Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis by Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang

“…Targeting CD38 therapy markedly reduces inflammatory response in primary monocytes and in sepsis mice model. …”
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Simulation and analysis of a high-k electron-scale turbulence diagnostic for MAST-U by D.C. Speirs, J. Ruiz Ruiz, M. Giacomin, V.H. Hall-Chen, A.D.R. Phelps, R. Vann, P.G. Huggard, H. Wang, A. Field, K. Ronald

“…Plasma turbulence on disparate spatial and temporal scales plays a key role in defining the level of confinement achievable in tokamaks, with the development of reduced numerical models for cross-scale turbulence effects informed by experimental measurements an essential step. …”
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Tregs levels and phenotype modifications during Amyotrophic Lateral Sclerosis course by Elisabetta Zucchi, Elisabetta Zucchi, Federico Banchelli, Cecilia Simonini, Sara De Biasi, Ilaria Martinelli, Giulia Gianferrari, Giulia Gianferrari, Domenico Lo Tartaro, Andrea Cossarizza, Andrea Cossarizza, Roberto D’Amico, Roberto D’Amico, Jessica Mandrioli, Jessica Mandrioli

“…Additionally, we explored whether measures of ALS progression, such as the decline over time in the revised ALS Functional Rating Scale (ALSFRS-r) or forced vital capacity (FVC) correlated Treg levels and whether Treg phenotype varied during the course of ALS.MethodsTotal Tregs (detected by CD3, CD4, FoxP3, CD25, and CD127) were quantified at five time points over 54 weeks in 21 patients in the placebo arm of the RAP-ALS trial; next they were characterized for the expression of surface markers including CD38, CD39, CXCR3, and PD1. …”
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Environmental Levels and Degradation Behavior of Pharmaceuticals and Personal Care Products (PPCPs) in the Water Environment by Zhaohe ZHANG, Dian CHEN, Wei ZHAO, Guoli YUAN, Jun LI, Xingchun JIAO

“…PPCP-like compounds were first detected in treated wastewater in Kansas City, USA in 1976 (concentrations of 0.8-2μg/L[6]), and subsequently detected in various countries. …”
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Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma by Verena Schweihofer, Verena Schweihofer, Daniela Schulz, Daniela Schulz, Raquel Blazquez, Gero Brockhoff, Gero Brockhoff, Tobias Ettl, Tobias Ettl, Mathias Fiedler, Mathias Fiedler, Sina Heimer, Sina Heimer, Juliane Schikora, Richard J. Bauer, Richard J. Bauer, Anja Kathrin Wege, Anja Kathrin Wege

“…In the peripheral blood, we detected elevated levels of soluble CD27 in patients compared to controls and distinct preoperative cytokine profiles (e.g., reduced IFN-γ, CCL3, CCL20; elevated IL-15/IL-16). …”
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Preparation of nanosized hypoxia-inducible factor 1α inhibitor and its application in reversing chemoresistance in colorectal cancer cells by ZHENG Chuanhao, DAN Ruijue, XI Xi

“…Methods‍　‍Nano-inhibitor mPEG350-YC-1 (MYC-1) was prepared by the carboxyl condensation reaction of the active functional group hydroxyl (-OH) in the YC-1 molecule with methoxy polyethylene glycol carboxylic acid, and was verified by 1H nuclear magnetic resonance (1H-NMR). …”
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Pathogenic KIAA0586/TALPID3 variants are associated with defects in primary and motile cilia by Jacqueline E. Taudien, Diana Bracht, Heike Olbrich, Sebastian Swirski, Fulvio D’Abrusco, Bert Van der Zwaag, Maike Möller, Thomas Lücke, Norbert Teig, Ulrika Lindberg, Kai Wohlgemuth, Julia Wallmeier, Anja Blanque, Christos Gatsogiannis, Sebastian George, Christoph Jüschke, Marta Owczarek-Lipska, Dorothee Veer, Hester Y. Kroes, Enza Maria Valente, G. Christoph Korenke, Heymut Omran, John Neidhardt

“…We performed histological and functional analyses in native and air-liquid interface (ALI) cultured respiratory cells. …”
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Neutrophil: Lymphocyte Ratio and Platelet: Lymphocyte Ratio related to Disease Activity among Rheumatoid Arthritis in Erbil governorate/Iraq by Zekra Ali Aziz, Dashty A. Al-Bustany

“…RA if not treated early and properly it could lead to short life expectancy, decrease quality of life, functional disability, morbidity, and increase mortality, which ends with the societal burden (Mohamad et al.,2021; Kugyelka et al.,2016). …”
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Análisis y modelado de una estructura sensorial ultrasónica MIMO basado en M-CSS y técnicas de correlación by Alberto Ochoa, Jesús Ureña, Álvaro Hernández, Apolinar González, Walter Mata, Ramón A. Félix

“…This processing algorithm employs a pseudorandom macro-sequence obtained from a complementary set of M sequences (M- CSS) which, by auto-correlation and cross-correlation functions, the impulse responses from environment are obtained. …”
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Metallurgical Waste for Sustainable Agriculture: Converter Slag and Blast-Furnace Sludge Increase Oat Yield in Acidic Soils by Olga V. Zakharova, Peter A. Baranchikov, Svetlana P. Chebotaryova, Gregory V. Grigoriev, Nataliya S. Strekalova, Tatiana A. Grodetskaya, Igor N. Burmistrov, Sergey V. Volokhov, Denis V. Kuznetsov, Alexander A. Gusev

