Platelet Membrane-Coated Poly (Lactic-Co-Glycolic Acid) Nanoparticles as a Targeting Drug Delivery System for Multidrug-Resistant Breast Cancer by Song B, Na YG, Kim BJ, Jin M, Song YH, Kim DE, Hwang S, Baek JS, Lee HK, Cho CW

“…To overcome these challenges, we developed a triple-functionalized nanocarrier system incorporating poly(lactide-co-glycolide) (PLGA)-based nanoparticles (PNs), D-α-tocopheryl polyethylene glycol succinate (TPGS) for P-gp inhibition, and platelet membrane (PM) coating for targeted tumor delivery.Methods: The PM-coated TPGS-modified PNs with PTX (PTPNs) was characterized by particle size analysis, transmission electron microscopy (TEM), and protein assay to confirm PM coating. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…UL16-binding protein 2 (ULBP2), always expressed or elevated on cancer cells, functions as a key NKG2D ligand. ULBP2-NKG2D ligation initiates NK cell activation and subsequent targeted elimination of cancer cells. …”
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Soil health indicators, farmer concepts and carbon market standards in agroforestation of underutilized lands in West Sumatra (Indonesia) by Kurniatun Hairiah, Paul Burgers, Ai Farida, Irma Ardi Kusumawati, Mila Oktavia Mardiani, Danny Dwi Saputra, Rika Ratna Sari, Leony Siska Aldini, Nandha Ardiansyah, Arega Dwi Putra, Avi Qurvanda Putri Pradani, Rizki Maulana Ishaq, Meine van Noordwijk

“…The initial decline in measured ‘functions’ (including a 50 % reduction in microbial biomass N on Andisols in the first two years after conversion), a surprise in dominant restoration’ discourse, indicates a transition between two plant-soil interaction systems.…”
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Knockdown of lncRNA XR_877193.1 suppresses ferroptosis and promotes osteogenic differentiation via the PI3K/AKT signaling pathway in SONFH by Yang Huixia, Ding Ning, Qing Shi, Hao Yinju, Zhao Cilin, Wu Kai, Li Guizhong, Zhang Huiping, Ma Shengchao, Bai Zhigang, Jiang Yideng

“…Furthermore, RNA-seq analysis reveals that the long noncoding RNA (lncRNA) XR_877193.1is significantly upregulated in Dex-treated MC3T3-E1 cells. …”
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Recombinant purified buffalo leukemia inhibitory factor plays an inhibitory role in cell growth. by Syed Azmal Ali, Dhruba Malakar, Jai Kumar Kaushik, Ashok Kumar Mohanty, Sudarshan Kumar

“…Additionally, the treatment of MECs (BuMEC and EpH4) displayed significant (P < 0.05) reduction in growth progression, as confirmed by qRT-PCR analysis, suggesting its strong involvement in the involution of the mammary gland in vivo. …”
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EBV-Derived miR-BART20-3p Influences Proliferation and Migration in EBV-Positive Gastric Cancer Models by Suppressing PPARα by Qiong Wu, Guiying Ye, Xiazhen Xu, Xianchang Zeng, Biyun Wu, Fan Xin, Lu Zhang, Xu Lin, Xinjian Lin, Wannan Chen

“…Epstein–Barr virus (EBV) is the first oncogenic DNA virus known to encode microRNAs (miRNAs) and has been implicated in the pathogenesis of multiple malignancies, including a distinct subset of gastric cancers (EBV-associated gastric cancer, EBVaGC). However, the functional roles of individual EBV-encoded miRNAs in EBVaGC remain poorly defined. …”
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Optimization of antibacterial and antifungal activities in Moroccan saffron by-products using mixture design and simplex centroid methodology by Abdellah Baraich, Amine Elbouzidi, Naoufal El Hachlafi, Mohamed Taibi, Mounir Haddou, Sanae Baddaoui, Reda Bellaouchi, Mohamed Addi, Redouane Benabbes, Abdeslam Asehraou, Bassem Jaouadi, Ammar AL-Farga, Saleh M. Al-Maaqar, Ennouamane Saalaoui

