Total flavonoids of Dracocephalum moldavica L. alleviate cognitive impairment via TNF-α/NF-κB p65 signaling pathway in vascular dementia rats by Shangjia Ma, Jianxin Jia, Jianxin Jia, Lie Wu, Kai Tian, Lu Wang, Hua Li, Jiayu Lv, Dewang Gao, Zhanjun Yang, Zhanjun Yang, Xia Guo

“…Moreover, TFDM exhibited anti-inflammatory properties by inhibiting TNF-α and NF-κB p65 production, thereby mitigating the neuroinflammatory response in VaD rats.ConclusionTFDM demonstrated significant improvement in cognitive function in VaD rats. This improvement was attributed to the multifaceted effects, including the improvement of blood-brain barrier integrity, promotion of angiogenesis, and reduction of neuroinflammation. …”
Get full text

“Do probiotics mitigate GI-induced inflammation and perceived fatigue in athletes? A systematic review” by R.P. Kearns, J.S.G. Dooley, M. Matthews, A.M. McNeilly

“…Probiotics, through their capacity to regulate the composition of the gut microbiota, may act as an adjunctive therapy by enhancing GI and immune function while mitigating inflammatory responses. This review investigates the effectiveness of probiotic supplementation on fatigue, inflammatory markers, and exercise performance based on randomized controlled trials (RCTs).Methods This review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and PICOS (Population, Intervention, Comparison, Outcome, Study design) framework. …”
Get full text

Arthrodesis of the Second and Third Tarsometatarsal Joints: Comparison of Radiological and Clinical Results Using Combined or Individual Plating Techniques by Tom Ankers, Anjani Singh, Christopher R Walker, Lyndon W Mason, Siva Sirikonda

“…We believe that individual plates permit a more anatomical reduction and greater compression at the site of arthrodesis as compared to a dual plate technique, achieving better union results and an early better functional outcome.…”
Get full text

Evaluating the Effectiveness of an Intelligent mHealth Intervention for Child Unintentional Injury Prevention: Protocol for a Cluster Randomized Controlled Trial by Yang Yuan, Yuying Jing, Jiyu Li, Jieyi He, David C Schwebel, Peishan Ning, Zhenzhen Rao, Li Li, Guoqing Hu

“…Secondary outcomes include children’s injury risk level and caregiver supervision behaviors assessed using a standard questionnaire. Data analysis will be conducted using generalized linear mixed models with a Poisson link function and generalized estimating equations to assess the effectiveness of the iCURE intervention, following intention-to-treat principles. …”
Get full text

Intravitreal injection of TA-III with sustained release to simultaneously impart anti-inflammatory, antioxidative, and vascular remodeling activities in diabetic retinopathy by Jie Zhang, Yu Liu, Yu Gong, Yanyu Shangguan, Pengli Wang, Yanlong Bi, Yong Xu, Bo Tao, Bing Li

“…Diabetes negatively impacts vision and retinal function. However, current therapeutic options for diabetic retinopathy (DR) often present limitations, including targeting specific pathways, short duration of action, and need for frequent injections. …”
Get full text

Thyroid storm during the recovery phase after non-thyroid surgery in a hyperthyroid patient: a case report and literature review by Jiyu Zeng, Ting Yang, Li Wu

“…This case report and literature review aim to highlight the clinical features and management strategies for perioperative thyroid storm in non-thyroid surgical patients through a case analysis and literature review.Case presentationA 53-year-old Chinese male with a 20-year history of poorly controlled hyperthyroidism (irregular medication adherence) underwent closed reduction and intramedullary nailing for a right femoral fracture. …”
Get full text

Social Determinants of Health‐Related Outcomes in an Intervention Following Initial Implantable Cardioverter‐Defibrillator Implantation by Megan M. Streur, Jonathan P. Auld, Wei‐Lun Chang, Fatemeh Choupani, Tao Zheng, Elizabeth Frazier, Ana Carolina Sauer Liberato, Kenneth C. Pike, Elaine A. Thompson, Cynthia M. Dougherty

“…Participants were followed for 1 year, and outcomes included ICD shocks, hospitalizations, death, physical function, psychological adjustment, and self‐efficacy. …”
Get full text

T cell immunophenotypes and IgE responses in patients with moderate‐to‐severe atopic dermatitis receiving dupilumab by Davender Redhu, Wojciech Francuzik, Philipp Globig, Margitta Worm

“…Objective This study assessed the peripheral phenotype and function of T‐cells, but also levels of total and sIgE and its receptors in AD patients receiving dupilumab. …”
Get full text

Characterizing Optimum N Rate in Waterlogged Maize (<i>Zea mays</i> L.) with Unmanned Aerial Vehicle (UAV) Remote Sensing by Bhawana Acharya, Syam Dodla, Brenda Tubana, Thanos Gentimis, Fagner Rontani, Rejina Adhikari, Dulis Duron, Giulia Bortolon, Tri Setiyono

“…High soil moisture due to frequent excessive precipitation can lead to reductions in maize grain yields and increased nitrogen (N) loss. …”
Get full text

Nitrite-driven anaerobic ethane oxidation by Cheng-Cheng Dang, Yin-Zhu Jin, Xin Tan, Wen-Bo Nie, Yang Lu, Bing-Feng Liu, De-Feng Xing, Nan-Qi Ren, Guo-Jun Xie

“…Batch tests demonstrated that ethane is essential for nitrite removal in this microbial culture. Metabolic function analysis revealed that a species affiliated with a novel genus within the family Rhodocyclaceae, designated as 'Candidatus Alkanivoras nitrosoreducens', may perform the nitrite-driven anaerobic ethane oxidation. …”
Get full text

