Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study by Michelle M. Mielke, Roger A. Fielding, Elizabeth J. Atkinson, Zaira Aversa, Marissa J. Schafer, Steven R. Cummings, Marco Pahor, Christiaan Leeuwenburgh, Nathan K. LeBrasseur

“…Most studies of the SASP have focused on frailty and other functional outcomes. Senescent cells have been detected in the brains of patients with Alzheimer’s disease, but few studies have examined associations between plasma SASP markers and cognition. …”
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Comprehensive Analysis of Differences in N6-Methyladenosine RNA Methylation Groups in CVB3-Induced Viral Myocarditis and Identification of the Anti-Apoptotic Role of RBM15B by Hu Y, Lin J, Yi L, Cheng S, You G, Chang H, Liu H, Yang Z, Chen S

“…MeRIP-seq identified 327 significantly altered m6A peaks (116 upregulated, 211 downregulated). RNA-seq detected 1,597 upregulated and 2,942 downregulated mRNAs. …”
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Sodium arsenite influences proliferation and apoptosis in normal thyroid cells via modulation of ER-PI3K/AKT signaling pathway by Zhihong JIANG, Hongyun LI, Xiaowei MA, Yuanyan LAI, Jun WU

“…BackgroundRecent advances in understanding the toxic effects of inorganic arsenic have revealed that arsenic exposure impacts multiple endocrine organs, thereby altering their functions. However, the mechanisms underlying arsenic-induced thyroid injury remain unclear. …”
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Bortezomib-releasing silica-collagen xerogels for local treatment of osteolytic bone- and minimal residual disease in multiple myeloma by Dirk Hose, Seemun Ray, Sina Rößler, Ulrich Thormann, Reinhard Schnettler, Kim de Veirman, Thaqif El Khassawna, Christian Heiss, Anne Hild, Daniel Zahner, Francisca Alagboso, Anja Henss, Susanne Beck, Martina Emde-Rajaratnam, Jürgen Burhenne, Juliane Bamberger, Eline Menu, Elke de Bruyne, Michael Gelinsky, Marian Kampschulte, Marcus Rohnke, Sabine Wenisch, Karin Vanderkerken, Thomas Hanke, Anja Seckinger, Volker Alt

“…In vitro, both materials reduce osteoclast activity and do not negatively interfere with osteoblast differentiation and function. …”
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Exploring the mechanism of Lingbao Huxin Dan in the treatment of bradycardia based on atrioventricular node electrical signal conduction by Jing Zhang, Guobin Zheng, Shangjing Liu, Yaodong Miao, Shu Yang, Sheng Li, Zhihui Yang, Danping Zhuo, Rui Guo, Yang Guo, Rongjiang Shao, Yunqing Hua, Chuanrui Ma

“…Background: Prolonged bradycardia leads to inadequate pumping of the heart, causing myocardial ischemia, which in turn affects cardiac function. Depending on its clinical features, improving the AV node conduction block may be an important tool to inhibit the progression of the disease. …”
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Mental Health in the Age of Hyperconnectivity: A Crisis Hidden in Plain Sight by Sitara Ejaz, Hafiz Muhammad Haseeb Khaliq

“…Exposure to screens before bedtime reduces melatonin production by 55% (±20.1%), according to sleep specialists, which causes sleep disturbances that negatively affect both mental function and mood patterns 9.  …”
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Effects of sun shading on anthocyanin components and the expression of genes related to anthocyanin synthesis in Marselan grape by FU Dongyan, WANG Lei, ZHANG Longsheng

“…The study showed that the expression levels of functional genes related to anthocyanin synthesis were different after shading at various stages. …”
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Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway by Qiuhong Jiao, Xiufeng Xu, Longwu Xu, Yuying Wang, Shulan Pang, Jie Hao, Xiaohong Liu, Yudan Zhao, Wanpeng Qi, Limin Qin, Tao Huang, Jingtian Li, Tao Wang

“…EndMT is a complex cell differentiation process, mainly showing the detachment of endothelial cell migration and reducing endothelial cell characteristics to varying degrees, acquiring mesenchymal cell characteristics. …”
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Pathogenetic Mechanisms of the Occurrence of Rheumatoid Arthritis and Ankylosing Spondylitis with the Activation-Enzymatic and Phenotypic Features of Lymphocytes by Lychkovska N., Chopyak V., Vorobets Z.

