Effects of di(2-ethylhexyl) phthalate on glucose homeostasis in rats due to impaired autophagy flux of islet β cells mediated by oxidative stress by Hongyang ZHOU, Yuting HU, Xue CHEN, Yunqiang ZHOU, Liping LI, Ling LI, Herong LIU

“…Western blot analysis was applied to detect the protein relative expression levels of p62, Beclin-1, LC3-I, LC3 II, AMPK, p-AMPK, mTOR, p-mTOR, ULK1, and Caspase-8.ResultsCompared to the 0 mg·kg−1 DEHP group, the 750 mg·kg−1 DEHP group exhibited a significant increase in fasting blood glucose levels at 2, 4, 6, and 12 weeks (P<0.05). …”
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The application of vicasole as a perspective nephrolithyiasis pharmacological correction’s drug by A. Yu. Zharikov, Ya. F. Zverev, V. V. Lampatov, V. M. Bryukhanov, O. V. Azarova, O. S. Talalayeva, Yu. G. Motin

“…In the second group since the third week was being administrated vicasole in dose 500 mkg/kg. Was being detected parameters of kidney’s function, markers enzymes activity and free oxygen’s radicals activity, was carried out morphological researches.It was concluded that vicasole’s therapy reduce experimental oxalate nephrolithiasis…”
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Design and Prototype of an Automatic Highway Streetlight Intensity Control System. by Wafula, Moses

“…This research focuses on an automated streetlight control system that significantly reduces energy consumption. The Smart Street Lighting system utilizes IR sensors to detect approaching vehicles. …”
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DOES BONE MINERAL DENSITY CHANGE IN EARLY AXIAL SPONDYLOARTHRITIS? by E. E. Gubar, T. V. Dubinina, A. B. Dyomina, O. A. Rumyantseva, S. V. Shubin, A. A. Godzenko, A. V. Smirnov, S. I. Glukhova, M. M. Urumova, Sh. F. Erdes

“…An association was found between inflammatory LS changes, as evidenced by MRI (MRI spondylitis), and reduced BMD in at least one of the examined regions. …”
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Intraarticular gold for knee osteoarthritis: An ancillary analysis of biomarkers and outcome of a pilot study by Sten Rasmussen, Christopher Aboo, Jacob Skallerup, Allan Stensballe

“…Clinical outcome measures at inclusion, 8 weeks, and 2 years, were the PainDetect questionnaire, WOMAC pain, stiffness, and function. …”
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Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients by Amgad Droby, Avital Yoffe-Vasiliev, Daniel Atias, Kyle B. Fraser, Omar S. Mabrouk, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Moran Artzi, Dafna Ben Bashat, Roy N. Alcalay, Avi Orr-Urtreger, Julia C. Shirvan, Jesse M. Cedarbaum, Nir Giladi, Anat Mirelman, Avner Thaler

“…Abstract Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson’s disease (PD) and can be detected through synuclein amplification assays (SAA). …”
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m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells by Qian Zhou, Xianyang Liu, Huiping Lu, Na Li, Jiayu Meng, Jiaxing Huang, Zhi Zhang, Jiangyi Liu, Wei Fan, Wanqian Li, Xingran Li, Xiaoyan Liu, Hangjia Zuo, Peizeng Yang, Shengping Hou

“…Our analysis revealed that retinal pigment epithelium (RPE) cells serve a crucial promotional function in angiogenesis. RPE cells were regulated by N6-methyladenosine (m6A). …”
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Towards interpretable drug interaction prediction via dual-stage attention and Bayesian calibration with active learning by Rongpei Li, Yufang Zhang, Heqi Sun, Shenggeng Lin, Guihua Jia, Yitian Fang, Chen Zhang, Xiaotong Song, Jianwei Zhao, Lyubin Hu, Yajing Yuan, Xueying Mao, Jiayi Li, Aman Kaushik, Dandan An, Dongqing Wei

“…While recent computational methods focus on improving prediction accuracy, they suffer from high false-positive rates (>45%) and often function as black-box models without biological interpretability. …”
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Taxonomic Profile of Cultivable Microbiota from Adult Sheep Follicular Fluid and Its Effects on In Vitro Development of Prepubertal Lamb Oocytes by Slavcho Mrenoshki, Letizia Temerario, Antonella Mastrorocco, Grazia Visci, Elisabetta Notario, Marinella Marzano, Nicola Antonio Martino, Daniela Mrenoshki, Giovanni Michele Lacalandra, Graziano Pesole, Maria Elena Dell’Aquila

