Investigation of the astringency-masking effect of ι-carrageenan on natural polyphenols and its differential mechanism at various concentrations by Qiang Yu, Yifan Zhang, Jun Liu, Xue Han, Mengqi Li, Junzhi Lin, Taigang Mo, Li Han, Haozhou Huang, Dingkun Zhang

“…These findings highlight the potential of CA in the development of low astringency functional foods, providing the food industry with a new strategy for masking astringency.…”
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Big Data Analytics for Uncovering Voxel Connectivity Patterns in Attention Deficit Hyperactivity Disorder by Caraka RE, Supardi K, Gio PU, Isnaniawardhani V, Chen RC, Djatmiko B, Pardamean B

“…Feature selection was performed using Boruta, Random Forest in combination with DALEX explainability tools, and Neural Networks. Dimensionality reduction and clustering techniques including Principal Component Analysis (PCA), KMeans, and MCLUST were used to explore underlying voxel patterns. …”
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The protective role of 3-Indoleglyoxylic acid in Bisphenol S-induced intestinal barrier dysfunction via mitochondrial ROS-Mediated IL-17/CXCL10/TNF-α signaling by Jing Wang, Guolei Niu, Huanzhuo Mai, Xianan Zhang, Jiahao Zhu, Bin Li, Yushuang Gao, Tengkai Huang, Qingtao Meng, Rui Chen

“…Using a DSS-induced colitis mouse model, it was found that BPS exposure exacerbates the progression of intestinal inflammatory diseases. Analysis of single-cell databases demonstrated a significant reduction in the expression of CHGA, a functional protein of enteroendocrine cells (EECs), in patients with inflammatory bowel disease (IBD). …”
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Monosaccharide coating modulate the intracellular trafficking of gold nanoparticles in dendritic cellsKey findings by Meshal A. Alobaid, Sarah-Jane Richards, Morgan R. Alexander, Matthew I. Gibson, Amir M. Ghaemmaghami

“…Gold nanoparticles (AuNPs) have garnered interest as a platform for targeted drug delivery due to their biocompatibility, low toxicity and precise control over size, morphology and surface functionalization. Our investigation aimed to elucidate the intracellular uptake and trafficking of AuNPs coated with different combinations of monosaccharides (mannose, galactose, and fucose) in DCs. …”
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CCR7+ selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo by Gray Kueberuwa, Hannah Gornall, Erik Marcelo Alcantar-Orozco, Deborah Bouvier, Zainul Abedin Kapacee, Robert Edward Hawkins, David Edward Gilham

“…This was validated through analysis of an array of surface markers and an observed reduction in effector cell functions ex vivo. …”
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Changes in the intestinal microbiota induced by the postnatal environment and their association with hypertension by Patrizia Dardi, Camille Perella Coutinho, Sarah de Oliveira, Simone Aparecida Teixeira, Renaide Rodrigues Ferreira Gacek, Eduardo Purgatto, Marco Aurélio Ramirez Vinolo, Marcelo Nicolás Muscará, Luciana Venturini Rossoni

“…The SW group had fewer significant genera identified at the Partial Least Squares Discriminant Analysis (PLS-DA), despite resembling the genera profile identified in the normotensive group. …”
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Exploring the Potential of a New Nickel(II):Phenanthroline Complex with L-isoleucine as an Antitumor Agent: Design, Crystal Structure, Spectroscopic Characterization, and Theoretic... by Jayson C. dos Santos, João G. de Oliveira Neto, Ana B. N. Moreira, Luzeli M. da Silva, Alejandro P. Ayala, Mateus R. Lage, Rossano Lang, Francisco F. de Sousa, Fernando Mendes, Adenilson O. dos Santos

“…Density functional theory (DFT) calculations, including solvation effects (in water and methanol), demonstrated strong agreement with the experimental geometric parameters and revealed higher affinity to the water solvent. …”
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CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages by Yisong Qian, Chuqiao Chen, Leliang Ma, Ziwei Wang, Ling-Fang Wang, Li Zuo, Yaqin Yang, Xiang Huang, Meixiu Jiang, Xiaolei Wang, Huidong Shi, Mingui Fu, Ke-Yu Deng, Hong-Bo Xin

“…CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. …”
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A Fungi-Driven Sustainable Circular Model Restores Saline Coastal Soils and Boosts Farm Returns by Fei Bian, Yonghui Wang, Haixia Ren, Luzhang Wan, Huidong Guo, Yuxue Jia, Xia Liu, Fanhua Ning, Guojun Shi, Pengfei Ren

“…The available phosphorus and potassium contents increased several-fold compared to untreated soil. Metagenomic analysis showed the enrichment of beneficial decomposer bacteria (<i>Hyphomicrobiales</i>, <i>Burkholderiales</i>, and <i>Streptomyces</i>) and functional genes involved in glyoxylate metabolism, nitrogen cycling, and lignocellulose degradation. …”
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The Physical Activity in the Management of Heart Failure with Reduced Ejection Fraction A Review of Current Evidence and Recommendations by Natalia Smyl, Mateusz Teofilak, Olga Śpiołek, Jan Siwiec, Aleksandra Słowikowska, Julia Szatkowska, Marcelina Paula Sztyler-Krąkowska, Agnieszka Alicja Wąsowicz, Franciszek Kędziora, Dariusz Paweł Fabian

