Effect and mechanism of sodium butyrate on the activation of Epstein-Barr virus in Epstein-Barr virus-positive gastric cancer cells by TIAN Zhaoxin, CHEN Yuying, LIU Wen

“…Differentially expressed genes (DEGs) were identified between groups A, B, and C, and the top 5 upregula-ted DEGs and the top 5 downregulated DEGs with smaller P values were considered significant DEGs, while RT-qPCR was used to measure the relative expression levels of significant DEGs. The GO functional enrichment analysis and the KEGG pathway enrichment analysis were performed for all DEGs identified, and the proteins enriched in significant pathways (the pathways with P<0.05 in the KEGG pathway enrichment analysis) were considered key pathway proteins, while Western blotting was used to mea-sure the relative expression levels of key pathway proteins in groups A, B, and C. …”
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A novel algorithm for streamlined surgeon-dominated patient-specific implant design in computer-assisted jaw reconstruction by Ankit Nayak, Jane Jingya PU, Xingna YU, Yu-Xiong Su

“…Screw holes are incorporated into the surface model, which is then converted into 3D printable file format. Finite element analysis is conducted to evaluate the functionality of the designed PSI. …”
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Influence of Algal Incorporation on Sensory and Physicochemical Attributes of Caseless Sausage—Ćevap (CSC) by Caba Siladji, Vesna Djordjevic, Branka Borovic, Volker Heinz, Nino Terjung, Nenad Katanic, Igor Tomasevic

“…Furthermore, sea spaghetti and wakame resulted in lower moisture levels and decreased cooking loss, while all algae varieties raised the salt content (<i>p</i> < 0.05) due to their inherent sodium levels. Texture analysis demonstrated that the inclusion of sea spaghetti and <i>Chlorella</i> led to reductions in hardness and chewiness, while wakame resulted in a firmer texture, highlighting its substantial impact on textural attributes. …”
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Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation. by Michael L McHenry, Jason Simmons, Hyejeong Hong, LaShaunda L Malone, Harriet Mayanja-Kizza, William S Bush, W Henry Boom, Thomas R Hawn, Scott M Williams, Catherine M Stein

“…We identified 3 SNPs (P<1.0 x 10-7) including one on chromosome 5, rs1848553, that was GWAS significant (meta-analysis p = 2.97x10-8). All three SNPs are in introns of RGS7BP and have effect sizes corresponding to clinically meaningful reductions in disease severity. …”
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Removal of Chemical Oxygen Demand (COD) from Swine Farm Wastewater by <i>Corynebacterium xerosis</i> H1 by Jingyi Zhang, Meng Liu, Heshi Tian, Lingcong Kong, Wenyan Yang, Lianyu Yang, Yunhang Gao

“…In addition, based on 16S rRNA gene sequencing analysis, SBR_H1 successfully colonized some H1 bacteria and had a higher abundance of functional microbiota than SBR_C. …”
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Rapeseed Green Manure Coupled with Biochar and Vermicompost Enhances Soil Aggregates and Fungal Communities in Gleyed Paddy Fields by Zhenhao Zhu, Shihong Gao, Yuhao Zhang, Guohan Si, Xiangyu Xu, Chenglin Peng, Shujun Zhao, Wei Liu, Qiang Zhu, Mingjian Geng

“…The GMB strategy mitigates reductive stress, enhances nutrient availability, and activates microbial functionality. …”
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Efficacy of a 6-month supported online programme (Feeling Safer) for the treatment of persecutory delusions: protocol for a randomised controlled trial by Richard Emsley, Verity Westgate, Daniel Freeman, Thomas Kabir, José Leal, Anthony Morrison, Kate Chapman, Robert Dudley, Laina Rosebrock, Felicity Waite, Louise Isham, Jason Freeman, Stephanie Common, Alex Kenny, Ariane Beckley, Natalie Rouse, Megan McGovern

“…We will also test whether Feeling Safer works equally across gender, age, ethnicity and cognitive functioning (moderation) and whether Feeling Safer works via the targeted psychological processes (mediation).Methods and analysis The study design is a multicentre, single-blind (outcome assessor), parallel, four-arm randomised controlled trial; 484 patients with persistent persecutory delusions will be randomised to one of the four conditions (1:1:1:1): Feeling Safer (added to treatment as usual (TAU)) supported by peer-support workers, or Feeling Safer (added to TAU) supported by graduate mental health workers including assistant psychologists, or Feeling Safer (added to TAU) supported by CBT therapists or TAU. …”
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Contribution and regulation of Ustilago maydis in carbohydrate metabolism during maize silage fermentation by Luo Chongyu, Ni Chengcheng, Dong Quanmin, Yang Fuyu

