Revisiting the Middle Molecule Hypothesis of Uremic Toxicity: A Systematic Review of Beta 2 Microglobulin Population Kinetics and Large Scale Modeling of Hemodialysis Trials In Sil... by Maria Eleni Roumelioti, Thomas Nolin, Mark L Unruh, Christos Argyropoulos

“…Only daily long sessions of hemodialysis consistently reduced mortality risk between 7-19% across the range of β2M generation rate.…”
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Sagittal Plane Kinematic Deviations and Spatio-Temporal Gait Characteristics in Children with Idiopathic Toe Walking: A Comparative Analysis Using Statistical Parametric Mapping by Rocio Pozuelo-Calvo, Almudena Serrano-Garcia, Yolanda Archilla-Bonilla, Angel Ruiz-Zafra, Manuel Noguera-Garcia, Kawtar Benghazi-Akhlaki, Miguel Membrilla-Mesa, Carla DiCaudo, Jose Heredia-Jimenez

“…The plantarflexion observed at the end of the gait cycle corresponded to early gait phases due to methodological considerations of the coordinate-based event detection algorithm. <b>Conclusions</b>: Children with ITW demonstrate distinct spatio-temporal adaptations, including increased single support and swing phases, along with reduced walking velocity compared to typically developing peers. …”
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Exosome Derived from Human Umbilical Cord Mesenchymal Cell Exerts Immunomodulatory Effects on B Cells from SLE Patients by Ying Zhao, Wenbin Song, Zilin Yuan, Min Li, Gang Wang, Liping Wang, Yueping Liu, Bo Diao

“…We found that hucMSCs-Exo promoted B cell apoptosis, prevented B cell overactivation, and reduced inflammation. MicroRNA-155 (miR-155) has a powerful regulatory function in B cells. …”
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Mechanism of Action of Exercise in Regulating Spontaneous Hypertension through the Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling Pathway by Yu Li, Xiaoju Song, Lianjing Dai, Yangyi Wang, Qiong Luo, Lei Lei, Yunfei Pu

“…After exercise, SHR rats showed a decrease in blood pressure and HR level, and an increase in glucose tolerance and myocardial insulin sensitivity. Exercise reduced SHR cardiomyocyte cross-sectional area and collagen deposition index, improved cardiac function, and decreased inflammation and oxidative stress. …”
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Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats. by Meilan Xue, Ying Liu, Rui Lyu, Na Ge, Man Liu, Yan Ma, Hui Liang

“…One hundred twenty to 190 genera of bacteria were detected by high throughput sequencing. Alcohol-induced changes in the gut microbial composition were detected at the genus level. …”
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Protective effect of L-carnitine on rhabdomyolysis-induced acute kidney injury via Nrf2/HO-1 activation by ZHANG Yuan-yuan, ZHANG Jian-rong, GENG Yan-qiu, ZHANG Yan-xia

“…Objective To observe the protective effects of L-carnitine on renal function in rhabdomyolysis-induced acute kidney injury(AKI) in rats and the underlying mechanism.Methods Thirty-six adult rats were randomly divided into 3 groups:control group,AKI model group,and L-carnitine treatment group[rhabdomyolysis-induced AKI rats given L-carnitine(200 mg/kg)].50%glycerin was intramuscularlly injected to establish rhabdomyolysis-induced AKI models in rats.Blood samples were taken from the heart from rats and the kidneys were harvested.Serum creatine kinase(CK),blood urea nitrogen(BUN),serum creatinine(SCr) levels were measured,and renal pathological changes were observed under light microscope.RT-PCR and immunohistochemistry were used to detect the expression of Nrf2 and HO-1 in renal tissues.Enzyme linked immunosorbent assay(ELISA) was applied to detect the expression of SOD and MDA in renal tissues.Results As compared with control group,CK,BUN,SCr,Nrf2,HO-1,MDA and ATN were significantly elevated,and SOD was significantly reduced in model group and L-carnitine treatment group(F = 8.78-200.77,q=S.42-19.40,P<0.05).As compared with model group,CK,BUN,SCr,MDA and ATN were significantly decreased,and Nrf2,HO-1 and SOD were significantly elevated in L-carnitine treatment group(q = 4.15-15.39,P<0.05).Conclusions L-carnitine can ameliorate rhabdomyolysis-induced AKI,which may be related with its anti-oxidative stress.…”
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ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration through Autophagy by Ziqiang Zhang, Mengyu Zhang, Zhixiang Zhang, Yingying Sun, Jiajia Wang, Chenhao Chang, Xinyan Zhu, Monan Li, Yumei Liu

