The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson’s disease with diabetes co-morbidity by Xiaomin Zhang, Pengyang Du, Bo Bai, Peng Feng, Xia Lian, Christian Hölscher, Yongqing Wang, Guofang Xue

“…After that, body weight and blood glucose of each group mice were measured, and the open field experiment and gait analysis experiment were performed to detect the motor and non-motor symptoms of mice, western blotting and immunohistochemistry experiments were performed to test the levels of necroptosis-related proteins tumor necrosis factor-α (TNF-α), receptor interacting serine/threonine kinase 1 (RIP1) and neuroinflammation-related proteins nuclear factor kappa-B p-p65 (NF-κB p-p65), nuclear factor kappa-B p65 (NF-κB p65), interleukin-1 beta (IL-1β), and monocyte chemoattractant protein-1 (MCP-1).ResultsThe GLP-1 receptor agonist liraglutide inhibited necroptosis and neuroinflammation via TNF-α signaling in diabetic PD mice, decreasing blood glucose and improving motor function and mood. …”
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Single-cell RNA sequencing reveals SLC31A1-mediated M2 polarization of macrophages promotes malignant progression in triple-negative breast cancer by Xiwei Zhang, Guoqing Li, Tieyan Chen, Haohang Sun, Ji Dai, Qi Chen, Mengze Chen, Meidi Yan

“…Cluster and pseudotime analyses showed that macrophages with high SLC31A1 expression are often in advanced stages of cell growth, accompanied by notable changes in oxidative stress. Functional studies revealed that knocking down SLC31A1 in macrophages significantly reduced M2-type polarization. …”
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Two novel pathogenic PDX1 variants in two Japanese patients with maturity-onset diabetes of the young by Satoshi Tanaka, Hiroyuki Akagawa, Michiyo Hase, Naoko Iwasaki

“…Abstract Maturity-onset diabetes of the young type 4 (MODY4, PDX1-MODY) is a monogenic diabetes caused by the PDX1 gene. Here we detected two novel heterozygous missense variants, NM_000209.4(NP_000200.1):c.443G>T, p.…”
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Fitness & Sports Medicine by Koehler K

“…A secondary purpose was to present practical approaches for the detection of energy-deficient athletes and strategies to alleviate some of the effects detrimental to athletic performance. …”
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At-Home Bioelectrical Impedance Analysis (BIA) Monitoring of Adult Females at Risk of Breast Cancer-Related Lymphedema: Nonrandomized One-Year Longitudinal Feasibility Study by Cheri Teranishi-Hashimoto, Monica Padilla, Yoomi Heo, Lori Bravi

“…Surveillance is key to identifying the earliest signs of breast cancer–related lymphedema, initiating treatment, reversing the disease process, and reducing the impact on function. ObjectiveThe primary goal of this study was to assess the feasibility of monitoring fluid levels in patients with cancer using a bioimpedance analysis home device and to detect any relevant changes that may correlate with an increased risk of developing lymphedema. …”
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Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S by Peter A van Veelen, Jacques Neefjes, Sjoerd H van der Burg, Thorbald van Hall, Marten Visser, Linda de Bruin, Lukas JAC Hawinkels, James CH Hardwick, Saskia J Santegoets, Tom J Harryvan, Léonie Plug, Lisa Griffioen, Arend Mulder, Gerbrand J van der Heden van Noort, Marlieke LM Jongsma, Miranda H Meeuwsen, Emmanuel JHJ Wiertz, Els ME Verdegaal

“…Cognate interaction between CD8+ T cells and cross-presenting CAFs suppressed T cell function, reflected by decreased cytotoxicity, reduced activation (CD137) and increased exhaustion (TIM3, LAG3 and CD39) marker expression.Conclusion These data indicate that CAFs may directly suppress tumor-specific T cell function in an antigen-dependent fashion in human CRC.…”
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Study on water quality analysis and early-warning technology based on rough set and evidence theory by ZHU Qiong-yao, ZHANG Guang-xin, FENG Tian-heng, HUANG Ping-jie, HOU Di-bo

“…Comparing to the result based on rough set and D-S evidence theories, the result based on multistage function fitting had larger deviation with the passage of time, and the result based on rough set theory had the case which could not be inferred by historical data.In conclusion, the method based on rough set and D-S evidence theories can reduce the influence of historical water data losses, conflicts and redundancy, and overcome the data shortage in practical systems. …”
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Dapagliflozin ameliorates kidney injury following limb ischemia-reperfusion via the AMPK/SIRT1/NLRP3 pathway by Qiuxiao Zhu, Huiyao Hao, Ya Gao, Na Li, Zibo Liu, Linyi Shu, Qian Wang, Lihui Zhang

“…The extent of kidney injury was detected through serum marker testing in the rat model. …”
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Hsa-miRNA-16-5p Of Urinary Exosomes A Reliable Biosignature Effective For Prostate Cancer Screening by Weng WH, Chiou YE, Zeng WZ, Chen MH, Pang ST

