Metabolic Activity in Central Neural Structures of Patients With Myocardial Injury by Michael Fiechter, Andrea Roggo, Achi Haider, Susan Bengs, Irene A. Burger, Monika Marędziak, Angela Portmann, Valerie Treyer, Anton S. Becker, Michael Messerli, Urs J. Mühlematter, Ken Kudura, Elia von Felten, Dominik C. Benz, Tobias A. Fuchs, Christoph Gräni, Aju P. Pazhenkottil, Ronny R. Buechel, Philipp A. Kaufmann, Catherine Gebhard

“…In a sex‐stratified analysis, these differences were observed in men, but not in women. …”
Get full text

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata by Xin Hou, Kelley R. Healey, Erika Shor, Milena Kordalewska, Cristina Jiménez Ortigosa, Padmaja Paderu, Meng Xiao, He Wang, Ying Zhao, Li-Yan Lin, Yan-Hai Zhang, Yong-Zhe Li, Ying-Chun Xu, David S. Perlin, Yanan Zhao

“…In conclusion, the high-level of echinocandin resistance in the clinical isolate of C. glabrata L74 was concluded to result from the combination of null function of Fks1 and the point mutation E655K in Fks2.…”
Get full text

N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells by Raghda A. Elsabbagh, Ghada Abdelhady, Doris Urlaub, Mina Sandusky, Ola Khorshid, Mohamed Z. Gad, Khaled Abou-Aisha, Carsten Watzl, Mona Rady

“…The impact of m6A alteration on corresponding mRNA and protein levels was assessed using RT-qPCR and Western blot analysis or flow cytometry, respectively. Additionally, NK cell functionality was evaluated through degranulation and 51Cr release cytotoxicity assays. …”
Get full text

PAI-1 participation in hepatocyte epithelial-mesenchymal transition induced by HCV NS5A or Core proteins. by Tania G. Heredia-Torres, Sonia A. Lozano-Sepúlveda, Ana R. Rincón-Sánchez, Ana María G. Rivas-Estilla

“…A gene silencing of 60% of PAI-1 was obtained in all groups. this silencing induces a reduction of 50% of vimentin expression at the translational level in all groups. …”
Get full text

Efficacy and safety of musculoskeletal manipulations in elderly population with musculoskeletal disorders: a systematic review by Alessandro Mauro, Donatella Bagagiolo, Michela Persiani, Luca Cicchitti, Luca Vismara, Irene Bruini, Francesca Buffone

“…For neck pain and low back pain, no statistically significant improvement in functional status and quality of life was observed with MM compared with any control group. …”
Get full text

A putative ABC transporter gene, CcT1, is involved in beauvericin synthesis, conidiation, and oxidative stress resistance in Cordyceps chanhua by Zhimin Liu, Jiahua Zhu, Ruixue Gong, Zhiyuan Wen, Yanwen Liu, Yulong Wang, Zengzhi Li, Bo Huang, Fan Peng

“…The findings in this study enrich the understanding of the function of ABC transporter in fungal metabolism and growth and development.…”
Get full text

Effects of the efficacy of the Yi Shen Tiao Gan formula on aromatase inhibitor associated musculoskeletal syndrome: a randomized controlled trial by Yan Zhang, Meiling Chu, Meina Ye, Yiqin Cheng, Hui Cong, Yulian Yin, Hongfeng Chen

“…The TCM symptom and sign score significantly decreased in both groups (p < 0.05), with a more pronounced reduction in the treatment group (p < 0.05). The bone mineral density T-score of both groups of patients showed a downward trend. …”
Get full text

VP3.15, a dual GSK-3β/PDE7 inhibitor, reduces glioblastoma tumor growth though changes in the tumor microenvironment in a PTEN wild-type context by Maria Castello-Pons, Maria A. Ramirez-Gonzalez, Patricia Iglesias-Hernández, Nermina Logo Lendo, Carlos Rodriguez-Martín, Laura Quiralte, Juan-Manuel Sepúlveda-Sánchez, Olaya de Dios, Carmen Gil, Ana Martínez, Pilar Sánchez-Gómez, Sergio Casas-Tinto

