Allelic Imbalance in TOR1A mRNA Expression in Manifesting and Non-Manifesting Carriers of the GAG-Deletion by Ioanna A. Armata, Andreas I. Diplas, Laurie J. Ozelius, Pullanipally Shashidharan

“…The expression ratio of the two alleles could be important for the manifestation or prevention of the disease since wild-type (WT) torsinA is thought to have protective function. Absence of an antibody discriminating WT from ΔE torsinA has precluded the determination ΔE and WT torsinA levels in manifesting and nonmanifesting carriers. …”
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Network Pharmacology Analysis of the Molecular Mechanism of Astaxanthin in Reversing Insulin Resistance in Type 2 Diabetic Mice by LI Lingyan, LI Ming, YANG Hui, LAN Yanshan, CHEN Moliang, ZHANG Jiayuan, XU Guanghui

“…It was found that astaxanthin significantly reduced blood glucose, TNF-α, and FRA levels, and enhanced islet function and alleviate insulin resistance in T2DM mice. …”
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Rock fracture type recognition based on deep feature learning of microseismic signals by LI Dianze, XU Huajie, ZHANG Bo

“…Microseismic monitoring has been widely used for detecting rock fractures. However, conventional machine learning methods for microseismic signal analysis exhibited limited feature extraction capabilities and were highly susceptible to noise, leading to reduced classification accuracy and poor generalization performance. …”
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Can the single-breath alveolar volume be adjusted to estimate true total lung capacity? by Simon Kristoffer Høgh Rasmusen, Jann Mortensen

“…Second, we compared the ability to detect restriction (reduced TLC) from adjusted TLC measured by single-breath (TLCsbadj) with gold standard TLCwbp.Methods Lung function data from 800 consecutive patients were analysed with multivariable linear regression. …”
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Surgical Rehabilitation of a Posttraumatic Iris Cyst, Cataract and Astigmatism Patient. Clinical Case by A. L. Onishchenko, V. K. Potehin, N. A. Vershinina

“…Positive optical and therapeutic effects were achieved as a result of the surgical treatment 44 years after an open eye injury: the eye is calm, the iris cyst is not detected, visual acuity has increased. The postoperative period showed the saving the stable and high visual and functional result with no recurrence of the iris cyst.…”
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Hyponatraemia Induced by Terlipressin in Patients Diagnosed with Decompensated Liver Cirrhosis and Acute Variceal Bleeding by Mahmoud Elshehawy, Richel Merin Panicker, Alaa Amr Abdelgawad, Patrick Anthony Ball, Hana Morrissey

“…This case aligns with existing reports, emphasizing the dual vasopressin receptor activity of terlipressin and its capacity to induce hyponatraemia, particularly in cirrhotic patients with preserved renal function and higher baseline sodium levels. <b>Conclusions:</b> This case and a literature review underscored the critical need for early fluid balance monitoring to detect retention. …”
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A Case of IFAP Syndrome with Severe Atopic Dermatitis by Catarina Araújo, Miguel Gonçalves-Rocha, Cristina Resende, Ana Paula Vieira, Celeste Brito

“…The phenotypic expression of disease is quantitatively related to a reduced function of a key cellular regulatory system affecting cholesterol and endoplasmic reticulum homeostasis. …”
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Surgical Rehabilitation of a Posttraumatic Iris Cyst, Cataract and Astigmatism Patient by A. L. Onishchenko, V. K. Potehin, N. A. Vershinina

“…Positive optical and therapeutic effects were achieved as a result of the surgical treatment 44 years after an open eye injury: the eye is calm, the iris cyst is not detected, visual acuity has increased. The postoperative period showed the saving the stable and high visual and functional result with no recurrence of the iris cyst.…”
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Mathematical Modeling of COVID-19 Disease Dynamics With Contact Tracing: A Case Study in Ethiopia by Shimelis Bekele Zerefe, Tigabu Kasie Ayele, Surafel Luleseged Tilahun

“…The new infections would decrease in the communities by detecting and isolating COVID-19 cases before they could spread the virus to others. …”
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Nucleolar sequestration of cannabinoid type-2 receptors in triple-negative breast cancer cells. by Linley P Prado-Celis, Rodrigo Zamora-Cárdenas, Javier Alamilla, Enrique A Sánchez-Pastor, Tania Ferrer, Eloy G Moreno-Galindo, Ricardo A Navarro-Polanco

“…It remains to determine the function and signaling ability of CB2R in the nucleolus. …”
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Change in Pattern of Head and Neck Lesions Diagnosed by FNAC in the Post-COVID-19 Period: Are Lymphoproliferative Disorders on the Rise? by Shiv Kumar, Shilpi Saxena, Anubhav Singh, Kamal Deep Joshi, Mirza Saleem Amjad, Vidushi Joshi, Abhinav Bhardwaj

“…Introduction: Coronavirus disease 2019 (COVID-19) infection is associated with a variety of immune dysregulations. Aberrant immune function can lead to a plethora of lymphoproliferative and autoimmune dysfunctions. …”
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Selection of stable reference genes for accurate reverse-transcription quantitative PCR in cotton-herbivore studies using virus-induced gene silencing by Mason K. Clark, Spencer T. Behmer, Gregory A. Sword

“…Conversely, normalization using GhUBQ7 reduced sensitivity to detect expression changes, highlighting the importance of stable reference gene selection for accurate expression normalization and interpretation. …”
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Adenosine Monophosphate-Activated Protein Kinase, Oxidative Stress, and Diabetic Endothelial Dysfunction by Ming-Hui Zou, Shengnan Wu, Tianyu Xu, Xiaoxia Fu.