“…The review included studies evaluating exercise interventions in HFrEF populations, focusing on clinical outcomes, safety considerations, and recommendations from leading cardiology societies. The analysis confirms that dynamic aerobic training, resistance training, and inspiratory muscle training for breathing and pulmonary rehabilitation constitute the most effective exercise strategies for HFrEF patients and their impact on exercise ability and functional quality of life is substantial. …”
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Amplification of Higher-Order Salivary Gland Volume Effects from External Beam Radiotherapy in Normal Tissue Complication Probability Modeling of Radiopharmaceutical Therapy by Chunming Gu, Robert F. Hobbs, Ana P. Kiess, Junghoon Lee, Todd McNutt, Harry Quon, Zhuoyao Xin, Tahir I. Yusufaly

“…Salivary glands are common organs at risk in both head and neck external beam radiotherapy (EBRT) and radiopharmaceutical therapy (RPT), but incidences of xerostomia in RPT are inconsistent with the EBRT Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) limits. …”
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Eco-friendly fabrication of ZnO-TiO2-rGO nanocomposite for efficient adsorption-assisted organic dyes elimination by Md Elias, Ehsanur Rahman, Sonia Akter, Mohammad Awlad Hossain, Rumana A. Jahan, Md Nizam Uddin, Shakhawat H. Firoz

“…X-ray Diffraction Spectroscopy (XRD), Field Emission Scanning Electron Microscope (FESEM), UV–visible spectroscopy (UV–vis), and Fourier Transform Infrared Spectroscopy (FTIR) were employed to characterize structural, morphological and optical properties as well as surface functional groups of the synthesized products. The XRD measurements of our synthesized samples confirm both structural crystallinity and phase purity, while the FTIR analysis verifies the complete reduction of graphene oxide (GO) to reduced graphene oxide (rGO). …”
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Cochlear and Bone Conduction Implants in Asymmetric Hearing Loss and Single-Sided Deafness: Effects on Localization, Speech in Noise, and Quality of Life by Oana Astefanei, Cristian Martu, Sebastian Cozma, Luminita Radulescu

“…Tinnitus severity, measured on a 10-point VAS scale, decreased significantly in CI users (mean reduction: 2.8 ± 2.0, <i>p</i> < 0.001), while changes in BCI users were small and of limited clinical relevance. …”
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PERCEIVED WAYS OF DIAGNOSTIC HELP OPTIMISATION TO PATIENTS WITH SYMPTOMATIC EPILEPSY ON CHRONIC HERPESVIRUS ENCEPHALITIS by N. A. Shnayder, N. I. Kamzalakova, S. V. Krijanovskaya, Yu. S. Panina

“…This indicates a highly probable functional deficiency of B-lymphocytes and is manifested in the reduction antiteloproduktsii that promotes slow accumulation of specific antibodies, chronic process, an increase in viral load and associated complications. …”
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Upregulation of 15-Hydroxyprostaglandin Dehydrogenase by Celecoxib to Reduce Pain After Laparoendoscopic Single-Site Surgery (POPCORN Trial): A Randomized Controlled Trial by Kyung Hee Han, Sunwoo Park, Seungmee Lee, Jiyeon Ham, Whasun Lim, Gwonhwa Song, Hee Seung Kim

“…These exploratory findings warrant confirmation in larger trials with functional validation of HPGD expression (ClinicalTrials.gov, NCT03391570).…”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…Additionally, M0 macrophages displayed a reduction in immunosuppressive signaling.Conclusion: The QDs-Ce6 nanocomplex exhibits robust photodynamic cytotoxicity and immunomodulatory potential. …”
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Research progress and prospects on resource utilization of coal gangue for soil remediation in China by Chengyong LIU, Wenzhe GU, Feng CUI, Yun ZHANG, Yanbin YANG, Fengqi QIU, Chaofeng YUAN, Haixing CHENG, Ming LI

“…Against this background, the ecological restoration and resource utilization of coal gangue is not only crucial for advancing a circular economy but also essential for achieving pollution reduction and carbon emission goals. Based on the analysis of the feasibility of coal gangue solid waste soil utilization, methods and technologies for the polymorphic separation of valuable and harmful components, and technical pathways for coal gangue soil utilization, the basic progress in the resource utilization of coal gangue solid waste by coal enterprises has been summarized. …”
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Effect of Static Balance Ability on Dual-Task Costs Under Different Walking TaskInterventions in Chinese Older Adults by WANG Chenglong, NIE Mingjian, XIAO Chenhui, WU Yini, WANG Jingjing

“…These findings highlight the importance of balance capacity in preserving functional mobility during daily multitasking activities.…”
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<i>Bacillus tropicus</i> YJ33 and <i>Medicago sativa</i> L. Synergistically Enhance Soil Aggregate Stability in Saline–Alkali Environments by Jingjing Li, Yajuan Che, Shiyang Chen, Mengge Liu, Mengmeng Diao, Chao Yang, Wenke Jia

“…Soil salinization represents a significant global environmental challenge, necessitating the urgent amelioration of saline–alkali lands. As a critical functional component of the soil system, soil aggregates play a pivotal role in enhancing soil structure and are essential for nutrient cycling and plant growth. …”
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Comparison of the effect of ranibizumab in retinal vein occlusion and macular edema with different optical coherence tomographic patterns by Yue Xu, Yue-Cong Yin, Ze-Yu Song, Xiao-Yu Zhou, Jia-Ju Zhang, Juan Liang

“…AIM: To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab (IVR) in treating macular edema (ME) secondary to retinal vein occlusion (RVO). …”
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