Single-cell and spatial transcriptomics analysis reveals that Pros1+ oligodendrocytes are involved in endogenous neuroprotection after brainstem stroke by Shaojun Li, Guanfeng Zeng, Chunmei Pang, Jie Li, Li Wu, Ming Luo, Zhihua Qiu, Yongjun Jiang

“…Notably, the overexpression of Myo1e within OLG8 cells led to a marked reduction in infarct volume while simultaneously improving the recovery of neurological function. …”
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Changes in Testosterone Levels Following Surgical Sperm Retrieval in Men with Non-Obstructive Azoospermia: Systematic Review and Meta-Analysis by Wael Zohdy, Rupin Shah, Christopher Chee Kong Ho, Gokhan Calik, Vineet Malhotra, Bircan Kolbaşı Erkan, Mesut Berkan Duran, Georgios Tsampoukas, Garaz Radion, Ramadan Saleh, Ahmed M. Harraz, Parviz Kavoussi, Eric Chung, Edmund Ko, Luca Boeri, Naveen Kumar, Selahittin Çayan, Amarnath Rambhatla, Osvaldo Rajmil, Mohamed Arafa, Rossella Cannarella, Omer Raheem, Taymour Mostafa, Widi Atmoko, Taha Abo-Almagd Abdel-Meguid Hamoda, Armand Zini, Ashok Agarwal

“…Patients underwent SSR and were followed in the postoperative period (one week to 32 months). The analysis showed a significant reduction in TT (mean difference [MD] 3.81 nmol/L, 95% confidence interval [CI] 0.55:7.06; p=0.02) compared to pre-SSR values. …”

Comparison of fibula plating versus fibula nailing: A systematic review with meta-analysis of all current comparative literature by Troy B Puga, McKenna W Box, Charles R Marchese, Alan Lam, Sam Stegelmann, John T Riehl

“…Outcomes of interest extracted included operative time, functional outcomes scores, hardware/loss of reduction, malunion/nonunion, re-operations, and wound complications. …”
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Lisdexamfetamine in the treatment of moderate-to-severe binge eating disorder in adults: systematic review and exploratory meta-analysis of publicly available placebo-controlled, r... by Fornaro M, Solmi M, Perna G, De Berardis D, Veronese N, Orsolini L, Ganança L, Stubbs B

“…Study eligibility criteria, participants, and interventions were considered focusing on major clinical and functional outcomes of either efficacy or tolerability of lisdexamfetamine in the treatment of moderate-to-severe BED in adults.Results: Meta-analysis of data pooled from three acute RCTs significantly favored lisdexamfetamine over placebo in the reduction of binge eating days/week, Yale-Brown Obsessive Compulsive Scale Modified for Binge Eating total score, weight, response, and remission rates (all, P≤0.01). …”
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The Semantic Evolution of Protest Slogans of the Last Three Decades in the Sphere of Political Discourses by Saeedeh Amini, Fatemeh Omidi

“…The themes of the slogans in 1988 (political justice) did not match the elements of the discourse of justice (reduction of poverty and deprivation), but it was in harmony with the functional dysfunction of the government in the field of politics. …”
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In silico and in vitro analysis of boAP3d1 protein interaction with bovine leukaemia virus gp51. by Adriana Patricia Corredor, Janneth González, Luis Alfredo Baquero, Hernando Curtidor, Nury Nathalia Olaya-Galán, Manuel Alfonso Patarroyo, María Fernanda Gutiérrez

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Self-organizing dynamic research based on phase coherence graph autoencoders: Analysis of brain metastable states across the lifespan by Hao Guo, Yu-Xuan Liu, Yao Li, Qi-Li Guo, Zhi-Peng Hao, Yan-Li Yang, Jing Wei

“…We developed a framework based on Phase Coherence Graph Autoencoder (PCGAE) that employs graph autoencoders (GAE) for non-linear dimensionality reduction of phase coherence matrices. This approach clusters to identify more distinct metastable brain states and is applied to the analysis of resting-state functional magnetic resonance imaging (rs-fMRI) data across the human lifespan. …”
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scRDEN: single-cell dynamic gene rank differential expression network and robust trajectory inference by Han Zhang, Wei Zhang, Xiaoying Zheng, Yuanyuan Li

“…This may correspond to the mechanism of cells gradually differentiating into stable functions. It is particularly noteworthy that scRDEN method yielded exceptional results when applied to the large-scale, multi-branched, double-batch mouse dentate gyrus data. …”
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From Breathlessness to Better Living: Transforming COPD Care with Home-Based Pulmonary Rehabilitation by Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam, Chinchu Kolakkanni, Sarankumar Ganesan, Adharshna Thangamalai Kannan

“…Cognitive and self-care scores remained stable, while improvements in mobility were observed but not significant. Regression analysis revealed a strong negative correlation between increases in FVC and reductions in WHODAS 2.0 total scores (r=−0.65), highlighting FVC as a key predictor of disability reduction. …”
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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children by Joana Llauradó-Pont, Nikos Stratakis, Giovanni Fiorito, Evangelos Handakas, Alexander Neumann, Henrique Barros, Anne Lise Brantsæter, Kiara Chang, Leda Chatzi, Janine F. Felix, Regina Grazuleviciene, Vincent W. V. Jaddoe, Marianna Karachaliou, Marion Lecorguillé, Carla Lopes, Christopher Millett, Rosemary R. C. McEachan, Eleni Papadopoulou, Remy Slama, Eszter P. Vamos, Paolo Vineis, Martine Vrijheid, John Wright, Trudy Voortman, Mariona Bustamante, Oliver Robinson, Camille Lassale

