Glucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression by Xiaoxu Yang, Qian Du, Rui Xie, Jianhong Ding, Weixi Shan, Jingyu Xu, Changmei Chen, Qiushi Liao, Jun Lou, Zhe Jin, Mingkai Chen

“…Oral glucose tolerance test was used to detect the glucose tolerance of OVX mice and women aged 20–30 years. …”
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Silent but significant: Functional elucidation of a synonymous ATP7B mutation in Wilson’s disease pedigrees by Qi Zhang, Qi Zhang, Xiaoming Xie, Hairong Li, Yulei Li, Hongyao Huang, Hongyao Huang

“…Bioinformatics tools (HSF, SpliceAI and ESEfinder 3.0) were used to predict the impact of mutations on the splicing function of precursor mRNA. The in vitro minigene experiment was conducted to verify the impact of the mutation on the splicing function of the precursor mRNA.ResultsWhole-exome sequencing of the proband identified a synonymous variant c.2145C>T (p. …”
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Innovative machine learning-based prediction of early airway hyperresponsiveness using baseline pulmonary function parameters by Hua Yang, Xingru Zhao, Zhuochang Chen, Lihong Yang, Guihua Zhao, Chenxiao Xu, Jinyi Xu

“…The machine learning-based predictive model demonstrates strong performance and clinical utility, offering potential as a visual tool for early detection and standardized treatment, thereby reducing the risk of symptom exacerbation, lung function decline, and airway remodeling.…”
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Downregulation of AdipoR1 in the hippocampus impairs synaptic function and structure and causes depression-like behavior by Peilin Zhu, Yanmin Luo, Yue Li, Jing Tang, Li Liu, Yuhui Deng, Jing Li, Lin Jiang, Wenyu Yang, Qian Xiao, Shun Wang, Yuning Zhou, Fenglei Chao, Lei Zhang, Chunni Zhou, Yong Tang, Xin Liang

“…Therefore, the aim of this study was to investigate whether changes in the adiponectin/AdipoR pathway in the hippocampus during depression are involved in the regulation of synaptic plasticity damage. We detected reduced plasma concentrations of adiponectin and lower expression levels of AdipoR1 but not AdipoR2 in the hippocampi of mice exposed to chronic unpredictable stress. …”
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SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function by Mihyun Bae, Junyeop Daniel Roh, Youjoung Kim, Seong Soon Kim, Hye Min Han, Esther Yang, Hyojin Kang, Suho Lee, Jin Yong Kim, Ryeonghwa Kang, Hwajin Jung, Taesun Yoo, Hyosang Kim, Doyoun Kim, Heejeong Oh, Sungwook Han, Dayeon Kim, Jinju Han, Yong Chul Bae, Hyun Kim, Sunjoo Ahn, Andrew M Chan, Daeyoup Lee, Jin Woo Kim, Eunjoon Kim

“…Abstract Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co‐agonist activity for NMDA receptors (NMDARs), have been considered to be important targets for the treatment of brain disorders with suppressed NMDAR function such as schizophrenia. However, it remains unclear whether other amino acid transporters expressed in the brain can also regulate brain glycine levels and NMDAR function. …”
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Effects of Du Meridian Electroacupuncture Combined with Treadmill Training on Motor Function of Rats with Spinal Cord Injury by CHENG Mei, TIAN Yu, PENG Jing, YU Shuangqi, ZHANG Xuejun, DING Fan

“…Before and after the operation, BBB scale was used to evaluate the recovery of motor function after SCI. After operation, magnetic resonance imaging (MRI) was used to detect the recovery of the SCI segment; immunohistochemistry was used to detect the protein expression levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF); Western blot was used to detect the protein expression levels of postsynaptic density-95 (PSD-95) and SynapsinⅠ.Results(1) BBB score: compared with the model group at the same time, BBB scores of the treadmill group, the electroacupuncture group and the treadmill+electroacupuncture group increased significantly at 2, 3, 4 weeks after operation, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
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STAT6 blockade ameliorates thyroid function in Graves’ disease via downregulation of the sodium/iodide symporter by Qian Yang, Qinnan Zhang, Fanfan Pan, Bingbing Zha

“…Previous studies demonstrated that blocking STAT6 can ameliorate thyroid function by reducing serum T3 and T4. Sodium/iodide symporter (NIS) is a key protein that mediates active iodine uptake and plays an important role in regulating thyroid function. …”
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Reveal genomic insights into cotton domestication and improvement using gene level functional haplotype-based GWAS by Guoan Qi, Yiqian Li, Wanying Zhang, Zegang Han, Jinwen Chen, Ziqian Zhang, Lisha Xuan, Rui Chen, Lei Fang, Yan Hu, Tianzhen Zhang

