IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection by Feifei Qi, Yiwei Yan, Qi Lv, Mingya Liu, Ming Liu, Fengdi Li, Ran Deng, Xujian Liang, Shuyue Li, Guocui Mou, Linlin Bao

“…Abstract Background The aim was to elucidate the function of IL‐37 in middle east respiratory syndrome coronavirus (MERS‐CoV) infection, thereby providing a novel therapeutic strategy for managing the clinical treatment of inflammatory response caused by respiratory virus infection. …”
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Disruption of glutamine transport uncouples the NUPR1 stress-adaptation program and induces prostate cancer radiosensitivity by Uğur Kahya, Vasyl Lukiyanchuk, Ielizaveta Gorodetska, Matthias M. Weigel, Ayşe Sedef Köseer, Berke Alkan, Dragana Savic, Annett Linge, Steffen Löck, Mirko Peitzsch, Ira-Ida Skvortsova, Mechthild Krause, Anna Dubrovska

“…The key parameters of mitochondrial functions were measured by Seahorse analysis. Analysis of the general oxidative stress level and mitochondrial superoxide detection were conducted using flow cytometry. γH2A.X foci analysis was used to assess the DNA double strand break. …”
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Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the... by Lavinia Morosi, Davide Golzato, Linda Bussini, Linda Bussini, Hygerda Guma, Federica Tordato, Federica Armanini, Zian Asif, Zian Asif, Francesco Carella, Francesco Carella, Paola Morelli, Michele Bartoletti, Michele Bartoletti, Giorgio Da Rin, Erminia Casari, Giuseppe Martano, Giuseppe Martano, Maria Rescigno, Maria Rescigno, Nicola Segata, Sara Carloni, Sara Carloni, Valeria Cento, Valeria Cento

“…This study demonstrates the utility of combining genomic and functional analyses to detect emerging mutations associated with antibiotic resistance. …”
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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

“…Ocular inflammation index and tear film function were evaluated by slim microscopy. Hematoxylin–eosin (HE) staining was used to observe conjunctival and corneal structure. …”
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Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation by Manzhen Liao, Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Wei Peng, Ting Huang, Huaiyang Chen, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao, Qiming Liu, Yunbin Xiao

“…Compared to the control group, SBRT-PADN reduced pulmonary artery systolic pressure and mean pulmonary artery pressure in ATEPAH rabbits. …”
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Impact of lead and nickel contamination on metabolic health: Associations with diabetes mellitus in a pakistani cohort by Ali Feezan, Samina Afzal, Syed Muhammad Shoaib, Muhammad Sajid Hamid Akash, Kanwal Rehman, Ahmed Nadeem, Sabry M. Attia, Asif Shahzad

“…The study also identified associations between heavy metal exposure and disruptions in various biomarkers related to DM, lipid profile, inflammation, oxidative stress, liver function, and kidney function. Pb-detected diabetics demonstrated elevated levels of glycemic index biomarkers, including fasting blood glucose (P < 0.0001) and HbA1c (P < 0.0001). …”
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A dual-reporter LDLR system integrating fluorescence and luminescence for understanding LDLR regulation and facilitating drug discovery by Peng Jiao, Peng Jiao, Peng Jiao, Peng Jiao, Na Yang, Na Yang, Qianfeng Jia, Baozhen Fan, Ke Feng, Ke Feng, Jian Yu, Shengtian Zhao, Shengtian Zhao, Shengtian Zhao

“…Enhancing LDLR expression is a promising strategy for treating hyperlipidemia and reducing the risk of atherosclerosis. However, current LDLR reporter systems have limitations in detecting both transcriptional and translational regulation. …”
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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes by Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck

“…Furthermore, CEG levels were higher in T2D patients who had developed complications compared to those without complications. Functionally, MG-modified luciferase mRNA exhibited decreased stability and reduced translational efficiency relative to unmodified mRNA. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Total number of major adverse cardiovascular events. Lung function (NB, during the COVID-19 pandemic, lung function could not be assessed in participants). …”
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A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome by Xiaoxiao Wang, Yingxue Liu, Guanghui Yuan, Jingjie Yang, Xiaowen Liu, Shuyuan Chen, Huaiqian Dou, Panpan Lu, Linfang Han, Duan Li, Cuifang Hao

“…ELISA and Co-IP were used to detect the effects of variants on protein secretion and interactions. …”
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The effect of dexmedetomidine on acute kidney injury after elective major abdominal surgery : a retrospective single-center propensity score matched study by Haibei Liu, Rong Luo, Liu Qian, Yujun Zhang, Wensheng Zhang, Juan Tan, Ling Ye

“…Secondary outcomes included intraopertive average urine output, renal function on the first day after surgery, incidence of postoperative dialysis, postoperative intensive care unit (ICU) admission, in-hospital mortality, length of hospital stay, incidence of intraoperative hypotension and bradycardia, and intraoperative use of inotropes and vasopressors. …”
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Effect of Every-other-day Fasting on Level of Serum TNF-α in Rats after Acute Spinal Cord Injury by Jiancheng LIU, Wenchun WANG, Shaojie LUO, Yanbo LI, Yunhui ZHAO, Rizhao PANG, Chao DONG, Shanshan ZHANG, Anren ZHANG