“…ROC analysis confirmed miR-16’s diagnostic potential, particularly in detecting mid-stage PCa.Conclusion: The proposed extraction method matches commercial kits in performance but offers notable advantages: a simplified five-step process, reduced extraction time (1.08 hours), and low cost ($0.13/test). …”
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To establish and validate autophagy related biomarkers for the diagnosis of IgA nephropathy by Sijia Ma, Chao Wang, Jing Liu, Hangyu Duan, Xiaoxin Tian, Shijie Xu, Yu Zhang

“…The gene ontology (GO) function, Kyoto Encyclopedia of Genes and Genome (KEGG) pathway, GeneSet Enrichment Analysis (GSEA) and DisGeNet enrichment were adopted to analyze the genes from the intersection of DEGs. …”
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The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage by Chengyu Huang, Chengyu Huang, Huichao Liang, Huichao Liang, Xiaohua Liang, Yueyi Liu, Jiaoling Wang, Haoran Jiang, Xinhui Kou, Xinhui Kou, Jun Chen, Jun Chen, Lili Huang, Lili Huang

“…Assessments included histopathological analysis, cytokine detection via ELISA, protein expression analysis using immunohistochemistry and Western blot, and gene transcription differential analysis. …”
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Consequences of coronavirus infection: Hemorheological disorders and possibilities for correction by Margarita V. Kruchinina, Andrei A. Gromov, Irina I. Logvinenko, Elina V. Kruchinina

“…The electrical, viscoelastic parameters of erythrocytes were studied by dielectrophoresis using an electro-optical cell detection system; hemostasis parameters were studied by standard methods. …”
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Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice by Yingdong Liu, Fengdan Hao, Haixin Liang, Wenqiang Liu, Yi Guo

“…Experiments included testicular transcriptome analysis, sperm metabolomics, sperm motility and fertilization assays, embryonic ROS detection, and RNA sequencing of 2-cell embryos, revealing the adverse effects of polystyrene exposure on sperm metabolism and embryo development.ResultsThe results revealed that oral gavage of polystyrene to male mice induced a pronounced immune-inflammatory response in testicular tissue, reduced sperm motility, and significantly lowered the fertilization rate. …”
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Research on over-the-horizon air combat guidance method based on dynamic RCS by SONG Shaomei, YU Yifei, LI Gai, YANG Qiming, ZHANG Jiandong

“…Firstly, the influence of dynamic RCS is considered to obtain the optimal attack situation, and then the situation evaluation function considering dynamic RCS constraints is established. …”
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LPS promotes the production of ROS in neutrophils to regulate their killing activity against Mycobacterium tuberculosis by Lina Jiang, Zhenxing Su, Yangxiao Zhang, Hongsheng Liu, Hongtao Wang

“…The killing function of neutrophils against M.tb increased with time. …”
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Multimodal sensor dataset for monitoring older adults post lower limb fractures in community settings by Ali Abedi, Charlene H. Chu, Shehroz S. Khan

“…The dataset includes data from smartphone and smartwatch sensors, motion detection sensors, sleep-tracking mattresses, and clinical questionnaires on social isolation and functional decline. …”
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Sirt2 Regulates Liver Metabolism in a Sex-Specific Manner by Alexandra V. Schmidt, Sivakama S. Bharathi, Keaton J. Solo, Joanna Bons, Jacob P. Rose, Birgit Schilling, Eric S. Goetzman

“…Despite the high number of putative mitochondrial Sirt2 targets, Sirt2 antigen was not detected in purified wild type liver mitochondria, suggesting that Sirt2’s regulation of mitochondrial function occurs from outside the organelle. …”
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Dual Antiplatelet Regimens for Transcatheter Aortic Valve Replacement and Corresponding Cardiac CT Evaluation of the Leaflets: Single-center Experience by Mirvat Alasnag, Waqar Ahmed, Ibrahim Al-Nasser, Khaled Al-Shaibi

“…Hypo-attenuated leaflet thickening was detected in 11 patients. Only one had accompanying reduced leaflet mobility and an increase in gradient. …”
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The impact of overall obesity on serotonin level in the acute phase of coronavirus infection and post-coronavirus sequelae: aspects of neuropsychological and cognitive impairments by O. V. Zinych, N. M. Kushnarova, A. A. Shuprovych, O. M. Trofymenko

“…Parameters of quality of life (QL), psycho-emotional state, and cognitive function were studied by a questionnaire method 6 months after recovery. …”
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Yougui pills prevent ovariectomy-induced bone loss by suppressing Th17 response and IL-17/NF-κB pathway by Peng Zhang, Luting Lin, Ningrui Wang, Ying Wang, Yuqi Miao, Jun Fei, Qimiao Hu

“…Meanwhile, Th17 response and the expression levels of CD4, IL-17A, RANKL, and RORγt increased in the OVX group compared with the sham group, while YGPs treatment significantly reduced the above conditions. We also found that the number and function of osteoclasts (OCs) were significantly increased by incubation with IL-17, while YGPs treatment inhibited osteoclast formation and function. …”
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