RNA-Seq Identification of Peanut Callus-Specific Promoters and Evaluation of Base-Editing Efficiency by Lulu Xue, Han Liu, Huanhuan Zhao, Pengyu Qu, Xiaona Li, Xiaobo Wang, Bingyan Huang, Ziqi Sun, Suoyi Han, Xiaodong Dai, Wenzhao Dong, Lei Shi, Xinyou Zhang

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Exploring biogeochemical transformation in a hypertrophic lake with dual focus on environmental cues and potential functional fingerprints of littoral bacteria by Milap Dashora, Manish Kumar, Garima Kaushik, Alok Kumar

“…Proteobacteria, Bacteroidota, and Firmicutes were abundant phyla; chemoheterotrophy and fermentation are the dominant potential putative functions; methylotrophy, nitrate reduction, and sulfate reduction are prominent nutrient cycling biogeochemical functions. …”
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Selective metabolic regulations by p53 mutant variants in pancreatic cancer by Sabrina Caporali, Alessio Butera, Alessia Ruzza, Carlotta Zampieri, Marina Bantula’, Sandra Scharsich, Anna-Katerina Ückert, Ivana Celardo, Ian U. Kouzel, Luigi Leanza, Andreas Gruber, Joan Montero, Angelo D’Alessandro, Thomas Brunner, Marcel Leist, Ivano Amelio

“…These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. …”
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Research on carbon compensation zoning guided by major function zones: A case study of the Yangtze River Delta region by Rui Shen, Yinan Yang, Jialong Xu, Li Wang, Yuhang Jiang, Yujing Xie, Yuan Wang

“…This study provides a more equitable framework for cross-regional carbon compensation through fine-scale analysis and functional zone perspectives, offering scientific support for collaborative emission reduction efforts.…”
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Quick pathway for patients with high pRobability of dislocatEd hemiarthroplasty or total hip arthroplasty to minimise the time from hospital aDmission to redUCtion of the prosthesi... by Louise Eggers Rasmussen, Thale Forberg Almas, Peter Joachim Kuhne-Qvist, Rikke Beese Dalby, Peter Biesenbach, Lars Lykke Hermansen

“…The purpose of this study is to design a fast-track pathway for patients with a dislocated hip prosthesis primarily to reduce the time from arrival to reduction and the total hospitalisation time. The secondary aim is to investigate whether quicker prosthesis reduction influences subsequent hip function and quality of life, reduces pain experience immediately and in the long term, and increases patient satisfaction.Methods and analysis This is a prospective observational cohort study, initiated on 1 December 2024 and continuing for 2 years. …”
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NebulaPlate: a droplet microfluidic platform to analyze platelet aggregation by Zheyi Jiang, Meng Wei, Jiawei Zhu, Chenguang Wang, Tiantian Zhang, Wenjie Zhu, Rong Zhang, Kandi Zhang, Peng Zhang, Yihua Lu, Alex Chia Yu Chang, Yifan Liu, Junfeng Zhang

“…In this study, we developed a microdroplet-based platelet function detection method, referred to as NebulaPlate, to achieve miniaturized and robust platelet activity assessment, thereby overcoming current challenges. …”
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Surgical Management of Thumb Carpometacarpal Osteoarthritis: A Systematic Review, Network Meta-analysis, and Longitudinal Analysis of Surgical Complications by Annora Ai-Wei Kumar, BBioMedSc, Matthew Lawson-Smith, MBBCh BAO

“…The outcomes of interest were long-term pain reduction (visual analog scale), complications, and functional improvement (Disabilities of Arm, Shoulder and Hand questionnaire). …”
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Effect of neurohormonal therapeutic in left ventricle global and regional function in Chagas cardiomyopathy in a translational animal experimental model by Denise Mayumi Tanaka, Beatriz de Paula Dias Zara, André Timoteo Sapalo, Arthur Lauand Vargas, José Antonio Marin-Neto, Antônio Carlos Leite de Barros-Filho, Cibele M. Prado Zinni, Keila Cardoso Barbosa Fonseca, Maykon Tavares de Oliveira, João Santana Silva, Felix Jose Alvarez Ramires, Maria de Lourdes Higuchi, Marcus Vinicius Simões, Minna Moreira Dias Romano

“…Echocardiography was performed through evolution and compared to histopathological myocardial analysis. At post-treatment, a significant reduction of LV global systolic function and segmental function was observed between the control group and all Chagas’ groups. …”
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Estimation and diagnostic for single-index partially functional linear regression model with $ p $-order autoregressive skew-normal errors by Lijie Zhou, Liucang Wu, Bin Yang

“…This work bridged significant gaps in functional data analysis by simultaneously addressing dimension reduction, temporal dependence, and distributional asymmetry, which are crucial challenges in modern energy analytics and biomedical studies.…”
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Vortioxetine improves symptomatic and functional outcomes in major depressive disorder: a novel dual outcome measure in depressive disorders by М. С. Christensen, Н. Loft, R. S. McIntyre