“…The level of serum TNF-α was increased in group A and group B after operation, and there were significant differences in the index between the two groups at 1st day, 3rd day and 7th day after operation (<italic>P</italic>&lt;0.05).Conclusion:EODF can improve the hind limb motor function of rats after acute spinal cord injury. The mechanism may be related with suppressing expression of inflammatory cytokines TNF-α, inhibiting inflammatory response and reducing secondary injury.…”
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Structural properties evaluation of extracted date fruit (Phoenix dactylifera L.) juice at different extraction temperatures by Afna Thaivalappil Abdul Asiz, Mohammed Tarique, Hassan Abdalla, Oni Yuliarti

“…DPPH antioxidant activity showed a slight improvement, as indicated by reduced IC₅₀ values. The juice colour darkened with higher extraction temperatures, while no HMF was detected, suggesting the processing method is safe and preserves juice quality. …”
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Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth by Akram Ghantous, Semira Gonseth Nusslé, Farah J. Nassar, Natalia Spitz, Alexei Novoloaca, Olga Krali, Eric Nickels, Vincent Cahais, Cyrille Cuenin, Ritu Roy, Shaobo Li, Maxime Caron, Dilys Lam, Peter Daniel Fransquet, John Casement, Gordon Strathdee, Mark S. Pearce, Helen M. Hansen, Hwi-Ho Lee, Yong Sun Lee, Adam J. de Smith, Daniel Sinnett, Siri Eldevik Håberg, Jill A. McKay, Jessica Nordlund, Per Magnus, Terence Dwyer, Richard Saffery, Joseph Leo Wiemels, Monica Cheng Munthe-Kaas, Zdenko Herceg

“…Hypermethylation was significantly associated with worse pre-B ALL patient survival and with reduced VTRNA2-1 expression (n=2,294 tissues; 26 types), supporting a functional and translational role for VTRNA2-1 methylation. …”
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Glutathione peroxidase 7 knockdown inhibits growth, invasion, and migration while enhancing oxidative stress and ferroptosis in osteosarcoma cells by Runze He, Xiao Xiao, Xinwen Tang, Chen Lv

“…Proliferation, apoptosis, invasion, migration, oxidative stress markers, Fe2+ levels, and ferroptosis markers were detected in human osteosarcoma cells. Results: GPX7 knockdown inhibited human osteosarcoma cell proliferation, as evidenced by reduced relative cell viability and 5-Ethynyl-2′-deoxyuridine positive cells. …”
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The role of printed and electroniс publications in development of vision disorders by S. V. Markelova

“…These numbers were significantly higher in university students (2.6 and 4.4 hours respectively for desktop computer and 2.9/3.7 hours for laptop). Functional vision loss was detected in 67.2% of high school students and 19% of university students while moderate or high myopia was diagnosed in 8.2% of high school students and 53.6% of university students. …”
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Direct and indirect effects of spliceosome disruption compromise gene regulation by nonsense-mediated mRNA decay by Caleb M. Embree, Debadrita Paul, Andreas Stephanou, Guramrit Singh

“…Pre-mRNA splicing, carried out in the nucleus by a large ribonucleoprotein machine known as the spliceosome, is functionally and physically coupled to the mRNA surveillance pathway in the cytoplasm called nonsense-mediated mRNA decay (NMD). …”
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Bifidobacterium longum subsp. longum dipro-O: a potential therapeutic agent for ameliorating metabolic disorders in high-fat diet-induced obesity mouse model by Ning Xu, Jiang Luo, Weiyang Chen, Weiwei Xiang, Yue Zhai, Wei Jiang, Junlin Wu, Yanqing Hao, Meiru Chen, Qinghua Yu

“…Functional enrichment analysis revealed that changes in the gut microbiota inhibited bacterial invasion of epithelial cells.ConclusionDipro-O effectively reduced HFD-induced obesity by decreasing body weight gain, serum lipid marker levels, and liver fat accumulation. …”
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Ameliorative Effect of Alginate Oligosaccharides on NG-nitro-L-arginine methyl ester-Induced Hypertension in Mice by CHEN Junbo, LI Yanxiao, YAN Qiaojuan, JIANG Jun, YANG Shaoqing, JIANG Zhengqiang

“…Furthermore, serum levels of total antioxidant capacity (TAC), nitric oxide, angiotensin II, and endothelin-1 were measured, and the protein expression of endothelial nitric oxide synthase (eNOS) in the aorta was also detected. Results: AOS (1.5 g/kg body weight) effectively reduced the systolic blood pressure value of 22.4 mmHg in L-NAME-induced hypertensive mice, and significantly ameliorated pathological changes and oxidative stress injury in the kidney, heart and aorta. …”
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Long-term dynamics of forage base and food supply for nekton in the upper epipelagic layer of the western Bering Sea. Part 2. Food supply for nekton by S. V. Naydenko, A. A. Somov

“…Feeding of other fish and squids species did not change noticeably in the years with reduced food supply. In general, abundance and species composition of plankton and nekton communities were rather stable in the western Bering Sea in the 2000-2010s, and this current state of the ecosystem provides stable functioning of nekton communities both in the deepwater and Navarin areas.…”
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