The influence of Dupuytren's disease fingers contracture degree on surgical treatment outcome by Stepić Nenad, Končar Jovana, Rajović Milica

“…Dupuytren’s disease is a progressive disease of the palmar and digital fascial structures, with functional limitations. There are no clear recommendations about the optimal time of surgical repair, concerning the hand impairment. …”
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Study on the Combined Application of Occlusal Splint and Intra-Articular Injection of Hyaluronic Acid in the Treatment of Non-Reducible Anterior Disc Displacement of the Temporoman... by Bi K, Cheng G, Wu X, Lv Z

“…The clinical treatment effects, pain levels (Visual Analog Scale [VAS]), temporomandibular joint dysfunction (Friction Temporomandibular Joint Dysfunction Index [CMI]), mandibular movement function (maximum mouth opening [MMO], left lateral excursion [LLE], right lateral excursion [RLE], protrusive movement [PM]), clinical aesthetic indicators (condylar height, joint space width), and adverse reactions were compared between the two groups.Results: (1) Clinical Efficacy: The observation group had a higher total effective rate (90.32% vs 67.74%, P < 0.05). (2) Pain & Dysfunction: Both groups showed significant improvement in VAS and CMI scores over time, with the observation group exhibiting greater reductions (P < 0.05). (3) Mandibular Function & Aesthetic Indicators: The observation group had greater improvements in MMO, LLE, RLE, PM, condylar height, and joint space width (P < 0.05). (4) Adverse Reactions: No significant difference in adverse reaction rates (P > 0.05).Conclusion: The combination of intra-articular injection of HA with occlusal splint therapy can further improve the treatment outcomes for ADDWoR patients, alleviate pain, improve temporomandibular joint dysfunction and mandibular movement function, promote aesthetic recovery, and does not increase the risk of adverse reactions.Keywords: occlusal splint, intra-articular injection of HA, non-reducible anterior disc displacement of the temporomandibular joint, ADDWoR, treatment efficacy…”
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Interaction of integral parameters of physical state and biological age of students aged 17-19 years old in the process of adaptation to standard and experimental physical educatio... by Oleksandr Pryimakov, Marek Sawczuk, Stanislav Prysiazhniuk, Georgiy Korobeynikov, Nataliya Mazurok

“…In the course of the research, the indices of functional state, physical fitness (PF) and physical development (PD), biological age (BA) were recorded in young men and women of the control (CG) and experimental (EG) groups. …”
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The Dynamic Characteristics and Influencing Factors of Soil Respiration in Different Types of Grasslands in the Barkol Lake Basin by Xiangdong Cao, Chengyi Zhao, Hongtao Jia, Jinyu Yang

“…Determining regional and global carbon cycles hinges on investigating the dynamic characteristics and influencing factors of soil respiration in various types of natural grasslands located in arid regions, and these characteristics are important indicators for assessing the structural and functional health of grassland ecosystems. Such investigations also provide theoretical support for carbon sink monitoring, energy conservation, emission reduction and low-carbon development in the western arid zone and are important for obtaining an in-depth understanding of the carbon cycle, as well as for ecosystem management, restoration and the reconstruction of arid areas. …”
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Ripening-Associated Changes in Fatty Acid Composition and Nutritional Indices in Caciocavallo Silano PDO Cheese by Giuseppe Tardiolo, Eleonora Di Salvo, Simona Tringali, Giovanni Bartolomeo, Claudia Genovese, Maria Elena Furfaro, Anna Maria Sutera, Antonino Nazareno Virga, Nicola Cicero, Alessandro Zumbo

“…The sum of MUFAs showed a slight decrease, mainly due to the reduction in oleic acid, which dropped from 22.6% to 21.3% over maturation. …”
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Relationship between cognitive impairments and psychopathological symptoms in female schizophrenia subsequent to 8 weeks treatment with antipsychotic drugs by Shuzhan Gao, Qing Xu, Yanlin Han, Jing Jiang, Fan Wu, Ting Peng, Chenxi Ling, Sulin Ni, Rongrong Zhang, Yidan Ming, Xuzhen Liu, Xijia Xu