“…As a result of the conducted studies, changes in the activity of the arginase-NO-synthase system of the lymphocytes of the blood, the violation of the functional activity of the cells of the phagocytic system, and the change in the ratio of T-lymphocyte subpopulations in patients with inflammatory diseases of the joints have been detected. …”
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Ursolic acid ameliorates cerebral ischemia-reperfusion injury by inhibiting NF-κB/NLRP3-mediated microglia pyroptosis and neuroinflammation by Junbin Liu, Junbin Liu, Junbin Liu, Xiaoting Zhang, Xiaoting Zhang, Xiaoting Zhang, Jingpei Guo, Jingpei Guo, Jingpei Guo, Yun Zhang, Yun Zhang, Yun Zhang, Jinming Fan, Jinming Fan, Jinming Fan, Junfeng Liu, Jiawen Chen, Jiawen Chen, Jiawen Chen, Jiawei Jiang, Benshuai Yu, Benshuai Yu, Ke Zhang, Ke Zhang, Ke Zhang, Bin Zhou, Bin Zhou

“…Western blot was used to evaluate the protein expression of pyroptosis markers.ResultsUA significantly reduced infarct volume, alleviated neuronal damage, and improved cognitive and functional recovery in tMCAO mice. …”
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Extracorporeal Methods of Hemocorrection in Patients with Abdominal Sepsis by O. V. Nikitina, S. I. Rey, Y. V. Zabrodskaya, V. I. Avfukov, A. G. Lebedev, P. A. Yartsev, G. A. Berdnikov, A. M. Kaziyeva, E. A. Ostrogina

“…We analyzed outcomes, assessments of the severity of functional disorders and sepsis-associated organ dysfunction according to the APACHE scales II and SOFA and their dynamics, probabilities of outcomes depending on the scores on the indices (logistic regression); life times, cumulative survival rate (Kaplan-Meier method).   …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…To explore the mechanism of action of transcranial magnetic stimulation through effective and functional connectivity, and gamma-aminobutyric acid and glutamate+glutamine in the prefrontal cortex, subgenual anterior cingulate cortex and right anterior insula. …”
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A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028 by Yan Zhang, Yan Zhang, Yan Zhang, Ye-Fan Hu, Ye-Fan Hu, Lingyu Ma, Lingyu Ma, Yifei Wu, Yifei Wu, Dandan Chao, Dandan Chao, Xian Chen, Xian Chen, Zhiyuan Xu, Zhiyuan Xu, Xiaoping Su, Xiaoping Su, Wei Dai, Wei Dai, Wei Dai, Jiandong Huang, Jiandong Huang, Jiandong Huang, Jiandong Huang, Pingfu Fu, Feng-Ming (Spring) Kong, Feng-Ming (Spring) Kong, Feng-Ming (Spring) Kong, Feng-Ming (Spring) Kong

“…Additionally, a basket-trial framework is employed, leveraging shared neoantigens across cancer types to improve efficiency and generalizability. This approach may reduce preparation time and cost, facilitating broader implementation of neoantigen-based immunotherapies. …”
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Anogeissus leiocarpus (DC.) Guill. & Perr. extract-protected rats against CCl4-induced liver fibrosis by Omokolade O. Alejolowo, MSc, Olarewaju M. Oluba, PhD, Oluyomi S. Adeyemi, PhD

“…Results: High-performance liquid chromatography analysis of AL detected 13 compounds, including gallic acid and castalagin. …”
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TWO CASES OF PRIMARY AMYLOIDOSIS PRESENTING WITH VERTEBRAL AMYLOIDOMA by Ebru Kavak Yavuz, Vehbi Demircan, Abdullah Karakus, Orhan Ayyildiz

“…After examinations, a compression fracture was detected that caused height loss at L5, and he underwent surgery by a neurosurgeon. …”
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The transcription factor PbeNAC83 positively regulates the Valsa canker resistance in apple and pear by DOU Zhiqi, CAI Minrui, DU Chenglong, HU Huanhuan, ZUO Cunwu

“…PbeNAC83 was transfected into the DuliG03 suspension cells, and three wellgrown overexpression cell lines were obtained. Functional analysis demonstrated that PbeNAC83-OE cells were more resistant to Vp and VpM compared to the control. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Three common causes of symptoms are: bladder obstruction due to non-cancerous growth of the prostate, reduced power of the bladder muscle and bladder overactivity. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…However, motivation for change reduced, and self-rated ability to change remained low. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Studies lacked power to detect differences between intervention groups. The review suggested that models of rehabilitation could decrease the length of hospital stay and reduce admissions to care. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…Treatment decision and delivery times, early neurological recovery and day 90 functional outcomes did not differ significantly between groups. …”
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