“…These findings highlight saffron by-products as highly effective and sustainable natural antimicrobials, providing a cost-efficient (40–60% reduction compared to conventional extracts) and multi-functional alternative to synthetic preservatives. …”
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PPARGC1A regulates transcriptional control of mitochondrial biogenesis in early bovine embryos by Muhammad Idrees, Muhammad Idrees, Zaheer Haider, Chalani Dilshani Perera, Safeer Ullah, Seo-Hyeon Lee, Seung Eun Lee, Sung-Sik Kang, Sung Woo Kim, Il-Keun Kong, Il-Keun Kong, Il-Keun Kong

“…Reduction in NRF1 protein’s nuclear localization in bovine blastomeres was also observed in PGC-1α-KD embryos. …”
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Validation of Strategic Memory Advanced Reasoning Training as an efficient and effective approach to treating warfighters with persistent cognitive complaints associated with mild... by Andrew J. Darr, Andrew J. Darr, Andrew J. Darr, Angela Basham, Angela Basham, Angela Basham, Jessica L. Ryan, Melissa Caswell, Melissa Caswell, Melissa Caswell, Juan Lopez, Juan Lopez, Juan Lopez, Jennifer Zientz, Erin Venza, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Chapman, Jason M. Bailie, Jason M. Bailie, Jason M. Bailie

“…Additionally, treatment improved patient perceived functionality (KBCI) from T1 to T2 and these gains remained stable at T3 (p &lt; 0.001, ηp2 = 0.377). …”
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Radionuclide diagnostics in St. Petersburg: сurrent status and development challenges by I. A. Zvonova, L. A. Chipiga, M. I. Balonov, V. Ju. Suhov

“…Over 10 years the radiodiagnostics structure has changed towards increased number of scintigraphic studies and reduction of “functional” (radiometric) procedures which reflects the changes in the equipment of the radionuclide diagnostics units, the replacement of the old equipment by new SPECT.         …”
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Photosynthetic response of Solidago gigantea Aition and Calamagrostis epigejos L. (Roth) to complex environmental stress on heavy metal contaminated sites by Wojciech Bąba, Agnieszka Kompała-Bąba, Edyta Sierka, Wojciech Bierza

“…Abstract Studies of in situ plant response and adaptation to complex environmental stresses, are crucial for understanding the mechanisms of formation and functioning of ecosystems of anthropogenically transformed habitats. …”
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Multicentre comparison of various microaxial pump devices as a bridge to durable assist device implantation by Marta L. Medina, Daniel Lewin, Hendrik Treede, Sebastian V. Rojas, Alexander Bernhardt, Michael Billion, Anna L. Meyer, Ivan Netuka, Janajade Kooij, Marina Pieri, Antonio Loforte, Mauro Rinaldi, Mariusz K. Szymanski, Adriaan O. Kraajieveld, Christian J.H. Moeller, Payam Akhyari, Khalil Jawad, Bastian Schmack, Gloria Färber, Assad Haneya, Daniel Zimpfer, Gaik Nersesian, Ilija Djordjevic, Diyar Saeed, Finn Gustafsson, Anna M. Scandroglio, Bart Meyns, Steffen Hofmann, Jan Belohlavek, Jan Gummert, Pia Lanmueller, Evgenij V. Potapov, Mehmet Oezkur

“…Abstract Aims Patients with acute decompensated advanced heart failure requiring left ventricular assist device (LVAD) implantation often experience progressive cardiac function deterioration, negatively impacting surgical outcomes. …”
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Good Governance and Seigniorage in a Selected OPEC Countries and Iran by ALI Rashid Shamkhal, Kambiz Paykarjou, beitollah Akbari Moghaddam

“…Therefore, based on the results obtained from the analysis of responce functions in empirical analysis, it is essential to pay attention to changing and improving the methods of governance and administration of the country. …”
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Development mechanism and practical significance of deep coalbed methane (coal rock gas) infiltration and displacement by Lihong ZHOU, Xia YAN, Hongtao LIU, Xianyue XIONG, Feng WANG, Shuguang LI, Jiyuan ZHANG, Chuanqing LIU, Xiong HU, Pu YUAN, Qianli MA, Xueguang ZHU

