Characterization of a periodontal-inflammatory microRNA profile during multibracket orthodontic treatment in adolescents by Florian Rolfes, Johannes Heck, Isabelle Riedel, Christian Bär, Boris Schmitz

“…Abstract This study aimed to identify functional microRNAs (miRNAs) and their respective targets as central regulatory factors of tooth movement during orthodontic treatment. …”
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Antitumor effects of plasma-activated sodium acetate solution on gastric cancer cells by Yuki Ito, Mitsuro Kanda, Hiromasa Tanaka, Kae Nakamura, Masaaki Mizuno, Masaru Hori, Hiroaki Kajiyama, Yasuhiro Kodera

“…The intraperitoneal administration of 3% PASA significantly reduced the number of peritoneal nodules, and no adverse events were detected. …”
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LncRNA FLG-AS1 inhibits esophageal squamous cell carcinoma by regulating the miR-23a-3p/HOXD10 axis by Zhigao Zhang, Fucheng Zhang, Chuan Xue, Xiaoling Song, Yaojun Wang

“…Long non-coding RNAs (lncRNAs) have been proven to be severely dysregulated in EC, but the functions of more lncRNAs still need to be explored. …”
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Turnip mosaic virus infection cleaves MEDIATOR SUBUNIT16 in plants increasing plant susceptibility to the virus and its aphid vector Myzus persicae by Swayamjit Ray, Tyseen Murad, Gabriella D. Arena, Kanza Arshad, Zebulun Arendsee, Venura Herath, Steven A. Whitham, Clare L. Casteel

“…This suggests MED16 functions in the nucleus may be impacted in virus infected plants. …”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…Transcriptomic sequencing and functional verification show that citrullination at the R167 site of IGF2BP1 promotes the proliferation, migration, and invasion of RA fibroblast-like synoviocytes (RA-FLSs) by improving the mRNA stability of Semaphorin 3D (SEMA3D). …”
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Progressive Alcohol-Related Brain Atrophy and White Matter Pathology Are Linked to Long-Term Inhibitory Effects on mTOR Signaling by Ming Tong, Camilla Homans, William Pelit, Busra Delikkaya, Suzanne M. de la Monte

“…Results: Chronic ethanol feeding caused significant brain atrophy that was detected within 4 weeks and sustained over the course of the study. …”
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Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression by Chunyang Xing, Wei Hu, Liyuan Zhao

“…Methods Differentially expressed proteins in hypoxic macrophage supernatants were detected by antibody array. Cell functional experiments, siRNA-mediated gene silencing, and overexpression transfection were used to study osteopontin (OPN) and its supernatant effect. …”
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Effects of Feather-Pecking Phenotype on Physiological and Neurobiological Characteristics and Gut Microbiota Profile of Goslings by Mingfeng Wang, Yujiao Guo, Zhengfeng Cao, Qi Xu, Guohong Chen, Yang Chen

“…From the predicted bacterial functional genes, the cAMP signaling pathway, cGMP–PKG signaling pathway, and pyruvate metabolism were activated in SFPs. …”
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EGCG attenuated spinal cord injury by inhibiting ferroptosis via activation of HMOX1 expression and suppression of HIF-1 signaling pathway by Han Yang, Fei Ye, Liuxu Chen, Linyu Yang, Jianping Kang

“…In vivo studies demonstrated that EGCG effectively promotes motor function recovery and reduces the expression of proteins and genes such as IL-1β, IL-6, HIF-1α, and 4HNE. …”
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LncRNA LYPLAL1, miR-204-5p, and SIRT1: novel signatures for risk assessment of diabetic macrovascular complications by Maysa A. Mobasher, Marwa A. Shabana, Mousa O. Germoush, Najlaa Yousef Abuzinadah, Amir Abd-elhameed, Shereen A. Baioumy, Moataz A. ElKot, Marwa M. Esawy

“…Abstract Long-term, uncontrolled diabetes mellitus can lead to micro- and macrovascular problems. The protective function of lncRNA LYPLAL1 is to reduce endothelium cell inflammation by upregulating sirtuin 1 (SIRT1) and reducing microRNA (miR)-204-5p. …”
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RESULTS OF LIFE’S QUALITY RESEARCH AT PATIENTS WITH GLOSSODYNIA by V.N. Kulygina, I. A. Dorosh

“…In component of physical health: physical functioning (PF), role-functioning due to physical condition (RPC), the intensity of pain (IP) and general health (GH), in psychological - vitality (PV), social function (SF), role functioning due emotional state (RES) and mental health (MH). …”
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Lactiplantibacillus plantarum IOB602 Postbiotic Ameliorates Depression-like Behaviors by Regulating Neuroendocrine Factors and Gut Microbiota in Mice by JING Zhaoxuan, LIANG Peixin, HAN Xuemei, ZHANG Yihua, DENG Langni, JIA Longgang, WANG Yanping, GENG Weitao

