Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…L. salivarius LZZAY01 improved CAC via suppressing the growth of colon cancer cells, promoting autophagy and apoptosis, enhancing intestinal tight junctions, reducing intestinal barrier degradation, modifying the gut microbiota abundance, and decreasing inflammatory reactions.IMPORTANCEAlthough similar probiotics have been shown to have anticancer potential in colorectal cancer (CRC), there is a paucity of research related to the preventive function of probiotics against CRC. …”
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Efficient dispersion of aggregated extracellular vesicles: a comparative study of water-bath sonication and regular pipetting by Suryeon Kim, Inhwan Oh, Juhyun Kim, Nayeong Lee, Jun Go, Yang Jin, Won June Kim, Heedoo Lee

“…However, freezing EVs at – 70 °C can induce aggregation, reducing their effective concentration and drug delivery efficiency. …”
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Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma by Junjue Chen, Huimin Zhong, Bingqiao Shen, Huan Yu, Yang Zhang, Ruiqi Han, Ping Huang, Shouyue Huang, Yisheng Zhong

“…Western blot, RT-PCR, immunofluorescence and F-VEP were used to detect neuroinflammation level, glial activation and RGCs survival in retina of wild type, TXNIP knockout and MCC950 treatment COH mice. …”
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The role of cardiac MRI in risk stratification for sudden cardiac death in patients with hypertrophic cardiomyopathy by M. S. Ishchenko, K. V. Rudenko, V. V. Lazoryshynets, Yu. I. Vitkovskyi, M. O. Tregubova, P. A. Danchenko

“…Risk factors for SCD were identified in 60 patients (25.4 %) with myocardial thickness exceeding 30 mm, 8 patients (3.3 %) with apical aneurysm, 4 patients (1.6 %) with reduced LV systolic function (LV ejection fraction <50 %), and 164 patients (69.4 %) with pathological late gadolinium enhancement. …”
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N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells by Raghda A. Elsabbagh, Ghada Abdelhady, Doris Urlaub, Mina Sandusky, Ola Khorshid, Mohamed Z. Gad, Khaled Abou-Aisha, Carsten Watzl, Mona Rady

“…Furthermore, artificially increasing transcripts’ m6A levels via MA in cultured primary NK cells reduced mRNA levels of NKG2D pathway genes and death receptor ligands but did not affect protein expression or NK cell functionality. …”
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Platelet membrane-modified catalase/silica nanoparticles inhibit radiation infection by XIONG Tainong, LI Chenwenya, CHEN Yin

“…Laser confocal microscopy was used to observe the intracellular fluorescence intensity of PCNP to evaluate the leukocytes targeting function. AHH-1 cells were divided into control, irradiation, platelet membrane, CNP (100 μg/mL) and PCNP (100 μg/mL) groups. …”
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Applying bioinformatic analysis for prognostic assessment of the <i>HS3ST6</i> missense mutations clinical significance in the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. R. Denisova, N. S. Podchernyaeva, A. A. Totolian

“…Currently, mutations in the HS3ST6 gene remain poorly understood; only one missense mutation (p.Thr144Ser, rs746467957) associated with the development of HAE has been described.The aim of our work was to study new mutations in the HS3ST6 gene and analyze in silico their prognostic nature and clinical significance for the development of hereditary angioedema.The material was whole blood samples obtained from 13 patients with symptoms of hereditary angioedema without reduced levels and function of C1-INH.Whole exome sequencing of patients, bioinformatic analysis of HS3ST6 gene mutations using a number of databases and Web resources to predict the effect of mutations on the protein and assess the conservatism of the positions of the mutations detected was involved in study methods.Mutations in the HS3ST6 gene were identified in four patients, including two cases with two mutations simultaneously. …”
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Comparative transcriptomic and proteomic analyses of hypoxia response in wild and cultivated tomato roots by Zhihan Zhang, Yabing Hou, Hao Yin, Song Lu, Daliang Liu, Lin Cheng, Houlin Yu, Tao Li, Yiyong Zhao

“…Results Compared with cultivated seedlings, wild tomato seedlings exhibited markedly reduced sensitivity to hypoxia, as demonstrated by lower growth inhibition and higher membership function values under low-oxygen conditions. …”
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Statin Therapy and Cognitive Impairment: Benefit or Harm? by O. D. Ostroumova, E. V. Chikh, E. V. Rebrova, A. Yu. Ryazanova

“…This review paper was written in the light of the search for information on a specific problem of the potential adverse effects of statins on the cognitive function. The purpose of the article is to seek advice for health professionals on monitoring and reducing the risk of potential cognitive impairment during statin therapy. …”
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Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling. by Mei Li, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Xiaohua An, Ying Zhao, Ying Gao

“…However, the expression and biological functions of PHB1/PHB2 in atherosclerosis (AS) remain unclear. …”
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Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates by Gonzalo Sanchez-Arsuaga, Damer P. Blake, Fiona M. Tomley, Virginia Marugan-Hernandez

