Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma by Minfeng Tong, Qi Tu, Lude Wang, Huahui Chen, Xing Wan, Zhijian Xu

“…We verified the effect of the marker gene on the function of GB cells at the cellular level. Results: The analysis of scRNA-seq data yielded 7 core cell types. …”
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Intranasal administration of stem cell derivatives for the treatment of AD animal models: a systematic review and meta-analysis by Zilin Hua, Nan Zhou, Zijing Zhou, Zewei Fu, Ruiyun Guo, Herman Yao Akogo, Jiayin Yang, Meixuan Yu, Yujie Jiang, Siyi Lan, Haixia Chang, Jun Ma, Huixian Cui

“…Using predominantly mouse and rat models from diverse geographical locations and employing various stem cell types (bone marrow, umbilical cord blood, adipose tissue, hiPSCs), the analysis revealed a significant reduction in amyloid-beta (Aβ) deposition (SMD = -2.69, p < 0.0001). …”
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Symmetrized Neural Network Operators in Fractional Calculus: Caputo Derivatives, Asymptotic Analysis, and the Voronovskaya–Santos–Sales Theorem by Rômulo Damasclin Chaves dos Santos, Jorge Henrique de Oliveira Sales, Gislan Silveira Santos

“…This synergy between neural operator theory, asymptotic analysis, and fractional calculus not only advances the theoretical landscape of function approximation but also provides practical computational tools for addressing complex physical systems characterized by long-range interactions and anomalous diffusion.…”
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Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample by Yoichi Sawada, Toru Satoh, Hideaki Saba, Yoshiki Kato, Tomoko Kuwada, Sayoko Shima, Kana Murakami, Megumi Sasaki, Yudai Abe, Kaori Harano

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Investigation of customized total knee implant with articular cartilage under loading conditions using finite element analysis. by Shady A Alshewaier, Mohamed Yacin Sikkandar, Ali Ahmed Ali Almakrami, S Sabarunisha Begum, Ahmad Alassaf, Ibrahim AlMohimeed, S Meenatchi Sundaram, Dheeraj Poojary, Natteri M Sudharsan, Eddie Y K Ng

“…The results indicated a 5% reduction in stress with implants designed for a 100 kg body weight, along with a significant reduction in ligament strain when compared to conventional knee joint stresses. …”
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Steering-Angle Prediction and Controller Design Based on Improved YOLOv5 for Steering-by-Wire System by Cunliang Ye, Yunlong Wang, Yongfu Wang, Yan Liu

“…To improve real-time accuracy in steering-angle prediction and enhance effectiveness in steering control, we update the bounding box regression loss function with the generalized intersection over union (GIoU) to Shape-IoU_Loss as a better-converging regression loss function for bounding-box improvement. …”
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Efficacy of Different Acupuncture Therapies for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Network Meta-Analysis by Qin P, Cao X, Ni H, Yang L, Tong Y, Dang M, Xu J

“…Long-needle acupuncture consistently demonstrated superior efficacy across both subjective symptoms and objective measures.Conclusion: Acupuncture therapies, especially long-needle acupuncture, are more effective than UT for CP/CPPS, providing comprehensive symptom relief, pain reduction, and functional improvement, with long-needle acupuncture emerging as the most robust intervention.Keywords: acupuncture, chronic prostatitis/chronic pelvic pain, network meta-analysis…”
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Enhanced thyroid nodule detection and diagnosis: a mobile-optimized DeepLabV3+ approach for clinical deployments by Changan Yang, Muhammad Awais Ashraf, Mudassar Riaz, Pascal Umwanzavugaye, Kavimbi Chipusu, Hongyuan Huang, Yueqin Xu

“…Preprocessing steps, including noise reduction and contrast optimization, were applied to enhance image clarity. …”
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A multi-center trial-based economic evaluation of the SELF-program: A function-focused care program for nursing staff providing long-term care for geriatric clients in nursing home... by Ruben M W A Drost, Ghislaine A P G van Mastrigt, Stan Vluggen, Silke F Metzelthin, Michel H C Bleijlevens, Getty Huisman-de Waal, Janneke M de Man-van Ginkel, Sandra M G Zwakhalen

“…From a healthcare perspective, the incremental costs amounted to €556, with ratios of €410 per point reduction on the GARS-4 and €8,356 per QALY.<h4>Conclusions</h4>The main analysis suggests that over 6 months from a societal perspective for both outcomes, the intervention is cost-effective as compared to care as usual.…”
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Assessing the relationship between wrist synovitis and anxiety: a study using clinical statistics and Mendelian randomization analysis by Xunhao Wang, Linyi Zhu, Jingyi Mi, Fei Xiong

