In Vivo distribution dynamics of Gold Nanoparticles: A quantitative analysis by Angélica Barbezan, Wilmmer Alexander Rosero, Luis Fernando Almeida, Maria Eduarda Rigo, Fabio Fernando Silva, Maria Elisa Rostelato

Get full text

Analysis of the SUMO2 Proteome during HSV-1 Infection. by Elizabeth Sloan, Michael H Tatham, Marine Groslambert, Mandy Glass, Anne Orr, Ronald T Hay, Roger D Everett

“…Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. …”
Get full text

In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase by Álvaro D. Fernández-Fernández, Francisco J. Corpas

“…Arabidopsis contains three 6PGDH genes that probably are encoded for cytosolic, chloroplastic/mitochondrial, and peroxisomal isozymes, although their specific functions remain largely unknown. This study focuses on the in silico analysis of the biochemical characteristics and gene expression of peroxisomal 6PGDH (p6PGDH) with the aim of understanding its potential function in the peroxisomal NADPH-recycling system. …”
Get full text

Analysis of the central zone of the retina in patients with diabetic macular edema by Mukharram Muhtaramovich Bikbov, Rinat Rustamovich Fayzrakhmanov, Alia Linarovna Yarmuhametova, Rinat Mukhametovich Zainullin

“…Analysis of MPOD revealed a significant reduction of all parameters in group A compared with the control group. …”
Get full text

Chemoproteomic analysis of the pharmacological properties of vitamin В12 derivatives by I. Yu. Torshin, O. A. Gromova, I. A. Dereven’kov, L. A. Maiorova

“…It was shown that the chemoproteomic profiles of each of the compounds form three groups of molecules with similar proteomic properties: (1) aquacobalamin, (2) diaquacobinamide, aquacyano-forms of heptaethanolamine and heptaethylenediamine cobyrinates, (3) aquacyano-forms of heptamethyl and heptabutyl cobyrinates. A more detailed analysis of the chemoproteomic profiles of the studied compounds using the GO (Gene Ontology) nomenclature of biological functions of proteins made it possible to identify functional GO categories indicating differences in the biological effects of the studied compounds: neuroprotective regulation of neurotransmitter activity (serotonin receptor activity, cholinergic synapses, regulation of dopamine secretion, receptor thyroid hormones), reduction of inflammation (inhibition of cytokine biosynthesis, including tumor necrosis factor alpha and interleukin 1 beta, I-kappa-B kinases / nuclear factor kappa В, leukocyte migration), etc.Conclusion. …”
Get full text

Clinical utility of a rapid two-dimensional balanced steady-state free precession sequence with deep learning reconstruction by Katerina Eyre, Moezedin Javad Rafiee, Margherita Leo, Junjie Ma, Elizabeth Hillier, Negin Amini, Josephine Pressacco, Martin A. Janich, Xucheng Zhu, Matthias G. Friedrich, Michael Chetrit

“…There were no significant differences found across left ventricular volumetry, function, or mass measurements. In contrast, an acceleration factor of 12 resulted in a 6% (5.51/90.16) reduction of measured ejection fraction when compared to the standard cine method and a 4% (4.32/88.98) reduction of measured ejection fraction when compared to Sonic DL at an acceleration factor of 8. …”
Get full text

Method of estimation of frequency variation relying on estimation of shift of spectral peaks by D. A. Kechik, Yu. P. Aslamov, I. G. Davydov

Get full text

The effect of probiotics on gestational diabetes mellitus: an umbrella meta-analysis by Guixia Sun, Hongli Hou, Shanshan Yang

“…To address this, we conducted an umbrella meta-analysis to evaluate the impact of probiotics on glycemic indicators in GDM. …”
Get full text

Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…For clinical practice, it is highly important to create functional cures that can enhance immune control of viral growth and infection of target cells with a subsequent reduction in viral load and restoration of the immune status. …”
Get full text

A Retrospective, Longitudinal Registry Study on the Long-Term Durability of Ivacaftor Treatment in People with Cystic Fibrosis by Christian Merlo, Teja Thorat, Lisa J. McGarry, Christina V. Scirica, Maral DerSarkissian, Catherine Nguyen, Yuqian M. Gu, Aruna Muthukumar, Joe Healy, Jaime L. Rubin, M. Alan Brookhart

Get full text

Clinical Study of MOTOmed Intelligent Training System Combined with Weight Support Gait Training on Improving Hemiplegic Gait of Stroke Patients with Hemiplegia by LI Na, LIANG Xueqin, PAN Fangfang, DUAN Yanan, ZHANG Xiangyu