“…The in vivo dependence on PTEN was further suggested with the results in fly gliomas. The analysis of the VP3.15-treated tissues revealed a notable reduction in the number of myeloid cells and in the degree of vascularization. …”
Get full text

PENERAPAN KODE ETIK JURNALISTIK TERHADAP ISI PEMBERITAAN COVID-19 DI SURAT KABAR SOLOPOS EDISI 23 MARET-23 APRIL 2020 by Triyas Chusnul Fatimah, Benni Setiawan

“…This study’s data was analyzed using the Miles Huberman models, namely data collection, data reduction and data verification. The result of this research show that (1) Solopos Daily has implemented the journalistic Code of Ethics, this is evidenced by the presentation of news wich generally applies article 7 more, but there are still several imbalances in article 3, (2) based on coding results, Solopos Daily issues 23 March-27April 2020 as local mass media has fully carried out its function in providing information, educating, persuasive, entertaining audiences, (3) based on coding results, the violations of the Solopos Daily KEJ edition on 23th of the March-27 April 2020 was most violations that ever happened in the news balance indicator. …”
Get full text

ARMH1 is a novel marker associated with poor pediatric AML outcomes that affect the fatty acid synthesis and cell cycle pathways by Mojtaba Bakhtiari, Sean C. Jordan, Sean C. Jordan, Hope L. Mumme, Hope L. Mumme, Richa Sharma, Mala Shanmugam, Swati S. Bhasin, Swati S. Bhasin, Manoj Bhasin, Manoj Bhasin, Manoj Bhasin

“…Mitochondrial function was assessed via Seahorse assay, ARMH1 interacting proteins were studied using co-immunoprecipitation. …”
Get full text

Microglial repopulation reverses radiation-induced cognitive dysfunction by restoring medial prefrontal cortex activity and modulating leukotriene-C4 synthesis by Yubo Hu, Zhe Li, Yafeng Zhu, Mengdan Xing, Xiaoru Xie, Panwu Zhao, Xin Cheng, Chuan Xiao, Yuting Xia, Jingru Wu, Yuan Luo, Ho Ko, Yamei Tang, Xiaojing Ye, Wei-Jye Lin

Get full text

Using 3D and 4D digital human modeling in extended reality-based rehabilitation: a systematic review by Mengdi Lu, Wim Saeys, Wim Saeys, Maria Maryam, Inva Gjeleshi, Hoda Nazarahari, Steven Truijen, Sofia Scataglini

“…The studies reveal positive impacts on functional (e.g., upper limb function, gait, balance, quality of life), physical (e.g., pain reduction, spasticity, joint range), psychological (e.g., depression, emotional regulation, body image), and general health outcomes (e.g., body composition, metabolic health).ConclusionDespite variability in study parameters, limited evidence suggests that 3D DHM in XR-based rehabilitation may enhance physical and psychological recovery across various pathologies. …”
Get full text

Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study by Yin Sun, Longteng Ma, Song Wang, Caohui Duan, Xinyu Wang, Xiangbing Bian, Shuqing Wang, Deqi Zhai, Siyuan Xie, Shuhua Zhang, Yingyuan Liu, Xiaoxue Lin, Ruobing Wang, Xiu Liu, Shengyuan Yu, Xin Lou, Zhao Dong

“…Moreover, fractional amplitude of low-frequency fluctuations (fALFF) values in the right putamen were significantly decreased and demonstrated a negative correlation with the frequency of acute pain medication use. Functional connectivity analysis further revealed significantly enhanced connectivity between the right putamen and regions such as the frontal lobe, middle cingulate gyrus, lingual gyrus, and precuneus, which positively correlated with the frequency of acute analgesic use. …”
Get full text