“…In silico analysis of three of these putative dense granule proteins - EtGRA9, EtGRA12a, and EtGRA12b - revealed the presence of signal peptides in EtGRA9 and EtGRA12b, while none was detected in EtGRA12a. Sequence analysis of E. tenella field isolates revealed a limited number of polymorphisms in the genes encoding these three proteins, suggesting purifying selection possibly related to their functional importance. …”
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Distributed variational sparse Bayesian compressed sensing based on factor graphs by Cui-tao ZHU, Fan YANG, Han-xin WANG, Zhong-jie LI

“…A distributed variational sparse Bayesian compressed spectrum sensing algorithm based on factor graph was proposed,which decomposed the global spectrum sensing problem into local problem based on factor and variation.Belief propagation was used for the statistical inference of the spectrum occupancy,to implement the “soft fusion”.The temporal and spatial correlation information providing two-dimensional redundancies was exchanged among cooperative cognitive users to improve the detection performance under low SNR.Meanwhile,the algorithm prunes the divergence of hyper-parameters and the corresponding basis functions for reducing the load of communication.The simulation results show that this method can effectively achieve performance of spectrum sensing under a low sampling rate and the low SNR.…”
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Effects of silkworm pupa protein on apoptosis and energy metabolism in human colon cancer DLD-1 cells by Xiaojiao Ji, Jing Wang, Aijin Ma, Duo Feng, Yue He, Wenjie Yan

“…Methods: CCK-8 was used to detect cell proliferation rate after 72 h of cell culture for the control group (normal cultured DLD-1 cells) and SPP dose groups; Annexin-V/PI was applied to observe cell apoptosis; XFe24 Extracellular Flux Analyzer was used to detect cell mitochondrial respiratory function and glycolytic function. …”
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Clinical characteristics of patients with chronic post-traumatic pain: data from a prospective study by A. A. Bialik, A. E. Karateev, M. A. Makarov, V. А. Nesterenko, V. E. Bialik, E. I. Bialik

“…All had moderate/severe pain with impaired function and reduced quality of life, one in five patients had symptoms of neuropathic pain, signs of depression and anxiety. …”
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miR‐92a aggravates metabolic syndrome via KLF2/miR‐483 axis by Zhe Zhao, Chaofeng Ma, Longzhi Wang, Yuhang Xia, Jun Li, Wei Yang, Juan Pang, Hui Ding, Haifeng Wang, Liang Bai, Fenqing Shang, Feng Zhang

“…Methods In this study, the serum of healthy controls and patients with metabolic syndrome were collected to detect the circulating level of miR‐92a and miR‐483. …”
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A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors by Kristin R. Anderson, Wenpeng Cao, Hui Sun Lee, Mark A. Crenshaw, Talulla B. Palumbo, Ethan Fisher-Perez, Amanda DeGraaf, Peter Rogu, Maria A. Beatty, Gabrielle M. Gracias, Gabrielle M. Gracias, Avani V. Pisapati, Katie Hoffman, Krystle J. McLaughlin, Almut Hupbach, Wonpil Im, Wonpil Im, X. Frank Zhang, Julie M. Miwa

“…Through computational modeling of the homopentameric α7 nicotinic receptor subtype and in vitro atomic force microscopy (AFM), we discovered that a specific LYNX2 SNP is linked to a reduced binding affinity between the LYNX2 protein and nAChRs, offering a potential functional explanation for the role that this mutation may play in anxiety.DiscussionA polymorphism in LYNX2, which codes for an inhibitory modulator of nicotinic acetylcholine receptors, has the potential to lead to sensitized nicotinic receptor activity in anxiety-related circuits. …”
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The origin of dyspnea and its role in the reduction of exercise endurance in patients with rheumatoid arthritis by Mikhail Vasil'evich Sheyanov, V A Sulimov, Mikhail Vasilyevich Sheyanov, V A Sulimov

“…Dyspnea is a common symptom and an important factor in reducing EE and QL in patients with RA. Dyspnea in these patients has a multifactorial origin. …”
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Serine/threonine protein kinase mediates rifampicin resistance in Brucella melitensis through interacting with ribosomal protein RpsD and affecting antioxidant capacity by Yaqin Yuan, Wenqing Ning, Junjie Chen, Jiquan Li, Tianqi Xue, Cuihong An, Lingling Mao, Guangzhi Zhang, Shizhong Zhou, Jiabo Ding, Xiaowen Yang, Jianqiang Ye

“…Recently, an increasing number of rifampicin-resistant Brucella strains have been isolated worldwide without detectable mutations in known antibiotic resistance genes. …”
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Software defined data center network with hybrid routing by Yue-ping CAI, Chang-ping WANG

“…SHR extends the OpenFlow scheme by offloading some basic functions such as flow statistical detection and mice flow forwarding to switches to reduce the switch-controller interaction overhead. …”
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Robust self-supervised denoising of voltage imaging data using CellMincer by Brice Wang, Tianle Ma, Theresa Chen, Trinh Nguyen, Ethan Crouse, Stephen J. Fleming, Alison S. Walker, Vera Valakh, Ralda Nehme, Evan W. Miller, Samouil L. Farhi, Mehrtash Babadi

“…CellMincer consistently outperforms existing methods in SNR gain (0.5–2.9 dB) and reduces SNR variability by 17–55%. Incorporating CellMincer into standard workflows significantly improves neuronal segmentation, peak detection, and functional phenotype identification, consistently surpassing current methods in both SNR gain and consistency.…”
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