“…However, few studies have thoroughly analyzed genes, the fundamental and most crucial functional units. Here, we develop an innovative strategy to translate genomic variants into gene-level functional haplotypes (FHs), effectively reducing the interference from complex genome structure and linkage disequilibrium (LD) present in the conventional genetic mapping framework. …”
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Lowering the osteotomized level of fibular osteotomy reduces neuromuscular complications while maintaining clinical efficacy in treating medial compartment knee osteoarthritis: a r... by Ting-Yu Chang, Chih-Wei Chang, Yen-Nien Chen, Chyun-Yu Yang, Jou-Hua Wang

“…Conclusions Lowering the osteotomy to the mid-third of the fibula significantly reduced peroneal nerve injury while preserving functional improvement. …”
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Prevalence and family function associated with suicide-related behaviors in vocational college population of southern China: the mediating role of depression by He Wang, Yingyu Zhong, Yueyun Wang

“…Improving family function could not only improve adolescent’s psychological status, but also reduce their suicide-related behaviors.…”
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Ensuring Effective Functioning of Gas-Discharge Counters, Used in the Military Dose Rate Meters, in the Arctic Zone by A. V. Vasiliev, Yu. A. Glukhov, I. Y. Kulagin, K. S. Abaeva

“…The aim of this work is to ensure the effective functioning of gas-discharge counters, used in the military dose rate meters, in the Arctic Zone. …”
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Physicochemical and functional assessment of messenger RNA 5′Cap-end impurities under forced degradation conditions by J. Hutchinson, F. Schweikart, R. Shannon, A. Murthy, S.M. Bates, S. Leone, T. Nissan, D. Sideris, C. Lal, J. Button, R. Rani, G. Thom, N. Bond, E. Örnskov, S. Trabulo

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MambaPose: A Human Pose Estimation Based on Gated Feedforward Network and Mamba by Jianqiang Zhang, Jing Hou, Qiusheng He, Zhengwei Yuan, Hao Xue

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An object detection model AAPW-YOLO for UAV remote sensing images based on adaptive convolution and reconstructed feature fusion by Yiming Wu, Xiaofang Mu, Hong Shi, Mingxing Hou

“…Experimental results show that: The proposed detection model reduces the parameter count by 30% and improves mAP@0.5 by 3.6% on the VisDrone2019 dataset; On the DOTA v1.0 dataset, the parameter count is reduced by 30%, with a 2.5% improvement in mAP@0.5. …”
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Improved A-Line and B-Line Detection in Lung Ultrasound Using Deep Learning with Boundary-Aware Dice Loss by Soolmaz Abbasi, Assefa Seyoum Wahd, Shrimanti Ghosh, Maha Ezzelarab, Mahesh Panicker, Yale Tung Chen, Jacob L. Jaremko, Abhilash Hareendranathan

“…However, accurately detecting and segmenting these lines remains challenging, due to their subtle blurred boundaries. …”
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Age-Related Mitochondrial Alterations Contribute to Myocardial Responses During Sepsis by Jiayue Du, Qing Yu, Olufisayo E. Anjorin, Meijing Wang

“…Cecal ligation and puncture (CLP) was conducted in young adult (12–18 weeks) and aged (19–21 months) male C57BL/6 mice. Cardiac function was detected 20 h post-CLP. Additionally, cardiomyocytes isolated from young adult and aged male mice were used for assessments of mitochondrial respiratory function +/– TNFα or LPS. …”
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Combined Utility of Speckle Tracking Echocardiography and Cardiac Biomarkers for Early Detection of Anthracycline-Induced Cardiotoxicity in Pediatric Oncology Patients by Cristiana Stolojanu, Ruxandra Steflea, Andrada Mara Micsescu-Olah, Ioana Alexandra, Anca Popoiu, Gabriela Doros

“…Background and Objectives: Anthracycline chemotherapy is a cornerstone in pediatric oncology but carries a significant risk of cardiotoxicity. The early detection of cardiac dysfunction is crucial for timely intervention. …”
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Frequency of detection and factors of elevated levels of diabetes-associated autoantibodies in the blood of patients with clinical type 2 diabetes mellitus by Y.A. Saienko, B.M. Mankovsky

“…Patients with GADA-positive T2DM have a distinct metabolic phenotype, with less pronounced insulin resistance but a more rapid decline in β-cell function, necessitating early insulin therapy. At the same time, data suggest that latent autoimmune diabetes shares certain risk factors with classic T2DM. …”
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Exercise improves pulmonary fibrosis and neurological symptoms via S100A12 inhibition by Yan Sun, Yan Sun, Meng Li, Meng Li, Jingmin Yuan, Jingmin Yuan, Wenrui Li, Hongli Quan, Yan Li, Zhenjing Kang, Hao Cheng, Hui Ren, Mingwei Chen

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Spatial Structure Analysis for Subsurface Defect Detection in Materials Using Active Infrared Thermography and Adaptive Fixed-Rank Kriging by Chun-Han Chang, Stefano Sfarra, Nan-Jung Hsu, Yuan Yao

“…The study focuses on reducing noise and nonstationary backgrounds in data collected through active infrared thermography (AIRT) for defect detection in materials. …”
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