Fimsbactin Siderophores From a South African Marine Sponge Symbiont, Marinomonas sp. PE14‐40 by Nompumelelo Philile Praiseworth Ikegwuoha, Thea Hanekom, Elzaan Booysen, Corbyn Jason, Shirley Parker‐Nance, Michael T. Davies‐Coleman, Leonardo Joaquim vanZyl, Marla Trindade

“…The study demonstrates functional conservation in seemingly disparate biosynthetic pathways and enzyme promiscuity's role in producing structurally diverse compounds.…”
Get full text

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein by Gang Zhao, Yajuan Li, Mengyuan Liu, Mengyuan Liu, Wei Chang, Hui Shen, Junhui Xue, Junhui Xue, Junhui Xue, Fengzhou Liu, Fengzhou Liu

“…Pharmacokinetic analysis revealed a reduction in pitolisant concentration in the brain under HH conditions. …”
Get full text

Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma by Shencheng Ren, Junkan Zhu, Guangyao Shan, Jiaqi Liang, Yunyi Bian, Han Lin, Haochun Shi, Binyang Pan, Guangyin Zhao, Huiqin Yang, Xiaolong Huang, Cheng Zhan, Di Ge, Guoshu Bi

“…Functional studies were performed using cell lines, organoids, and xenograft models to assess the role of ZNF266 in LUAD progression. …”
Get full text

The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress by Kunbin Li, Liming Lu, Xianli Yao, Zhiyuan Wu, Pingge Sun, Xiaopeng Wen, Xiaoxing Li, Kai Wang, Xiran Yin

“…Mechanistically, NFATC2 could activate Nrf2 transcription and promote its expression. Nrf2 reduction exerted a counteracting impact on NFATC2's anti-inflammation, anti-apoptosis and anti-oxidative stress functions in PC12 cells under OGD/R conditions. …”
Get full text

RNA binding protein HuR regulated by OIP5-AS1 may be involved in maternal transcript degradation during the human maternal-to-zygotic transition by Yan-na Liu, Ke-Yi Li, Hao Wei, Wen-xiu Li, Yue-hua Zhang, Jia-jun Qiu, Fanyi Zeng, Jing-bin Yan

“…Moreover, RNA immunoprecipitation sequencing in human induced pluripotent stem cells (iPSCs) revealed HuR and OIP5-AS1 are likely to tightly bind together and involved in functions related to the cell cycle and transcriptional regulation. …”
Get full text

Neuroprotective properties of GABA and its derivatives in diabetic encephalopathy in old animals by I. N. Tyurenkov, D. A. Bakulin, A. V. Smirnov, M. R. Ekova, A. I. Bisinbekova, G. L. Snigur, Yu. I. Velikorodnaya, E. I. Morkovin, D. V. Verkholyak, O. S. Vasilyeva

“…After the treatment, an oral glucose tolerance test and a set of behavioral tests aimed at studying sensory-motor (Open Field, Adhesion test, Rotarod) and cognitive functions (New Object Recognition and Morris Water Maze), as well as the functional state evaluation of the endothelium were performed. …”
Get full text

Formation of a comprehensive rehabilitation program for patients considering the clinical and diagnostic features of the course of vertebral thoracic pain due to degenerative-dystr... by Ye. I. Maramukha

“…All patients had a functional block of the 2nd degree in the thoracic spine. …”
Get full text

Effectiveness of a Virtual Reality Serious Video Game (The Secret Trail of Moon) for Emotional Regulation in Children With Attention-Deficit/Hyperactivity Disorder: Randomized Clin... by Marina Martin-Moratinos, Marcos Bella-Fernández, María Rodrigo-Yanguas, Carlos González-Tardón, Chao Li, Ping Wang, Ana Royuela, Pilar Lopez-Garcia, Hilario Blasco-Fontecilla

“…The primary hypothesis, a 3- or 4-point reduction in the global Strengths and Difficulties Questionnaire score, was not met. …”
Get full text

NEW DIRECTION IN LOCAL THERAPY OF OSTEOARTHRITIS OF THE KNEE JOINT by Ye. S. Tsvetkova, L. N. Denisov

“…Due to the therapy, morning stiffness was evidently decreased and functional activity was increased in the main group. …”
Get full text

Reparative effects of paricalcitol and calcitriol in patients with cardiorenal syndrome and chronic allograft nephropathy by A. N. Kharlamov, A. N. Perrish, Ya. L. Gabinskyi, Kh. Ronne, E. Yu. Ivanova

“…A decrease in the chronic heart failure functional class (NYHA classification) was also observed. …”
Get full text

Dynamics of cellular immunity indicators in the complex treatment of acute optic neuritis by D. A. Storozhilova, O. V. Kolenko, L. P. Danilova, L. P. Emanova, I. V. Vasilieva