“…Finally, 16S rDNA sequencing was utilized to analyze gut microbiota composition, gas chromatography (GC) was used to measure short-chain fatty acids (SCFAs), and hematoxylin-eosin (H&E) staining and immunofluorescence techniques were employed to assess the function of the intestinal barrier. The results showed that postbiotic LP602 significantly increased the sucrose preference of CUMS mice and the time spent in the central area, while significantly reducing the immobility time in the forced swimming test (FST) and the tail suspension test (TST). …”
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Application of Concentration-Area fractal modeling and artificial neural network to identify Cu, Zn±Pb geochemical anomalies in Hashtjin area, NW of Iran by Ali Imamalipour, Hamed Ebrahimi, Amir reza Abdollahpur

“…Autoencoder consists of two functions: an encoder function that encodes the input data into a lower-dimensional hidden layer and a decoder function that reconstructs the encoded input data. …”
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Prevalence of Hypertension and Diabetes and Coexistence of Chronic Kidney Disease and Cardiovascular Risk in the Population of the Republic of Moldova by Igor Codreanu, Vera Sali, Sergiu Gaibu, Luminita Suveica, Sergiu Popa, Norberto Perico, Bogdan Ene-Iordache, Sergio Carminati, John Feehally, Giuseppe Remuzzi

“…In 2005, the International Society of Nephrology (ISN) established the Global Outreach Program (GO) aimed at building a capacity for detecting and managing chronic kidney disease and its complications in low- and middle-income countries. …”
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In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug D... by Obinna C. Ubah, Andrew J. Porter, Caroline J. Barelle

“…In stark contrast, Humira® trough serum concentrations in the 1 mg/kg treatment group ranged from <0.008 μg/mL to 4 μg/mL with trace levels detected in 7 of the 8 animals treated. Trough serum Humira® and Quad-X™ concentrations in 3 mg/kg treatment samples were comparable; however, the functionality of the detected Humira® serum was significantly compromised due to neutralising ADA. …”
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Noninvasive monitoring of vascular alterations in mice with acute lower limb ischemia using multimodal photoacoustic imaging by Heng Wang, Keyi Fan, Yijie Ning, Chuanlong Lu, Yuhang Zhang, Qian Wang, Hongjiu Zhang, Yaling Li, Zeyu Zhang, Xiaohua Jia, Sheng Yan, Ruijing Zhang, Honglin Dong

“…However, major challenges exist in rapidly diagnosing and assessing collateral vascular compensatory capacity, leading to appropriate clinical treatment strategies to improve limb preservation and reduce recurrence rates. Traditional imaging methods, such as digital subtraction angiography (DSA) and ultrasound, have high demands on patient kidney function and operator maneuvers and are unable to monitor the temporal and spatial variability of collateral circulation establishment in the limb. …”
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Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…We screened 84 differentially expressed genes (DEGs) and performed the functional enrichment analysis. Next, we integrated the results obtained from the degree algorithm provided by the Cytohubba plug-in, Molecular complex detection (MCODE) plug-in, weighted gene correlation network analysis (WGCNA), and Least absolute shrinkage and selection operator (LASSO) logistic regression. …”
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Bioinformatics and experimental insights into F2RL1 as a key biomarker in cervical cancer diagnosis and prognosis by Yonggang Dai, Chunxiang Li, Shiliang Cheng, Hongya Wang, Xuewei Zhuang

“…Immune-related genes were identified with F2RL1-related genes through ImmPort database analysis. Functional enrichment analysis was carried out using GO, KEGG, and GSEA. …”
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Features of management and treatment of elderly patients with type 2 diabetes mellitus by L. Yu. Morgunov, E. V. Zemskova

“…Despite the available therapy, a significant number of elderly patients with diabetic nephropathy have progressive renal failure and adverse cardiac outcomes, therefore, research is needed to study methods for early detection of diabetic nephropathy and new therapeutic interventions. …”
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AIRWAY ASSESSMENT IN OUTPATIENT DENTAL PRACTICE by I. А. Khrypachenko, T. V. Diomina, O. А. Udod

“…Mask ventilation with high positive pressure in obese patients increase inflow of air in the stomach. Lungs functional residual capacity in obese patients’ decreased and rapid decrease of oxygen saturation accelerate hypoxemia development and reduce the time for achievement of adequate ventilation both by mask and endotracheal tube. …”
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