HEALTH TECHNOLOGY ASSESSMENT: INTERNATIONAL EXPERIENCE by M.V. Avksent'eva, O.M. Omel'yanovskii

“…It is convincingly shown that the evaluation of new technologies before their widespread introduction into practice not only contributes to increasing the availability of the effective approaches to diagnosis and treatment of various diseases, but it is also regarded as an element of the state costs reduction to the health.Key words: health technology assessment, agency for the evaluation of medical technologies, evidence-based medicine, clinical and economic analysis, economic evaluation.…”
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598 Neutrophils propagate inflammation and fibrosis in primary sclerosing cholangitis by Abid Anwar, Sofia Jerez Ortega, Maleeha Kalaiger, Kaitlin Friesland, Jordan Young, Amaury E. Tuerlinckx, Usman Yaqoob, Robert C. Huebert, Nidhi Jalan-Sakrikar

“…CyTOF analysis showed a significant reduction in CD8+ T cells upon neutrophil depletion, implying neutrophils sustain CD8+ T cells in PSC liver. …”
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Virtual Reality-Based Multisensory Exercise Enhances Balance Control in Community-Dwelling Older Adults: A Preliminary Randomized Controlled Trial by Seongryu Bae, Jaewon Choi, Jiwon Yang, Kai Wang, Eun-Seon Noh, Hyuntae Park

“…RESULTS After the 8-week intervention, the VR group demonstrated significant improvements in postural stability (COP path length: 10.0% reduction, p=.04) and functional lower extremity strength (FTSST: 17.4% reduction, p=.04) compared to controls. …”
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Green synthesis and detailed characterization of selenium nanoparticles derived from Alangium salviifolium (L.f) Wangerin by Karunya Saravanan, Manivannan Madhaiyan, Prabu Periyasamy, Prasath Manivannan, Alpaslan Bayrakdar, Dr. V. Balakrishnan

“…The FTIR study elucidated the functional groups in the extracts and their interactions with selenium throughout the reduction process. …”
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CRISPR-Analytics (CRISPR-A): A platform for precise analytics and simulations for gene editing. by Marta Sanvicente-García, Albert García-Valiente, Socayna Jouide, Jessica Jaraba-Wallace, Eric Bautista, Marc Escobosa, Avencia Sánchez-Mejías, Marc Güell

“…It achieves higher accuracy than current tools and expands the functionality. The analysis includes mock-based noise correction, spike-in calibrated amplification bias reduction, and advanced interactive graphics. …”
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Type II diabetes in systemic sclerosis patients: insights from an observational, multicenter study of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) by Vasiliki Liakouli, Giulio Forte, Piero Ruscitti, Luca Navarini, Francesca Bellisai, Francesco Caso, Giuliana Guggino, Lidia La Barbera, Chiara Rizzo, Ada Corrado, Paola Triggianese, Alberto Lo Gullo, Giuseppe Mandraffino, Luca Cantarini, Bruno Frediani, Paola Cipriani, Francesco Paolo Cantatore, Maria Sole Chimenti, Elvira Favoino, Federico Perosa, Annamaria Iagnocco, Roberto Giacomelli, Francesco Ciccia

“…These patients more frequently assumed angiotensin-converting enzyme inhibitors (ACEi) (P < 0.005) when compared to their non-T2D counterparts, while the use of immunosuppressive therapies was similar between groups. Multivariate analysis identified older age, SRC, and reductions in both TLC and FVC as independent SSc-specific associated factors of T2D. …”
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Gut microbiome and metabolome interactions in Crohn’s disease: mechanistic insights into exclusive enteral nutrition-induced remission by Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Quan Zhou, Quan Zhou, Mengli Xue, Mengli Xue, Mengli Xue, Mengli Xue, Xing Yu, Xing Yu, Xing Yu, Xing Yu, Xue’e Chen, Xue’e Chen, Xue’e Chen, Xue’e Chen, Jintong Chen, Jintong Chen, Jintong Chen, Jintong Chen, Chengdang Wang, Chengdang Wang, Chengdang Wang, Chengdang Wang

