Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis by Haizheng Wu, Haojun Zhu, Quanjie Li, Jiancao Gao, Jinliang Du, Liping Cao, Yi Sun, Gangchun Xu

“…This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. …”
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Comprehensive analysis of faecal metagenomic and serum metabolism revealed the role of gut microbes and related metabolites in detecting colorectal lateral spreading tumours by Hao Lin, Yudai Chen, Ming Zhou, Hongli Wang, Lichun Chen, Li Zheng, Zhixin Wang, Xiaoling Zheng, Shiyun Lu

“…Metagenomic and metabolomic analysis revealed a strong positive correlation between Escherichia and Ruminococcus sp-AM41-2AC abundance and the enriched pathways, whereas reductions in Roseburia species, including Roseburia-OF03–24 and Roseburia intestinalis_CAG13—exhibited negative correlations. …”
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Early real-world outcomes of intravitreal aflibercept 8 mg in treatment-Naïve neovascular AMD: AI-assisted fluid volume analysis by Jennifer Cattaneo, Eva C. De Oliveira Figueiredo, Andrea Montesel, Sandra Vermeirsch, Chiara M. Eandi

“…Abstract Background This study was conducted as a retrospective, exploratory analysis to assess early anatomical and functional effects of intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (nAMD) in a small cohort of patients. …”
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Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis. by Paul McCrone, Michael Sharpe, Trudie Chalder, Martin Knapp, Anthony L Johnson, Kimberley A Goldsmith, Peter D White

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Comparative transcriptome analysis reveals abscisic acid-induced bHLH transcription factors involved in saikosaponin biosynthesis in Bupleurum chinense DC by Han Wang, Shanqun Hu, Tong Li, Xuejie Qu, Jiaqi Zhang, Baoshun Wang, Yixuan Sun, Rui Cao, Yutong Yan, Ze Song, Xia’nan Zhang, Rong Luo, Yuru Tong, Changli Liu

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High-throughput sequencing metabarcoding and network analysis elucidate the effects of soil fumigation and biostimulant on potato yield, rhizoctonia canker, and fungal community by Honoré Tekeu, Honoré Tekeu, Honoré Tekeu, Joël D’Astous-Pagé, Thomas Jeanne, Richard Hogue

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Identification and whole genome sequencing analysis of Bacillus subtilis K35-1, a highly efficient cellulose in forage degrading bacterium by Dan Wu, Jing Feng, Dongxu Wen, Hongzhuang Wang, Sijia Lu, Kun Li, Rizwana Sultan, Bin Li

“…Comparative genomic analysis showed K35-1 possesses 40% more glycoside hydrolases than reference strains (Srivastava et al., Mol Genet Genomics 298:361–74, 2023), explaining its enhanced degradation efficiency (53.2% cellulose reduction vs. 7.3% in conventional treatments). …”
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Real-world clinical insights and aqueous humor biomarker analysis of diabetic macular edema subtypes classified by OCT following intravitreal injections by Liangzhang Tan, Shoukuan Liu, Wenrui Linghu, Yifeng Ke, Yongtao Li, Emmanuel Eric Pazo, Xinjun Ren

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Simulation of Suitable Distribution and Differentiation in Local Environments of <i>Cercospora arachidicola</i> in China by Ying Lin, Xue Pei, Chunhao Liang

“…This study aimed to develop a predictive model, optimized using the Biomod tuning function, to assess the future risk and spatial distribution of ELS under various climate change scenarios. …”
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Probing rare von Willebrand disease–causing mutations in the D4 and C-domains of von Willebrand factor by Golzar Mobayen, Sammy El-Mansi, Alain Chion, Thomas D. Nightingale, Thomas A.J. McKinnon

“…Background: von Willebrand disease (VWD) is characterized by absence or reduction of plasma von Willebrand factor (VWF) levels or reduced protein function. …”
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Three-Band Spectral Camera Structure Design Based on the Topology Optimization Method by Kai Hu, Yuzhu Wan, Jialong Guo, Chunbo Zou, Xiangtao Zheng