“…Furthermore, it revealed the potential interference of this infection with microbial community structure and functional metabolic pathways through metagenomic sequencing. …”
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Variability in Response to Valsartan and Its Relationship With AGT M235T Genotype and Other Nongenetic Parameters Among a Sample of Hypertensive Individuals in Jordan: A Prospectiv... by Hussein Alhawari, Yazun Jarrar, Malek Zihlif, Ayman Wahbeh, Sameeha Alshelleh, Khaled Ojjoh, Dalia Abdelrazaq, Hussam Alhawari

“…The angiotensinogen (AGT) gene variant M235T, a functional genetic variant, influences the renin‐angiotensin system. …”
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Characterization of the salivary microbiome in healthy individuals under fatigue status by Xianhui Peng, Na Han, Yanan Gong, Lihua He, Yanli Xu, Di Xiao, Tingting Zhang, Yujun Qiang, Xiuwen Li, Wen Zhang, Jianzhong Zhang

“…Functional pathway analysis (PICRUSt2) revealed an enrichment of pathways such as "Neuroactive ligand-receptor interaction" in the FTG group, whereas pathways pertinent to energy metabolism (e.g., Citrate cycle (TCA cycle), Oxidative phosphorylation) and amino acid metabolism (e.g., Phenylalanine metabolism, Histidine metabolism) were significantly enriched in the ENG group.ConclusionThis study provides novel evidence that physiological fatigue induces significant structural and functional alterations in the salivary microbiome of healthy individuals. …”
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Conventional Versus Regenerative Methods for Wound Healing: A Comparative Experimental Study on a Sheep Model by Rossella Elia, Michele Maruccia, Pietro Giovanni Di Summa, Rodrigo Trisciuzzi, Giuditta Lovero, Gerardo Cazzato, Luca Lacitignola, Francesco Staffieri, Alberto Maria Crovace

“…Wound healing progression was monitored over 42 days through wound dimension measurements, exudate analysis, and histopathological evaluations. <i>Results</i>: The results indicated that all wounds healed completely by day 42, with significant reductions in wound size and exudate over time. …”
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The Circular Kitchen by Bas Jansen

“…To support the development of circular products, existing LCC techniques were adapted to (1) consider products as composite entities with varying use cycles, (2) include post-use processes, (3) offer practical information to stakeholders, and align functional units and system boundaries with life cycle analysis (LCA). …”
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Does weightbearing status impact mortality and other complications in hip fracture patients when accounting for frailty? by Makoa Mau, Tyler Thorne, Kai Rossbach, Eleanor H. Sato, Chong Zhang, Angela P. Presson, Justin M. Haller

“…Logistic regressions and receiver operating characteristic (ROC) curve analysis were conducted to determine the frailty measure which best predicts 30-day mortality among American Society of Anesthesiologists grade (ASA), five-factor modified Fraility Index (mFI-5), and Risk Analysis Index Recalibrated Version (RAI-Rev). …”
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Family Intervention Models for Young Adults with Substance Abuse: A Systematic Review by Kodikuthiyel Vijayan Binumon, Sinu Ezhumalai, Navaneetham Janardhana, Prabhat Kumar Chand

“…Specifically, family interventions were associated with significant reductions in behavioural problems and improvements in family functioning.…”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…The primary outcome in the economic analysis was incremental cost per QALY gained. The analysis was conducted on an intention-to-treat basis, with missing data imputed and costs reported in 2022 UK pounds. …”
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The use of modern military technologies in the light of the law of weapons and the law of targeting by Behzad Seyfi

“…The stability of rights over time and the continuity of their application are among the basic features that are necessary for the functioning of an organized human society. A look at the historical background of international law confirms the fact that with the entry of certain technologies into the field of the international community, a great effort has been made to regularize their use. …”
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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…Previous studies have highlighted the economic and environmental benefits of unmanned ships, such as cost reduction, increased efficiency, and decreased emissions. …”
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Current Advancements of and Future Developments for Fourth Party Logistics in a Digital Future by Hans-Joachim Schramm, Carolin Nicole Czaja, Michael Dittrich, Matthias Mentschel

“…Moreover, relationships between 4PL providers and their clients become closer and more strategic, which leads to a customer valuing not only direct cost reductions but rather improvements resulting from optimized operations through superior analysis and planning functions.…”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Treatment with insulin is aimed at replicating the function of the pancreas to manage hyperglycaemia and avoid hypoglycaemia. …”
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PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits by Lindsay J. Walsh, Izabella M. Espinal-San Miguel, Ana V. Rodriguez, Ursula M. Peña, Kiley E. Flynn, Will C. Remillard, Siena R. Brazier, Natalia I. Anderson, Aidan J. Clark, Tiffany A. De Varona, Ileana Soto

“…We found that Pten loss disrupts dendritic growth by altering mTOR signaling and reducing AMPK phosphorylation, leading to early motor deficits and sex-specific behavioral alterations. In vivo analysis revealed significant reductions in mitochondrial and lysosomal volume in developing dendrites. …”
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