Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…IntroductionThe HIV regulatory protein Tat enhances viral transcription and also modifies host gene expression, affecting cell functions like cell cycle and apoptosis. Residual expression of Tat protein is detected in blood and other tissues even under antiretroviral treatment. …”
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Pseudogene BNIP3P1 Regulates H. pylori–Induced Apoptosis in Gastric Mucosal by Acting on the miR-411-5p/BNIP3 Axis by Andong Zhang, Xin Yan, Ningzhe Li, Shiying Yan, Shu Li, Hua Yang, Yimeng Liu, Jian Zhang, Jia Wang, Jian Zhao, Mei Cao

“…Our findings suggest that BNIP3P1 functions as a competing endogenous RNA (ceRNA) within the BNIP3/miR-411-5p axis during H. pylori infection, which ultimately hinders cell proliferation and promotes apoptosis in GES-1 cells. …”
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Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction by Huimei Huang, Chuman Huang, Yinghua Li, Xingwei Liang, Namhyung Kim, Yongnan Xu

“…Among these, methyl paraben (MP) serves as an antimicrobial preservative in processed foods, pharmaceuticals, and cosmetics, and it is particularly detected in baby care products. Studies indicate that MP functions as an endocrine-disrupting compound with estrogenic properties, negatively affecting mitochondrial bioenergetics and antioxidant activity in testicular germ cells. …”
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Ambiguous results of balloon angioplasty for central vein stenosis in hemodialysis patients with native arteriovenous fistula by Z. B. Kardanakhishvili, A. B. Zulkarnaev, B. V. Baykov, V. A. Stepanov

“…In the experimental group, strong negative correlation between primary patency and functional primary patency was detected: r = –0.627 [95% CI –0.787; –0.388], p < 0.0001. …”
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Combined [18F]Fluorodeoxyglucose PET and [123I]Iodometomidate-SPECT for diagnostic evaluation of indeterminate adrenal neoplasias—the cross-sectional diagnostic test accuracy study... by Stefanie Hahner, Philipp Hartrampf, Felix Beuschlein, Matthias Miederer, Konstanze Miehle, Wiebke Schlötelburg, Carmina Teresa Fuß, Thomas Pfluger, Christian Fottner, Anke Tönjes, Ken Herrmann, Holger Amthauer, Martin Reincke, Mathias Schreckenberger, Osama Sabri, Johanna Werner, Miriam Reuter, Stefan Kircher, Wiebke Arlt, Martin Fassnacht, Andreas Konrad Buck, Hans-Helge Müller, Andreas Schirbel, Christian Furth, Knut Mai, Marcus Quinkler, Frank Weber, Henning Dralle, Benjamin Sandner, Thomas Lincke, Regine Kluge, Nada Rayes, Matthias Weber, Martina Gräsl, Wolfgang Saeger, Joachim Reibetanz

“…We also investigated its accuracy in detecting or excluding adrenocortical carcinoma (ACC) and evaluated FDG and unenhanced CT in assessing malignancy. …”
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Formation of a comprehensive rehabilitation program for patients considering the clinical and diagnostic features of the course of vertebral thoracic pain due to degenerative-dystr... by Ye. I. Maramukha

“…All patients had a functional block of the 2nd degree in the thoracic spine. …”
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Review and Comparative Evaluation of Mobile Apps for Cardiovascular Risk Estimation: Usability Evaluation Using mHealth App Usability Questionnaire by Adrijana Svenšek, Lucija Gosak, Mateja Lorber, Gregor Štiglic, Nino Fijačko

“… Abstract BackgroundCardiovascular diseases (CVD) are the leading cause of death and disability worldwide, and their prevention is a major public health priority. Detecting health issues early and assessing risk levels can significantly improve the chances of reducing mortality. …”
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Does neuropathic low back pain negatively influence work capacity? A cross-sectional study among Hungarian workers by Imre Varadi, Tibor Toth, Eva Fejes, Zsolt Nemeskeri, Miklos Kovacs, Antal Tibold, Rita Nyulas, Gergely Feher

“…Targeted interventions addressing depression and sleep disturbance in individuals with NLBP may help preserve or improve work ability and overall functioning.…”
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Humic substance application improves haematological indices of dog’s patients with myxomatous mitral valve disease by V. V. Rimskyi, V. S. Nedzvetsky

“…Positive changes in leukocyte indices were also detected, which indicates the positive effect of humic compounds on reducing the aseptic inflammatory process, as a complication of mitral valve endocardiosis. …”
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Strength development and microstructural characterization of eco-cement paste with high-volume fly ash by Lanh Si Ho, Le Van Quang, Dan-Thuy Van-Pham, Trong-Phuoc Huynh

“…There are strong correlations expressed by exponential functions between drying shrinkage and curing period with a high coefficient of determination for all pastes. …”
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Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. …”
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Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2 by Zheng Cui, Xiaobai Liu, Tiange E, Hongda Lin, Di Wang, Yunhui Liu, Xuelei Ruan, Ping Wang, Libo Liu, Yixue Xue