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Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy by Zhihe Chen, Zhongying Yang, Lifen Rao, Changgen Li, Na Zang, Enmei Liu

“…Results GSEA analysis showed significant enrichment of gene sets related to endothelial functions (barrier, defense, and regeneration) and ALI in the HAdV-7-infected group. …”
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Mechanisms and network pharmacological analysis of Yangyin Fuzheng Jiedu prescription in the treatment of hepatocellular carcinoma by Yuqing Xie, Fengna Yan, Xinhui Wang, Lihua Yu, Huiwen Yan, Qing Pu, Weihong Li, Zhiyun Yang

“…The production of serum cytokines was detected using the Milliplex® MAP mouse high sensitivity T cell panel kit. …”
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Questions about a risk of malignancy of toxic adenomas and the problems of their preoperative diagnosis by Yu.V. Buldygina, H.V. Zelinska, Yu.M. Tarashchenko, S.L. Shlyakhtych, O.I. Kefeli-Yanovska, V.V. Ulishchenko

“…The purpose was to study the cytomorphological structure of autonomously functioning thyroid nodules and the prevalence of cancer in this group based on a retrospective analysis of laboratory, instrumental and morphological data. …”
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Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice by Yan Gong, Yuzhuo Zhang, Xingda Chen, Zelin Zhou, Weicheng Qin, Yanchi Gan, Jiahui He, Jizhi Ma, Guifeng Chen, Qi Shang, Kai Tang, Honglin Chen, Yu Liu, De Liang, De Liang, Gengyang Shen, Xiaobing Jiang, Zhaojun Cheng, Zhaojun Cheng, Zhaojun Cheng

“…However, the precise mechanism by which MA functions in relation to IDD remains unclear.MethodsIn vivo, a naturally aged animal model was used. …”
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Improving consistency in methane emission quantification from the natural gas distribution systems across measurement devices by J. Tettenborn, D. Zavala-Araiza, D. Zavala-Araiza, D. Stroeken, H. Maazallahi, H. Maazallahi, C. van der Veen, A. Hensen, I. Velzeboer, P. van den Bulk, F. Vogel, L. Gillespie, L. Gillespie, S. Ars, J. France, J. France, D. Lowry, R. Fisher, T. Röckmann

“…We show that repeated transects can reduce this uncertainty and improve the categorization into different leak categories. …”
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Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment by Ziqin Wei, Ziqin Wei, Hongfang Mu, Fangfang Qiu, Fangfang Qiu, Minghui Zhao, Minghui Zhao, Xiaojing Zhang, Wenbin Li, Hai Jia, Rong Wang, Rong Wang

“…Rhodamine 123 accumulation assay was performed to examine the effect of HDAC inhibitors on ABCB1 functional activity. HDAC5 was targeted by siRNA technology to detect ABCB1 and H3K9ac expression. …”
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Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol by Christine Mouton, Nicolas Nesseler, Antoine Bénard, Mathieu Pernot, Alexandre Ouattara, Antoine Beurton, Alexandre Mansour, Victor-emmanuel Brett, Corinne Batsale, Anais Aitgougam, Anais Cordon, Aurelie Fresselinat, Geraldine Robert, Julien Imbault

“…A total of 570 patients (285 per group) are required to achieve 80% statistical power for detecting clinically significant differences. Eligible patients will be randomised to either a centrifugation-based or filtration-based autotransfusion group. …”
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RESULTS OF PREVENTIVE WORK IN CHILDREN WITH DIFFERENT FREQUENCY OF ACUTE RESPIRATORY VIRAL INFECTIONS FOLLOWING PREVENTIVE MEASURES IMMEDIATELY AND IN 5 YEAR LONG PERIOD by O.S. Pavlenkova

“…There are many etiological factors, which can cause the carious process, namely: endogenous or general (poor nutrition, low fluoride content in drinking water, the state of the child's overall health, adverse environmental living conditions, genetic predisposition, etc.) and exogenous, or local (poor oral hygiene, excessive use of refined carbohydrates, changes in the composition and properties of oral fluid (saliva), reduced resistance of dental tissues, insufficient functional load of the maxillofacial system, etc.). …”
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Effect of Astragalus polysaccharide combined with Ginsenoside Rg3 on PD-1/PD-L1 in colon cancer by Wang Ya’nan, Zhang Zhikuan, Gao Feng

“…[Conclusion] APS combined with Ginsenoside Rg3 can inhibit the growth of colon cancer and PD-L1, improve the immune function of colon cancer mice, and reduce the expression levels of IL-6, TNF-α and IFN-γ.…”
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C-Reactive Protein Monitoring Identifies Urinary Tract Infections in Ambulatory Kidney Transplant Recipients by Emily Wang, Abdelhamid Aboghanem, Niki Dacouris, Lindita Rapi, Sami Mahmud, Weiqiu Yuan, Rosane Nisenbaum, Michelle M. Nash, G. V. Ramesh Prasad

“…Urine infections may more easily be detected when patients visit the clinic frequently. …”
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