Harnessing Raman spectroscopy and multimodal imaging of cartilage for osteoarthritis diagnosis by Anna Crisford, Hiroki Cook, Konstantinos Bourdakos, Seshasailam Venkateswaran, Douglas Dunlop, Richard O. C. Oreffo, Sumeet Mahajan

“…Abstract Osteoarthritis (OA) is a complex disease of cartilage characterised by joint pain, functional limitation, and reduced quality of life with affected joint movement leading to pain and limited mobility. …”
Get full text

The Efficacy and Mechanism of Qinghua Jianpi Recipe in Inhibiting Canceration of Colorectal Adenoma Based on Inflammatory Cancer Transformation by Ting Liu, Juping You, Qingjian Gao, Yufeng Zhang, Wei Xu, Desong Kong, Li Chen, Bao Yuan, Haibing Hua

“…Western blot was used to detect the protein expression of the related signaling pathways. …”
Get full text

Kolmogorov–Arnold Networks for Automated Diagnosis of Urinary Tract Infections by Anurag Dutta, A. Ramamoorthy, M. Gayathri Lakshmi, Pijush Kanti Kumar

“…These models, experimented on an open-source pathological dataset, outperforms the state-of-the-art deep learning models (particularly those inheriting the MLP architecture) by nearly <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>7.8361</mn><mo>%</mo></mrow></semantics></math></inline-formula>. By rapid UTI detection, the proposed methodology reduces diagnostic delays, minimizes human error, and streamlines laboratory workflows. …”
Get full text

Integrating genome and transcriptome analysis to decipher balanced structural variants in unsolved cases of neurodevelopmental disorders by Simona Mellone, Alice Spano, Denise Vurchio, Giulia Borgonovi, Giulia Borgonovi, Alessandro Ugonotti, Giulia Paglino, Alba Bianco, Sara Ronzani, Maurizio Sciancalepore, Flavia Prodam, Flavia Prodam, Amanda Papa, Maurizio Viri, Umberto Dianzani, Umberto Dianzani, Mara Giordano, Mara Giordano

“…RNA sequencing (RNA-Seq), by enabling the detection of gene expression changes and fusion transcripts, provides complementary functional insights into the consequences of genomic alterations. …”
Get full text

JiangyaTongluo decoction ameliorates tubulointerstitial fibrosis via regulating the SIRT1/PGC-1α/mitophagy axis in hypertensive nephropathy by Yun Zhao, Qi Jia, Gaimei Hao, Lin Han, Yushan Gao, Xiaoyu Zhang, Ziming Yan, Boyang Li, Yiping Wu, Boya Zhang, Yubo Li, Jianguo Qin

“…In vivo validation showed that JYTL decoction could improve kidney function, ameliorate tubulointerstitial fibrosis (TIF), and improve mitochondrial function by inhibiting ROS production and regulating mitochondrial dynamics in SHRs. …”
Get full text

The renin-angiotensin system in healthy human platelets: expressed but inactive by François Panosetti, François M. Cuenot, Damian S. Saint Auguste, Ana C. Martins Cavaco, Allancer D. C. Nunes, Philip H. J. Lu, Céline Magrini, Max Molot, Gabriel Sanglard, Rodi Günçü, Yassine Zouaghi, Charles Béguelin, Augusto Martins Lima, Nikolaos Stergiopulos

“…Our findings suggest that while RAS receptors are expressed in platelets, RAS peptides do not impact platelet function, at least in our experimental setting. COVID-19 coagulopathy may occur independently of the RAS.…”
Get full text

Co-targeting of EGFR by co-expressed miRNA-193a-3p/−5p in lung cancer by Kegan Zhu, Hanying Ding, Ao Yu, Zhicong Liao, Zheng Fu, Yeting Hong, Xiaojun Wang, Chen-Yu Zhang, Xi Chen

“…Abstract MicroRNAs (miRNAs) function as important oncogenes or tumor suppressors in each stage of cancer development. …”
Get full text

There is no transfer of mitochondria from donor hematopoietic cells to recipient mesenchymal stromal cells after allogeneic hematopoietic stem cells transplantation in humans by Natalya Sats, Vadim Surin, Tatiana Abramova, Aleksandra Sadovskaya, Nataliya Petinati, Nikolay Kapranov, Ksenia Nikiforova, Nina Drize, Luisa Karaseva, Olga Pokrovskaya, Larisa Kuzmina, Elena Parovichnikova

“…Mitochondria, which can be transferred between cells via nanotubes or extracellular vesicles, play a key role in the functions of mesenchymal stromal cells. In a murine model, donor hematopoietic stem and progenitor cells transfer functional mitochondria to bone marrow mesenchymal stromal cells of the recipient. …”
Get full text

CHANGES IN PHYSICAL AND CHEMICAL PROPERTIES OF ORAL FLUID IN PATIENTS WITH PERIODONTAL DISEASES IN THE SETTINGS OF CHRONIC HEPATITIS C DURING ANTIVIRAL THERAPY by H.A. Sichkoriz, L.Yu. Minko

“…The increase in violations of these parameters is observed on the 1st-3rd months of AVT and characterized by decreased rate of stimulated secretion and increased viscosity of the mixed saliva, shift of acid-base balance toward acidosis and reduced buffer capacity. The negative dynamics of physical and chemical properties of oral fluid during AVT requires correction to prevent the development of PD and reduce the number of complications. …”
Get full text