“…Results Significant reductions in SAS and VAS scores were observed at 2 and 4 weeks postoperatively, along with improvements in wrist function as measured by the Mayo Wrist Score. …”
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Comparative safety and efficacy of manual therapy interventions for cervicogenic headache: a systematic review and network meta-analysis by Xueliang Xu, Yan Ling

“…CSM exhibited significantly greater VAS reductions compared to exercise, massage, and mobilization, while mobilization was superior to exercise and massage for VAS. …”
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Optimization of Mechanical Properties and Manufacturing Time through Experimental and Statistical Analysis of Process Parameters in Selective Laser Sintering by Adrian Korycki, Christian Garnier, Valerie Nassiet, Charles Tarek Sultan, France Chabert

“…A statistical analysis of the response of the parameters has been led by a design of experiments to extract the most influential parameters in the selective laser sintering process. …”
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Noise and Vibration Analysis of Electric Oil Pump with Asymmetric Pitch Control for Gearbox in Hybrid and Battery Electric Vehicle by Chinchul Choi

“…A formula for the shape of instantaneous motor torque is proposed for the analysis of pressure fluctuations of pumps, which is a combination of trigonometric and exponential functions. …”
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Rescue Stenting after Unsuccessful Recanalization of Endovascular Thrombectomy of the Posterior Circulation: A Systematic Review and Meta Analysis by Aaron Brake, Emmanuel Danso, William Liu, Vince Galate, Lane Fry, Michael Abraham

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Frequency domain analysis of steady-state visual evoked potentials in dogs with optic neuritis: a pilot study by Teck-Geun Lee, Joon-Young Kim

“…Visual evoked potentials (VEP) are electrophysiological signals used to assess visual pathway function, with applications in diagnosing optic nerve disorders. …”
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16S rRNA and transcriptome analysis revealed the regulatory mechanism of Romboutsia lituseburensis on serum immunoglobulin levels in geese by Zhiyu He, Mengge Guo, Xi Zhang, Shangmin Wang, Tanze Liu, Yueyue Lin, Qingyuan Ouyang, Shenqiang Hu, Hua He, Liang Li, Hehe Liu, Jiwen Wang

“…Concurrently, it might downregulate the “Intestinal immune network for IgA production” pathway in the spleen (CCR9, TNFRSF13B, AICDA) via KEL, SERPING1, CALR, and OSTN, thereby contributing to the reduction of serum immunoglobulin levels. These findings offer new insights into how R. lituseburensis influences immune function in female geese and provide a theoretical basis for further research into its other physiological roles in geese.…”
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Systematic Review of Total Hip Arthroplasty Outcomes in Cerebral Palsy Patients and a Comparative Analysis with Rheumatoid Arthritis by Christos Costa, Foteini Moniati, Michalis Chatzimatthaiou, Christos Papaioannou, Sapfo Athanasakopoulou, Marios Chatzimatthaiou

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Efficacy and safety of Tai Chi for Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials. by Xiaojia Ni, Shaonan Liu, Fuchang Lu, Xiaogeng Shi, Xinfeng Guo

“…Improvements in the Unified Parkinson's Disease Rating Scale Part III (mean difference (MD) -4.34, 95% confidence interval (CI) -6.67--2.01), Berg Balance Scale (MD: 4.25, 95% CI: 2.83-5.66), functional reach test (MD: 3.89, 95% CI: 1.73-6.04), Timed Up and Go test (MD: -0.75, 95% CI: -1.30--0.21), stride length (standardized MD: 0.56, 95% CI: 0.03-1.09), health-related quality of life (standardized MD: -1.10, 95% CI: -1.81--0.39) and reduction of falls were greater after interventions with Tai Chi plus medication. …”
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The reliability of talonavicular uncoverage to indicate forefoot abduction in progressive collapsing foot deformity: a finite element analysis by Yulin Wei, Hua Liu, Can Xu

“…While medializing displacement calcaneal osteotomy (MDCO) and lateral column lengthening (LCL) are commonly employed as corrective surgeries, their impact on foot structure and functionality necessitates detailed biomechanical analysis. …”
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Comparative analysis of biopolymer films derived from corn and potato starch with insights into morphological, structural and thermal properties by N. Pooja, Soumyabrata Banik, Ishita Chakraborty, H. C. Sudeeksha, Sib Sankar Mal, Pornsak Srisungsitthisunti, Ajeetkumar Patil, Krishna Kishore Mahato, Nirmal Mazumder

“…X-ray diffraction (XRD) analysis revealed a reduction in crystallinity of the starch during film formation, enhancing flexibility. …”
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