“…Further, our studies demonstrate that AMPK's functions as a redox sensor and modulator are vital to maintain endothelial cell function under physiological conditions. …”
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Altered phenotypic and metabolic characteristics of FOXP3+CD3+CD56+ natural killer T (NKT)-like cells in human malignant pleural effusion by Zi-Hao Wang, Pei Zhang, Wen-Bei Peng, Lin-Lin Ye, Xuan Xiang, Xiao-Shan Wei, Yi-Ran Niu, Si-Yu Zhang, Qian-Qian Xue, Hao-Lei Wang, Qiong Zhou

“…Similar to Treg cells, FOXP3+ NKT-like cells highly expressed monocarboxylate transporter 1 (MCT1) and lactate dehydrogenase B to uptake and utilize lactate, thereby maintaining their immunosuppressive function and hyperlactylation in MPE. Furthermore, we found that MCT1 small molecule inhibitor 7ACC2 significantly reduced FOXP3 expression and histone lactylation levels in NKT-like cells in vitro. …”
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Syntenin Controls Extracellular Vesicle‐Induced Tumour Migration by Regulating the Expression of Adhesion Proteins on Small Extracellular Vesicles by Barnabas Irmer, Allegra Angenendt, Luc Camoin, Stéphane Audebert, Christiane Geyer, Mirjam Gerwing, Hanna Spiessbach, Mira Hebel, Émilie Baudelet, Darius Wlochowitz, Uwe Hansen, Annalen Bleckmann, Pascale Zimmermann, Kerstin Menck

“…In this study, we aimed to characterise a distinct sEV species under the control of Syntenin, a key regulator of endosomal sEV biogenesis, regarding its proteomic cargo and pro‐tumourigenic functions. Using mass spectrometry (MS), we detected 178 down‐ and 236 up‐regulated proteins on sEVs from breast cancer cells upon Syntenin knockout (KO). …”
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Changes in Protein Metabolism and Early Development of Sarcopenia in Mice With Cholestatic Liver Disease by Ottavia Agrifoglio, Solvig Görs, Quentin Sciascia, Zeyang Li, Elke Albrecht, Sophie Achilles, Meike Statz, Manuela Bastian, Tobias Lindner, Karen Friederike Gauß, Sarah Rohde, Karen Rischmüller, Peggy Berlin, Georg Lamprecht, Robert Jaster, Cornelia C. Metges, Luise Ehlers

“…Compared to controls, BDL mice showed lower N‐BAL (p < 0.05), reduced TEE (p < 0.01), and lower FPSR in the liver (p < 0.05) and quadriceps muscle (p < 0.001). …”
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Humidity Sensing in Graphene-Trenched Silicon Junctions via Schottky Barrier Modulation by Akeel Qadir, Munir Ali, Afshan Khaliq, Shahid Karim, Umar Farooq, Hongsheng Xu, Yiting Yu

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Contemporary Perspectives on Congestion in Heart Failure: Bridging Classic Signs with Evolving Diagnostic and Therapeutic Strategies by Mihai Grigore, Camelia Nicolae, Andreea-Maria Grigore, Ana-Maria Balahura, Nicolae Păun, Gabriela Uscoiu, Ioana Verde, Adriana-Mihaela Ilieșiu

“…Future approaches should prioritize personalized decongestive therapy, addressing both intravascular and tissue congestion, while aiming to preserve renal function and limit neurohormonal activation. Refinement of these strategies holds promise for improving long-term outcomes, reducing rehospitalizations, and enhancing overall patient prognosis.…”
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Preliminary observations of glucose metabolism dysregulation in pediatric Huntington’s disease by Federica Graziola, Federica Rachele Danti, Martina Penzo, Antonio Spagarino, Eleonora Minacapilli, Marco Moscatelli, Federica Zibordi, Caterina Mariotti, Giovanna Zorzi, Giovanna Zorzi

“…However, systemic biochemical indicators of glucose transport deficiency, including erythrocyte GLUT1 function and CSF glucose, were not significantly altered. …”
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Radiation diagnostics of the state of ventilation and pulmonary circulation in patients with COPD by O. S. Sementsov, S. V. Stepanenko

“…Also a promising area is the use of functional CT (inspiratory-expiratory CT) - which should improve the assessment of respiratory function, including early detection of patients with COPD, which will promote the in time start of specific treatment, reduce episodes of exacerbations during the disease, assess the dynamics of the pathological process and the effectiveness of treatment, as well as improving the prognosis of work and life expectancy of patients. …”
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