“…The analysis demonstrates that the optimized housing and bracket exhibit excellent dynamic and static performance, meeting all testing requirements, and, under gravitational conditions, the spot diagram and modulation transfer function effect are negligible. …”
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Performance Optimization of a Formula Student Racing Car Using the IPG CarMaker, Part 1: Lap Time Convergence and Sensitivity Analysis by Dominik Takács, Ambrus Zelei

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Cost‐effectiveness of Resonance® metallic ureteral stent compared with standard polyurethane ureteral stents in malignant ureteric obstruction: A cost‐utility analysis by Dawn M. Cooper, Rachel Lines, Iqbal Shergill

“…Patients have poor prognoses, treatment aims to improve quality‐of‐life while optimising renal function. Standard practice in the United Kingdom is to use polyurethane stents, which require frequent surgical replacements for blockages and encrustation. …”
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Triglyceride-glucose indices predict all-cause mortality after stroke in NHANES 1999–2018 by Jiaqian Zheng, Jiaqian Zheng, Jiaqian Zheng, Weiwen Mao, Mengqian Sang, Xinyu Pan, Yiluo Xie, Yichi Xie, Yichi Xie

“…This study was analyzed using a multivariate Cox proportional risk regression model incorporating sampling weights, while a restricted cubic spline function was introduced to assess trends in non-linear associations between exposure variables and outcomes. …”
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Sweet Shield: Enhancing Oral Health with Bioactive HETAFU Candies in Adults – A Dose-Dependent Study by Sowjanya Lakkoju, Deepika Bolisetty, Ranjith Kumar

“…Functional foods incorporating probiotics, essential oils, and DHA, PhosphatidylSerine have been explored as innovative approaches to improving oral health. …”
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Third-line multiple myeloma treatment of inpatients in a German cancer center: analysis of potential cost savings due to decreased renal insufficiency by F. Jakobs, P. Ahmadi, V. Osterkamp, J. Jeck, U. Holtick, C. Scheid, Florian Kron

“…Conclusion The analysis quantifies for the first time the economic saving potential of improved renal function in patients with relapsed/refractory multiple myeloma in the German healthcare system through the administration of isatuximab.…”
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Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT by Mandana Zanganeh, John Belcher, James Fotheringham, David Coyle, Elizabeth J Lindley, David F Keane, Fergus J Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie H Macdonald, Ivonne Solis-Trapala, Julius Sim, Simon J Davies, Lazaros Andronis

“…Background The BioImpedance Spectroscopy to maintain Renal Output randomised controlled trial investigated the effect of bioimpedance spectroscopy added to a standardised fluid management protocol on the risk of anuria and preservation of residual kidney function (primary trial outcomes) in incident haemodialysis patients. …”
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Analysis Method for the Pouring Stage of Concrete-Filled Steel Tube (CFST) Arch Bridges Considering Time-Varying Heat of Hydration and Elastic Modulus by Mengsheng Yu, Xinyu Yao, Kaizhong Xie, Tianzhi Hao, Xirui Wang

“…Firstly, based on the composite index model of the hydration heat and through the reduction of the participating materials, the heat source function of the hydration heat of the arch rib was obtained, and its accuracy was verified by using two test components. …”
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Effects of combination antihypertensive therapy on intracardiac hemodynamics and blood vessels in patients with coronary heart disease, post-infarction cardiosclerosis and arterial... by M. M. Dolzhenko, S. A. Bondarchuk, L. Ye. Lobach

“…When analyzing the indicators of diastolic function in the second group, a highly significant (p < 0.05) decrease in E/A, E/E’, IO of the LA has been revealed; data analysis on the morphofunctional state indicators of the extracranial arteries has shown a CIM reduction and a decrease in PSV and RI. …”
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Semen Quality, Testicular Cell Apoptosis, and Transcriptome Analysis Following Mild Scrotal Heat Stress in Wugu–Hu Crossbred and Hu Rams by Shikun Chen, Mingxu Jiang, Yanyun Wang, Qingjie Pan, Henry Annandale, Peter Charles Irons, Huansheng Dong

“…Wugu–Hu rams demonstrate more transcriptomic changes. Further GO analysis revealed enrichment in spermatogenesis-related processes, while KEGG analysis identified Oocyte meiosis and cell cycle pathways, with a downregulation of key genes (CDK1, CDK2, CDC20, and PLK1) indicating impaired meiosis in Wugu–Hu rams. …”
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