DNA aptamer AptERA 2 targets ERA from Staphylococcus aureus and limits GTP hydrolysis by Katherin Peñaranda, Nicolle Pereira, Orestis Savva, Dezemona Petrelli, Roberto Spurio, Rebecca M. Corrigan, Pohl Milon

“…Abstract Ribosome assembly is a multistep process that ensures a functional ribosome structure. The molecular mechanism that ribosome­associated GTPases (RA­GTPases) use to enhance ribosome assembly accuracy remains largely to be elucidated. …”
Get full text

Mechanistic insights into nitrogen removal performance and electron competition with mixed electron donor supply in a biofilm electrode reactor by Xin Yuan, Chunfang Chao, Jiaojiao Niu, Jinxin Song, Yiwen Liu, Siyuan Zhai, Yingxin Zhao

“…Notably, nitrite reductase (Nir) emerged as the weakest competitor, resulting in a constrained NO2- reduction capacity. Based on the analysis of the electron competition characteristic, the potential NO3- metabolic pathway in the BER system was primarily driven by heterotrophic denitrification processes. …”
Get full text

Metabolic Variations in Bamboo Shoot Boiled Liquid During <i>Pediococcus pentosaceus</i> B49 Fermentation by Juqing Huang, Meng Sun, Xuefang Guan, Lingyue Zhong, Jie Li, Qi Wang, Shizhong Zhang

“…These findings elucidate metabolic regulation in BSBL fermentation, supporting development of functional fermented bamboo products.…”
Get full text

Structural connectome manifold changes related to body mass index and their associations with eating psychopathology by Yurim Jang, Jong Young Namgung, Eunchan Noh, Bo-yong Park

“…Brain connectome analysis provides insights into body mass index (BMI)-related brain topology and cognitive functions. …”
Get full text

Impact of Race and Social Determinants on Operative Management of Distal Radius Fractures in Medicare Patients by Nicole J. Newman-Hung, MD, Amil R. Agarwal, BA, Ambika E. Paulson, MD, Uma Srikumaran, MD, MBA, MPH, Dawn Laporte, MD, Lauren E. Wessel, MD

“…Operative fixation of distal radius fractures (DRFs) in high-demand patients may provide functional benefit, particularly in the setting of significant displacement. …”
Get full text

Green and facile synthesis of silver nanoparticles (Ag NPs) using Rhamnus prinoides (Gesho) leaf extract for antibacterial, antioxidant and photocatalytic activities by Bekalu Lake Bogale, Teshiwal Bizuayen Adamu, Mekuriaw Assefa kebede, Misganaw Tegegne Ayana, Wudu Wale Kebede, Tsehaynew Fetene

“…UV-Vis spectroscopy (λmax = 407 nm) verified the production of AgNPs, while FTIR analysis revealed the functional groups in charge of stabilization and reduction. …”
Get full text

Investigation into the Antibacterial and Freshness Preservation Efficacy of Dry Porous Bags of Biomass Ash from Agricultural Residues by Chunxia Fan, Shujuan Pan, Lejia Shu, Shuting Huang, Fangmei Zhou

“…Safety evaluations revealed no genotoxicity, with lead content below the 0.2 mg/kg safety threshold and the micronucleus tests within safe limits. Elemental analysis detected high potassium content (103.127 g/kg), while SEM and FTIR revealed a porous structure and functional groups that may contribute to its antibacterial and preservative properties. …”
Get full text

Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc by Roberta Santarelli, Claudia Di Dio, Michele Di Crosta, Paola Currà, Roberta Gonnella, Mara Cirone

“…We also explored whether these epigenetic changes could affect c-Myc expression in these cells. By Western blot analysis and RT-qPCR, we found that the downregulation of EZH2; G9a; and, to a lesser extent, KDM1, which was also reduced by curcumin, correlated with the decrease in mutp53 and that the reduction of EZH2 and KDM1 correlated with the activation of wtp53. …”
Get full text

Systematic evaluation of the isolated effect of tissue environment on the transcriptome using a single-cell RNA-seq atlas dataset by Daigo Okada, Jianshen Zhu, Kan Shota, Yuuki Nishimura, Kazuya Haraguchi

“…Results This study introduces a novel data analysis framework, named the Combinatorial Sub-dataset Extraction for Confounding Reduction (COSER), which addresses statistical confounding by using graph theory to enumerate appropriate sub-datasets. …”
Get full text

Metabolomics study on fermented soybean meal by Rhizopus oligosporus RT-3 and its improvement on the growth status of malnourished mice by Teng Sun, Zhaojun Wang, Yiqiang Dai, Kang Zhai, Xiangna Fang, Yitian Chen, Baomin Zhao, Mingsheng Dong

“…As to amino acid metabolites, essential amino acids for human bodily functions such as lysine, histidine, and threonine were significantly upregulated. …”
Get full text