Excretory/secretory products from Hymenolepis nana adult worms alleviate ulcerative colitis in mice via tuft/IL-13 signaling pathway by Rong Mou, Xuanyin Cui, Hongyan Wang, Zhenfen Zhang, Yi Cheng, Wenlan Wu, Jinfu Li, Ke Zhang

“…The protective mechanism of ESPs might be related to the activation of the tuft/IL-13 signaling pathway, regulating intestinal barrier function and promoting the regeneration of intestinal stem cells. …”
Get full text

Aerosol Inhalation of Luteolin-7-O-Glucuronide Exerts Anti-Inflammatory Effects by Inhibiting NLRP3 Inflammasome Activation by Jianliang Li, Ling Song, Han Li, Yunhang Gao, Tengfei Chen, Zhongxiu Zhang, Hongping Hon, Zuguang Ye, Guangping Zhang

“…<b>Results:</b> In this study, we found that inhalation of L7Gn aerosol significantly reduced pulmonary injury by inhibiting inflammatory infiltration and enhancing lung function. …”
Get full text

Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer by Fang Fang, Mei Zhao, Jinming Meng, Jiaqi He, Chunlei Yang, Changhong Wang, Jiaxiao Wang, Sheng Xie, Xiaowei Jin, Wei Shi

“…Tweety homolog 3 (TTYH3) reportedly functions vitally in the development of diverse cancers, including NSCLC; nevertheless, its role in NSCLC metastasis remains ambiguous. …”
Get full text

Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…It is known that T cells are essential for limbic system development/function. Treatment with thymosin α1 (Tα1) is capable to increase the thymus output of naïve T cells. …”
Get full text

High prevalence of carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital over a decade by Shiqi Cai, Jingjing Quan, Zhengan Wang, Huangdu Hu, Xinhong Han, Yan Jiang, Qing Yang, Yunsong Yu, Zhihui Zhou

“…For carbapenem-resistant strains, efflux inhibitor assay and quantitative real-time PCR (qRT-PCR) were performed to evaluate the function of efflux pumps. A total of 82 CRECC isolates were detected, and the rate of resistance for carbapenems was 8.8%, increasing from 5.5% in 2011 to 18.3% in 2019, with an overall increasing trend, with Enterobacter hormaechei subsp. hoffmannii being the predominant species. …”
Get full text

Metabolic Health Consequences of Switching to the Bictegravir/Emtricitabine/Tenofovir Alafenamide and Dolutegravir Plus Lamivudine Regimens in Virologically Suppressed People Livin... by Shi J, Zhang W, Han J, Zhang Z, Yan D, Zheng R, Li F, Wang Y

“…The transition to B/F/TAF demonstrated dual clinical benefits, significantly reducing hyperglycemia incidence while preserving renal function.Keywords: people living with HIV, virological suppression, antiretroviral therapy, metabolic indices…”
Get full text

The Effect of Different Processing Methods on Metabolite Profiles by Comparative Metabolomics in Kernels and Sprouted Seeds of Foxtail Millet by Lingda Han, Qi Li, Xiaowen Wang

“…However, ultra-polishing has greatly reduced its nutrition. Germination can enhance nutrition value. …”
Get full text

Cardiac implications of chicken wooden breast myopathy by Thea Parsberg Støle, Andreas Romaine, Thea Kleiberg, Vibeke Høst, Marianne Lunde, Almira Hasic, Tiril Aurora Lintvedt, Karen Wahlstrøm Sanden, Svein O. Kolset, Jens Petter Wold, Addolorata Pisconti, Sissel Beate Rønning, Cathrine Rein Carlson, Mona Elisabeth Pedersen

“…Other myopathy conditions, such as Duchenne muscular dystrophy, also affect the cardiac muscle and are associated with fibrosis and reduced cardiac function. To determine potential cardiac implications of wooden breast disease and identify whether molecular and fibrotic changes were similar to what we have previously found in the breast, we have investigated the hearts of commercial Ross 308 broilers.MethodsHearts from male Ross 308 broiler chickens from mildly and severely wooden breast-affected chickens categorized in previous studies were analyzed. …”
Get full text

Development and Validation of a LC-MS/MS Method for the Determination of Nitrofuran Metabolites in Soft-Shell Turtle Powder Health Food Supplement by EunChae Ryu, Ji Sung Park, Sib Sankar Giri, Se Chang Park

“…Thus, in this study, we propose a reliable and quick method to reduce the time required for the detection of four NFMs in SST powder that conventional methods are unable to quantify. …”
Get full text

Thickness-Tunable PDMS-Based SERS Sensing Substrates by Diego P. Pacherrez Gallardo, Shu Kawamura, Ryo Shoji, Lina Yoshida, Binbin Weng

“…However, due to PDMS’s high viscosity, conventional PDMS-SERS substrates are typically thick and stiff, limiting their freedom for engineering flexible micro/nano functioning devices. To address this issue, we propose to adopt a low viscosity decamethylcyclopentasiloxane (D5) solvent as a diluent solution. …”
Get full text

Novel application of CHUANG BI FU biologic protein sponge in promoting peripheral nerve injury repair by regulating vascular regeneration by Yunhao Cai, Jiahao Liu, Renwei Han, Zizhao Ma, Kaihang Yu, Ping Wu, Xiaokun Li, Zhouguang Wang, Jian Wang

“…Methods This study used a 3.5-mm nerve defect model in mice, and wrap CHUANG BI FU around the nerve defect site, connecting the distal and proximal ends of the damaged nerve without suturing the nerve. The repair function of the nerve by the wound was tested by detecting mouse footprints, electrophysiology, NF200 staining, CD31 staining, and gastrocnemius muscle Masson staining. …”
Get full text