Deceleration of liver regeneration by knockdown of hepatic stimulator substance gene expression in mice by Han Lihong, Yan Bin

“…In addition, HSS can protect liver cells and reduce the damage of CCl4, galactosamine, thioacetamide and other drugs on liver cells. …”
Get full text

Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin by Can Wang, Hongfeng Cheng, Xiaoying Dong, Yue Zhan, Ying Liu, Nianhong Wu, Rui Tang, Hongye He, Yuting Cao, Liping Yang, Jianli Ren, Xingsheng Li, Pan Li

“…The results demonstrated that delayed myocardial contrast-enhanced echocardiography (DMCE) provided dynamic VR monitoring, with contrast intensity values showing a negative correlation with cardiac function parameter changes. POC@L/TI NPs significantly improved cardiac structural and functional parameters in rats with myocardial infarction and reperfusion and delayed the progression of heart failure by increasing tissue oxygenation, reducing the inflammatory response, inhibiting fibrotic scar formation and preventing myocardial cell apoptosis. …”
Get full text

INDICATION OF THE BIOCHEMICAL TARGETS OF RARE EARTH ELEMENTS IN BIVALVE MOLLUSCS UNDER MULTIPLE EXPOSURE by V. Khoma, K. Yunko, V. Martyniuk, M.Zarian, V. Havryshkiv

“…The changes in the Zn distribution within the cells and Zn-dependent functions were indicated, confirming the impact of REEs on the functionality of the essential metal. …”
Get full text

Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei. by Yonghui Feng, Wenyan Gao, Chengqi Wang, Shuangrui Shi, Dan Zhou, Lin Sun, Liying Zhu, Liwang Cui, Yaming Cao, Xiaotong Zhu

“…Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which is associated with the plasma membrane of macrogametes and ookinetes. …”
Get full text

LncRNA TMPO-AS1 facilitates cervical cancer cell tumorigenesis and ferroptosis resistance via interaction with LCN2 by Ying Ju, Xu Liu, Jintong Na, Jian He, Liangliang Wu, Zhuoran Wang, Chunxiu Peng, Yuan Liao, Zhiyong Zhang

“…Loss- and gain-of-function experiments with TMPO-AS1 were performed using the CCK-8 assay, transwell assays, clone formation assays, and xenograft models. …”
Get full text

Thermocouple-integrated resonant microcantilever for on-chip thermogravimetric (TG) and differential thermal analysis (DTA) dual characterization applications by Yuhang Yang, Hao Jia, Zechun Li, Zhi Cao, Haozhi Zhang, Pengcheng Xu, Xinxin Li

“…Moreover, the cantilever offers picogram (10–12g) level mass resolution, reducing sample consumption from milligrams to nanogram levels. …”
Get full text

Jinxinkang granule alleviates chronic heart failure by enhancing GPER/AMPK/PCG-1α-mediated fatty acid oxidation by Haixiang Zhong, Liu He, Wanru Zhong, Lili Wang, Jianmin Luo, Qi Chen, Rong Li, Rong Zhang, Zhongqiu Liu, Yuanyuan Cheng

“…Methods: Sprague-Dawley (SD) rats under left anterior descending artery ligation model, C57BL/6 mice subcutaneously injected isoproterenol (ISO) model in vivo and H9c2 cells under oxygen glucose deprivation (OGD) in vitro were used to evaluate the effect of JXK against CHF. Cardiac function and morphology assessment using M-mode echocardiography, H&E/Masson/WGA staining, western blotting analysis, real-time PCR detection, ATP and cAMP assays were used to explore the mechanism of JXK against CHF. …”
Get full text

Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease by Chelsea N. Johnson, Mara R. Evans, Anneka E. Blankenship, Casey S. John, Michaella J. Rekowski, Michael P. Washburn, Andy Phan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Paige C. Geiger, Jill K. Morris

“…Alzheimer's disease (AD) is associated with reduced lean mass and impaired skeletal muscle mitochondrial and motor function. …”
Get full text

Investigating the Associations Between Hmga2 Overexpression, R-Loop Reduction, and Bone Loss in Aging Mice by Yangyang Cao, Yantong Wang, Dengsheng Xia

Get full text

Rethinking timing residuals: advancing PET detectors with explicit TOF corrections by Stephan Naunheim, Stephan Naunheim, Luis Lopes de Paiva, Luis Lopes de Paiva, Vanessa Nadig, Yannick Kuhl, Yannick Kuhl, Stefan Gundacker, Stefan Gundacker, Florian Mueller, Volkmar Schulz, Volkmar Schulz, Volkmar Schulz, Volkmar Schulz

“…PET is a functional imaging method that can visualize metabolic processes and relies on the coincidence detection of emitted annihilation quanta. …”
Get full text

MeetSafe: enhancing robustness against white-box adversarial examples by Ruben Stenhuis, Dazhuang Liu, Yanqi Qiao, Mauro Conti, Manos Panaousis, Kaitai Liang

