female; 87,758/145,947, 60.13% White) with 2,685,103 therapy visits were included in the sample. Baseline depression (ie, PHQ-9) and anxiety (ie, GAD-7) scores averaged 9.41 (SD 6.61) and 9.45 (SD 5.65), respectively, decreasing to 6.37 (SD 5.83) and 6.50 (SD 5.01) within 12 visits. …”
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Differential expression of cytokines and vitamin D in benign and malignant thyroid diseases by Huimin Li, Xin Jin, Meng Zhang, Xin Wang, Hai Wang

“…Methods: Peripheral blood samples were collected from benign nodule patients (n = 24, pre- and post-operative), PTC (n = 39, pre- and post-operative), and healthy controls (n = 35) who were treated at Tongde Hospital of Zhejiang Province between June 2023 and May 2024. …”
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Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer by Zhe Zhao, Kailun Fei, Hua Bai, Zhijie Wang, Jianchun Duan, Jie Wang

“…Methods We analyzed baseline stool samples from patients with locally advanced and advanced lung cancer before chemotherapy treatment, through metagenomics of the gut microbiota. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…At the start, at 8 weeks and 8 weeks after the last injection, the HDRS was recorded and blood samples drawn for measuring naïve and memory T cells, Th17 and Treg cells, hsCRP, IL-6 and IL-7. …”
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The single-cell immune landscape of HIV-associated aggressive B-cell lymphoma by Xiaomei Zhang, Zailin Yang, Xiaoqing Xie, Jun Li, Qing Xiao, Guofa Xu, Ben Ma, Xudong Xie, Yi Liu, Liuyue Zhai, Yifeng Tang, Huihui Fu, Sanxiu He, Tingting Liu, Dehong Huang, Censi Zeng, Yixing Zhou, Renzhi Hu, Binling Guo, Chaoyu Wang, Shunsi Liang, Qin Luo, Jing Lv, Yingyu Nan, Jieping Li, Qiying Li, Shengqiang Wang, Yongzhong Wu, Yao Liu

“…Additionally, HAL exhibited senescence-like dysfunction in T cells, characterized by the reductions in regulatory activity of Treg and cytotoxic activity of CD8+ T cells, as well as decreases expression of IL7R genes and increases expression of FOS and FOSB genes. …”
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Changes in lymphocyte subsets pre- and post-particle radiotherapy in head and neck bone and soft tissue tumors by Haojiong Zhang, Haojiong Zhang, Haojiong Zhang, Jing Gao, Jing Gao, Jing Gao, Jiyi Hu, Jiyi Hu, Jiyi Hu, Weixu Hu, Weixu Hu, Weixu Hu, Qingting Huang, Qingting Huang, Qingting Huang, Lin Kong, Lin Kong, Lin Kong

“…Treatment modalities included proton or carbon-ion radiotherapy, with or without chemotherapy, targeted therapy, or immunotherapy. Peripheral blood samples were collected both before and after the completion of radiotherapy. …”
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