KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity by Yixin Li, Li Peng, Yang Zhou, Yan You, Jin Jiang, Yong Luo

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Early signs of damage to the brain as a target organ in hypertension by T. M. Ostroumova, O. D. Ostroumova, V. A. Parfenov

“…The signs of early brain damage in hypertension can be considered as deteriorated control functions, white matter hyperintensities (WMH), as evidenced by the standard modes of magnetic resonance imaging (MRI), decreased fractional anisotropy in the frontal lobes, as shown by diffusion tensor MRI, and reduced cerebral perfusion. …”
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Symptomatic Hypercalcemia in Patients with Primary Hyperparathyroidism Is Associated with Severity of Disease, Polypharmacy, and Comorbidity by C. Aresta, E. Passeri, S. Corbetta

“…Serum PTH levels and total alkaline phosphatase activity were higher in HS-PHPT. Reduced kidney function (eGFR < 45 ml/min) was prevalent in HS-PHPT patients (42% vs. 5%, P=0.05). …”
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Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype. by Sarah J B Snelling, Sylvette Bas, Gabor J Puskas, Stephanie G Dakin, Domizio Suva, Axel Finckh, Cem Gabay, Pierre Hoffmeyer, Andrew J Carr, Anne Lübbeke

“…Osteophytes, sclerosis and minimum joint space width were significantly reduced in patients with detectable IL-17 in synovial fluid. …”
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Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephr... by Yang Wang, Kaiwen Li, Siya Yan, Ge Li, Meifang Cheng, Qian Chen, Yuzheng Wu, Dan Wang, Dan Wang, Tao Wang, Tao Wang

“…Establish pseudo-sterile mice through the combined treatment of ampicillin, neomycin, and vancomycin to verify the role of gut microbiota in improving HN in C. spicatus.ResultsIn HN mice, C. spicatus could significantly reduce serum uric acid levels and improve renal function. …”
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Hybrid subnet-based node failure recovery formal procedure in wireless sensor and actor networks by Hamra Afzaal, Nazir Ahmad Zafar, Fahad Alhumaidan

“…The dynamic model is developed by defining its state space, functions, and possible operations to describe the failure recovery procedure. …”
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Construction of Graphene Oxide Probes Loaded with Antisense Peptide Nucleic Acid and Doxorubicin for Regulating Telomerase Activity and Inducing Apoptosis of Cancer Cells by Yanyan Zhu, Qinghong Ji, Min Hong

“…The nanoplatform was strategically functionalized with folic acid ligands to enable folate receptor-mediated tumor targeting. …”
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Herb pair of Astragali Radix-Descurainiae Semen attenuate heart failure through the myosin VI-Tom1 complex mediated autophagy by Mengyue Wang, Songlin Ni, Tong Wang, Mo Sun, Qiaolan Wu, Xiaolin Wu, Guangying Lu, Guangying Lu, Peiwei Su, Zu Gao, Qian Chen, Qian Chen

“…Molecular docking to detect the binding energy and binding site of the MYO6-Tom1 complex to the major components of AR-DS.ResultsAR-DS effectively improved cardiac function and mitigated myocardial pathology in heart failure rats; it reduced serum levels of BNP, NT-pro BNP, and ANP, and suppressed cardiomyocyte apoptosis; AR-DS significantly downregulated the gene and protein expression of LC3 and Beclin1, upregulated p62, and reduced autophagy in myocardial tissue; AR-DS can effectively down-regulate the gene and protein expression of MYO6 and Tom1 in heart failure rat myocardium; protein docking results demonstrated the formation of a stable MYO6-Tom1 complex; lastly, the molecular docking results showed that the binding energies of the main components of AR-DS: Ononin, Astragaloside-IV, Rutin, Folic-acid, Daidzein, Isorhamnetin, Quercetin, Beta-Sitosterol, Kaempferol, and Formononetin can bind to the MYO6-Tom1 complex.ConclusionsAR-DS exerts a protective effect on myocardial tissue in heart failure rats by inhibiting myocardial autophagy, potentially through the modulation of the MYO6-Tom1 complex. …”
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High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy by Xin Sun, Yao Chen, Feifei Hu, Yumeng Qiao, He Wu, Yao Su, Yue Hu, Jie Wu, Jie Wu, Mingli Huang

“…Weighted gene co-expression network analysis (WGCNA) identified six co-expression modules, of which the black module (most strongly AMA-associated) contained six hub genes (SIRT3, TLR6, AOX1, ARG1, CRYAB, HGF) exhibiting high intramodular connectivity. Functional studies confirmed that placental SIRT3 expression was markedly reduced in AMA (P &lt; 0.05), while both impaired vascular perfusion and oxidative stress were significantly more severe.ConclusionOur findings indicate that reduced placental SIRT3 expression is a key molecular feature in advanced maternal age. …”
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Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach by Wen-Di Wang, Xin-Yi Fan, Xiao-Qi Wei, Wang-Jing Chai, Fang-He Li, Kuo Gao, Bin Liu, Bin Liu, Shu-Zhen Guo

