Research on the Targeted Treatment of Squamous Cell Carcinoma by Nanographene Drug Delivery System by Xiangyu Zhang, Liwei Guo, Zhenbang Sun, Deming Han, Lihui Zhao

“…For this purpose, we prepared a nano-graphene oxide using an oxidation method, functionally modified with polyethylene glycol (PEG) and branched polyethyleneimine (BPEI) and loaded with the antitumor drug cisplatin (CDDP), a compound with preliminary anticancer efficacy. …”
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Counseling an alcohol abuse patient by Zh. V. Maksimova, D. M. Maksimov

“…However, it is precisely this that causes the massive prevalence of alcohol-related physical and mental health problems, as well as social functioning. The situation can be improved, including through early detection and effective behavioral counseling, especially in primary health care. …”
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Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease by Maria Olaru, Amelia Hahn, Maria Shcherbakova, Simon Little, Wolf-Julian Neumann, Reza Abbasi-Asl, Philip A. Starr

“…Entraining levodopa-induced gamma oscillations at either site reduced their prodyskinetic effects. Cortical entrained gamma oscillations had reduced variance in peak frequency, increased spectral power, and higher variance in spectral power than levodopa-induced gamma oscillations. …”
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LncRNA PELATON regulates Th2 cell differentiation by miR-10b-5p/GATA3 axis in allergic rhinitis by Zhen Liu, MD, Yumei Li, PhD, Xiangkun Zhao, MM, Qi Sun, MD, Yu Zhang, MD, Yaqi Wang, MM, Han Fang, MD, Yujuan Yang, MD, Yakui Mou, MD, Xicheng Song, MD

“…This study investigated the immunomodulatory function of lncRNA PELATON in AR pathogenesis by exploring its regulatory effects on Th2 cell differentiation. …”
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Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…The risk of getting infected is a function of numerous factors where mathematical modeling would not yield fruitful results. …”
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Effects of Bufexamac, a class IIb HDAC inhibitor, on behavior and neuropathological features in an Aβ-induced rat model of Alzheimer's disease by Monireh Mirehei, Fereshteh Motamedi, Nader Maghsoudi, Zahra Mansouri, Soudabeh Naderi, Fariba Khodagholi, Fatemeh Abbaszadeh

“…Male rats injected with Aβ25–35 for AD-like symptoms were treated with 20 μg/rat Bufexamac for 8 days. Cognitive function, depression, and anxiety were assessed through behavioral tests, while Western blotting, H&E staining, and ELISA were used to detect protein expression, morphological changes, and enzyme activity. …”
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Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease by Romain Castelot, Aline Zarea, David Wallon, Anne Rovelet-Lecrux, Catherine Schramm, Muriel Quillard-Muraine, Anne Beaume, Frédéric Blanc, Olivier Bousiges, Julien Dumurgier, Maïté Formaglio, Gwenael Leguyader, Sylvain Lehmann, Cecilia Marelli, Matthieu Martinet, Leonor Nogueira, Jérémie Pariente, Isabelle Quadrio, Adeline Rollin-Sillaire, Susanna Schraen, Gaël Nicolas, Magalie Lecourtois

“…Recently, we demonstrated that a large proportion (~25%) of rare SORL1 missense variants found in AD patients alter SorLA trafficking along the constitutive secretory pathway, resulting in reduced delivery of SorLA to the plasma membrane and thus a loss of function. …”
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Chen’s peiyuan tang and premature ovarian failure: unveiling the mechanisms through network pharmacology by Xiao Yang, Yi-Ming Mao, Chong Yao, Chong Yao, Ding-ming Song, Yi-bo He, Wei Shen

“…BackgroundChen’s Peiyuan Tang (CSPYT) is a compound herbal formula that has shown the potential to enhance ovarian function and reduce autophagy in ovarian granulosa cells, which plays a crucial role in follicular development and maturation. …”
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A clinical case of exocrine pancreatic insufficiency in a patient with type 1 diabetes mellitus by M. R. Ragimov, T. V. Nikonova, E. V. Marchenko, N. M. Malysheva, O. S. Derevyanko

“…In the course of further studies, antibodies to lactoferrin and a reduced prostate volume, determined by MRI data, high levels of antibodies to glutamate decarboxylase and zinc co-transporter 8, as well as residual insulin secretion based on the level of C-peptide on an empty stomach detected.…”
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In Vitro Evaluation of Ruminal Fermentation and Methane Production in Response to the Addition of Modified Nano-Bentonite with or Without <i>Saccharomyces cerevisiae</i> to a Forag... by Sohila Abo-Sherif, Sobhy Sallam, Ali M. Allam, Mounir El-Adawy, Yosra Soltan