“…This analysis evaluated the combined effect of vortioxetine on depressive symptoms and functional capacity in adults with MDD.Methods: NCT01564862, a multinational, double-blind, placebo-controlled, duloxetine-referenced study, con-ducted between April 2012 and February 2014, in 602 adult outpatients (18–65 years) with moderate-tosevere MDD (Montgomery-Asberg Depression Rating Scale (MADRS) ≥ 26), a major depressive episode of ≥ 3 months’ duration, and self-reported cognitive symptoms were randomized to once-daily vortioxetine (10 or 20 mg), duloxetine (60 mg), or placebo for 8 weeks. …”
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Pasteurized <i>Akkermansia muciniphila</i> Ameliorates Preeclampsia in Mice by Enhancing Gut Barrier Integrity, Improving Endothelial Function, and Modulating Gut Metabolic Dysregu... by Linyu Peng, Qinlan Yin, Xinwen Wang, Yawen Zhong, Yu Wang, Wanting Cai, Ruisi Zhou, Ying Chen, Yu Hu, Zhixing Cheng, Wenqian Jiang, Xiaojing Yue, Liping Huang

“…As a postbiotic, pAKK may support existing treatments for preeclampsia by improving gut barrier function, restoring endothelial function, and regulating metabolic dysregulation, offering a safer alternative to live bacteria. …”
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Impact of Chronic Intermittent Hypoxia on Cognitive Function and Hippocampal Neurons in Mice: A Study of Inflammatory and Oxidative Stress Pathways by Zhang K, Ma D, Wu Y, Xu Z

“…Abnormal hippocampal neuron morphology was observed, with a significant reduction in hippocampal neurons (p < 0.05). RNA-seq analysis revealed numerous differentially expressed genes, mainly enriched in biological processes such as inflammation and oxidative stress, as well as multiple signaling pathways. …”
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Spirometric Evaluation among Individuals Working in Stone Chip Crushing Factories: A Cross-sectional Study by Sujoy Mukherjee, Parthasarathy Sinha, Debalina Sengupta, Sanhita Mukherjee

“…Aim: To determine the alterations in pulmonary function status (by spirometry) and evaluate the gender differences in pulmonary mechanics among workers affected by occupational silica dust. …”
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Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment by Fangxu Sun, Huafeng Wang, Jing Wu, Imran H. Quraishi, Yalan Zhang, Maysam Pedram, Benbo Gao, Elizabeth A. Jonas, Viet Nguyen, Sijia Wu, Omar S. Mabrouk, Paymaan Jafar-nejad, Leonard K. Kaczmarek

“…The potassium sodium-activated channel subtype T member 1 (<i>KCNT1</i>) gene encodes the Slack channel K_Na1.1, which is expressed in neurons throughout the brain. Gain-of-function variants in <i>KCNT1</i> are associated with a spectrum of epilepsy syndromes, and mice carrying those variants exhibit a robust phenotype similar to that observed in patients. …”
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Robotic Process Automation-Based Functional Test Automation of High-Speed Analog-to-Digital Converter Customer Evaluation Boards by Ace Dominic Alcid, Glenn Magwili

“…This reduces process complexity for evaluation board functional testing, providing an effective solution to meet the growing demands of electronic components.…”
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Left atrium stress echocardiography: correlation between left atrial volume, function, and B-lines at rest and during stress by Costantina Prota, Lauro Cortigiani, Ettore Campagnano, Karina Wierzbowska-Drabik, Jaroslaw Kasprzak, Paolo Colonna, Elisa Merli, Fiore Manganelli, Nicola Gaibazzi, Antonello D’Andrea, Emma Cerracchio, Laura Meola, Rodolfo Citro, Bruno Villari, Quirino Ciampi

“…Aim: Left atrial volume index (LAVI), left atrial reservoir function through left atrial reservoir strain (LASr), and B-lines in lung ultrasound serve as supplementary indicators of left ventricular filling pressures. …”
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Density Functional Theory-Based Study of UC₂ and Cr-Doped UO₂ by Barbara Szpunar, Jayangani I. Ranasinghe, Jerzy A. Szpunar

“…A density functional theory-based study of UC₂ and Cr-doped UO₂ using the phono3py and VASP computational simulation packages is presented. …”
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Trends in indirect liver function marker testing in Wales from 2000 to 2017 and their association with age and sex: an observational study by Joe West, Joanne R Morling, Trevor Alexander Hill, Colin John Crooks

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Improved immersed boundary/wall modeling method for RANS solver coupled with wall functions: application to Cartesian grid systems by Xueying Yu, David R. Fuhrman, Yanlin Shao

“…For channel flow simulations, our implementation of generalized wall functions using the proposed strategy results in a remarkable reduction of grid nodes by over 80%. …”
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Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger’s disease with mild cognitive impairment by Haiyi Zhang, Lu Zhang, Juan Lu, Jiajun Yue, Zhengzhen Yuan, Jidan Hu, Qi Yao, Yuting Fu, Guiquan Chen, Jiliang Fang, Jie Zhao

“…The multiparameter functional magnetic resonance imaging (fMRI) including amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo), independent component analysis (ICA), and edge-link analysis was utilized to explore the abnormal brain networks of BD-MCI patients. …”
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