“…The composition of the gut microbiome was analyzed through 16S rRNA gene sequencing, while metabolomic profiling was conducted using liquid chromatography–mass spectrometry (LC–MS). Functional analysis of microbial pathways was performed utilizing the KEGG Orthology (KO) and MetaCyc databases.ResultsEEN therapy induced significant structural shifts in the gut microbiome, including a reduction in the abundance of pro-inflammatory bacteria such as Fusobacterium and Veillonella. …”
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Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement by Duvuru Geetha, Frank B. Cortazar, Annette Bruchfeld, Andreas Kronbichler, Alexandre Karras, Georges N. Nakhoul, Peter A. Merkel, Sarah Bray, Alana M. Bozeman, David R.W. Jayne, C. Au Peh, A. Chakera, B. Cooper, J. Kurtkoti, D. Langguth, V. Levidiotis, G. Luxton, P. Mount, D. Mudge, E. Noble, R. Phoon, D. Ranganathan, A. Ritchie, J. Ryan, M. Suranyi, A. Kronbichler, A. Rosenkranz, K. Lhotta, N. Demoulin, C. Bovy, R. Hellemans, J. Hougardy, B. Sprangers, K. Wissing, C. Pagnoux, S. Barbour, S. Brachemi, S. Cournoyer, L. Girard, L. Laurin, P. Liang, D. Philibert, M. Walsh, C. Rigothier, J. Augusto, A. Belot, D. Chauveau, D. Cornec, N. Jourde-Chiche, M. Ficheux, P. Zaoui. Paris, A. Karras, A. Klein, F. Maurier, R. Mesbah, O. Moranne, A. Neel, T. Quemeneur, D. Saadoun, B. Terrier, P. Zaoui, M. Schaier, U. Benck, R. Bergner, M. Busch, J. Floege, F. Grundmann, H. Haller, M. Haubitz, B. Hellmich, J. Henes, B. Hohenstein, C. Hugo, C. Iking-Konert, F. Arndt, T. Kubacki, I. Kotter, P. Lamprecht, T. Lindner, J. Halbritter, H. Mehling, U. Schönermarck, N. Venhoff, V. Vielhauer, O. Witzke, I. Szombati, G. Szucs, G. Garibotto, F. Alberici, E. Brunetta, L. Dagna, S. De Vita, G. Emmi, A. Gabrielli, L. Manenti, F. Pieruzzi, D. Roccatello, C. Salvarani, H. Dobashi, T. Atsumi, S. Fujimoto, N. Hagino, A. Ihata, S. Kaname, Y. Kaneko, A. Katagiri, M. Katayama, Y. Kirino, K. Kitagawa, A. Komatsuda, H. Kono, T. Kurasawa, R. Matsumura, T. Mimura, A. Morinobu, Y. Murakawa, T. Naniwa, T. Nanki, N. Ogawa, H. Oshima, K. Sada, E. Sugiyama, T. Takeuchi, H. Taki, N. Tamura, T. Tsukamoto, K. Yamagata, M. Yamamura, P. van Daele, J. de Zoysa, A. Rutgers, Y. Teng, R. Walker, I. Chua, M. Collins, K. Rabindranath, J. de Zoysa, M. Svensson, B. Grevbo, S. Kalstad, M. Little, M. Clarkson, E. Molloy, I. Agraz Pamplona, J. Anton, V. Barrio Lucia, S. Ciggaran, M. Cinta Cid, M. Diaz Encarnacion, X. Fulladosa Oliveras, M. Jose Soler, H. Marco Rusinol, M. Praga, L. Quintana Porras, A. Segarra, A. Bruchfeld, M. Segelmark, I. Soveri, E. Thomaidi, K. Westman, T. Neumann, M. Burnier, T. Daikeler, J. Dudler, T. Hauser, H. Seeger, B. Vogt, D. Jayne, J. Burton, R. Al Jayyousi, T. Amin, J. Andrews, L. Baines, P. Brogan, B. Dasgupta, T. Doulton, O. Flossmann, S. Griffin, J. Harper, L. Harper, D. Kidder, R. Klocke, P. Lanyon, R. Luqmani, J. McLaren, D. Makanjuola, L. McCann, A. Nandagudi, S. Selvan, E. O'Riordan, M. Patel, R. Patel, C. Pusey, R. Rajakariar, J. Robson, M. Robson, A. Salama, L. Smyth, J. Sznajd, J. Taylor, P. Merkel, A. Sreih, E. Belilos, A. Bomback, J. Carlin, Y. Chang Chen Lin, V. Derebail, S. Dragoi, A. Dua, L. Forbess, D. Geetha, P. Gipson, R. Gohh, G.T. Greenwood, S. Hugenberg, R. Jimenez, M. Kaskas, T. Kermani, A. Kivitz, C. Koening, C. Langford, G. Marder, A. Mohamed, P. Monach, N. Neyra, G. Niemer, J. Niles, R. Obi, C. Owens, D. Parks, A. Podoll, B. Rovin, R. Sam, W. Shergy, A. Silva, U. Specks, R. Spiera, J. Springer, C. Striebich, A. Swarup, S. Thakar, A. Tiliakos, Y. Tsai, D. Waguespack, M. Chester Wasko

