Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis by Jie Li, Xiujuan Yang, Xiaolong Lian, Baojian Li, Quhuan Ma, Lingling Yang, Guangmiao Gao, Yi Deng, Zhijun Yang

“…Treatment of the CP-induced toxicity in the rat model with GC significantly improved liver function, reduced liver lesions, decreased liver ROS. …”
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A Deep Learning Approach for Extracting Cyanobacterial Blooms in Eutrophic Lakes From Satellite Imagery by Nan Wang, Zhenyu Tan, Chen Yang, Jinge Ma, Hongtao Duan

“…A hybrid loss function combining cross-entropy and boundary losses addressed the imbalance between CyanoHABs and normal waters. …”
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Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis by Jiaxin He, Jialin Cui, Yimin Shi, Tao Wang, Junyan Xin, Yimeng Li, Xiaomeng Shan, Zhiyao Zhu, Yanbin Gao

“…The treatment of AS-IV can improve renal function and protect podocytes exposed to high glucose. …”
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Establishment of human periodontal ligament cell lines with ALPL mutations to mimic dental aspects of hypophosphatasia by Jana Schiffmaier, Jana Schiffmaier, Sofia Rehling, Sofia Rehling, Katharina Marnet, Katharina Marnet, Angela Borst, Drenka Trivanović, Drenka Trivanović, Drenka Trivanović, Denitsa Docheva, Franz Jakob, Stephanie Graser, Marietta Herrmann, Daniel Liedtke

“…Further assessment of cell line features showed significantly reduced cell growth, partly lower levels of intracellular ATP as well as mitochondrial function proteins. …”
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Tunable Energy-Efficient Approximate Circuits for Self-Powered AI and Autonomous Edge Computing Systems by Shubham Garg, Kanika Monga, Nitin Chaturvedi, S. Gurunarayanan

“…Furthermore, we implemented a simple CNN for pattern detection and integrated our proposed solution to validate its benefits, achieving 15% lower power consumption and 7% lower area overhead without functionality loss.…”
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hsa_circ_0000518 Facilitates Non-Small-Cell Lung Cancer Progression via Moderating miR-330-3p and Positively Regulating SLC1A5 by Huilai Lv, Zhihua Shi, Aixia Sui, Yan Zhang, Liangbiao Peng, Mingbo Wang, Fan Zhang

“…Results. circ_0000518 expression was enhanced in NSCLC. si-circ_0000518 inhibited cell proliferation, invasion, and glutamine metabolism. circ_0000518 functioned as a molecular sponge for miR-330-3p, and inhibition of miR-330-3p in cells markedly reversed circ_0000518 interference-mediated antitumor effects. miR-330-3p interacted with 3′-UTR of SLC1A5. miR-330-3p inhibitor-mediated protumor effect was remarkably reversed in cells after the knockdown of SLC1A5. circ_0000518 knockdown reduced glutamine, glutamate, and α-KG by targeting miR-330-3p. …”
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Home surveillance system based on LoRa backscattering by Marc Lazaro, Antonio Lazaro, Ramon Villarino, David Girbau

“…This novel method leverages the intrinsic frequency detection function of commercial LoRa transceivers to determine the origin of backscattered LoRa packets, thereby enabling the integration of a large number of sensors within the same frequency channel, all using a single receiver. …”
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Congestion control strategy of VANET channel based on load prediction by Yang Ge, Zhu Yonghao

“…The strategy is divided into three steps. Firstly, use the detection function in the carrier-sensing multiple access protocol to obtain the busy and busy status of the channel, and perform load evaluation according to the proportion of the busy time of the channel. …”
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Cardioprotective effect of Yiqi Huoxue decoction on post-myocardial infarction injury mediated by Ca2+ flux through MAMs by Yufei Li, Tianhui Du, Yunshu Zhang, Yang Lu, Xinyi Li, Weibin Xie, Shuwen Guo, Shuwen Guo

“…It ameliorated MAMs ultrastructure and function, enhancing CypD, MCU, Sig-1R, and NOGO-B expression while reducing IP3R2, GRP75, and VDAC1. in vitro, YQHX significantly increased viability, reduced oxygen-glucose deprivation-induced mPTP opening and Ca2+ levels, upregulated CypD, MCU, Sig-1R, and NOGO-B, and downregulated IP3R2, GRP75, and VDAC1. …”
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Dorema Aucheri and exercise training in enhancing PPARγ/mTOR/PI3K gene expression in muscle tissue of hypothyroid mice: experimental approaches using a hypothyroid mouse model by Malihe Bakhti, Farzaneh Taghian, Khosro Jalali Dehkordi, Rezvan Mirsafaei Rizi

“…The mRNA expression levels were detected via real-time qPCR. Results: The data indicated that PPARγ, mTOR, and PI3K levels are reduced in hypothyroidism. …”
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Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II by Zhiyong Wu, Zhiwei Wang, Feifeng Dai, Huagang Liu, Wei Ren, Jinxing Chang, Bowen Li

