Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota by Yunjiao Shen, Yunjiao Shen, Yansong Gao, Ge Yang, Zijian Zhao, Yujuan Zhao, Lei Gao, Shengyu Li

“…The level of apoptosis and expression of various proteins in the tumor tissues were detected by immunohistochemistry and Western blot. …”
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Immunosuppression of spleen in mice treated with erythropoietin: transcriptomic and immunological analysis by Xinyi Lyu, Jiahao Shi, Qi Liu, Mingjun Jiang, Xilian Liu, Yulan Li, Shuqin Ding, Xianpeng Dai

“…The differential expression genes (DEGs) were identified using RNA sequencing (RNA-Seq), verified with the real-time quantitative polymerase chain reaction (RT-qPCR). The functional-enrichment analysis including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Reactome enrichment analysis were performed to reveal the functional characteristics and related biological pathways of DEGs. …”
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AN INFLUENCE OF SPONTANEOUS MICROFLORA OF FERMENTED HORSEMEAT PRODUCTS ON THE FORMATION OF BIOLOGICALLY ACTIVE PEPTIDES by I. M. Chernukha, I. N. Nikonov, N. G. Mashentseva, D. L. Klabukova, D. A. Afanasev, L. I. Kovalyov, L. А. Ilina

“…For example, in samples 1 and 2, the fractions of amilo-1,6-glucosidase, fast-type muscle myosin-binding-protein C; glucose-6-phosphate isomerase; fast skeletal muscle troponin I, phosphoglycerate kinase, pyruvate kinase and skeletal muscle actin were found, which were absent or reduced in sample 3. Therefore, in the studied product, good preservation of the main spectra of muscle proteins was observed, and the identified fractions, apparently, can be sources of new functional peptides. …”
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Can repetitive transcranial magnetic stimulation promote recovery of consciousness in patients with disorders of consciousness? A randomized controlled trial by Zhenyu Liu, Shanshan Wu, Shuwei Wang, Huijuan Wu, Hongliang Gao, Xiao Lu

“…Different microstates served as tools to detect the activity of respective corresponding resting state cerebral functional networks. …”
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The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress by Kunbin Li, Liming Lu, Xianli Yao, Zhiyuan Wu, Pingge Sun, Xiaopeng Wen, Xiaoxing Li, Kai Wang, Xiran Yin

“…IL-1β and TNF-α levels were detected by ELISA. The oxidative stress was tested by assessing ROS and MDA contents and SOD and GSH-Px activity. …”
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Inhibition of VEGF signaling prevents exhaustion and enhances anti-leukemia efficacy of CAR-T cells via Wnt/β-catenin pathway by Suwan Wu, Yiyi Wei, Yingqi Qiu, Kexin Ai, Mu Chen, Hao Wang, Honghao Zhang, Qingyan Cen, Peiyun Liao, Xiangyang Ding, Xiaoling Xie, Yuhua Li

“…Methods The effects of Axitinib, a VEGFR inhibitor, on the biological functions of CAR-T cells in vitro and in vivo were investigated by comparing CAR-T cells pre-treated ex vivo with Axitinib, as well as utilizing a B-ALL mouse model. …”
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Chronic Variable Stress May Induce Apoptosis in the Testis and Epididymal Sperm of Young Male Rats by Yeimy Mar De León-Ramírez, Leticia Nicolás-Toledo, Eliut Pérez-Sánchez, Omar Arroyo-Helguera

“…Stressor stimuli induce oxidative stress and functional abnormalities in sperm, which are linked to a reduced sperm quality and male infertility. …”
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The TRPA1 channel regulates temperature preference in the green peach aphid Myzus persicae by Lulu Yang, Tianyu Huang, Jie Shen, Bing Wang, Guirong Wang

“…They are involved in detecting the ambient temperature and play vital roles in insect survival and reproduction. …”
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Allelic variation in a cluster of epsilon glutathione S-transferase genes contributes to DDT and pyrethroid resistance in the major African malaria vector Anopheles funestus by Mersimine F. M. Kouamo, Sulaiman S. Ibrahim, Abdullahi Muhammad, Mahamat Gadji, Jack Hearn, Charles S. Wondji

“…Methods Transcriptomic and genomic analyses of GSTe genes were conducted, followed by in silico structural analysis, and functional characterization of GSTe3, GSTe4 and GSTe6 using metabolic assay and transgenic expression in Drosophila flies. …”
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NFLUENCE OF CYP4F2*3 ON RESPONSE TO CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME by K. B. Mirzaev, O. D. Konova, E. A. Grishina, K. A. Ryzhikova, Zh. A. Sozaeva, D. A. Andreev, M. Y. Gilyarov, D. A. Sychev

“…Platelet functional activity was evaluated by a portative aggregometer – the VerifyNow P2Y12 assay.Results. …”
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Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma by Wenhao Hou, Jiaqi Jiang, Liyuan Zhu, Hongwei Xu, Lihui Zhu