“…On day 7, autophagy was observed and gait was detected on days 7, 14, 21, and 28. On the 28th day, the sciatic nerve of rats’ renewal was detected. …”
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Accounting for contact tracing in epidemiological birth-death models. by Anna Zhukova, Olivier Gascuel

“…We proposed a non-parametric test for detecting contact tracing in pathogen phylogenetic trees. …”
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Simplified radar architecture based on information metasurface by Si Ran Wang, Zhan Ye Chen, Shao Nan Chen, Jun Yan Dai, Jun Wei Zhang, Zhen Jie Qi, Li Jie Wu, Meng Ke Sun, Qun Yan Zhou, Hui Dong Li, Zhang Jie Luo, Qiang Cheng, Tie Jun Cui

“…This study presents an innovative radar system paradigm that integrates RF front ends and signal processors onto an information metasurface platform, achieving essential sensing functions with reduced system complexity and cost.…”
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Relationships Among In-Line Milk Fat-to-Protein Ratio, Metabolic Profile, and Inflammatory Biomarkers During Early Stage of Lactation in Dairy Cows by Karina Džermeikaitė, Justina Krištolaitytė, Neringa Sutkevičienė, Toma Vilkonienė, Gintarė Vaičiulienė, Audronė Rekešiūtė, Akvilė Girdauskaitė, Samanta Arlauskaitė, Árpád Csaba Bajcsy, Ramūnas Antanaitis

“…Moreover, high serum NEFA levels adversely affect immune function, increasing vulnerability to infections such as mastitis. …”
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Intranasal administration of stem cell derivatives for the treatment of AD animal models: a systematic review and meta-analysis by Zilin Hua, Nan Zhou, Zijing Zhou, Zewei Fu, Ruiyun Guo, Herman Yao Akogo, Jiayin Yang, Meixuan Yu, Yujie Jiang, Siyi Lan, Haixia Chang, Jun Ma, Huixian Cui

“…Subgroup analyses indicated that stem cell source, stem cell derivative types and Aβ detection method were not primary drivers of heterogeneity. …”
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Unveiling the Regulatory Mechanism of Tibetan Pigs Adipogenesis Mediated by WNT16: From Differential Phenotypes to the Application of Multi-Omics Approaches by Qiuyan Huang, Kunli Zhang, Fanming Meng, Sen Lin, Chun Hong, Xinming Li, Baohong Li, Jie Wu, Haiyun Xin, Chuanhuo Hu, Xiangxing Zhu, Dongsheng Tang, Yangli Pei, Sutian Wang

“…This cross-level regulatory mechanism of “phenotype detection–multi-omics analysis–gene function research” highlighted WNT16 as a potential key regulator of site-specific fat deposition, providing new molecular targets for optimizing meat quality through nutritional regulation and genetic modification.…”
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Interferon-stimulated circHOMER1 attenuates antiviral innate immunity by Ao Zhang, Ranran Yao, Shijin Geng, Haiying Wang, Rong-Chun Tang, Hengxiang Yu, Rui Xu, Hong-Yan Chen, Yunxuan Zhou, Lan Zhang, Jun Zhang

