Psychosis Recovery Orientation in Malawi by Improving Services and Engagement (PROMISE) protocol. by Stephen Lawrie, Charlotte Hanlon, Lucinda Manda-Taylor, Martin Knapp, Martyn Pickersgill, Robert C Stewart, Jen Ahrens, Judith Allardyce, Action Amos, Annette Bauer, Erica Breuer, Dennis Chasweka, Kate Chidzalo, Saulos Gondwe, Sumeet Jain, Demoubly Kokota, Kazione Kulisewa, Olive Liwimbi, Angus MacBeth, Thandiwe Mkandawire, Anthony Sefasi, Wakumanya Sibande, Michael Udedi, Eric Umar

“…Our aim is to work with people with lived experience (PWLE), caregivers, local communities and health leaders to develop acceptable and sustainable psychosis detection and management systems to increase psychosis awareness, reduce DUP, and to improve the health and lives of people with psychosis in Malawi. …”
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Development of a relapse-related RiskScore model to predict the drug sensitivity and prognosis for patients with ovarian cancer by Zhixin Jin, Xuegu Wang, Xiang Li, Shasha Yang, Biao Ding, Jiaojiao Fei, Xiaojing Wang, Chengli Dou

“…The effects of relapse-related prognostic genes on OC cells were detected with in vitro assays. Results The single-cell atlas revealed that compared to primary OC, fibroblasts were reduced but epithelial cells were increased in relapse OC. …”
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Speckle-tracking and conventional echocardiography in MIS-C: tracking cardiac involvement and recovery by Nima Mehdizadegan, Sajedeh Omidbakhsh, Eslam Shorafa, Hossein Hosseini, Hamid Amoozgar, Hamid Mohammadi, Amir Naghshzan, Mohammadreza Edraki, Katayoon Hozhabri, Narjes Abootalebi, Mohammad Hasan Mohammadi

“…This study evaluates mid-term cardiac function in MIS-C patients, with and without cardiac involvement, using transthoracic echocardiography (TTE) and speckle-tracking echocardiography (STE). …”
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Case Report: A case of first-line treatment for rare ROS1 fusion mutation lung adenocarcinoma with entrectinib by Yifan Yang, Yifan Yang, Qing Yi, Wei Yang, Yongzhong Luo, Lemeng Zhang

“…A CD74:exon6 ~ ROS1: exon 35 fusion was identified, which could mediate the full kinase function. A biopsy of the right supraclavicular lymph node confirmed the diagnosis of lung adenocarcinoma. …”
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Quantification of liver fat fraction using T1-weighted mDixon MRI in young patients with ataxia telangiectasia undergoing whole-body MRI: an exploratory study by Soma Kumasaka, Rafal Panek, Renata Neves, Mohnish Suri, Sumit Jagani, Yuka Kumasaka, Yoshito Tsushima, Robert A. Dineen

“…Conclusion T1-weighted mDixon MRI is feasible for detecting steatosis in children with A–T, although motion artefacts reduced data completeness. …”
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Gubi Decoction Ameliorates Porous Cartilage Endplate in an Intervertebral Disc Degeneration Model Mouse Through Inhibition of NF-κB Activity and Pyroptosis by Yao S, Li Y, Ruan H, Wu L, Zeng H

“…After 8 weeks of LSI modeling, the therapeutic efficacy on IVDD was evaluated through changes in lumbar spine function, histopathological morphology, extracellular matrix (ECM) metabolism, nucleus pulposus (NP) cell viability, and cartilage endplate (CEP) cell pyroptosis; at 4 weeks after modeling, the activation of NF-κB signaling was detected.Results: GBD can attenuate the progression of IVDD in mice, resulting in substantially increases disc height index (DHI) and NP matrix, reduced the degree of annulus fibrosus (AF) tear and the formation of cavity in CEP. …”
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Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…Knockdown of GSTO1 significantly reduced the antioxidant and therapeutic effects on renal IRI of hypoxic MSC-EVs. …”
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ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization. by Ulyana V Desiderio, Xiaoling Zhu, Janice P Evans

“…<h4>Methodology/principal findings</h4>An anti-β(1)/ITGB1 function-blocking antibody that reduces sperm-egg binding significantly inhibited ADAM2 binding to mouse eggs. …”
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Sustained release of ubiquitin-like protein ISG-15 enhances tendon-to-bone healing following anterior cruciate ligament reconstruction in a mouse model by Jun-Cheng Yao, Jun-Cheng Yao, Jun-Cheng Yao, Jun-Cheng Yao, Jie-Xin Zhang, Jie-Xin Zhang, Jie-Xin Zhang, Jie-Xin Zhang, Xuan Wang, Xuan Wang, Xuan Wang, Xuan Wang, Yu-Hao Wu, Yu-Hao Wu, Hao-Lin Ke, Hao-Lin Ke, Hao-Lin Ke, Jia-Rong Liang, Yan Shao, Yan Shao, Jin-Tao Li, Jin-Tao Li, Jin-Tao Li, Yuan Liu, Dao-Zhang Cai, Dao-Zhang Cai, Jian-Ying Pan, Jian-Ying Pan

