Synchronized stepwise control of firing and learning thresholds in a spiking randomly connected neural network toward hardware implementation by Kumiko Nomura, Yoshifumi Nishi

“…Therefore, we propose hardware-oriented models of these functions. To implement the function of IP, a variable firing threshold is introduced to each excitatory neuron in the RNN that changes stepwise in accordance with its activity. …”
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Adaptive Scheduling in Cognitive IoT Sensors for Optimizing Network Performance Using Reinforcement Learning by Muhammad Nawaz Khan, Sokjoon Lee, Mohsin Shah

“…To address these challenges and to establish a connected network, there is always a need for a system to evaluate the contents of detected data values and dynamically switch sensor states based on their function. …”
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The effects of rifaximin and lactulose on the gut-liver-brain axis in rats with minimal hepatic encephalopathy. by Xueyan Lin, Zhengchao Zhang, Yi Lin, Shiyun Lu, Rongrong Chen

“…<h4>Results</h4>Both rifaximin and lactulose were effective in reducing ammonia concentrations in MHE rats and ameliorating cognitive deficits, although they exhibited a minimal impact on hepatic function. …”
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Anti-epileptic and gut-protective effects of trioctanoin and the critical role of gut microbiota in a mouse model of epilepsy by Fei Yu, Jia-Lin Ji, Ying Wang, Yi-Di Liu, Yi-Mei Lian, Meng-Zhen Wang, Zheng-Xu Cai

“…Behavioral assessments, electroencephalogram monitoring, immunofluorescence staining, neurotransmitter detection, gut microbiota sequencing, intestinal barrier function tests, and Fecal Microbiota Transplantation (FMT) were performed to systematically study the anti-epileptic effects of trioctanoin and the potential role of microbiota. …”
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Association of anemia and cognitive impairment in patients undergoing maintenance hemodialysis: a cross-sectional study by Lin Huang, Yan Zhang, Jinbao Wang, Hongjin Tang, Jiajun Zhou

“…Conclusions Anemia is significantly associated with CI in MHD patients, and can still serve as a clinical marker for early detection and intervention in CI. Maintaining adequate hemoglobin levels may be linked with a reduced CI occurrence in hemodialysis patients. …”
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Gpbar1-mediated SIRT1-PGC-1α axis maintains mitochondrial homeostasis and mitigates renal injury in obstructive jaundice by Mingchen Li, Kai Luo, Xu Sun, Yuting Zhao, Haiyang Chen, Courtney Quan, Caiming Xu, Guixin Zhang

“…Mitochondrial function changes were assessed through electron microscopy, SOD, MDA, GSH and ATP detection. …”
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Myocardial perfusion scintigraphy in the diagnostics of takotsubo syndrome by A. I. Abdrakhmanova, G. B. Saifullina, N. B. Amirov

“…In segments with impaired contractile function, it is possible to detect normal or reduced perfusion. …”
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ATP6V1A deletion leads to impaired clearance of septic cardiac resident macrophages by YANG Shunxin, ZHOU Yuanqun, XIANG Xinming

“…Then DQ-BSA-RED lysosomal activity detection probe, Lyso-Sensor yellow/bule dye, ELISA, and Western blotting were applied to detect the lysosomal function of cardiac resident macrophages, activity and expression of important lysosomal hydrolases, changes in contents and related subunits of vacuolar-type adenosine triphosphatases (V-ATPase). …”
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A clinical study on ozone autohemotherapy for the treatment of acute ischemic stroke by Heyun Cheng, Rui Lu, Juan Du, Xingjuan Zhao, Zhijiang Zhuang

“…The efficacy was primarily evaluated through neurological function scoring, motor function scoring, cognitive scoring, and the detection of neuron-specific enolase (NSE) and S100β protein (A neurotrophic factor), which are markers of neuronal cell damage. …”
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Autonomic nervous dysfunction in hamsters infected with West Nile virus. by Hong Wang, Venkatraman Siddharthan, Jeffery O Hall, John D Morrey

“…Clinical studies and case reports clearly document that West Nile virus (WNV) can cause respiratory and gastrointestinal (GI) complications. Other functions controlled by the autonomic nervous system may also be directly affected by WNV, such as bladder and cardiac functions. …”
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An Antimicrobial and Antifibrotic Coating for Implantable Biosensors by Sofia Wareham-Mathiassen, Pawan Jolly, Nandhinee Radha Shanmugam, Badrinath Jagannath, Pranav Prabhala, Yunhao Zhai, Alican Ozkan, Arash Naziripour, Rohini Singh, Henrik Bengtsson, Thomas Bjarnsholt, Donald E. Ingber

“…Here, we describe a nanocomposite coating composed of a cross-linked lattice of bovine serum albumin and pentaamine-functionalized reduced graphene that is covalently coupled to antibody ligands for analyte detection as well as antibiotic drugs (gentamicin or ceftriaxone), which actively combats biofouling while retaining high electroconductivity and excellent electrochemical immunosensor behavior. …”
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Learning physics and temporal dependencies: real-time modeling of water distribution systems via Kolmogorov–Arnold attention networks by Zekun Zou, Zhihong Long, Gang Xu, Raziyeh Farmani, Tingchao Yu, Shipeng Chu

