Impact of a pharmacy-led screening and intervention in people at risk of or living with chronic kidney disease in a primary care setting: a cluster randomised trial protocol by Natasa Gisev, Sanjyot Vagholkar, Kamal Sud, Judy Mullan, Ines Krass, Anh Tran, Rita McMorrow, Wubshet Tesfaye, David W. Johnson, Connie Van, Vincent L. Versace, Judith Fethney, Breonny Robson, Lukas Kairaitis, Mariam Fathima, Vivien Tong, Natali Coric, Ronald L. Castelino

“…Introduction Chronic kidney disease (CKD) is increasingly recognised as a growing global public health problem. Early detection and management can significantly reduce the loss of kidney function. …”
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Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma by Juan Wang, Xiaolin Diao, Hong Zhu, Bei He

“…Tiotropium treatment significantly reduced airway inflammation and remodeling in asthmatic mice and intensified the lung function. …”
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Dynamic EIT technology for real-time non-invasive monitoring of acute pulmonary embolism: a porcine model experiment by Junyao Li, Mingxu Zhu, Yitong Guo, Weichen Li, Qing He, Yu Wang, Yuxuan Liu, Benyuan Liu, Yang Liu, Weice Wang, Zhenyu Ji, Xuetao Shi

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Identifying risk factors associated with the health-related quality of life for coronary heart diseases elderly using association rule mining by Chunzi Wang, Yunwei Zhang, Shuangcheng Wang, Yi Wang, Yifei Shen, Hansheng Ding

“…Early detection and management of these four symptoms could be crucial in reducing the disease burden and improving outcomes. …”
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pytom-match-pick: A tophat-transform constraint for automated classification in template matching by Marten L. Chaillet, Sander Roet, Remco C. Veltkamp, Friedrich Förster

“…Template matching (TM) in cryo-electron tomography (cryo-ET) enables in situ detection and localization of known macromolecules. …”
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Mitochondrial Translation Inhibition Uncovers a Critical Metabolic–Epigenetic Interface in Renal Cell Carcinoma by Kazumi Eckenstein, Beyza Cengiz, Matthew E. K. Chang, Jessie May Cartier, Mark R. Flory, George V. Thomas

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Dietary baking soda (NaHCO3) therapy recovered urolithiasis-induced kidney injury in mice by inhibition of oxidative stress, pyroptosis, and inflammation through gut-kidney axis by Shuai Liu, Yuchen Gao, Jun Luo, Yanhua Chen, Heng Cao, Zhuifeng Guo, Hongmin Zhou, Zhongwen Hong, Bowen Chen, Xiao Xu, Jingcheng Zhang, Nengliang Duan, Xiangcheng Zhan, Xudong Yao, Tiancheng Xie, Yunze Dong, Yunfei Xu

“…Meanwhile, 5% NaHCO3 was added to drinking water in the treatment group. Biochemical detection, immunohistochemical staining, RT-qPCR, and Western blotting were used to assess kidney function and levels of inflammation and pyroptosis. …”
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Meloxicam Alleviates Sepsis-Induced Kidney Injury by Suppression of Inflammation and Apoptosis via Upregulating GPNMB by Shilei Zhao, Lei Cui, Xiufeng Zheng, Ying Ji, Chengyuan Yu

“…The HK-2 cells were treated with LPS (1 μg/mL) and Mel (40 μM). The renal function and renal pathological changes as well as renal inflammation and apoptosis were detected in SAKI mice. …”
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Overall architecture design of row/column scanning silicon-based focal plane switch array LiDAR transmitter system by Yu Wang, Yue Wang, Zeyang Zhang, Hang Cheng, Yuanhui Li, Guohui Yang, Kuang Zhang, Chunhui Wang

“…The focal plane switch array (FPSA) is one of the most promising solutions for optical detection and ranging—light detection and ranging (LiDAR)—due to its ease of control and lack of sidelobes. …”
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Role of Computed Tomography and Other Non-Invasive and Invasive Imaging Modalities in Cardiac Allograft Vasculopathy by Siddhant Passey, Jagriti Jha, Nirav Patel, Vincent Lipari, Saurabh Joshi, Raymond McKay, Joseph Radojevic, Joseph Ingrassia