A 30-Day Randomized Crossover Human Study on the Safety and Tolerability of a New Micellar Berberine Formulation with Improved Bioavailability by Afoke Ibi, Chuck Chang, Yun Chai Kuo, Yiming Zhang, Min Du, Yoon Seok Roh, Roland Gahler, Mary Hardy, Julia Solnier

“…<b>Results</b>: Compared to placebo, no statistically significant changes in any of the safety markers related to liver or kidney health were detected. Within-group analysis revealed a significant reduction of total cholesterol (TC) in females after 30 days of Berberine LipoMicel^® treatment. …”
Get full text

Chronic kidney disease and orthostatic hypotension in hospitalised older adults by Francesco Curcio, Rosaria Chiappetti, Mattia De Furio, Veronica Flocco, David Della Morte, Gianluca Testa, Gaetano Gargiulo, Francesco Cacciatore, Pasquale Abete, Gianluigi Galizia

“…Purpose Orthostatic hypotension (OH) may predispose older adults to health complications leading to functional impairment. Despite the central role of the kidney in blood pressure control, the contribution of renal function in orthostatic hypotension is poorly investigated. …”
Get full text

Genetic context modulates aging and degeneration in the murine retina by Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

“…Analysis of cell type-specific marker genes predicted age-related loss of photoreceptors and retinal ganglion cells (RGCs) in WSB and NZO, respectively. …”
Get full text

Characterization of a GH43 Bifunctional Glycosidase from Endophytic <i>Chaetomium globosum</i> and Its Potential Application in the Biotransformation of Ginsenosides by Yao Lu, Qiang Jiang, Yamin Dong, Runzhen Ji, Yiwen Xiao, Du Zhu, Boliang Gao

“…In this study, we identified a GH43 family glycoside hydrolytic enzyme, <i>Xyaf313</i>, derived from the plant endophytic fungus <i>Chaetomium globosum</i> DX-THS3, which is capable of transforming several common ginsenosides. The enzyme function analysis reveals that Xyaf313 exhibits dual functionality, displaying both α-L-arabinofuranosidase and β-D-xylosidase activity. …”
Get full text

The CONSTANS-LIKE SlCOL1 in tomato regulates the fruit chlorophyll content by stabilizing the GOLDEN2-LIKE protein by Long Cui, Fangyan Zheng, Chenhui Zhang, Sunan Gao, Jie Ye, Yuyang Zhang, Taotao Wang, Zonglie Hong, Zhibiao Ye, Junhong Zhang

“…The suppression of SlCOL1 expression led to a reduction in the chlorophyll content of immature green fruit, while the overexpression of SlCOL1 increased it. …”
Get full text

Alterations in the Morphology of the Testis and Epididymis Caused by the Consumption of Hyperlipidic Diets in Wistar Rats by Rosario Tarragó Castellanos, Maria Mendoza Delgado, Lorena Ruiz Valderrama, Isabel Arrieta Cruz, Edith Cortés Barberena, Adriana Morales Otal, Ernesto Rodríguez Tobón, Ahiezer Rodríguez Tobón, Javier Olvera Ramírez, Edith Arenas Ríos

“…Morphometry was analyzed through histological analysis. The changes described affect testicular function in hormone and sperm production. …”
Get full text

Research on soybean leaf disease recognition in natural environment based on improved Yolov8 by Chen Chen, Chen Chen, Xiaolei Lu, Lei He, Lei He, Ruoxue Xu, Ruoxue Xu, Yi Yang, Yi Yang, Jing Qiu, Jing Qiu

“…Experimental results demonstrate that YOLOv8-DML achieves a mAP50 of 96.9%, marking a 1.8% improvement over the original YOLOv8 algorithm, while also achieving an 18.6% reduction in parameters. Comparative analysis with other mainstream object detection models indicates that YOLOv8-DML delivers superior overall performance, highlighting its significant potential for effective soybean leaf disease identification.…”
Get full text

Gait-based Parkinson’s disease diagnosis and severity classification using force sensors and machine learning by Navita, Pooja Mittal, Yogesh Kumar Sharma, Anjani Kumar Rai, Sarita Simaiya, Umesh Kumar Lilhore, Vimal Kumar

“…Parkinson’s disease is the primary neurodegenerative disorder that results in a gradual reduction in motor function. Early detection and monitoring of the disease progression is highly challenging due to the gradual progression of symptoms and the inadequacy of conventional methods in identifying subtle changes in mobility. …”
Get full text

Transoral versus extraoral approach for mandibular angle fractures: A comparative study by Sathya Kumar Devireddy, R.V. Kishore Kumar, Rajasekhar Gali, Sridhar Reddy Kanubaddy, Mallikarjuna Rao Dasari, Mohammad Akheel

“…Fracture line starting posterior or distal to the third molar or posterior to the insertion of the masseter muscle to the angle of the mandible or fracture line extending high in the ramus, extraoral approach provides a better choice for reduction and fixation of the fractured segments with restoration of anatomical and functional occlusion.…”
Get full text

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. by Suneng Fu, Jason Fan, Joshua Blanco, Alfredo Gimenez-Cassina, Nika N Danial, Steve M Watkins, Gökhan S Hotamisligil

“…We discovered that ER from livers of obese mice exhibits a general reduction in protein synthesis, and comprehensive analysis of polysome-bound transcripts revealed extensive down-regulation of protein synthesis machinery, mitochondrial components, and bile acid metabolism in the obese translatome. …”
Get full text