“…The aims of the present study were to analyze the taxonomic profile and to evaluate the functional effects of sheep FF cultivable microbiota on prepubertal lamb oocytes PLOs developmental potential. …”
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Dehydrodiisoeugenol alleviates palmitate-induced mitochondrial dysfunction in human vascular smooth muscle cells through the activation of SIRT1-mediated Drp1 deacetylation by Jianjun Zhao, Zhiyun Shu, Xiangjun Li, Wenqing Zhang, Mengze Sun, Wenxiao Song, Hongyuan Cheng, Shaomin Shi

“…Methods A PA-induced high-fat model of VSMCs was established, and the effect of PA on the VSMCs on function was detected by evaluating the oxidative stress and apoptosis of cells, as well as mitochondrial function. …”
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Fault diagnosis technology for three-level inverter based on ICEEMDAN-FE and SVM by CAO Ruijun, GUO Qiyi

“…In order to improve the accuracy to diagnose complex open-circuit faults for three-level inverters, a new fault diagnosis method of three-level inverters was proposed, combining improved complete ensemble empirical mode decomposition with adaptive noise-fuzzy entropy (ICEEMDAN-FE) and support vector machine (SVM). First, the detection signal is supplied at three-phase load voltage, which was converted into α-β phase voltage by Concordia to reduce the dimension of the eigenvector. …”
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Astrocytes and the Warning Signs of Intracerebral Hemorrhagic Stroke by Annalisa Scimemi

“…Here, we discuss current knowledge on the risk factors and molecular pathology of ICH and the functional properties of astrocytes and their role in ICH. …”
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The gut microbiota-mediated ferroptosis pathway: a key mechanism of ginsenoside Rd against metabolism-associated fatty liver disease by Wenjing Liu, Xian Zhou, Liyu Xiao, Xiaolan Huang, Dennis Chang, Xiaomei Zhong, Minjie Zeng, Yanfang Xian, Yanfang Zheng, Wei Huang, Rui Huang, Mingqing Huang

“…It also significantly reduced the abundances of Faecalibaculum rodentium while increasing Muribaculum intestinale, with its functional role being relevant to lipid metabolism regulation. …”
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CRISPR/Cas9-mediated knockout of SLC15A4 gene involved in the immune response in bovine rumen epithelial cells by Mao-cheng JIANG, Zi-xuan HU, Ke-xin WANG, Tian-yu YANG, Miao LIN, Kang ZHAN, Guo-qi ZHAO

“…In order to gain further insight into the potential function of SLC15A4, we utilized transcriptome data, which revealed a change in the genes between WT-BRECs and SLC15A4-KO. …”
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Uricase-Expressing Engineered Macrophages Alleviate Murine Hyperuricemia by Yu-Zhong Feng, Hao Cheng, Guo-Qing Xiong, Jia-Zhen Cui, Zhi-Li Chen, Yuan-Yuan Lu, Zhi-Xin Meng, Chen Zhu, Hao-Long Dong, Xiang-Hua Xiong, Gang Liu, Qing-Yang Wang, Hui-Peng Chen

“…Serum uric acid and bio-indicators for renal and hepatic functions were detected by an automatic biochemical analyzer; inflammatory cytokines were determined by ELISA; the livers and kidneys of the mice were sectioned for histological examination. …”
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Solar panel fault diagnosis based on the intelligentrecursive method by Saadat Boulanouar, Fengal Boualem

“…Quantitatively, this method achieves high diagnostic accuracy (over 90%), reduces error rates by up to 30% under dynamic conditions, and provides real-time fault detection with minimal latency. …”
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Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms by Shuzhen Mao, Jiahui Huang, Junyan Li, Fang Sun, Qilian Zhang, Qing Cheng, Wei Zeng, Dongya Lei, Shiyan Wang, Jing Yao

“…IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its therapeutic mechanisms in UC remain undefined. …”
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Proinflammatory Cytokines in Women with PCOS in Atypical Pathogen Infections by Izabela Chudzicka-Strugała, Iwona Gołębiewska, Grzegorz Brudecki, Wael Elamin, Beata Banaszewska, Marta Chudzicka-Adamczak, Dominik Strugała, Barbara Zwoździak

“…It is associated with excess androgens and ovarian dysfunction, reduced fertility, the presence of obstetric disorders, but also metabolic disorders, and, among others, insulin resistance, obesity and type II diabetes. …”
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Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism by Manhang Hu, Xiaolu Hua, Xiaolu Hua, Wei Xiong, Enhui Zheng, Xingyue Yang, Yu Lu, Bing He, Xiaolin Zhong, Zongzhe Jiang, Qingbi Zhang, Qingbi Zhang, Yan Liu

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Features of the daily blood pressure in patients with ischemic chronic heart failure and renal dysfunction by V. D. Syvolap, D. A. Lashkul

“…Arterial hypotension was detected in 5 (4.7%) patients with SBP24 and in 11 (10.4%) patients with DBP24. …”
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