Analysis of RBP expression and binding sites identifies PTBP1 as a regulator of CD19 expression in B-ALL by Nicole Ziegler, Mariela Cortés-López, Francesca Alt, Maximilian Sprang, Arsenij Ustjanzew, Nadine Lehmann, Khalifa El Malki, Arthur Wingerter, Alexandra Russo, Olaf Beck, Sebastian Attig, Lea Roth, Julian König, Claudia Paret, Jörg Faber

“…Mechanistically, we show that downregulation of PTBP1, but not of NONO, in 697 cells reduces CD19 total protein by increasing intron 2 retention. …”
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Pterostilbene induces pyroptosis in mouse breast cancer cells through the caspase-3/Gasdermin E signaling pathway and reshapes the tumor immune microenvironment by Xiaoxia Huang, Wenhui Yang, Xinyi Hu, Li Peng, Jing Dong, Lin Li

“…Consequently, this study has significant implications for the development of PTE and PTE-containing functional foods, dietary supplements, immunomodulatory drugs, and breast cancer treatment adjuvants.…”
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Optimization of the Preparation Process of Flavonoid Solid Beverage from Ficus hirta Vahl. by Lin YANG, Shanyan ZHAO, Fan YANG, Hangying ZHANG, Bocheng HUANG, Juncheng ZHANG

“…A total of 32 flavones were detected in the purified Ficus hirta, including 24 flavonoids and 8 isoflavonoids. …”
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METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…Methods Quantitative reverse transcription polymerase chain reaction and western blotting assays were employed to detect RNA and protein expression, respectively. Colony formation assay, 5-Ethynyl-2’-deoxyuridine assay, flow cytometry, and transwell assays were conducted for cell functional analysis. …”
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Microplastics as an Emerging Potential Threat: Toxicity, Life Cycle Assessment, and Management by Sameh S. Ali, Mohammed Hussein M. Alsharbaty, Rania Al-Tohamy, Maha A. Khalil, Michael Schagerl, Majid Al-Zahrani, Jianzhong Sun

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The overview and role of heat shock proteins (HSP) especially HSP 60 and 70 in reproduction and other pathologies (a literature review) by V.O. Berestoviy, Ahmad Mahmood, I.B. Venckivska, V.G. Ginzburg, I.V. Sokol, O.O. Berestoviy, D.O. Govsieiev

“…Heat shock proteins are responsible for normal folding of other proteins and prevent its abnormal folding and cause degradation of abnormally folded proteins, mitochondrial protein transport, DNA metabolism, regulation of apoptosis are their significant functions. HSP 60 is a homologue of bacterial HSP 60 (GroEL) and needs co-chaperonin HSP 10 for its proper functioning. …”
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Investigating Brain Responses to Transcutaneous Electroacupuncture Stimulation: A Deep Learning Approach by Tahereh Vasei, Harshil Gediya, Maryam Ravan, Anand Santhanakrishnan, David Mayor, Tony Steffert

“…Saliency maps were applied to identify the most critical EEG electrodes, potentially reducing the number needed without sacrificing accuracy. …”
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Effects and safety of high-frequency repetitive transcranial magnetic stimulation in trigeminal neuralgia by A. G. Poydasheva, I. S. Bakulin, D. Yu. Lagoda, N.   A.  Suponeva, M.  A.   Piradov

“…Significant changes were detected in the physical health measure of SF‑36 quality of life questionnaire, particularly, in the “bodily pain” domain, as well as in such aspects of the mental health measure as “vitality” and “social functioning”. …”
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Regulatory puzzle of xyn1 gene (xylanase1) expression in Trichoderma reesei by Robert L Mach, Elisabeth Würleitner, Astrid R Stricker, Roman Rauscher, Christian Wacenovsky

“…The results indicated that the basal as well as the induction level of xyn1 gene transcription is dependent on an interaction of Xyr1 with the GGCTAA motif while formation of the CCAAT-Hap2/3/5 complex slightly reduces induction. It can be concluded that mutations impairing protein binding in vitro lead to a loss of distinct regulatory functions in xyn1 gene expression in vivo. …”
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Comprehensive Evaluation of Chestnut Quality Based on Principal Component and Cluster Analysis by Yanqi YU, Mingyuan YANG, Chunmao LÜ, Shaoci BAI, Qunfang ZHANG, Chenyang ZOU, Han JIANG

“…The first group was ideal for developing functional beverages, the second was suited for kernel processing into canned food, preserved fruit, or chestnut powder for baked goods. …”
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Hemodynamic indicators of doppler test within arteria profunda linguae in patients with combined pathology of mucous membrane of oral cavity and rheumatoid arthritis by A. V. Povsheniuk, B.Yu. Komnatskyi, V. M. Kulygina, E. V. Beliaiev