“…The rehabilitation outcomes of the two groups were compared by using Barthel index, Holden walking function assessment, hemiplegic gait analysis rating scale, Fugl-Meyer assessment lower extremity (FMA-LE) and Berg balance scale (BBS).ResultsAfter 4 weeks of treatment, both groups showed improvements in Barthel Index score, Holden walking function classification, and hemiplegic gait analysis results (<italic>P</italic>&lt;0.05). …”
Get full text

Translucent Si Solar Cells Patterned with Pulsed Ultraviolet Laser Beam by Ashif H. Chowdhury, Heayoung P. Yoon

Get full text

Objective nutritional indices as an independent predictor of functional outcome after endovascular therapy for acute ischemic stroke: a cohort study in a Chinese population by Weiwei Gao, Weiwei Gao, Weiwei Gao, Lingfeng Yu, Yifen Zhang, Shouyue Jin, Shouyue Jin, Shouyue Jin, Zhongjie Chen, Zhongjie Chen, Zhongjie Chen, Zhongjie Chen, Xingyu Chen, Xingyu Chen, Xingyu Chen, Lijuan Cai, Lijuan Cai, Lijuan Cai, Renjing Zhu, Renjing Zhu, Renjing Zhu, Renjing Zhu

“…RCS analysis revealed a significant non-linear relationship between HALP score and functional outcomes (P-non-linear = 0.021), characterized by a steep risk reduction as scores increased at lower values, followed by a plateau effect. …”
Get full text

Sex differences and age-related changes of large-scale brain networks by Shujun Zhang, Meiqin Li, Anqiang Chen, Liping Jiang, Hao Yu, Yueqin Chen

“…Methods Resting-state functional MRI data from 436 healthy adults were analyzed using independent component analysis to extract large-scale brain networks. …”
Get full text

New findings in preventing recurrence and improving renal function in AHUS patients after renal transplantation treated with eculizumab: a systemic review and meta-analyses by Zheng Chun Tang, Huang Hui, Chunru Shi, Xiangmei Chen

“…Our analysis suggests that the use of eculizumab is associated with a reduced likelihood of AHUS recurrence (odds ratio (OR) = 0.05, 95% CI: 0.00–0.13), as well as a significant reduction in the need for dialysis (odds ratio (OR) = 0.13, 95% CI: 0.01–0.32). …”
Get full text

Coronary cross-sectional area stenosis severity determined using coronary CT highly correlated with coronary functional flow reserve: a pilot study by Takuto Koumoto, Shozo Kusachi, Takumi Tomiya, Takuya Akagi, Hiroshi Kawamura, Satoshi Hirohata, Hirosuke Yamaji, Takashi Murakami, Shigeshi Kamikawa, Masaaki Murakami

Get full text

Application of headless cannulated compression screws for treatment of Delbet-Colonna II and III femoral neck fractures in children by Yikun Jiang, Yanbing Wang, Chuangang Peng, Baoming Yuan, Dankai Wu

“…The extent of fracture reduction and postoperative hip function were assessed according to the Haidukewych standard and with the Harris score, respectively. …”
Get full text

Functional Characterization of <i>PeMep</i> Gene Reveals Its Roles in the Vegetative Growth, Stress Adaptation, and Virulence of <i>Penicillium expansum</i> by Juanying Huang, Chenyang Zhu, Mengyue Wu, Guanghao Li, Luning Zhao, Xiaoshuang Xia, Yun Wang

Get full text

A socially prescribed creative play intervention for new parents: investigating post traumatic stress around birth and changes in postnatal depression and reflective function by Paige E. Davis, Susanna Kola-Palmer

“…Results The participants experienced a statistically significant reduction in postnatal depression scores following the intervention, but no changes were found in reflective function or birth trauma scores; secondly, birth trauma scores predicted later depression scores as well as reflective functioning uncertainty scores (but not certainty scores). …”
Get full text

Remodeling characteristics of H3K27me3-marked silencers in gastric signet-ring cell carcinoma and its transcriptional regulatory function by DU Aibei, DU Aibei, REN Yuanfeng, CHU Zhaole

“…H3K27me3 related differentially expressed genes (|Log2FC|>1, FDR<0.05) were screened using DESeq2. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to analyze the enrichment function, and Homer was employed to identify transcription factor motifs. …”
Get full text