“…Abstract Real-time modeling is vital for the intelligent management of urban water distribution systems (WDSs), enabling proactive decision-making, rapid anomaly detection, and efficient operational control. In comparison with traditional mechanistic simulators, data-driven models offer faster computation and reduced calibration demands, making them more suitable for real-time applications. …”
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Dynamic changes of lung sRAGE in mice with chronic obstructive pulmonary disease induced by cigarette smoke exposure. by Yue He, Hongyu Liang, Xiaohui Yang, Fengyun Hao, Kai Huang, Qiang Wang

“…With long-term exposure to cigarette smoke, the inflammatory response is gradually aggravated in lung, and the expression of sRAGE is significantly decreased, and its reduction degree is closely related to the degree of reduced lung function and inflammation.…”
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Severity of obstructive sleep apnea and its impact on coronary artery disease outcomes: A cross-sectional study in Egypt by Hossam Eldin M. Mahmoud, Ahmed Hussein, Esraa A. Taha, Eptehal M. Dongol, Ahmed G. Bakry

“…Objectives: Coronary artery disease (CAD) and obstructive sleep apnea (OSA) share mechanisms such as intermittent hypoxia, inflammation, and sympathetic activation, worsening cardiac function and CAD severity. This study aimed to assess OSA prevalence in CAD patients and its relationship to CAD severity and cardiac function, while evaluating the diagnostic performance of the STOP-BANG questionnaire. …”
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A growth posture identification method of immature peaches in natural environments by Jidong Lv, Liangliang Niu, Ying Han, Xiaoqin Sun, Lingyun Wang, Hailong Rong, Ling Zou

“…The CIOU loss function was ultimately substituted with the SIOU loss function to further optimize the boundary frame loss and target detection accuracy. …”
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Identification of bacterial key genera associated with breast cancer using machine learning techniques by Md. Kaderi Kibria, Isteaq Kabir Sifat, Md. Bayazid Hossen, Farhana Hasan, Md Parvez Mosharaf, Md Ziaul Hassan

“…These findings highlight the potential of fecal microbiota as non-invasive biomarkers for BC detection and prognosis. Future research should focus on the functional roles of these bacterial alterations and their implications in BC pathogenesis, aiming to develop microbiota-based diagnostic and therapeutic strategies.…”
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Anatomically Guided Deep Learning System for Right Internal Jugular Line (RIJL) Segmentation and Tip Localization in Chest X-Ray by Siyuan Wei, Liza Shrestha, Gabriel Melendez-Corres, Matthew S. Brown

“…To reduce the workload of clinicians, deep learning-based automated detection algorithms have been developed to detect CVCs in CXRs. …”
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LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells by Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin

“…ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and induced to differentiate into Th17 cells.XIST was over-expressed and silenced by plasmid transfection.Proliferation and apoptosis of Th17 cells with different levels of XIST expression were detected by flow cytometry and CCK-8 assay.Levels of XIST，TLR9 mRNA and protein were detected by quantitative reverse transcription-polymerase chain reaction （qRT-PCR） and Western blot.The effect of XIST on TLR9 expression was predicted by luciferase report analysis and TLR9 mRNA half-life detection.Potential RNA-binding proteins interacting with XIST were searched through Starbase database and detected by RNA immunoprecipitation and Western blot.GraphPad8.0 was utilized for statistical analysis and variables were expressed as average±SD.Student T test or one-way ANOVA was employed.ResultsXIST was distributed predominantly in cytoplasm.It hinted that XIST might be involved in post-transcriptional regulation.A down-regulation of lncRNA XIST expression promoted apoptosis and DNA damage and arrested cell proliferation by regulating TLR9.With an over-expression of lncRNA XIST，TLR9 expression spiked and XIST up-regulated the expression of TLR9 by promoting the stability of TLR9 mRNA.As an RNA-binding protein （RBP），FUS interacted with XIST and FUS antibodies could significantly enrich XIST transcripts.A down-regulation of lncRNA XIST expression had no effect on FUS protein expression.It suggested that XIST might affect FUS function rather than expression.It was further confirmed that a down-regulation of XIST significantly reduced FUS-TLR9 mRNA binding and FUS over-expression rescued a down-regulation and degradation of TLR9 mediated by si-XIST.ConclusionlncRNA XIST and TLR9 play a critical role in Th17 cell proliferation in IgAN through a FUS-mediated signaling pathway.This finding provides new therapeutic ideas for IgAN..…”
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To study the burden of post tubercular obstructive airway diseases in patients visiting chest OPD at a tertiary level chest OPD in North India: a descriptive cross-sectional study by Imrana Masood, Nosheen Neyazi, Shah Mohd Abbas Waseem, Hilal Hussain

“…The mean latency of COPD symptoms after completion of ATT was found to be 5.38 &amp;plusmn; 6.77 years.Conclusion: Post-tuberculosis subjects presented with lung function decline without confounding factors like smoking; thus, early screening of COPD is required once diagnosed; appropriate treatment should be initiated as early detection and treatment of these patients can help in better disease management and optimum treatment outcomes.…”
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FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2 by Ming Wang, Fulin Ge, Cheng Wu, Binbin Su, Xiaoyu Dong, Shiping Xu, Hui Shi

“…Mechanistic assays included cholesterol detection, SREBP2 Western blot, fatostatin rescue experiments, ferroptosis markers (ferrous ions, ROS, MDA, 4-HNE, mitochondrial function), and FASN-SREBP2 co-immunoprecipitation.ResultsFASN was overexpressed in CRC tissues (TCGA) and cell lines, with highest levels in HCT116. …”
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