“…Relapse rate after remission was lower in the avacopan than in the prednisone taper group (9.4% vs. 20.9%; hazard ratio [95% confidence interval, CI]: 0.43 [0.22–0.85]). Recovery of kidney function, speed of reduction in albuminuria and hematuria, and changes in GTI favored the avacopan group. …”
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Lecanemab in clinical practice: real-world outcomes in early Alzheimer’s disease by Noa Bregman, Talya Nathan, Dror Shir, Nurit Omer, Mori Hai Levy, Aya Bar David, Orna Aizenstien, Eyal Lotan, Yifat Alcalay, Anan Abu Awad, Avi Gadoth, Elissa Ash, Tamara Shiner

“…Abstract Background Lecanemab, a monoclonal antibody targeting amyloid beta, has recently been approved for treatment of early-stage Alzheimer’s disease (AD), demonstrating amyloid plaque reduction and slowing of cognitive decline in clinical trials. …”
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The intestinal microbiota modulates the visceral sensitivity involved in IBS induced by restraint combined with tail clustering by Na Deng, Na Deng, Siqin Xie, Qin Liu, Huiyi Peng, Leyao Fang, Junxi Shen, Xiaoyuan Lin

“…The mice in the BCTM group had significantly higher gastric residue rates and 5-HT levels, with a marked reduction in pain tolerance. The gut microbiota of the mice in the BM, CTM, and BCTM groups all exhibited dysbiosis, with changes in the diversity, structural composition, and function of the microbial community. …”
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Research on Analyzing the Emotional Polarity of Malicious Swipe Comments on E-commerce Platforms Based on NPL by Ren Chaoyi

“…The PCA results are further leveraged for dimensionality reduction, simplifying the dataset. Subsequently, the BERT model is employed to perform semantic similarity analysis, allowing for the screening and expansion of the experimental dataset with similar malicious comments. …”
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Predicting and preventing sudden cardiac death in myocardial infarction patients by S. A. Boldueva, A. V. Shabrov, D. S. Lebedev, T. Ya. Burak, I. A. Leonova, M. V. Samokhvalova, V. S. Zhuk, E. G. Bykova