“…Psychopathological symptoms and overall cognitive functioning improved significantly (p < 0.05), with the exception of verbal learning and social cognition (p > 0.05). …”
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The Effect of Liv.52 DS in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Pilot, Randomized, Double-Blind, Placebo-Controlled, Clinical Study by Jalihal U, Nanda RA, Katariya K, Ramanathan B, Kumawat R

“…After completion of the study, data from 47 subjects were available for analysis (31 in the Liv.52 DS group and 16 in the placebo group).Results: The mean LSM score, was reduced from 7.3 to 6.0 (Change From Baseline = 17.5%) in the active group with statistically significance (p = 0.007) compared to placebo group with LSM score reduction from 7.5 to 6.9 (CFB = 7.29%). …”
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Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity a... by Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu

“…The current developability assessment strategy provided comprehensive, precise characterization of antibody binding activity in the stability studies, enabling us to perform correlation analysis and establish the structure–function relationship between relative binding activity and quality attributes. …”
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Overexpression of the STOX1B isoform of STOX1 triggers preeclampsia-like symptoms through HNF4α-dependent alterations of coagulation cascades in mice by Hélène Collinot, Louise Strubé, Ikram Benouda, Johan Castille, Sandrine Floriot, Nathalie Daniel-Carlier, Bruno Passet, Franck Lager, Isabelle Lagoutte, Gilles Renault, Benjamin Saintpierre, Maryline Favier, Djihane Djeridane, Céline Méhats, Francisco Miralles, Jean-Luc Vilotte, Daniel Vaiman

“…The two isoforms have opposite function on major genes involved in trophoblast syncytialization and oxidative stress management. …”
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The Impact of a Plant-Based Diet on Inflammatory Symptoms In Rheumatoid Arthritis: A Review by Justyna Moszkowicz, Tomasz Ufniarski, Aleksandra Piech, Martyna Grodzińska, Maria Kleczkowska, Karol Poplicha, Piotr Sobkiewicz, Karolina Pasierb, Patrycja Kardasz, Bartłomiej Siuzdak, Marta Jutrzenka

“…Plant-based diets that are rich in fibre, antioxidants, and unsaturated fatty acids, have demonstrated anti-inflammatory properties that may modulate disease activity and improve clinical outcomes in RA patients. A systematic analysis of clinical trials and observational studies reveals that vegan, vegetarian, and plant-forward dietary patterns contribute to significant reductions in disease activity scores (DAS28), inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and subjective pain and physical function assessments with vegan, vegetarian, and plant-forward dietary patterns. …”
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Cardiac implications of chicken wooden breast myopathy by Thea Parsberg Støle, Andreas Romaine, Thea Kleiberg, Vibeke Høst, Marianne Lunde, Almira Hasic, Tiril Aurora Lintvedt, Karen Wahlstrøm Sanden, Svein O. Kolset, Jens Petter Wold, Addolorata Pisconti, Sissel Beate Rønning, Cathrine Rein Carlson, Mona Elisabeth Pedersen

“…Functional enrichment analysis of RNA sequencing also suggested a different molecular footprint of biological processes and pathways between the two groups.ConclusionHearts from wooden breast-affected chickens did not display the same fibrotic alterations as those previously found in the breast. …”
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Therapeutic Effects of Forest Bathing on Human Health: A Systematic Review by Adrianna Samoraj, Jakub Zajączkowski, Paulina Krzeszowska, Kacper Stępniak, Karolina Marrodán-Wojtczak, Jan Wilk, Jakub Jarmołowicz, Aleksandra Kujawa, Karolina Krochmal, Radosław Kuźma

“…In patients with dementia symptoms, forest bathing interventions resulted in improvements in language function and memory, among other cognitive domains.   …”
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Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial by Rosa Nguyen, David Cullins, Barbara Rooney, Natasha Sahr, April Sykes, Mary Beth McCarville, Sara M Federico, Amanda Sooter, William E Janssen, Gwendolyn Anthony, Michael A Dyer, Alberto S Pappo, Wing H Leung, Wayne L Furman

“…However, the impact of chemoimmunotherapy on NK cell kinetics, phenotype, and function is understudied.Methods We prospectively examined NK cell properties from 63 children with newly diagnosed neuroblastoma enrolled in a phase II trial (NCT01857934) and correlated our findings with tumor volume reduction after 2 courses of chemoimmunotherapy. …”
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Dynamic changes in DNA methylation play a regulatory role in gene expression during the formation of callus from immature barley embryos by Xinguo Huang, Jing Zhan, Haonan Wei, Siying Lou, Hongwu Bian, Junhui Wang, Ning Han