Design and Validation of an Edge-AI Fire Safety System with SmartThings Integration for Accelerated Detection and Targeted Suppression by Seung-Jun Lee, Hong-Sik Yun, Yang-Bae Sim, Sang-Hoon Lee

“…A probabilistic risk analysis based on ISO 31000 and NFPA 551 frameworks showed risk reductions of 75.6% in life safety, 58.0% in property damage, and 67.1% in business disruption. …”
Get full text

Sustainable transformation of cotton stalk waste as a biochar-based copper-silicon composite for chromium (VI) detoxification by Sana Shakil, Salah Ud Din, Khawaja Ansar Yasin, Muhammad Sheraz Ahmad, Muhammad Imran, Abdurahman Hajinur Hirad, Jamoliddin Razzokov, Sirajul Haq

“…Electrostatic interactions and reduction by oxygen-containing functional groups facilitated chromium removal. …”
Get full text

ANGPTL3 overcomes sorafenib resistance via suppression of SNAI1 and CPT1A in liver cancer by Yang-Hsiang Lin, Cheng-Yi Chen, Hsiang-Cheng Chi, Meng-Han Wu, Ming-Wei Lai, Chau-Ting Yeh

“…Additionally, ANGPTL3 was downregulated in HCC tissues, with its expression positively correlated with good prognosis. Functionally, ectopic expression of ANGPTL3 re-sensitized sorafenib-resistant cells, enhancing the sorafenib-induced reduction in cell viability and migration by suppressing zinc finger protein SNAI1 (SNAI1) expression and the protein stability of carnitine O-palmitoyltransferase 1, liver isoform (CPT1A). …”
Get full text

Highland Barley Tartary Buckwheat Coarse Grain Biscuits Ameliorated High-Fat Diet-Induced Hyperlipidaemia in Mice Through Gut Microbiota Modulation and Enhanced Short-Chain Fatty A... by Xiuqing Yang, Xiongfei Kang, Linfang Li, Shaoyu Zhang

“…This research provides novel insights into functional food development for hyperlipidemia.…”
Get full text

Acute and subacute psychophysiological responses in body weight HIIT sessions: a systematic review by Paulo Vinicios C. Zovico, Carine Danielle Leite, Roberta L. Rica, Bruna Massaroto Barros, Alexandre F. Machado, Elis Aguiar Morra, Alexandre L. Evangelista, Richard D. Leite, Valerio G. Barauna, Danilo S. Bocalini

“…Descriptors such as: high-intensity whole-body, high-intensity functional training, whole-body, whole-body training, whole-body calisthenics, high-intensity calisthenic training, and HIIT bodywork were used. …”
Get full text

Visual biofeedback for paradoxical vocal fold motion (PVFM) by Rachelle Alyce LeBlanc, Daniel Aalto, Caroline C. Jeffery

“…Pre- and post-intervention analysis showed significant improvement in DI scores (p < 0.001) and reduction in bronchodilator use (p = 0.003). …”
Get full text

the first experience of phakoemulsification with vacuum trabeculoplasty ab interno for combined cataract and glaucoma by V. N. Trubilin, N. A. Kaira, A. V. Trubilin

“…In both groups there was performed the ultrasonic phakoemulsification of the lens on the phakoemulsificator Infinity (Alcon, US).Results: the analysis of intraocular pressure measurements showed that among patients from I and II group eye pressure had a downward trend in the early postoperative period, however, the average dynamics of reduction of the intraocular pressure in the group of patients where phakoemulsification and vacuum trabeculoplasty ab interno performed was higher than in the control group. …”
Get full text

Facile synthesis of Fe3O4 via co-precipitation method: The role of Moringa oleifera in substituting chemical reducing agents by Rizqi A’mal Hibatullah Tabrani, Ganesha Antarnusa, Fazri Firdaus

“…Characterization techniques, including XRD, FTIR, SEM-EDX, TEM-SAED, and VSM, revealed that the partial substitution of NH4OH with MO extract affected the phase composition, crystallite size, and magnetic properties of the nanoparticles. XRD analysis showed the emergence of a secondary Fe2O3 phase and a reduction in crystallite size from 8.38 nm to 1.17 nm. …”
Get full text

Ecological fitness impairments induced by chronic exposure to polyvinyl chloride nanospheres in Daphnia magna by Andrea Masseroni, Lorenzo Federico, Sara Villa

“…It is hypothesised that the ingestion of PVC-NPs by D. magna may have resulted in an impairment of ecdysone hormone functionality and that the increased moulting events potentially representing an adaptive response to the negative effects of PVC-NP adhesion to the organism's body surfaces. …”
Get full text

Experience with tocilizumab in patients with rheumatoid arthritis (according to the data of the LORNET multicenter trial) by E Yu Panasyuk, V N Amirdzhanova, Anastasia Sergeyevna Avdeyeva, E L Luchikhina, E N Aleksandrova, A A Novikov, E L Nasonov

“…There were improvements in functional status and quality of life according to the EQ-5D and SF-36 questionnaires. …”
Get full text