A Smart Semi‐Implantable Device Integrating Microchannel‐Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification by Qilin Li, Chunyu Wei, Luming Xu, Jiao Zhang, Yuyu Li, Xiaohuan Lu, Rengui Xu, Honglian Guo, Peng Cao, Chenke Ouyang, Jiarong Xu, Wei Chen, Zheng Wang, Lin Wang

“…Herein, a smart system is proposed that enables in situ monitoring of deep wounds’ status through a semi‐implantable device composed of 2 seamlessly connected functional components: 1) the well‐designed, microchannel‐structured sampling needles that efficiently and conveniently collect samples from deep wound anatomical locations, and 2) the multiplex biochemical testing compartment that facilitates the immediate and persistent detection of multiple biochemical indicators based on a color image processing software accessible to a conventional smartphone. …”
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Expert consensus on the technical specifications of the in vitro skin penetration test of cosmetic product by Franz diffusion cell by Bingwen Liang, Liling Zhou, Chuanbin Wu, Liang Fang, Lisheng Wang, Lihua Peng, Peng Shu, Lifeng Tang, Yu Bei, Xiaodong Cui, Xiaojia Chen, Yuan Gao, Chong Han, Yan Jia, Huaqing Lin, Yifang Li, Ying Liu, Yiguang Li, Zhiwei Li, Zixiu Liu, Shaohua Ren, Jun Shi, Wanyang Sun, Lijuan Tian, Qun Wang, Yuan Wang, Yuehong Xu, Ming Zeng, Quangang Zhu, Shu Zhang, Yifan Zhang, Qi Xiang

“…Conclusion: This consensus provides technical operation recommendations for the detection of cosmetic percutaneous permeation in in vitro diffusion cells to reduce the differences between studies. …”
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The influence of altered lower-limb muscle strength on dynamic plantar pressure distribution in participants who underwent anterior cruciate ligament reconstruction by Karolína Matov, Michal Bozděch, Marta Gimunová, Martin Komzák, Marek Dostál, Miloslav Maršálek, Tomáš Vespalec, Milan Mojžíš, Tomáš Vodička

“…Combining plantar pressure metrics with conventional strength and functional assessments may better identify residual gait deficits and guide targeted rehabilitation to lower reinjury risk.…”
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Inhibition of -type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment by Supak Yothaisong, Hasaya Dokduang, Naohiko Anzai, Keitaro Hayashi, Nisana Namwat, Puangrat Yongvanit, Sakkarn Sangkhamanon, Promsuk Jutabha, Hitoshi Endou, Watcharin Loilome

“…Our previous study reported that l -type amino acid transporter-1 and its co-functional protein CD98 were highly expressed and implicated in cholangiocarcinoma progression and carcinogenesis. …”
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Genetic regulation of sperm DNA methylation in cattle through meQTL mapping by Corentin Fouéré, Valentin Costes, Chris Hozé, Amrita Raja Ravi Shankar, Florian Besnard, Gabriel Costa Monteiro Moreira, Valentin Sorin, Chrystelle Le Danvic, Aurélie Chaulot-Talmon, Francesca Ali, Marie Christine Deloche, Aurélie Bonnet, Eliaou Sellem, Hélène Jammes, Sébastien Fritz, Mekki Boussaha, Didier Boichard, Hélène Kiefer, Marie-Pierre Sanchez

“…Abstract Background DNA methylation (DNAm) plays an important functional role and is influenced by genetic variants known as methylation QTLs (meQTLs). …”
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Nuclear keratin 6A upregulates human papillomavirus oncogene expression through TEAD1 interaction by Tomoya Miyamura, Seiichiro Mori, Mamiko Onuki, Akihiko Sekizawa, Koji Matsumoto, Iwao Kukimoto

“…Conversely, ectopic expression of shRNA-resistant K6A in the K6A-depleted cells restored E7 expression, and further siRNA knockdown of TEAD1 in the K6A-rescued cells attenuated E7 expression. K6A was detected in the nuclear fraction of cervical cancer cells with a functional bipartite nuclear localization signal in its N-terminus. …”
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MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data by Katarzyna Arturi, Eliza J. Harris, Lilian Gasser, Beate I. Escher, Georg Braun, Robin Bosshard, Juliane Hollender

“…Abstract MLinvitroTox is an automated Python pipeline developed for high-throughput hazard-driven prioritization of toxicologically relevant signals detected in complex environmental samples through high-resolution tandem mass spectrometry (HRMS/MS). …”
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Sodium alginate microspheres loaded with Quercetin/Mg nanoparticles as novel drug delivery systems for osteoarthritis therapy by Jun Chen, Guoya Wu, Jian Wu, Zhijian Jiao

“…Conclusion The functionalized Que-Mg@SA microspheres developed in our study hold great promise as a drug delivery system for OA and potentially other biomedical applications. …”
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Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway by Xueyan Li, Lu Ding, Zirui Li, Zhenghua Cao, Min Li, Kai Yin, Siyu Song, Liyuan Cao, Qinjing Xia, Zihan Wang, Daqing Zhao, Xiaolin Tong, Xiangyan Li, Zeyu Wang

“…The asthma model was evaluated using ovalbumin (OVA) and pulmonary function tests, while pathological examination was conducted using hematoxylin and eosin (HE), periodic acid-Schiff (PAS), and Masson trichrome stains. …”
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No difference in endothelial microvasculation measured by peripheral arterial tonometry in patients with Sjögren’s disease and matched controls by Franziska Maria Tapken, Nadine Zehrfeld, Malin Abelmann, Malin Abelmann, Malin Abelmann, Anna Charlotte Müller-Vahl, Sabrina Benz, Tabea Seeliger, Thomas Skripuletz, Torsten Witte, Kristina Sonnenschein, Kristina Sonnenschein, Johann Bauersachs, Udo Bavendiek, Thomas Thum, Anselm A. Derda, Anselm A. Derda, Diana Ernst