“…Non-invasive imaging modalities, such as cardiac magnetic resonance imaging, computed tomography angiography, and positron emission tomography, provide complementary insights into CAV with myocardial perfusion and allograft function while reducing procedural risks. Our aim is to guide clinicians in selecting appropriate imaging strategies tailored to individual recipients, to improve detection, monitoring, and outcomes in CAV.…”
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Extracellular Vesicles: A Novel Target for Exercise-Mediated Reductions in Type 2 Diabetes and Cardiovascular Disease Risk by Natalie Z. M. Eichner, Uta Erdbrügger, Steven K. Malin

“…Regular exercise is important for reducing type 2 diabetes (T2D) and/or cardiovascular disease (CVD) risk. …”
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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest). by Rea P Anunciado-Koza, Justin Manuel, Randall L Mynatt, Jingying Zhang, Leslie P Kozak, Robert A Koza

“…Global profiling of WAT gene expression of HFD-fed control and MestpKO mice detected few differences between genotypes; nevertheless, genes with reduced expression in MestpKO mice were associated with immune processes and consistent with improved glucose homeostasis. …”
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Brd4 expression in CD4 T cells and in microglia promotes neuroinflammation in experimental autoimmune encephalomyelitis by Anup Dey, Matthew Butcher, Anne Gegonne, Ryoji Yagi, Keita Saeki, Eunju Lee, Dinah S. Singer, Jinfang Zhu, Keiko Ozato

“…Consequently, Brd4cKO mice had markedly reduced EAE pathology, namely reduced paralysis, absence of axonal demyelination and inhibited expression of inflammatory cytokines. …”
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Electret integrated magnetic field sensor based on magnetostrictive polymer composite with nT resolution by Lukas Zimoch, Stefan Schröder, Eric Elzenheimer, Sören Kaps, Thomas Strunskus, Franz Faupel, Michael Höft, Rainer Adelung

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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

“…NIK inhibitor B022 significantly reduced B-cell activation, proliferation, ASCs differentiation and pathogenic function, as well as CD4+T cell activation and Th17 cells differentiation in vitro. …”
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Research on path planning for coal mine rescue robots by ZHU Hongbo, YIN Hongliang

“…Firstly, an adjustment mechanism of collision constraint function is incorporated into the bidirectional A* algorithm to improve path safety. …”
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Statistical model for assessing the reliability of non-destructive testing systems by solving inverse problems by A. E. Alexandrov, S. P. Borisov, L. V. Bunina, S. S. Bikovsky, I. V. Stepanova, A. P. Titov

“…The calculation data were used to construct curves of the probability density of detected defects as a function of the defect size, recover the values of the defect distribution parameters under various test conditions, and estimate the error of recovering the parameters. …”
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Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway by Xiaoping Wang, Chen Jiang, Qing Li

“…In vivo, to evaluate the function of Serinc2 on tumor growth, a xenograft mouse model was used. …”
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Trimethylamine N-oxide Supplementation Enhances the Quality of Oocytes in Mice of Polycystic Ovary Syndrome by Jiayu Huang, Yin Tian, Xuemei Liu, Zixin Xu, Chong Li, Ling Zhu, Xiru Liu, Jiying Hou, Jingyu Li

“…Consequently, we supplemented TMAO in PCOS mice and found that the abnormal estrous cycle and reduced ovarian function induced by PCOS could be restored. …”
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Deep multimodal representations and classification of first-episode psychosis via live face processing by Rahul Singh, Rahul Singh, Rahul Singh, Yanlei Zhang, Dhananjay Bhaskar, Dhananjay Bhaskar, Vinod Srihari, Cenk Tek, Xian Zhang, Xian Zhang, J. Adam Noah, J. Adam Noah, Smita Krishnaswamy, Smita Krishnaswamy, Smita Krishnaswamy, Joy Hirsch, Joy Hirsch, Joy Hirsch, Joy Hirsch, Joy Hirsch, Joy Hirsch

“…Schizophrenia is a severe psychiatric disorder associated with a wide range of cognitive and neurophysiological dysfunctions and long-term social difficulties. Early detection is expected to reduce the burden of disease by initiating early treatment. …”
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