“…The course of treatment lasted 10 days. The analysis of the data showed a more significant positive dynamics of cellular immunity parameters in those who received immunotherapy. …”
Get full text

Gold(III) Complexes with 2-(1-Ethylbenzyl)pyridine as Promising Antimicrobial and Antitumor Agents by Antonio Zucca, Bruna Canu, Maria I. Pilo, Sergio Stoccoro, Giacomo Senzacqua, Sara Fais, Giuseppina Pichiri, Alessandra Scano

“…Metal ions in biological systems can essentially have two roles: structural or functional. In the former, the metal ion serves to stabilize structures, especially proteins, while in the latter, the metal is involved in bio-site reactivity (essentially in metallo-enzymes). …”
Get full text

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker

“…Thus, our findings indicate that the TRPV5 S682P mutant is functionally significant and study of HCALC1, a novel model for autosomal dominant hypercalciuria, may help further our understanding of renal calcium reabsorption and hypercalciuria.…”
Get full text

Formation of statistical indicators system to create objects of the primary real estate market by D. V. Dianov

“…However, only the statistics of the primary market and the characteristics of the creation of new facilities can show the participation of the population in the financing of the growth of national wealth, that part of it, which is determined by the international methodology, as the accumulated property created by the work of current and previous generations.It should be noted that the statistical analysis of the primary real estate market and the complex processes of creating objects that turn on it, is associated with a certain Russian paradox: a large-scale information attack, which is subjected to the domestic society, says about the reduction in recent years the standard of living of the population on various parameters, including the range and quantity of food consumption; at the same time, the volume of the area entered and realized in the primary real estate market, exactly, as well as the prices for it, grow uncontrollably that indicates inexhaustible solvent demand of the population for the acquired objects of long-term use.Results. …”
Get full text

Proteomic profiling of cotton fiber developmental transition from cell elongation to secondary wall deposition by Zhou Xiaoyun, Hu Wenran, Li Bo, Yang Yang, Zhang Yong, Thow Kieran, Fan Ling, Qu Yanying

“…Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotton species, Gossypium hirsutum (Gh) and G. barbadense (Gb). …”
Get full text

Features of the dynamics of serum C-reactive protein and IL-6 concentrations in case of experimental carrageenan-induced inflammation of temporomandibular joints by D.O. Kovalchuk, N.M. Savielieva, A.Yu. Nikonov, N.M. Breslavets

“…The temporomandibular joint is a complex anatomical and functional structure, consisting of the mandibular condyle, mandibular fossa, articular tubercle of the temporal bone, intra-articular disc, and joint capsule. …”
Get full text

Up-regulation of miR-338-3p alleviatesIL-13-induced injury of human bronchial cell line BEAS-2B by FU Haiwei, GUO Weiwei, SHENG Fen, LIU Donghong

“…The targeting relationship between miR-338-3p and Ras homologous (Rho) was investigated using bioinformatics analysis, luciferase assay, Western blot, and functional repair assay. …”
Get full text

A novel technique for posterior internal fixation of acetabular fractures by Ming Li, Jingwei Xiao, Dian Wang, Fangzhu Xu

“…Methods A retrospective analysis of 155 patients with complete follow-up data from December 2014 to December 2020 was conducted. …”
Get full text

Effects of multisystem exercises on balance, postural stability, mobility, walking speed, and pain in patients with diabetic peripheral neuropathy: a randomized controlled trial by Sidra Khurshid, Aruba Saeed, Muhammad Kashif, Aniqa Nasreen, Huma Riaz

“…The outcome measures used for assessing the balance, postural stability, mobility, and pain included the Berg balance scale (BBS), functional reach test (FRT), time up and go test (TUG), 10 min walk test (10-MWT), and numeric pain rating scale (NPRS). …”
Get full text

Modificação das propriedades das fibras de curauá por acetilação Modification of the properties of curauá fibers by acetylation by Fernanda F. M. Lopes, Gilmar T. Araújo, Saionara Luna, José W. B. do Nascimento, Valneide R. da Silva

“…The resistance of plant fiber to alkali attack can be improved by chemical surface treatments such as acetylation that can reduce the hygroscopic nature of lignocellulosic introducing hydrophobic functional groups in its chemical structure. Thus, the aim of this study was the application of the acetylation treatment at different levels to improve the durability of the fibers.The acetylation treatment in curauá fiber was applied at different temperatures and reaction times, and its efficiency, considering the reduction of hydrophilicity and maintenance of the physical-mechanical performance of fibers was evaluated by water absorption, mechanical resistance, infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis and diffraction of x-rays. …”
Get full text