“…These findings suggest that EndoPAT measurements may not be a suitable method for detecting changes in endothelial function specific to patients with SjD.…”
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INFLUENCE OF THE CYP3A4 ISOENZYME METABOLIC ACTIVITY AND CYP2C19 GENE POLYMORPHISMS ON CLOPIDOGREL ANTIPLATELET EFFECT IN PATIENTS WITH ACUTE CORONARY SYNDROME UNDERGOING PERCUTANE... by K. B. Mirzaev, R. E. Kazakov, V. V. Smirnov, D. A. Andreev, D. A. Sychev

“…Carriership of CYP2C19*2 allelic variant and reduced CYP3A4 activity can affect the formation of clopidogrel’s active metabolite and, respectively, its antiplatelet effect. …”
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VOPP1 as a Novel Susceptibility Gene in Rheumatoid Arthritis: Insights Into Its Mechanisms From Mendelian Randomization and Experimental Validation by Wu W, Cai H, Nan Y, Tang J, Wang Y

“…VOPP1 stimulates the proliferation of RA-FLSs and the inflammatory response through the p38 MAPK signaling pathway according to functional experiments. We showed that VOPP1 knockdown reduced articular damage and synovial inflammation in vivo using a CIA rat model.Conclusion: This study identifies VOPP1 as a novel gene associated with rheumatoid arthritis susceptibility. …”
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A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds by C. Persichilli, S. Biffani, G. Senczuk, M. Di Civita, M.K. Bitew, A. Bosco, L. Rinaldi, S. Grande, G. Cringoli, F. Pilla

“…In sheep, gastrointestinal nematodes (GINs) can cause disease, reduced feed intake, and nutritional deficiencies. …”
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The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer by Hongyan Sun, Liehao Yang, Nan Li, Yue Hu, Qianying Hu, Zilong Zhou, Xianling Cong

“…A DKK1 expression plasmid was transfected into cells to assess the functional significance of DKK1 in CRC progression via CCK8, wound healing and migration assays. …”
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Metagenomic analysis reveals the diversity of the vaginal virome and its association with vaginitis by Xiang Lu, Qiang Lu, Rong Zhu, Mingzhong Sun, Hongmei Chen, Zhihu Ge, Yuchen Jiang, Zhipeng Wang, Lingzhi Zhang, Wen Zhang, Ziyuan Dai

“…Anelloviruses, detected in both groups, showed extensive lineage diversity, frequent recombination, and pronounced phylogenetic divergence. …”
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Vestibular Atelectasis: A Narrative Review and Our Experience by Andrea Tozzi, Andrea Castellucci, Salvatore Martellucci, Pasquale Malara, Michael Eliezer, Giuseppe Ferrulli, Rosanna Rita Ruberto, Pasquale Brizzi, Enrico Armato, Alessio Marchetti, Daniele Marchioni, Angelo Ghidini, Claudio Moratti

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In vitro vascular differentiation system efficiently produces natural killer cells for cancer immunotherapies by Yekaterina Galat, Yuchen Du, Mariana Perepitchka, Xiao-Nan Li, Irina V Balyasnikova, William T Tse, Svetlana Dambaeva, Sylvia Schneiderman, Philip M Iannaccone, Oren Becher, Douglas K Graham, Vasiliy Galat

“…CAR T-cell therapy displayed reduced efficiency against glioblastoma (GBM), likely due to mutations underlying disease progression. …”
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Development of Cardiac Computed Tomography for Evaluation of Aortic Valve Stenosis by Hiroyuki Takaoka, Haruka Sasaki, Joji Ota, Yoshitada Noguchi, Moe Matsumoto, Kazuki Yoshida, Katsuya Suzuki, Shuhei Aoki, Satomi Yashima, Makiko Kinoshita, Noriko Suzuki-Eguchi, Yoshio Kobayashi

“…This includes evaluating restricted AV opening and cardiac function using four-dimensional imaging, assessing AV annulus diameter and AS severity via calcium scoring with a novel motion correction algorithm, and detecting myocardial damage through late-phase contrast imaging using new reconstruction techniques. …”
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Nicotinamide mononucleotide improves the ovarian reserve of POI by inhibiting NLRP3-mediated pyroptosis of ovarian granulosa cells by Yue Ma, Weihua Nong, Ou Zhong, Ke Liu, Siyuan Lei, Chen Wang, Xi Chen, Xiaocan Lei

“…Results In POI rats, NMN treatments can improve blood hormone levels and partially improve the number of follicles, enhance ovarian reserve function and ovarian index.The evidence is that the increase in NAD+ levels and the activation of SIRT2 expression can reduce the expression of NLRP3, Gasdermin D (GSDMD), Caspase-1, IL-18, and IL-1β in the ovary. …”
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Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease by Shengxiang Liang, Huanhuan Liu, Xiuxiu Wang, Huawei Lin, Ling Zheng, Yusi Zhang, Lixin Peng, Saie Huang, Lidian Chen

“…Conclusions: Swimming training can rescue the function of the glymphatic system, increase the CSF-ISF exchange, promote the polarization distribution of AQP4, and reduce the deposition of Aβ in the hippocampus, thereby improving the learning and memory ability of APP/PS1 mice.…”
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