Acute Exposure to Aerosolized Nanoplastics Modulates Redox-Linked Immune Responses in Human Airway Epithelium by Joshua D. Breidenbach, Benjamin W. French, Upasana Shrestha, Zaneh K. Adya, R. Mark Wooten, Andrew M. Fribley, Deepak Malhotra, Steven T. Haller, David J. Kennedy

“…Airway epithelium was exposed to aerosolized 50 nm polystyrene NPs at concentrations ranging from 2.5 to 2500 µg/mL for three minutes per day over three days. Functional assays revealed no significant alterations in tissue integrity, cell survival, mucociliary clearance, or cilia beat frequency, suggesting intact epithelial function post-exposure. …”
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Lung Mesenchymal Stem Cells Ameliorate Elastase-Induced Damage in an Animal Model of Emphysema by Donato Cappetta, Antonella De Angelis, Giuseppe Spaziano, Gioia Tartaglione, Elena Piegari, Grazia Esposito, Loreta Pia Ciuffreda, Angela Liparulo, Manuela Sgambato, Teresa Palmira Russo, Francesco Rossi, Liberato Berrino, Konrad Urbanek, Bruno D’Agostino

“…Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. …”
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MINERAL DENSITY AND METABOLISM OF BONE TISSUE IN PATIENTS WITH CHRONIC HEART FAILURE INSUFFICIENCY OF SENIOR AGE by S. V. Topolyanskaya, I. O. Osipovskaya, L. S. Lifanova, T. A. Eliseeva, O. N. Vakulenko

“…Greater differences in BMD were detected in female patients (p=0.002). The reduced osteoblast function was observed in CHF-patients; mean osteocalcin level was 1.23 ng/ml in the CHF-group and 4.16 ng/ml — in the control group (p=0.03). …”
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Lactobacillus plantarum SAL delays aging-associated oxidative stress and gut microbiota dysbiosis in mice by Wen Dong, Yongzhi Lun, Jie Sun, Ben Liu

“…While Lactobacillus plantarum generally enhances gut microbiota structure/function, improving health and lifespan in model organisms, the in vivo effects, mechanisms, and potential anti-aging properties of the SAL strain remain unexplored. …”
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Subclinical Aortic Root Pathology in Close Relatives of Patients with Bicuspid Aortic Valve by Ivaniv Y., Lozynska N., Ivaniv I.

“…However, the degree of dilation of the aorta does not correspond to the severity of the valve function disorder. In many studies, it is emphasized that in persons with BAV the elastic properties of the proximal aorta are significantly reduced. …”
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Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73 by Bo Shao, Hong-da Wang, Shao-hua Ren, Qiang Chen, Zhao-bo Wang, Yi-ni Xu, Tong Liu, Cheng-lu Sun, Yi-yi Xiao, Hong-yu Jiang, Yi-cheng Li, Peng-yu Zhao, Guang-mei Yang, Xu Liu, Yu-fan Ren, Hao Wang

“…ELISA and Treg proliferation assays detected the function of macrophages. Furthermore, the role of the MAPK pathway in CD73-positive Exo-induced macrophage polarization was also elucidated. …”
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Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer’s disease by Hongli Chen, Na Li, Na Liu, Hongyu Zhu, Chunyan Ma, Yutong Ye, Xinyu Shi, Guoshuai Luo, Xiaoxi Dong, Tao Tan, Xunbin Wei, Huijuan Yin

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Potential guidelines for cataract surgery and rehabilitation in visually impaired patients: Literature analysis by Paolo Giuseppe Limoli, Celeste Limoli, Marcella Nebbioso

“…Patients with visual impairments rely on retinal regions with the greatest residual function, and cataract surgery aims to enhance focus on these areas, improving reading quality and reducing scotoma perception. …”
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Caveolae in smooth muscle cells mediates vasoconstriction of renal artery in rats by ZHANG Hai-jun, SU Yu-ting, MENG Xing-xing, CHENG Yao-ping, XIE Xiao-ping, CHANG Yao-ming, BAO Junxiang

“…Objective To investigate the role of caveolae on vascular smooth muscle cells(VSMCs)in vasoconstriction of renal artery(RA)and the possible mechanisms.Methods The RA was pretreated with methyl-beta-cyclodextrin(MCD)and cholesterol(CHO)to reduce and enhance the formation of caveolae,respectively.Isometric force recording system was used to detect the vascular function.Real-time polymerase chain reaction(RT-PCR) and Western blotting were conducted to examine the expression of mRNA and protein of caveolin-1 and Angiotensin type 1 receptor(AT1R).Immumoprecipitation with Western blotting was carried out to test the binding of caveolin-1 and AT1 R.Results Incubation with MCD reduced the caveolae number in VSMCs significantly(P<0.05),which could be reversed by CHO treatment.Neither the MCD nor CHO influenced the gene or protein expression of caveolin-1.The vasoconstriction of RA to KCl or PE did not change after MCD or CHO incubation.However,MCD could inhibit the vasoconstriction of the artery to Ang Ⅱ with lower Emax(P<0.05)and higher EC50(P<0.05),which again could be reversed by CHO pretreatment The protein expression of AT1 R was not affected by MCD or CHO incubation.In the case of normal RA,Ang Ⅱ would promote the binding of AT1 R to caveolin-1(P<0.05),while the response was blocked substantially in MCD-incubated RA,which was restored if the RA was treated by MCD and CHO simultaneously.Conclusions The caveolae regulate the vasoconstriction of RA to Ang Ⅱ by controlling the binding of caveolin-1 with AT1 R.…”
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Bardoxolone Methyl Ameliorates Myocardial Ischemia/Reperfusion Injury by Activating the Nrf2/HO-1 Signaling Pathway by Anwu Huang, Zhaolin Wang, Hua Tang, Zhuyin Jia, Xiaojun Ji, Xuehua Yang, Wenbing Jiang