Comparison of low-pressure and standard-pressure pneumoperitoneum laparoscopic cholecystectomy in patients with cardiopulmonary comorbidities: a double blinded randomized clinical... by Feng Tian, Xiaowei Sun, Yang Yu, Ning Zhang, Tao Hong, Lu Liang, Bihui Yao, Lei Song, Changhong Pei, Yu Wang, Wenlong Lu, Qiang Qu, Junchao Guo, Taiping Zhang, Xiaodong He

“…Surgical safety variables, patient recovery, pulmonary function parameters, and surgeon comfort were also compared between groups. …”
Get full text

LINGUISTIC FEATURES OF BUSINESS ENGLISH DISCOURSE THESAURUS by Nataliia V. Zinukova

“…Based on the continuous sampling method (to identify lexical units of institutional Business English discourse for further analysis), the method of dictionary definitions (to study the semantics of lexical units), contrastive method (to establish common and distinctive features for translation) and descriptive method (to identify and systematization of features and difficulties of translation of lexical units of Business English discourse) the features of functioning of Business English discourse thesaurus are analyzed. …”
Get full text

Sirtuin 1 expression in elderly patients with type 2 diabetes mellitus by Mohamed M. M. Hassaan, Imam M. Esmayel, Mayada M. Mousa, Samia Hussein, Ahmed K. Y. Alkolaly, Batoul A. Hegazy, Rodalia M. Makhlouf

“…SIRT3 is a mitochondrial enzyme that regulates mitochondrial functions, including ATP synthesis, reactive oxygen species production, fatty acid oxidation, ketone metabolism, and cellular death. …”
Get full text

Lethal neonatal acidosis: Multiomic investigation of a novel HIBCH variant as the underlying cause by Sonali Patel, Muhammad Zain-ul-abideen, Genevieve Guyol, Lance H. Rodan, Casie A. Genetti, Amy Z. Ren, Philip Connors, Patricia Davenport, Ruby Bartolome, Inderneel Sahai, Vijay S. Ganesh, Monica H. Wojcik

“…Biochemical abnormalities such as lactic acidosis and hyperammonemia may also be seen due to disruption of mitochondrial function, and the diagnosis may also be suspected by the presence of elevated hydroxy-C4-carnitine (C4-OH) detected from a blood sample with a definitive diagnosis obtainable by genetic analysis. …”
Get full text

Effect of perioperative ONS combined with intestinal microecology in patients with colorectal cancer: a randomized clinical trial by Xuanjun Liu, Weixu Mao, Guowei Zhao, Juan Liao, Qigang Li, Gan He

“…Fecal DNA fingerprint analysis revealed that, compared with the control group, the test group presented significantly greater intestinal flora species richness and abundance. …”
Get full text

Associations between Japanese calligraphy practice and sleep quality in community-dwelling older adults: A cross-sectional Study by Georg von Fingerhut, Keitaro Makino, Osamu Katayama, Ryo Yamaguchi, Daiki Yamagiwa, Jessica K. Bone, Hiroyuki Shimada

“…Japanese calligraphy is a traditional art practice previously associated with various health benefits, such as stress reduction and improved cognitive function; however, its association with sleep quality has not been fully explored. …”
Get full text

Impact of elevated sclerostin levels on bone resorption: unravelling structural changes and mineral metabolism disruption by María Encarnacion Rodríguez-Ortiz, Juan Miguel Díaz-Tocados, Ana Isabel Torralbo, Karen Valdés-Díaz, Antonio Rivas-Domínguez, Fátima Guerrero, Irene Reina-Alfonso, Manuel Naves-Díaz, Cristina Alonso-Montes, Cristian Rodelo-Haad, Mariano Rodríguez, Juan Rafael Muñoz-Castañeda, IMIBIC Nephrology Group

“…In male healthy rats, the effects of three elevated doses of sclerostin over a 14-day period were studied, involving bone histomorphometry, micro-CT (μCT), immunohistochemistry, and analysis of mineral metabolism parameters. Results: Although there was increased bone formation, high doses of sclerostin led to a higher reduction in trabecular bone volume due to a significant increase in bone resorption through the direct activation of osteoclastogenesis. …”
Get full text