“…However, its specific function in tendon-to-bone interface regeneration has not been well characterized. …”
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Risk Assessment of Glaucoma in the Kyrgyz Republic by O. A. Bolbachan, G. K. Omorova, K. N. Bolbachan

“…The identification of risk factors contributes to the early diagnosis and detection of the clinical and functional features of glaucoma, as well as to the timely treatment that reduces the complications of glaucoma. …”
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EP300 Modulates MCM8 Transcription and Augments the Malignant Phenotype of Hepatitis B Virus–Positive Hepatocellular Carcinoma Cells by Fang Xue, Tian‐Feng Sun

“…This study focused on the role of E1A‐binding protein p300 (EP300) in the malignant phenotype of HBV‐positive HCC cells and its functional mechanism. Increased EP300 expression was detected in HBV‐positive tumor tissues and cells compared to their control counterparts. …”
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Brain Imaging Findings in Dyslexia by Ying-Fang Sun, Jeun-Shenn Lee, Ralph Kirby

“…Gray matter deficits have been demonstrated in dyslexics using structural magnetic resonance imaging. Reduced neural activities in the left temporal and left parietal cortices, and diffuse widespread activation patterns in the cerebellum could be detected using functional magnetic resonance imaging. …”
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Colo‐Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: N... by Fatemah A. Alherz, Mahmoud S. Abdallah, Esraa M. Mosalam, Mostafa M. Bahaa, Thanaa A. Elmasry, Mohamad A. El‐Gammal, Walaa A. Negm, AyaIbrahim Elberri, Nora Elshorbagi, Hend E. Abo Mansour, Amir O. Hamouda, Muhammed M. Salahuddin, Mohamed Yasser, Mamdouh Eldesoqui, Sarah Alrubia, Amsha S. Alsegiani, Eman El‐Khateeb, Mohamed Kh. ElMahdy, Eman Wahsh

“…Intracolonic AA induced marked functional, biochemical, and inflammatory damage to colonic tissue. …”
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Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition by Yuhao Chen, Yuankang Zhu, Xiaoli Ren, Lu Ding, Yubin Xu, Miqi Zhou, Runze Dong, Peifeng Jin, Xiufang Chen, Xiaofang Fan, Ming Li, Yongsheng Gong, Yongyu Wang

“…These MFS–hiPSC‐derived ECs were characterized using immunofluorescence, reverse transcription‐quantitative polymerase chain reaction, and Western blotting. Functional assays including cell proliferation, scratch wound, tube formation, NO content detection, and senescence‐associated β‐galactosidase staining were conducted. …”
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Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis by Jiaqi Wang, Yan Zhang, Duo Luo, Jing Xu, Xin Nie, Chen Huang, Hailan Zhao, Minzheng Zhu, Xue Guo, Yong Zhang, Wenjing Qiu, Haoming Xu, Yuqiang Nie, Youlian Zhou

“…These findings suggest that both Sg-derived metabolites and host immune signaling may serve as potential targets for CRC intervention. Functional validation of individual metabolites is currently in progress.…”
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Application of Artificial Intelligence in rheumatic disease classification: an example of ankylosing spondylitis severity inspection model by Chih-Wei Chen, Hao-Hung Tsai, Chao-Yuan Yeh, Cheng-Kun Yang, Hsi-Kai Tsou, Pui-Ying Leong, James Cheng-Chung Wei

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On the usage of artificial intelligence in leprosy care: A systematic literature review. by Hilson Gomes Vilar de Andrade, Elisson da Silva Rocha, Kayo H de Carvalho Monteiro, Cleber Matos de Morais, Danielle Christine Moura Dos Santos, Dimas Cassimiro Nascimento, Raphael A Dourado, Theo Lynn, Patricia Takako Endo

“…It can result in physical disabilities and functional loss and is particularly prevalent amongst the most vulnerable populations in tropical and subtropical regions worldwide. …”
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Vascular depression and cognitive dysfunction by A. N. Bogolepova

“…Depression, in turn, also has a negative impact on the course of cardiovascular disease, contributing to its progression, worsens quality of life in patients, reduces functional activity, increases mortality, and increases the risk of stroke. …”
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Occurrence of Alternaria Toxins, Ochratoxin A and Aflatoxins B1 in Green Arabic Coffee (Coffea arabica) in Saudi Arabia: Risk Assessment on HepG-2 Cell Line and Male Albino Rats by Ahmed Hashim Almusallam, Ahmed Mahmoud Ismail

“…In addition, Aflatoxin B1 was also detected with low quantity ranged 0.89 to 3.22 μg/g. …”
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EXPERIMENTAL RESEARCH MODELS IN THE STUDY OF LIVER PATHOLOGY AFFECTING PREGNANCY OUTCOMES by Гулрухсор Хайбуллоевна Толибова, Марина Александровна Крышня, Елена Витальевна Мозговая

“…Until now, there is a correlation between liver function and the outcome of pregnancy: even moderate changes in liver function indicators (both before pregnancy and in the early stages) can lead to complications that prevent a successful pregnancy, childbirth and the birth of a healthy child. …”
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