The role of SFRP1 in human dermal papilla cell growth and its potential molecular mechanisms as a target in regenerative therapy by Chaofan Wang, Yimei Du, Changpei Lu, Lingbo Bi, Yunbu Ding, Weixin Fan

“…Also, SFRP1 regulates the cell proliferation capacity of IDPCs and reduces their migration functions. The DPCs' living activity, proliferation, and migration function exhibited a negative correlation with the level of SFRP1. …”
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Inhibition of renin-angiotensin system attenuates type I alveolar epithelial cell necroptosis in rats after hyperbaric hyperoxic exposure by CuiHong Han, PeiXi Zhang, Ying Liu, JiaJun Xu, XuHua Yu, YuKun Wen, ShiFeng Wang, WenWu Liu

“…After hyperbaric exposure, lung function was non-invasively detected, and then animals were sacrificed for the detection of wet to dry ratio of the lung, blood gas and lung inflammatory factors, and lung tissues were collected for double immunofluorescence staining. …”
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Association between mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) and PCOS by Liying Huang, Xiao Qin, Chun Tian, Shaohua Ling, Xiaoqiong Luo, Bingsheng Huang, Yanlan Ling, Shenwen Zhong, Zhi Li, Li Qin

“…We collected peripheral blood mononuclear cells and follicular fluid granulosa cells (GCs) from the two groups of patients, and used PCR to detect the expression of SIRTs, oxidative stress indexes, and mitochondrial function indexes. …”
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Metabolism and immune responses of striped hamsters to ectoparasite challenges: insights from transcriptomic analysis by Xinchang Lun, Yiguan Wang, Ning Zhao, Yujuan Yue, Fengxia Meng, Qiyong Liu, Xiuping Song, Ying Liang, Liang Lu

“…Notably, the chemical carcinogenesis - reactive oxygen species pathway was upregulated during flea parasitism, with downregulation of hub genes ATP5MC1 and ATP5MC2, highlighting the importance of mitochondrial function in oxidative stress. ELISA findings revealed that on day 3, flea parasitism groups showed elevated ROS expression and reduced SOD and CAT levels compared to the control group. …”
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Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein O-GlcNAcylation by Zhen Wang, Fujia Chen, Yun Li, Chaoying Liu, Lizhen Wang, Weilun Shao, Zhen Lu, Li Hu, Longxuan Li, Yue Wang, Jinyang Lin, Yaxuan Yu, Shengjun Sun, Yurong Yang, Zhijian Zhu, Siqiang Li, Enzhong Li

“…After five weeks of treatment, evaluations based on organ coefficients, sperm count detection, testicular pathology analysis, and hormone level assessments determined the most effective curcumin dosage.Results and disccusionThe findings indicated that cryptorchidism had a detrimental impact on reproductive function, evident by decreased testicular coefficient, cessation of sperm production, abnormal testicular tissue morphology, and hormonal imbalances. …”
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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury by Ting Zhou, Ziyao Zhang, Yawen Zhan, Meiying Wang, Meiying Wang, Meiying Wang, Mi Wu, Xiufang Weng, Xiufang Weng, Xiufang Weng, Xiufang Weng, Younian Xu, Younian Xu, Younian Xu

“…The ratio, number, phenotype, and function of immune cells and cytokine levels were measured. …”
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The scRNA-sequencing landscape of pancreatic ductal adenocarcinoma revealed distinct cell populations associated with tumor initiation and progression by Ying Wang, Zhouliang Bian, Lichao Xu, Guangye Du, Zihao Qi, Yanjie Zhang, Jiang Long, Wentao Li

“…The knockdown of S100A2 significantly reduced the motility of pancreatic cancer cell lines in both wound healing and transwell migration assays. …”
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Potential induction of the relative mRNA expression levels of CYP450 by Zhicaowu-Hezi (Aconiti kusnezoffii radix preparata and Terminalia chebula Retz.) by Junxuan Zhu, Ming An, Weiting Wang, Jingjing Guo, Mengting Chen, Longlong Fang, Cen Wang, Dong Zhang, Guodong Wu

“…At the molecular level, RT-qPCR analysis demonstrated that Zhicaowu significantly suppressed hepatic CYP1a2, CYP2d2, CYP3a1, and CYP2c11 mRNA expression, while Hezi co-treatment restored their expression to normal or elevated levels.ConclusionHezi dose-dependently induced CYP450 enzyme activity, reversing Zhicaowu’s inhibition of CYP1a2/2d2/3a1/2c11 and markedly improving liver function and histopathology. These results elucidate the scientific basis for toxicity reduction in Zhicaowu-Hezi herb pair through metabolic enzyme regulation, supporting its traditional use. …”
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Brachial plexus nerve block versus haematoma block for closed reduction of distal radius fracture in adults: The BLOCK Trial – a protocol for a multicentre randomised controlled tr... by Janus Christian Jakobsen, Anders Kehlet Nørskov, Mikkel Brabrand, Ole Mathiesen, Bjarke Viberg, Christian Rothe, Lars Hyldborg Lundstrøm, Kai Henrik Wiborg Lange, Stig Brorson, Christoffer Calov Jørgensen, Jonas Askø Andersen, Cecilie Dupont Harwood, Anne-Sofie Linde Jellestad, Aurelien-Xuan Rosendal Bahuet, Rasmus Linnebjerg Knudsen, Lana Chafranska Andersen, Per Hviid Gundtoft, Mads Terndrup