“…Its functions in the immune system are not discovered. …”
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Bitter taste receptor T2R14-Gαi coupling mediates innate immune responses to microbial quorum sensing molecules in cystic fibrosis by Nisha Singh, Ryan H. Cunnington, Anjali Bhagirath, Ankita Vaishampayan, Mohd Wasif Khan, Tejas Gupte, Kangmin Duan, Abdelilah S. Gounni, Shyamala Dakshisnamurti, John W. Hanrahan, Prashen Chelikani

“…Summary: Cystic fibrosis (CF) is an autosomal recessive disease characterized by microbial infection and progressive decline in lung function, leading to significant morbidity and mortality. …”
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Prevalence, correlative and statistical relationships of renal dysfunction in patients with chronic ischemic heart failure by D. A. Lashkul

“…Thus, ischemic heart failure characterized by reduced filtration capacity of the kidneys and is inversely related to age and functional class. …”
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Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas–FasL pathway activation and metabolic reprogramming by Liang Yao, Liang Yao, Liang Yao, Chen Gu, Chen Gu, Chen Gu, Ruipeng Ge, Ruipeng Ge, Ruipeng Ge, Xiaoqian Zhang, Xiaoqian Zhang, Xinqian Meng, Xinqian Meng, Lei Wang, Lei Wang, Lei Wang, Lei Wang, Daiyin Peng, Daiyin Peng, Daiyin Peng, Daiyin Peng, Guozhuan Li, Guozhuan Li

“…Additionally, immunoprecipitation, quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting, and biomarker detection were utilized to investigate the mechanisms underlying DHP’s inhibition of HCT116 cells and its impact on metabolic reprogramming.ResultsIn the present study, we observed that DHP treatment at 600 μg/ml for 24 h reduced HCT116 cell viability to 54.87%. …”
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Legality of bringing to administrative responsibility for an offense under Art. 130 Code of Ukraine on Administrative Offenses: retrospective analysis by K. O. Chyshko

“…Driving under the influence of alcohol, drugs or other intoxicants or under the influence of drugs that reduce attention and speed of reaction, in the period from July 1, 2020 to March 17, 2021: 1) was recognized not as an administrative offense, but as a criminal offense; 2) detection, termination and documentation of such a criminal offense was carried out mainly by patrol police officers, and not by investigators, as required by current criminal procedure legislation; 3) a report on an administrative offense and other administrative-procedural documents were drawn up upon the fact of committing a criminal offense; 4) the prosecution of a person did not take place as a result of a pre-trial investigation, but within the framework of proceedings in cases of administrative offenses. …”
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A vascular endothelial cell, neuron, and microglia tri-culture model to study hypertension-related depression by Hongxia Zhao, Hongxia Zhao, Lingge Huang, Jian Liu, Min Feng, Yeqian Liu, Hong Li, Shan Gong, Chunming Chen, Shuiqing Zeng, Weiqiong Ren

“…Vascular endothelial function and inflammatory levels were assessed using fluorescent probes and enzyme-linked immunosorbent assays. …”
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Optimizing additive manufacturing workflows using model-based systems engineering by Mohamed Amine Daoud, Khadija Bekkay Haouari, Meriem Hayani Mechkouri, Amine Ennawaoui, Hicham El hadraoui, Ilias Naser, Mustapha Ouardouz, Kamal Reklaoui

“…The ASAM framework utilizes the CESAM architecture and System Modelling Language (SysML) to create multi-architecture models of the AM process, integrating operational, functional, and constructional perspectives. These models formalize the system architecture, providing a foundation for developing automated design validation, flaw detection, and optimization mechanisms. …”
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Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…Epithelial-mesenchymal transition (EMT)-associated proteins were determined by Western blotting. The function of miR-613 in COPD was further detected. Functional rescue experiments were performed to determine the mechanism of ARHGAP18 in COPD.Results: Our study identified ARHGAP18 as the key gene associated with epithelial dysfunction in COPD. …”
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