“…Conclusion: It was found that character and degree of violations of local hemodynamic in patients with glossopathy which combined with rheumatoid arthritis depends on the type of glossitis and due to functional and structural changes in the vascular system in the benign migratory glossitis and atrophic glossitis and aggravation on the background of rheumatoid arthritis.…”
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Reliable Low-Latency Multicasting in MANET: A DTN7-Driven Pub/Sub Framework Optimizing Delivery Rate and Throughput by Xinwei Liu, Satoshi Fujita

“…In such networks, efficient information dissemination is critical, particularly in scenarios where an event detected by one node must be reliably communicated to a designated subset of nodes. …”
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Development and Comparative Evaluation of Two Polyherbal Nutraceuticals, BobyGuards A and B: Phytochemical Composition, Antioxidant Potential, and Nutritional Value by Borelle Mafogang, Stephane Zingue, Charles Taptue Kotue, Michelle Djouhou, Franck Armand Fozing Fomo, Roger Ponka, Elie Fokou

“…Research in nutrigenomics highlights the ability of nutrients to modulate oxidative stress and reduce free radical production, playing a key role in chronic disease prevention and management, particularly cancer. …”
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Impact of Subthreshold Micropulse Laser on the Vascular Network in Diabetic Macular Edema: An Optical Coherence Tomography Angiography Study by Barbara Sabal, Edward Wylęgała, Sławomir Teper

“…<b>Conclusions</b>: SMPL may improve the macular microvasculature in mild DME by reducing FAZ size in the SCP. It provides visual and functional benefits while maintaining a favorable safety profile.…”
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KNEE OSTEOARTHRITIS AND METABOLIC SYNDROME: NEW APPROACHES TO THERAPY by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, S. G. Anikin, E. A. Strebkova, T. А. Korotkova, T. A. Raskina, E. V. Zonova, E. N. Otteva

“…During therapy, there is a rapid and considerable reduction in pain and stiffness and an improvement in the functional state. In addition, the pleiotropic effects of the drug make it possible not only to effectively reduce weight, but also perhaps to improve the course of MS-associated conditions by the observed corrections of metabolic disturbances.…”
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Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum. by Yide Wong, Bruce A Rosa, Luke Becker, Mali Camberis, Graham LeGros, Bin Zhan, Maria Elena Bottazzi, Ricardo T Fujiwara, Edita Ritmejeryte, Thewarach Laha, Sujittra Chaiyadet, Piyanan Taweethavonsawat, Paul J Brindley, Bethany K Bracken, Paul R Giacomin, Makedonka Mitreva, Alex Loukas

“…We characterized these proteins based on functional annotation, KEGG pathway analysis, InterProScan signature and gene ontology. …”
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TFDense-GAN: a generative adversarial network for single-channel speech enhancement by Haoxiang Chen, Jinxiu Zhang, Yaogang Fu, Xintong Zhou, Ruilong Wang, Yanyan Xu, Dengfeng Ke

“…Since the discriminator loss can observe the correlations between spectra that traditional loss functions cannot detect, we train TFDense-Net as a generator against the multi-spectrogram discriminator, resulting in a significant improvement in the denoising performance, and we name this enhanced model TFDense-GAN. …”
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Nutritional, Phytochemical, and In Vitro Antioxidant Activity Analysis of Different States of Soy Products by Rahat Bin Robbani, Md. Munnaf Hossen, Kanika Mitra, Md. Zahurul Haque, Md. Abu Zubair, Shumsuzzaman Khan, Md. Nazim Uddin

“…Altogether, these findings suggest that soy flours, particularly DF and SPC, could be a beneficial food ingredient in the formulation of functional foods.…”
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Nutritional Properties, Antioxidant Activity, and Consumer Acceptability of Sourdough Bread Supplemented with Marine Algae Powder Using Selected Traditional Starters by Mounir EL Boujamaai, Imane Brahimi, Meryem Benyamane, Nouhaila Belasla, João Miguel Rocha, Faouzi Errachidi, Abdellah Zinedine

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Crop classification with deep convolutional neural network based on crop feature by Mohamad Reza Gili, Davoud Ashourloo, Hosein Aghighi, Ali Akbar Matkan, Alireza SHakiba

“…Then the algorithm was implemented using these feature channels in the test area and the overall accuracy was upgraded to 86% and the kappa coefficient to 0.82 compared to which indicated a significant improvement in the results compared to the previous case.Conclusion:The deep convolutional neural network is very sensitive to the type of input channels for detecting agricultural crops and selecting the channels with suitable tempo-spectral characteristics for different types of crops, has a great impact on the accuracy of network training and can reduce the loss of training network and increase its efficiency in the classification of various crops.…”
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