“…This indicates a regulatory function of DNA methylation in transcriptional regulation during callus induction. …”
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Olive oil protects against cardiac hypertrophy in D-galactose induced aging rats by Siamak Shahidi, Khadijeh Ramezani-Aliakbari, Abdolrahman Sarihi, Ali Heshmati, Elham Shiri, Shiva Nosrati, Sayedpayam Hashemi, Mitra Bahrami, Fatemeh Ramezani-Aliakbari

“…The heart tissues were harvested to assay the oxidative stress, molecular parameters, and histological analysis. Results The D-GAL given rats indicated increased cardiomyocyte diameter as cardiac hypertrophy marker (21 ± 0.8, p < 0.001), an increased Malondialdehyde (MDA) level (27 ± 3, p < 0.001), a reduced Superoxide dismutase (SOD) (p < 0.001, 18.12 ± 1.3), and reduction in gene expression of Sirtuin 1 (SIRT1) (p < 0.05, 0.37 ± 0.06), Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α (p < 0.001, 0.027 ± 0.04), and Transcription Factor A, Mitochondrial (TFAM) (p < 0.001, 0.023 ± 0.01), Bcl2 (p < 0.001, 0.04 ± 0.004) and an increase in gene expression of Bax (p < 0.001, 23.5 ± 5.4) in comparison with the control animals. …”
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Characterization of Low-Temperature Sensitivity and Chlorophyll Fluorescence in Yellow Leaf Mutants of Tomato by Shujing Ji, Yifan Zhang, Minghua Xu, Mingrui Zhao, Huixin Chen, Yongen Lu, Shengqun Pang, Wei Xu

“…Leaf color mutants serve as valuable models for studying the regulation of plant photosynthesis, alternations in chloroplast structure and function, and the analysis of associated gene functions. …”
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Early assessment of responsive neurostimulation for drug-resistant epilepsy in China: A multicenter, self-controlled study by Yanfeng Yang, Penghu Wei, Jianwei Shi, Ying Mao, Jianmin Zhang, Ding Lei, Zhiquan Yang, Shiwei Song, Ruobing Qian, Wenling Li, Yongzhi Shan, Guoguang Zhao, Rongman Jia

“…Efficacy was assessed through metrics including median seizure count, seizure frequency reduction (SFR), and response rate. Multivariable linear regression analysis was conducted to explore the relationships of basic clinical factors and intracranial electrophysiological characteristics with SFR. …”
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CDK14 regulates the development and repair of lung by Jian-wei Chen, Yu-xiang Wang, Rong-rong Gao, Lan-yue Ma, Jing Zhong, Jia-xin Yang, Zhao-hua Deng, Yu-yan Li, Xiao-ling Li, Ya-hai Shu, Wen-jing Guo, Zi-yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu, Qi Chen

“…Abstract Cyclin-dependent kinases (CDK) 14 regulates cell cycle, tumor expansion by influencing the downstream targets of the canonical Wnt signaling pathway. However, the function of CDK14 during organ development and regeneration has not been investigated in genetically-modified animals. …”
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Application of artificial intelligence system based on control theory feedback model in ultrasound diagnosis and treatment medical insurance payment by CUI Xiaomei, HUANG Shengxi, ZHANG Qinghong, XU Lijuan, LI Junmei, LYU Xiaoping, HUANG Yanli, CUI Junfang, LI Tingrui

“…Objective To analyzes the optimization function of artificial intelligence system based on control theory feedback model applied to medical insurance payment. …”
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Outcome of Transjugular Intrahepatic Portosystemic Shunt in Budd-Chiari Syndrome: Long-Term Outcomes of 118 Patients; A Single-center Experience by Mohamed Shaker, Mohammad Sakr, Hany Dabbous, Sara M. Abdelhakam, Ahmed Samir, Hend Ebada, Amir M. Farid, Mohamed El-Gharib, Ahmed Eldorry

“…Chi-square test and Kaplan–Meier survival curve were used to examine the association between short- and long-term occlusion, liver function and survival outcomes. P < 0.05 was considered statistically significant. …”
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