“…Methods We conducted a meta-analysis of epigenome-wide association studies (EWAS) from a total of 3152 children aged 5–11 years from four European studies (HELIX, Generation XXI, ALSPAC, and Generation R). …”
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Cellular interactions and Ion channel signatures in atrial fibrillation remodeling: insights from single-cell analysis and machine learning by Bin He, Yan Cheng, Juan Wang, Ya Zhan, YanQun Liu

“…Additionally, a cell-cell interaction analysis was performed using the CellChat package, and biological function and pathway enrichment analyses were done using GO, KEGG and GSEA pathways. …”
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Identification of DCAF5 as a novel cancer prognostic and immunotherapy biomarker through pan-cancer analysis and renal clear cell carcinoma clinical data validation by Huaqing Yan, Liqi Zhang, Fan Xu, Tieding Chen, Rubing Li

“…This highlights its potential as a dual-functional biomarker for prognosis and immunotherapy personalization, particularly in SMARCB1-deficient malignancies.…”
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Experimental analysis on residual ultimate bearing capacity of thin plate with internal explosion dent damage under biaxial compression by Lei AO, Zhizhong SHI, Lei ZHANG, Ziqi DING, Zhiyong PEI, Weiguo WU

“…This analysis is essential for evaluating the ship's damage tolerance and determining its ability to safely return to port. …”
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Melatonin regulated through GhTDC5 enhances tryptophan decarboxylase against drought stress in cotton by Xin Yu, Xiugui Chen, Ning Wang, Maohua Dai, Zhining Yang, Yapeng Fan, Yuping Sun, Xinrui Zhang, Ruize Song, Menghao Zhang, Hao Lan, Fange Wu, Hui Huang, Xiao Chen, Lidong Wang, Xuke Lu, Shuai Wang, Lixue Guo, Junjuan Wang, Lanjie Zhao, Keyun Feng, Jing Jiang, Wuwei Ye

“…Functional characterization of GhTDC5 in Gossypium hirsutum was performed using virus-induced gene silencing (VIGS), with the following key findings: gene silencing efficiency reached 67.5%, leading to a significant 50.31% reduction in melatonin content. …”
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Structural modification of Naproxen; physicochemical, spectral, medicinal, and pharmacological evaluation by Md Omor Farque, Rahat Moinul Islam, Md Ferdous Rahman Joni, Mimona Akter, Shilpy Akter, Mohammad Didarul Islam, MD Jubaer Bin Salim, Ahamed Abdul Aziz, Emranul Kabir, Monir Uzzaman

“…The geometry of the modified compounds was optimized via DFT with the B3LYP functional and 6-31+G (d, p) basis set, facilitating physicochemical and spectral analysis. …”
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Wood Species Recognition Based on Visible and Near-Infrared Spectral Analysis Using Fuzzy Reasoning and Decision-Level Fusion by Peng Zhao, Zhen-Yu Li, Cheng-Kun Wang

“…First, the wood spectral curve—with spectral bands of 376.64–779.84 nm and 950–1650 nm—was processed using the principal component analysis (PCA) dimension reduction algorithm. The wood spectral data were divided into two datasets, namely, training and testing sets. …”
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Effectiveness of Single-Person Reset Fixed System for Pediatric Supracondylar Humeral Fractures: Case Series and a Meta-Analysis by Di Shen, Manman Cui, Qiang Fu, Jiajia Lu, Xiaojian Shi

“…Postoperatively, Baumann’s Angle ranged from 64 to 81 degrees, indicating restoration of normal joint mobility as Range of Motion (ROM) exceeded 90%. The meta-analysis highlighted the significant advantage of the Single-Person RFS in improving the excellent treatment rate with low heterogeneity.Conclusion The single-person RFS demonstrates remarkable effectiveness in pediatric SHF treatment, evident through reduced surgical times, decreased fluoroscopy frequency, minimal complications, and positive functional recovery for patients. …”
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An analysis of ramie fiber (Boehmeria nivea L. Gaud) treated with low temperature plasma using a mathematical model by Markus Paramahasti, Valentinus Galih Vidia Putra, Yusril Yusuf

“…According to the findings, plasma treatment caused: (1) ramie fiber became more hydrophilic, as indicated by the presence of hydrophilic functional groups such as hydroxyl (O–H), carboxyl (O–C), and carbonyl (C=O) in FT-IR with a deeper T%, (2) ramie fiber mass reduction was accompanied by an increase in surface roughness via SEM testing and image processing, and (3) plasma-treated fiber had a coefficient of mass variation (CV) of 0.7211 higher than untreated fiber. …”
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Integrative multi-omics analysis of the microbiome and metabolome in bronchoalveolar lavage fluid from patients with early-stage lung cancer by Jiajun Xie, Nengyang Zhu, Weiguo Xu

“…Furthermore, reductions in cholecalciferol may serve as a robust predictor of early-stage lung cancer. …”
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Metagenomic analysis reveals methanogenic and other archaeal genes in the digestive tract of invasive Japanese beetle larvae and associated soil by Helena Avila-Arias, Michael E. Scharf, Ronald F. Turco, Diego J. Jiménez, Audrey Simard, Douglas S. Richmond

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