“…In vivo, Z-LIG/CGA significantly improved cardiac function and reduced the fibrotic area in mice post-MI, surpassing the results in groups treated with Z-LIG or CGA alone. …”
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Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington’s disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition by Ayooluwa Gabriel Ibiayo, Peeraporn Varinthra, Mukundan Nagarajan, Ingrid Y Liu

“…Results CFA treatment significantly improved motor function, preserved neuronal architecture, and reduced apoptosis, as confirmed by Nissl and TUNEL staining. …”
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Ultrasound Biomicroscopy Eye Anterior Segment in the Diagnosis of Senile Scleral Plaques. Clinical Case by A. S. Stoyukhina, D. V. Andzhelova, O. V. Eksarenko

“…Currently, it is believed that the primary cause of SSP formation is collagen degradation, reduced elastin content, and the deposition of calcium and lipids. …”
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Thermally radiative water-based hybrid nanofluid with nanoparticles and gyrotactic microorganisms past a stretching surface with convective conditions and porous media by Humaira Yasmin, Rawan Bossly, Fuad S. Alduais, Afrah Al-Bossly, Anwar Saeed

“…The analysis is done via the bvp4c MATLAB function in order to analyze the current model numerically by implementing convective boundary conditions. …”
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Efficacy and Renal Safety of Dapagliflozin in Patients with Type 2 Diabetes Mellitus Also Receiving Metformin: A Real-Life Experience by Alessandro Scorsone, Gabriella Saura, Mattia Fleres, Lucia Spano, Vito Aiello, Davide Brancato, Anna Di Noto, Francesca Provenzano, Vincenzo Provenzano

“…Over the 12-month treatment period, dapagliflozin significantly reduced BMI in both groups. No significant changes in lipid parameters were observed in either group and no detrimental effects on renal function were detected. …”
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Cancer evolution is associated with pervasive positive selection on globally expressed genes. by Sheli L Ostrow, Ruth Barshir, James DeGregori, Esti Yeger-Lotem, Ruth Hershberg

“…In contrast, in the cancer evolutionary process the dominance of purifying selection is much reduced, allowing for a much easier detection of the signals of positive selection (adaptation). …”
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Will Artificial Intelligence Replace Physicians or Augment Their Capabilities? by Sara Rahmati Roodsari, Alireza Zali, Mohammad Rahmati-Roodsari, Behina Forouzanmehr

“…The aim is to enable physicians to function efficiently with machines rather than to make robots physicians18, 21. …”
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microRNA-576-5p ameliorates dexamethasone-induced BMSC injury by suppressing ANXA2 by Yuelei Zhang, Ying Deng, Weihai Yao, Ke Xia, Lecheng Zhang, Gang Wang

“…Finally, BMSC proliferation, apoptosis, mineralization, and its capacity for pro-osteoclastogenesis after increasing miR-576-5p levels or reducing ANXA2 expression were detected with 10−5M DEX exposure. …”
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Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis. by Olaf Eickmeier, Daniela Fussbroich, Klaus Mueller, Friederike Serve, Christina Smaczny, Stefan Zielen, Ralf Schubert

“…<h4>Methods</h4>In this study, our aims were to detect and quantitate Resolvin D1 (RvD1) in sputum and plasma from patients with CF and compare levels of RvD1 with biomarkers of inflammation and lung function. …”
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Influence of high flux hemodialysis on microinflammatory and nutritional status of uremic patients by LIU Na, ZHOU Lu, DING Kun, CHEN Ren-gui, ZHAO Wen-qi, YE Ting, SU Dong-dong

“…Conclusions Compared with hemodiafiltration + hemoperfusion（HDF + HP）,high flux hemodialysis could effectively improve the microinflammatory,renal function and nutritional status of uremic patients.…”
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FEATURES OF CHEMILUMINESCENT ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC GASTRITIS, CHRONIC ATROPHIC GASTRITIS AND GASTRIC CANCER by O. V. Smirnova, V. V. Tsukanov, A. A. Sinyakov

“…When measuring spontaneous and induced NG chemiluminescence, we diagnosed a decreased phagocytic activity characterized by prolonged time-to-peak and area under the curve for spontaneous and induced CL, thus presuming longer activation time required in cases of reduced phagocytic function. The NG activity in patients with chronic gastritis is not impaired, but, similar changes of time-to-peak and area under were detected. …”
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