“…According to Cox multivariate regression analysis, the most important predictors included the following six parameters: LVP, HRV reduction, left ventricular ejection fraction &lt;40 %, ventricular arrhythmias, previous MI, and hypotension in AOT Prognostic accuracy and positive predictive value of this model were high enough to assess SCD risk. …”
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A Study on the Management and Evolution of Land Use and Land Cover in Romania During the Period 1990–2022 in the Context of Political and Environmental Changes by Jenica Călina, Aurel Călina, Gheorghe Marian Vangu, Alin Constantin Croitoru, Marius Miluț, Nicolae Ion Băbucă, Ion Stan

“…Land use and land cover are the main anthropogenic factors that lead to the rapid and aggressive degradation of land and interfere with the functioning of ecosystems, especially through the expansion of urbanization and the reduction in forested areas. …”
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Roux-en-Y gastric bypass and sleeve gastrectomy induce substantial and persistent changes in microbial communities and metabolic pathways by Jerry T. Dang, Valentin Mocanu, Heekuk Park, Michael Laffin, Naomi Hotte, Shahzeer Karmali, Daniel W. Birch, Karen L. Madsen

“…A multi-omics approach was used to perform integrated microbial-metabolomic analysis to identify functional pathways in which weight loss and metabolic changes occur after surgery. …”
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Hybrid Framework To Exclude Similar and Faulty Test Cases In Regression Testing by Muhammad Asim Siddique, Wan M.N. Wan-Kadir, Johanna Ahmad, Noraini Ibrahim

“…   Regression testing is a crucial phase in the software development lifecycle that makes sure that new changes/updates in the software system don’t introduce defects or don’t affect adversely the existing functionalities. However, as the software systems grow in complexity, the number of test cases in regression suite can become large which results into more testing time and resource consumption. …”
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Molecular properties of linear amino acids in water by Roman Boča, Richard Imrich, Juraj Štofko, Beáta Vranovičová, Cyril Rajnák

“…Abstract Four linear amino acids of increased separation of the carboxyl and amino groups, namely glycine (aminoacetic acid), β-alanine (3-aminopropanoic acid), GABA (4-aminobutanoic acid) and DAVA (5-aminopentanoic acid), have been studied by quantum chemical ab initio and DFT methods including the solvent effect in order to get electronic structure and molecular descriptors, such as ionisation energy, electron affinity, molecular electronegativity, chemical hardness, electrophilicity index, dipole moment, quadrupole moment and dipole polarizability. Thermodynamic functions (zero-point energy, inner energy, enthalpy, entropy, and the Gibbs energy) were evaluated after the complete vibrational analysis at the true energy minimum provided by the full geometry optimization. …”
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Regional cerebral hypoperfusion as a cause of symptoms and progression of multiple sclerosis by L. N. Prakhova, A. G. Ilves, Z. I. Savintseva, N. M. Kuznetsova, K. S Rubanik, G. V. Kataeva

“…This reduction did not depend on the severity of the disease and correlated negatively with the fatigue score. …”
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RESEARCH INTO SPEECH-TO-TEXT TRANFROMATION MODULE IN THE PROPOSED MODEL OF A SPEAKER’S AUTOMATIC SPEECH ANNOTATION by Olesia Barkovska

“…The proposed model of the speaker’s speech automatic annotation has two major functional modules: speech-to-text (STT) і summarization module (SUM). …”
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An Environmental and Economic Assessment of Household Food Waste Management Scenarios in Ireland by Majid Bahramian, Courage Krah, Paul Hynds, Anushree Priyadarshini

“…The functional unit is 1000 tons of daily HFW treatment. …”
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Evaluation of the Effectiveness of Compression Therapy Combined with Exercises Versus Exercises Only Among Lipedema Patients Using Various Outcome Measures by Monika Czerwińska, Marcin Gruszecki, Jacek Rumiński, Rita Hansdorfer-Korzon

“…The effectiveness of the treatment was assessed before and after the intervention using several measures: an SF-36 questionnaire, a symptom severity survey, circumference (via 3D scanning), and body composition analysis. Significant improvements were observed in the SF-36 Physical Functioning and SF-36 Energy/Fatigue scores among participants in the compression group. …”
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