“…Introduction Distal radius fractures account for one-fifth of all fractures in the active elderly population and may cause chronic pain, loss of hand function and reduced work productivity, imposing a significant socioeconomic burden. …”
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Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis by Jialin Li, Jialin Li, Fang Xiao, Fang Xiao, Bingsen Lin, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Jie Xu, Fu-Li Xiang, Fu-Li Xiang

“…We found that ejection fraction (EF) remained normal at 6h after CLP, but the contractility detected by cardiac muscle strain analysis was significantly reduced, along with increased immune cell infiltration. …”
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Protein Binding Characteristics of the Principal Green Tea Catechins: A QCM Study Comparing Crude Extract to Pure EGCG by Elsadig E. Ali, Mohamed O. Elmakki, Miranda L. Gavette, Brian J. Doyle, Shannon J. Timpe

“…The adsorbed mass levels onto BSA-functionalized surfaces were measured at various solution concentrations. …”
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Ion-selective electrode-based sensors from the macro- to the nanoscale by Yerim Kim, Minjee Seo, Seol Baek

“…Miniaturized solid-state ISEs provide low limits of detection with reduced sample volume requirements, extended stability, and rapid response times. …”
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Osteocalcin deficiency attenuates neointima formation after vascular injury in rat by Ming Yi, Yan Li, Jinghao Sun, Jin Si, Huirong Liu, Jing Li

“…OCN-/- rats maintained normal carotid artery architecture and function under physiological condition. After carotid artery injury, OCN-/- rats exhibited significantly reduced neointimal thickness and VCAM-1 expression of injured vessels compared to WT rats. …”
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Oral Astragalus polysaccharide alleviates adenine-induced kidney injury by regulating gut microbiota–short-chain fatty acids–kidney G protein-coupled receptors axis by Wenbo Liu, Yuanyuan Zhang, Dongmei Hu, Lihua Huang, Xusheng Liu, Zhaoyu Lu

“…Kidney G protein-coupled receptor (GPR) levels were also detected in renal tissue. APS supplementation can reduce serum creatinine and urea nitrogen levels in mice model (Ade) and attenuate renal tubular interstitial injury and renal fibrosis. …”
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RDM-YOLO: A Lightweight Multi-Scale Model for Real-Time Behavior Recognition of Fourth Instar Silkworms in Sericulture by Jinye Gao, Jun Sun, Xiaohong Wu, Chunxia Dai

“…Second, standard convolutional layers are replaced with distribution shifting convolution (DSConv), leveraging dynamic sparsity and quantization mechanisms to reduce computational complexity. Additionally, the minimum point distance intersection over union (MPDIoU) loss function is proposed to enhance bounding box regression efficiency, mitigating challenges posed by overlapping targets and positional deviations. …”
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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…The key elements of hypoxic training in diabetes encompass activities geared toward activating metabolic pathways, enhancing mitochondrial function, and regulating blood glucose levels. Such interventions can potentially lead to improvements in insulin resistance, a reduction in glycemia, and an overall enhancement of cardiorespiratory function. …”
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Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway by Zouyu Zhao, Panpan Yu, Yan Wang, Hong Li, Hui Qiao, Chongfeng Sun, Lina Zhu, Ping Yang

“…Materials and methods The expression of STEAP3 protein in CC tissues and cell lines was identified using immunohistochemistry. The Reduced Representation Bisulfite Sequencing (RRBS) was used to detect global gene DNA methylation in CC tissues and paracancerous tissues. …”
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Ginkgo biloba extract alleviates oxygen and glucose deprivation/reperfusion injury in cardiac microvascular endothelial cells by regulating NF-κB and CHOP signaling pathways throug... by Mukaddas ABDURAHMAN, Zhenyang GUO, Junbo GE, Hua LI

“…The expressions of PERK/eIF2α/CHOP, nuclear factor kappa B (NF-κB), and endothelial cell function markers were detected by Western blotting. …”
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Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway by Ju Huang, Ju Huang, Jing Li, Jing Li, Zhijun Geng, Zhijun Geng, Lixia Yin, Lixia Yin, Minzhu Niu, Qingqing Li, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Xue Song, Yueyue Wang, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu, Jianguo Hu

“…Additionally, the Cyn intervention group showed significant improvements in both the intestinal barrier structure (elevated tight junction protein levels and proper localization) and function (reduced serum FD4 levels, increased intestinal TEER, and decreased bacterial translocation rates in mesenteric lymph nodes [MLNs] and livers). …”
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P77 | MEMBRANE SKELETAL PROTEIN, MEMBRANE PALMITOYLATED PROTEIN 6 (MPP6), IN MOUSE CEREBRAL SYNAPSES

“…These findings suggest that MPP6 plays a role in synaptic function by forming protein complexes with other MPP family members and signal proteins. …”
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