“…Serum amyloid A2 (SAA2) was detected and further validated in HCC tissues by immunohistochemistry (IHC) and western blot analysis. …”
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Protective Effect of Low-molecular-weight Fucoidan on Lead-induced Oxidative Damage in HepG2 Cells Based on Cellular Metabolomics by Fan YU, Na LI, Yingying GUO, Xinyue DAI, Wenjia ZHU, Lin YAO, Yanhua JIANG, Lianzhu WANG

“…Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was performed to detect intracellular endogenous metabolites, identify potential differential metabolites, and analyze related metabolic pathways. …”
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Blue Light and Green Light Fundus Autofluorescence, Complementary to Optical Coherence Tomography, in Age-Related Macular Degeneration Evaluation by Antonia-Elena Ranetti, Horia Tudor Stanca, Mihnea Munteanu, Raluca Bievel Radulescu, Simona Stanca

“…<b>Results:</b> Both FAF modalities correlated well with OCT in detecting RPE abnormalities. G-FAF demonstrated improved visibility of central lesions due to reduced masking by macular pigment and enhanced contrast in the macula. …”
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Daidzein Promotes the Proliferation of Porcine Mammary Epithelial Cells Through the mTOR Signaling Pathway by Mengmeng Xu, Le Liu, Wenjing Duan, Lizhu Niu, He Cheng, Chenyang Du, Mengyun Li, Wenying Huo, Hongyu Deng, Pan Zhou, Wen Chen, Long Che

“…The present work not only characterizes new functional properties of daidzein but also establishes mechanistic evidence supporting its role in augmenting sow lactation efficiency.…”
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LncRNA targeted by coordinate zygotic genome activation during porcine embryonic development by Mengxin Liu, Enhong Li, Haiyuan Mu, Zimo Zhao, Xinze Chen, Jie Gao, Dengfeng Gao, Zhiyu Liu, Jianyong Han, Liang Zhong, Suying Cao

“…These results implied that the functional axis of TPRA1 - XLOC-040580 -downstream genes involved in ZGA-related functions also coordinated early embryonic development in porcine.…”
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Facial Expression Recognition and Digital Images Infosecurity for Prevention Care System Application in Sudden Infant Death Syndrome Monitoring by Chih-Te Tsai, Chia-Hung Lin, Hsiang-Yueh Lai, Yu-En Cheng, Ping-Tzan Huang, Neng-Sheng Pai, Chien-Ming Li

“…In the FER, the YOLOv10 (You Only Look Once, version 10)-based classifier functions as an automatic object detection (OD) framework, enabling infant facial capture and expression recognition. …”
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A Robust Cross-Platform Solution With the Sense2Quit System to Enhance Smoking Gesture Recognition: Model Development and Validation Study by Anarghya Das, Juntao Feng, Maeve Brin, Patricia Cioe, Rebecca Schnall, Ming-Chun Huang, Wenyao Xu

“…The app was developed using the Flutter framework to ensure seamless functionality across Android and iOS platforms, with robust synchronization between the smartwatch and smartphone for real-time monitoring. …”
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Predator‐specific mortality of sage‐grouse nests based on predator DNA on eggshells by Nolan A. Helmstetter, Courtney J. Conway, Shane Roberts, Jennifer R. Adams, Paul D. Makela, Lisette P. Waits

“…Cattle grazing is often assumed to adversely affect sage‐grouse recruitment by reducing grass height (and hence cover), thereby facilitating nest detection by predators. …”
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Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. by Minerva M Carrasquillo, Olivia Belbin, Olivia Belbin, Fanggeng Zou, Mariet Allen, Nilufer Ertekin-Taner, Morad Ansari, Samantha L Wilcox, Mariah R Kashino, Li Ma, Linda H Younkin, Samuel G Younkin, Curtis S Younkin, Toros A Dincman, Melissa E Howard, Chanley C Howell, Chloe M Stanton, Christopher M Watson, Michael Crump, Veronique Vitart, Caroline Hayward, Nicholas D Hastie, Igor Rudan, Harry Campbell, Ozren Polasek, Kristelle Brown, Peter Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Patrick G Kehoe, David M Mann, A David Smith, Helen Beaumont, Donald Warden, Clive Holmes, Reinhard Heun, Heike Kölsch, Noor Kalsheker, V Shane Pankratz, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Alan F Wright, Steven G Younkin, Kevin Morgan

“…<h4>Background</h4>The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD).…”
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COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis by Yuxiao Zheng, Lei Jiang, Feng Qi, Bo Peng

“…As a pivotal E3 ubiquitin ligase, COP1 mediates substrate-specific ubiquitination to regulate protein stability. However, its functional role in RCC remains poorly characterized. …”
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