“…Key findings include:Hydrophilic characteristics: Mineralogical analysis, high-temperature/high-pressure (HTHP) wettability experiments, and macromolecular modeling revealed that deep coal exhibits macroscale hydrophilicity and microscale strong hydrophilicity due to hydrophilic clay mineral filling and oxygen-containing functional groups. …”
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Structural Characterization and Hypolipidemic Activity of Highland Barley Polysaccharide-Polyphenol Complexes by Zibin GUO, Yang YANG, Bei FAN, Litao TONG, Yatao HUANG, Lili WANG, Ting ZHANG, Liya LIU, Peipei SUN, Jing SUN, Fengzhong WANG

“…The structural characteristics and potential to regulate lipid metabolism of HVP provide new insights into its application in functional foods.…”
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Efficient removal of cadmium (II) and arsenic (III) from water by nano-zero-valent iron modified biochar-zeolite composite by Mengyuan Wu, Lijuan Wu, Wen Zhang, Xianbao Zhong, Runfeng Guo, Ziying Cui, Yajun Yang, Jialong Lv

“…For the removal of Cd(II) and As(III) from water, this study synthesized a nano-zero-valent iron-loaded biochar-zeolite composite material (nZVI-BCZo) using a liquid-phase reduction method, with biochar, zeolite, and FeSO₄·7H₂O as precursors. …”
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Mobilization with movement plus exercise versus exercise alone for patients with central sensitization associated with chronic subacromial pain syndrome: a sham-controlled randomiz... by Volkan Deniz, Bayram Kelle

“…The CSI was used to assess emotional and somatic symptoms associated with central sensitization; PPTs evaluated local and widespread pain hypersensitivity; and the Q-DASH assessed upper extremity physical function and symptoms. A two-factor repeated-measures analysis of variance (group × time) with Bonferroni post-hoc correction was performed to analyze the main outcome variables. …”
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Phytochemical Profiling of Processed Açaí Pulp (<i>Euterpe oleracea</i>) Through Mass Spectrometry and Its Protective Effects Against Oxidative Stress in Cardiomyocytes and Rats by Jefferson Romáryo Duarte da Luz, Eder Alves Barbosa, Rubiamara Mauricio de Sousa, Maria Lúcia de Azevedo Oliveira, Marcela Fabiani Silva Dias, Ingrid Reale Alves, Gisele Custódio de Souza, Elenilze Figueiredo Batista Ferreira, Carla Guzmán-Pincheira, Maria das Graças Almeida, Gabriel Araujo-Silva

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Assessing the Impact of the Prostate Cancer Patient Empowerment Program (PC-PEP) on Relationship Satisfaction, Quality of Life, and Support Group Participation: A Randomized Clinic... by Cory Burgher, Gabriela Ilie, Ross Mason, Ricardo Rendon, Andrea Kokorovic, Greg Bailly, Nikhilesh Patil, David Bowes, Derek Wilke, Cody MacDonald, Markos Tsirigotis, Calvin Butler, David Bell, Jesse Spooner, Robert David Harold Rutledge

“…The intervention included daily emails with video instructions on mental and physical health, diet, social support, fitness, stress reduction, and intimacy. Outcomes were assessed using the Dyadic Adjustment Scale (DAS) and the Functional Assessment of Cancer Therapy–Prostate (FACT-P). …”
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Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry by Tai Hwan Park, Keun‐Sik Hong, Yong‐Jin Cho, Wi‐Sun Ryu, Dong‐Eog Kim, Man‐Seok Park, Kang‐Ho Choi, Joon‐Tae Kim, Jihoon Kang, Beom‐Joon Kim, Moon‐Ku Han, Jun Lee, Jae‐Kwan Cha, Dae‐Hyun Kim, Jae Guk Kim, Soo Joo Lee, Jee‐Hyun Kwon, Wook‐Joo Kim, Dong‐Ick Shin, Kyu Sun Yum, Sung Il Sohn, Jeong‐Ho Hong, Jay Chol Choi, Byung‐Chul Lee, Kyung‐Ho Yu, Mi‐Sun Oh, Jong‐Moo Park, Kyusik Kang, Kyungbok Lee, Sang‐Hwa Lee, Hae‐Bong Jeong, Kwang‐Yeol Park, Ji Sung Lee, Juneyoung Lee, Philip B. Gorelick, Hee‐Joon Bae

“…Background This study aims to evaluate temporal trends of advanced treatments and related clinical outcomes of ischemic stroke through a decade‐long trend analysis, using data from a comprehensive, national, multicenter registry. …”
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