“…However, the precise functions of snoRNAs and ADARs in glycolipid metabolism within GBM cells remain elusive. …”
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Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling by Zhang H, Zhang H, Wang L, Zhang Y, Hu L, Liu J, Zhou Y, Wang J

“…According to in vivo experiments, GMK could reduce mucus obstruction and airway inflammation (P < 0.05), decrease airway hyperresponsiveness (P < 0.05), and inhibited the PI3K-Akt pathway (P < 0.05). …”
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Boosting with Subtype C CN54rgp140 Protein Adjuvanted with Glucopyranosyl Lipid Adjuvant after Priming with HIV-DNA and HIV-MVA Is Safe and Enhances Immune Responses: A Phase I Tri... by Agricola Joachim, Agricola Joachim, Asli Bauer, Sarah Joseph, Christof Geldmacher, Patricia J Munseri, Said Aboud, Marco Missanga, Philipp Mann, Britta Wahren, Guido Ferrari, Victoria R Polonis, Merlin L Robb, Jonathan Weber, Roger Tatoud, Leonard Maboko, Michael Hoelscher, Eligius F Lyamuya, Gunnel Biberfeld, Eric Sandström, Arne Kroidl, Muhammad Bakari, Charlotta Nilsson, Sheena McCormack

“…Binding antibodies to subtype C Env (included in HIV-DNA and protein boost), subtype B Env (included only in HIV-DNA) and CRF01_AE Env (included only in HIV-MVA) were significantly boosted by the CN54rgp140/GLA-AF immunizations. Functional antibodies detected using an infectious molecular clone virus/peripheral blood mononuclear cell neutralization assay, a pseudovirus/TZM-bl neutralization assay or by assays for antibody-dependent cellular cytotoxicity (ADCC) were not significantly boosted. …”
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Frontal Transcranial Direct Current Stimulation in Moderate to Severe Depression: Clinical and Neurophysiological Findings from a Pilot Study by Florin Zamfirache, Gabriela Prundaru, Cristina Dumitru, Beatrice Mihaela Radu

“…<b>Conclusions</b>: These findings indicate that frontal tDCS is effective in reducing depressive symptoms, particularly in cases of moderate to severe depression. …”
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Characteristics of soil microbial phospholipid fatty acids in artificial, black-soil mountain degraded, and natural grasslands in the source region of the Three Rivers by Lele Xie, Yushou Ma, Yanlong Wang, Yuan Ma, Xiaoli Wang, Ying Liu

“…Results The establishment of artificial grassland significantly increased aboveground biomass and the contents of soil organic carbon, total nitrogen, and total phosphorus, while notably reducing species richness. A total of 29 PLFA biomarkers were detected across the three grassland types, with AG showing significantly higher biomarker content than BG and NG. …”
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A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma by Yuan Zhang, Xiaochen Du, Yujuan Yang, Yaqiong Ren, Lijun Zhou, Jun Hua, Hongying Wang

“…Despite extensive genome-wide analyses pinpointing multiple susceptibility loci, the precise functional contributors to asthma pathogenesis remain elusive. …”
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Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma by Lin Shi, Lin Shi, Lin Shi, Lin Shi, Dongqi Yuan, Dongqi Yuan, Dongqi Yuan, Fuyi Zhu, Yuchao He, Yuchao He, Ran Zuo, Ran Zuo, Liwei Chen, Liwei Chen, Yi Luo, Yi Luo, Yu Wang, Yu Wang, Dingzhi Huang, Dingzhi Huang, Peng Chen, Peng Chen, Hua Guo, Hua Guo

“…Finally, the biological functions of the key gene were examined by in vitro and in vivo experiments.ResultsThe score model was used to divide patients with MPM into low- and high-risk groups. …”
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95 Assessing genetic diversity of the Pfs25 vaccine candidate: Implications for malaria transmission-blocking vaccine in Africa by Alessandra Orfano, Awa Cisse, Zizhang Sheng, Yicheng Guo, Leeah Han, Laty G. Thiam, Khadidiatou Mangou, Adam J. Moore, Aboubacar Ba, Rebecca Li, Mariama N. Pouye, Fatoumata Diallo, Seynabou D. Sene, Elhadji Malick Ngom, Bacary D. Sadio, Alassane Mbengue, Christopher Membi, Thomas Bazié, Fabrice Anyirékun Somé, Natalie Olson, Saurabh Patel, Lawrence Shapiro, Sunil Parikh, Brian Foy, Michael Cappello, Zul Premji, Roch K. Dabiré, Jean-Bosco Ouedraogo, Amy K. Bei

“…Further research exploring the functional implications of these variations will be important to elucidate their role in malaria transmission.…”
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Cardioprotective Effect of Growth Differentiation Factor 15 Against Isoproterenol-Induced Cardiomyocyte Apoptosis via Regulation of the Mitochondrial Fusion by Yan Zhang, Zhu Mei, Xiaodong Jia, Haixu Song, Jing Liu, Xiaoxiang Tian, Tianyu Xu, Xiaoxia Fu

“…Growth differentiation factor 15 (GDF15) dramatically increases during cardiac hypertrophy and dysfunction, but its functions and mechanisms are barely known. This study aims to elucidate the role and mechanism of GDF15 in HF. …”
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