“…Transendothelial resistance was used to detect the permeability of endothelial barrier. Phosphorylation of Y685-VE-cadherin was significantly reduced after AngII stimulation (P<0.05), together with skeletal rearrangement, and elevation of endothelial permeability which finally induced endothelial barrier injury. …”
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Protective effect of Huanglian Pingwei San on DSS-induced ulcerative colitis in mice through amelioration of the inflammatory response and oxidative stress by Gengting Dong, Xiaoyan Pang, Ximin Wang, Lin Peng, Qili Xiao, Shunan Guo, Weibo Dai

“…The protein expression in the colonic tissue was validated via immunohistochemistry (IHC) and Western blotting.ResultsHLPWS significantly improved UC symptoms and colon tissue histology in mice. The structure and function of the intestinal barrier were restored by HLPWS treatment, as shown by increased DAO content, reduced levels of FITC-dextran, and increased protein expression of ZO-1, occludin, claudin, and MUC2. …”
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Upregulation of miR-152 inhibits proliferation and migration of human vascular smooth muscle cells induced by ox-LDL by ZHOU Jing, QU Miao

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Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner by Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui

“…Abstract Background Mitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology. MPP+ accumulation in mitochondria, a key factor in MPTP-induced neurodegeneration, leads to mitochondrial dysfunction, such as respiratory chain inhibition, ultimately leading to neuronal death. …”
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Intercropping and Nitrogen Fertilization Altered the Patterns of Leaf Senescence in Sorghum by Peter E. Moi, Onesmus M. Kitonyo, George N. Chemining’wa, Josiah M. Kinama

“…Irrespective of the cowpea variety, intercropping reduced sorghum grain yield by 50%. The addition of N increased yield by 27% but no effect was detected between 40 and 80 kg·N ha−1. …”
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Cryoablation combined with programmed cell death protein 1 (PD-1) inhibitors regulates myeloid-derived suppressor cells (MDSCs) through the JAK2-STAT3-S100A8/A9 axis in mice with L... by Jiao Li, Xiaoyu Zhao, Man Qi, Xuxin Chen, Wei Chen, Shuo Zhang, Zhouli Tan, Chunyang Zhang, Zhihai Han

“…QRT-PCR and western blot were used to detect the levels of effector molecules related to the immunosuppressive function of MDSCs and signaling pathways.Results Cryo + PD-1 inhibitor significantly inhibited the growth of right-side untreated tumors and promoted tumor cell apoptosis in LLC mice. …”
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Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model by Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer

“…Ovalbumin‐(GA)10 immunization largely rescued the motor function in (GA)149‐CFP transgenic mice and reduced poly‐GA inclusions. …”
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Neuroprotective Effect of PBCA Nanoparticles Delivering pEGFP-BDNF in a Mouse Model of Intracerebral Hemorrhage by Xue Lai, Yu Xiong, Xing Guo, Chunbo Chen

“…Results: Treatment with PBCA-pEGFP-BDNF NPs significantly improved neurological function and reduced acute brain edema and neuroinflammation in the mouse model of ICH. qPCR, ELISA, and western blot results showed that PBCA-pEGFP-BDNF NPs increased BDNF expression, inhibited NF-κB signaling pathway activity, and decreased the levels of inflammatory factors (IL-6, TNF-α, IL-1β) when compared with the recombinant plasmid pEGFP-BDNF. …”
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Correction of Alcoholic Postcomatose Disorders by Intravenous Laser Blood Irradiation: A Clinicoexperimental Study by L. T. Idrisova, D. A. Yenikeyev, G. A. Baiburina

“…Intravenous laser blood irradiation as part of complex detoxification therapy positively affected the altered function of the higher nervous activity, contributed to earlier conscious recovery and emergence from coma, diminished neurological deficit in the early postcomatose period — alleviated brain edema, a drastic relief of pyramidal insufficiency and cramps, which was detectable in the visual assessment of electroencephalograms, their spectral coherent analysis, as well in the analysis of systemic and regional electroretinography.…”
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Role of endosomal toll-like receptors in immune sensing of Klebsiella pneumoniae by Giuseppe Valerio De Gaetano, Agata Famà, Germana Lentini, Francesco Coppolino, Mario Venza, Isabella Venza, Pasqualina Laganà, Alessia Berbiglia, Federica Grasso, Luigi Fiore, Giuseppe Teti, Concetta Beninati, Concetta Beninati

“…We investigate here the mechanisms underlying innate immune recognition of this pathogen by focusing on the role of endosomal Toll-like receptors (TLRs), which sense prokaryotic nucleic acids, in comparison with TLR4, which recognizes the cell-wall lipopolysaccharide component. Lack of functional endosomal TLRs made mice more susceptible to pulmonary infection by K. pneumoniae, in association with reduced production of proinflammatory and chemotactic cytokines and reduced neutrophil recruitment to the lung. …”
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