“…Sulfur and related functional groups were detected only in MNB. No differences were observed in total GP, while both the monensin diet and the MNB_High-with-yeast diet significantly reduced CH₄ emissions compared to the control (<i>p</i> < 0.05). …”
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Effects of direct moxibustion on antigen-presenting cells in gastric tissue of rat models with gastric cancer: Understanding the immunological mechanisms by Tian-yu GAO, Fei-cheng ZHANG, Ru-fang PAN, Shu-ya MA, Xiao-qi ZHANG, Li-jia PAN, Chun-sheng JIA

“…Its mechanisms may involve effects on the state of antigen-presenting cells, thereby promoting T cell activation and enhancing immune function.…”
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A RARE DISEASE ASSOCIATED WITH IG4, CHARACTERIZED BY SYSTEMIC AMYLOIDOSIS AND LYMPHOPLASMACYTIC CELL DOMINANCE: A CASE PRESENTATION by Şerife Emre Ünsal, Mihriban Yıldırım, Hacı Ahmet Aslaner, Neslihan Mandacı Şanlı, Gülşah Akyol, Muzaffer Keklik, Özlem Canöz, Olgun Kontaş, Ali Ünal

“…With therapy, patients often experience a reduction in symptoms, a decrease in the size of masses in affected organs, improvement in organ function, and a general decline in serum IgG4 levels over several weeks. …”
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Manganese superoxide dismutase 4 interacting with WRKY6 enhances cadmium tolerance in potato plants by Gang Zu, Zicheng Guo, Huiqing Yang, Yueyue Tang, Yeqing He, Tengbin He, Guandi He

“…To reduce costs, we proposed to truncate the protein, retaining only the core domain, and verify whether it maintains the Cd tolerance function. …”
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Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity by Marcella Balbo, Rachel Leproult, Eve Van Cauter

“…During waking, an association between cortisol secretory bursts and indices of central arousal has also been detected. Abrupt shifts of the sleep period induce a profound disruption in the daily cortisol rhythm, while sleep deprivation and/or reduced sleep quality seem to result in a modest but functionally important activation of the axis. …”
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RNAi Screen Identifies AXL Inhibition Combined with Cannabinoid WIN55212-2 as a Potential Strategy for Cancer Treatment by Feifei Li, Hang Gong, Xinfei Jia, Chang Gao, Peng Jia, Xin Zhao, Wenxia Chen, Lili Wang, Nina Xue

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Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review by Kurdo A. Abdullah, Aryan Fathulla Qader, Rebaz Anwar Omer, Rebaz Obaid Kareem, Musher Ismael Salih

“…Abstract Nebivolol, a beta-blocker commonly prescribed for the treatment of hypertension and heart failure, functions by decelerating heart rate and promoting vasodilation, thereby enhancing blood flow and reducing blood pressure. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Experiments in mice, Ag43β 700_RBD OMVs was successfully proven to be safe and effective; they produced a detectable level of nAbs with 39– 58% neutralisation and reduced viral titres in the lungs and brain without weight loss.Conclusion: The developed viral mimetic Ag43β 700_RBD OMVs may therefore be applied as a nanovesicle-theranostic platform for further emerging infectious disease-related diagnosis, vaccination, and treatment. …”
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Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway by Yue Xu, Na Rentuya, Tianyuan Yu, Jiawang Yan, Hongzheng Zhang, Yingqi Zhang, Hanyu Zhang, Jiawei Sun, Jiayue Liu

“…The SWE results showed that Tuina reduced Emax and Smax. Piezo1, Ca2+ expression were reduced, YAP, TAZ, MBP, NF200, S100β expression were enhanced by Tuina. …”
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HawkEye: AI-Driven Software for Objective Analysis and Characterization of Nodular Cast Iron Microstructures by Javier Nieves, Antonio Serena-Barriuso, Guillermo Elejoste-Rementeria

“…In fact, the proposed approach achieves 99% accuracy in nodule classification compared to manual expert assessment, reduces manual image processing steps, and introduces a novel method for ferrite/perlite measurement in combination with carbide detection using YOLO and SAM models.…”
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Prevalence and Risk Factors of Postpartum Depressive Symptoms among Parents by Ashamol Malethu Babu, Vineetha Jacob

“…This study provides further insights to understand the importance of early detection and counseling interventions for parents and their families to reduce the incidence of PPD and mitigate its adverse effects on children.…”
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