“…We observe a non-uniform distribution of Z-scores between clean samples and adversarial examples (AEs) among hidden features and propose two utility functions to select those most relevant to AEs. We process critical hidden features using feature engineering methods: local outlier factor (LOF), feature squeezing, and whitening, which estimate feature density relative to its k-neighbors, reduce redundancy, and normalize features. …”
Get full text

Mapping indicator species of segetal flora for result-based payments in arable land using UAV imagery and deep learning by Caterina Barrasso, Robert Krüger, Anette Eltner, Anna F. Cord

“…Plant height was crucial for species detection, with accuracy ranging between 49–100 %. …”
Get full text

Development and Investigation of Vision System for a Small-Sized Mobile Humanoid Robot in a Smart Environment by Amer Tahseen Abu-Jassar, Hani Attar, Ayman Amer, Vyacheslav Lyashenko, Vladyslav Yevsieiev, Ahmed Solyman

“…To ensure the high speed of the computer vision system based on the ESP32-CAM module, the neural network was improved by replacing the Visual Geometry Group 16 (VGG-16) network as the base network for extracting the functions of the Single Shot Detector (SSD) network model with the tiny-YOLO lightweight network model, which made it possible to preserve the multidimensional structure of the network model feature graph, resulting in increasing the detection accuracy, while significantly reducing the amount of calculations generated by the network operation, thereby significantly increasing the detection speed, due to a limited set of objects. …”
Get full text

Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway by Xize Wu, Xue Pan, Jian Kang, Yuxi Huang, Jiaqi Ren, Jiaxiang Pan, Kaifeng Yu, Yue Li

“…In vitro experiments demonstrated that FA reduces lipid accumulation, increases cell viability, improves mitochondrial function, and decreases reactive oxygen species content. …”
Get full text

M6A Methyltransferase METTL3 Modulates Traumatic Brain Injury by Targeting Ferroptosis by Fei Qin, Fan Li, Wenxiao Zhao, Suqin Zhang, Jiang Shen, Xinyu Yang

“…Overexpression of METTL3 improved cognitive function and brain recovery while simultaneously reducing ferroptosis and neuroinflammation. …”
Get full text

Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction by Feng Shao, Johanna Wieland, Yixin Wang, Merve Keles, Zenghui Meng, Santosh Lomada, Miao Qin, Veronika Leiss, Abel Martin-Garrido, Manuela Fuhrmann, Yi Qiu, Felix A. Trogisch, Christiane Vettel, Joerg Heineke, Yuxi Feng

“…In line with cardiac dysfunction, the phosphorylation of myocardial phospholamban (PLN) and the expression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) in the NDPKB deficient LVs were significantly reduced. Moreover, the accumulation of collagen, fibronectin as well as the upregulation of transforming growth factor β (TGF-β), were detected in NDPKB deficient LVs. …”
Get full text

Experimentally profiling dielectric properties of Escherichia coli and Staphylococcus aureus by movement velocity and force by Akmal Suhaimi, Arash Zulkarnain, Noraziah Mohamad Zin, Abdullah Abdulhameed, Aminuddin Ahmad Kayani, Ramdzan Buyong

Get full text

Detour-Straddle 3D-like path planning of unmanned mining truck in open pit mines based on optimized ant colony algorithm by Mingyu GAO, Jiusheng BAO, Yan YIN, Deping HU, Kekun ZHANG, Chenzhong ZHU, Maosen WANG, Kai WANG

“…Adaptive multi-step movement mode is introduced, and a multi-objective heuristic function is designed to introduce cross-obstacle evaluation. …”
Get full text

The Impact of Hotspot-Targeted Interventions on Malaria Transmission in Rachuonyo South District in the Western Kenyan Highlands: A Cluster-Randomized Controlled Trial. by Teun Bousema, Gillian Stresman, Amrish Y Baidjoe, John Bradley, Philip Knight, William Stone, Victor Osoti, Euniah Makori, Chrispin Owaga, Wycliffe Odongo, Pauline China, Shehu Shagari, Ogobara K Doumbo, Robert W Sauerwein, Simon Kariuki, Chris Drakeley, Jennifer Stevenson, Jonathan Cox

“…Secondary outcome measures were parasite prevalence inside hotpots, parasite prevalence in the evaluation zone as a function of distance from the hotspot boundary, Anopheles mosquito density, mosquito breeding site productivity, malaria incidence by passive case detection, and the safety and acceptability of the interventions. …”
Get full text

The mechanism of miR-155 targeting PIK3R1 in the pathogenesis of preeclampsia by Yi Zhou, Qiu Lian Xu

“…Abstract To explore the molecular mechanism of miRNA-155-5p regulating placental trophoblast cell function and affecting preeclampsia. RNA was measured via RT-qPCR, and protein was detected with Western blot as well as Immunohistochemistry. …”
Get full text