“…The animal’s cardiac function was measured. Myocardial I/R injury serum markers were detected via ELISA. …”
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Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K+ currents. by Bin Li, Yating Chen, Maoxiang Zhao, Zhijie Chen, Zhuhui Lin, Jie Liu, Xueping Wang, Jiancheng Zhang, Yang Li

“…Downregulated expression of KV4.2 and KChIP2, comprising functional Ito channel pore-forming (α) and accessory (β) subunits, was detected in HFD mice. …”
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Nrf2 Deficiency Brings About Increased Sensitive to IR and 7,12-dimethylbenz(a)anthracene and Leukemia Predisposition by Mingxin Dong, Ping Yang, Xinyu Zhang, Shasha Nie, Xiaohui Sun

“…Conclusions We demonstrate that the genetic deficiency of Nrf2 in mice leads to reduced antioxidant capacity and suppression of hematopoietic and immune system function, resulting in increased sensitivity to IR or DMBA.…”
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Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages. by Elaine Carvalho de Oliveira, Rafael Tibúrcio, Gabriela Duarte, Amanda Lago, Léon de Melo, Sara Nunes, Gustavo Gastão Davanzo, Ana Júlia Martins, Bruno Vinagre Ribeiro, Deborah Mothé, Juliana B P Menezes, Patrícia Veras, Natalia Tavares, Pedro M Moraes-Vieira, Cláudia Ida Brodskyn

“…Macrophages represent a fundamental component of the innate immune system that play a critical role in detecting and responding to pathogens as well as danger signals. …”
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Ensemble learning driven Kolmogorov-Arnold Networks-based Lung Cancer classification. by Abdul Rahaman Wahab Sait, Eid AlBalawi, Ramprasad Nagaraj

“…Early Lung Cancer (LC) detection is essential for reducing the global mortality rate. …”
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Web-based assessment of dual-task costs at different ages: an analysis across cognitive domains by Vincenzo Livoti, Vincenzo Livoti, Fiorella Del Popolo Cristaldi, Giulio Contemori, Maria Silvia Saccani, Mario Bonato, Mario Bonato

“…We also tested whether DTCs were task-specific or related to general abilities by employing three dual-tasks, each focused on different cognitive functions. We measured the performance of 419 Italian-speaking healthy participants (18–76 years old) in: (i) a digital version of the Trail Making Test (A + B); (ii) the divided-attention subtest of the Test of Attentional Performance battery, adapted for online administration; (iii) a visuo-mnestic dual-task, validated in previous studies with healthy younger and older adults.ResultsResults showed that with increasing age and cognitive load performance significantly reduced across all tasks. …”
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Towards liquid biopsy on chip for Triple Negative Breast Cancer: preliminary results on monitoring circulating miRNA-21 using portable diagnostics by Alessandra Glovi, Panagiota M. Kalligosfyri, Antonella Miglione, Sima Singh, Gabriella Iula, Antonio Giordano, Michelino De Laurentiis, Stefano Cinti

“…In this work, miRNA-21 was selectively detected using a complementary DNA probe modified with methylene blue, as a redox mediator, immobilized onto an AuNPs-functionalized, paper-based screen-printed electrode. …”
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RETRACTED: MicroRNA‐425‐3p inhibits myocardial inflammation and cardiomyocyte apoptosis in mice with viral myocarditis through targeting TGF‐β1 by Junhua Li, Jiehong Tu, Hong Gao, Lu Tang

“…On the 7th day after CVB3 infection, 10 mice in each group were euthanized to assess the heart function indices of mice, observe the pathological conditions, detect myocardial tissue apoptosis, and measure the inflammatory factor levels in myocardial tissues. …”
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Does peatland rewetting mitigate flooding from extreme rainfall events? by S. Karimi, V. Mosquera, E. Maher Hasselquist, J. Järveoja, H. Laudon

“…Our rainfall-runoff analysis revealed that rewetting significantly decreased peak flow and the runoff coefficient and reduced the overall flashiness of hydrographs, making the rewetted sites function more like the pristine control peatland. …”
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IGF2BP1-mediated methylation of ABCA1 facilitates tumor progression by affecting cholesterol metabolism in lung adenocarcinoma by Shaohua Xu, Kai Liu, Zhao Chen, Weijian Tang, Zhoumiao Chen

“…Subsequently, a cell model with overexpressed ABCA1 was constructed for verification through cell experiments. Cell function was evaluated using the Transwell assay and the colony formation assay. …”
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Effects and underlying mechanisms of novel phenothiazine derivative DA414 in rats with intracerebral hemorrhage by MA Yufan, WANG Bingqiao, LIN Sen

“…Results‍　‍DA414 significantly promoted the absorption of hematoma, reduced neuronal injury, and improved neurological function scores. …”
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