KaiXinSan-JiaWei ameliorates cognitive dysfunction in APP/PS1 mice by intervening in gut microbiota and its metabolites by Lulu Mana, Fang Chen, Xiaoxia Yuan

“…Meanwhile, KXSJW restored the intestinal barrier function and improved the release level of intestinal peptide hormones (Glucagon, GHRP-Ghrelin) in AD model mice. …”
Get full text

Probing Equatorial Ionospheric TEC at Sub-GHz Frequencies with Wide-Band (B4) uGMRT Interferometric Data by Dipanjan Banerjee, Abhik Ghosh, Sushanta K. Mondal, Parimal Ghosh

“…The small diffractive scale implies high phase variability across the field of view and reduced temporal coherence, which poses challenges for calibration and imaging.…”
Get full text

Protease-activated receptor-2 (PAR2) mutation attenuates airway fibrosis in mice during the exacerbation of house dust mite‑induced allergic lung disease by multi‑walled carbon nan... by Logan J. Tisch, Ryan D. Bartone, Silvio Antoniak, James C. Bonner

“…Quantitative morphometry revealed a significant decrease in airway fibrosis in PAR2-mutant mice compared to WT mice, accompanied by reduced Col1a1 mRNA as detected by PCR. Despite this reduction, the pro-fibrotic mediator arginase 1 (Arg-1) protein and mRNA levels were significantly upregulated in PAR2-mutant mice. …”
Get full text

Brain-derived neurotrophic factor but not beta-secretase 1, vascular endothelial growth factor, glial fibrillary acidic protein and interleukin-1β correlate with cognitive impairme... by Kamini Bhavsar, Manjari Tripathi, Jyotirmoy Banerjee, Arpna Srivastava, Nidhi, Shivam Pandey, Divya Vohora

“…Noteworthy alterations were detected across various MoCA subscales, encompassing visuospatial and executive functions, attention, language, abstraction, and delayed recall, with statistical significance established (p < 0.05). …”
Get full text

MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…The effects of these exosomes on HSCs were analyzed using the same methods as those used to assess MSCs function. Results Our findings demonstrated that MDS-MSCs exhibited significant functional impairments, including reduced proliferation, impaired differentiation, diminished support for hematopoiesis, and increased apoptosis. …”
Get full text

Characteristics of glucose-6-phosphate dehydrogenase mutations in newborns with deficiency from 2021 to 2022 in the Heze area of China by Xin Zhang, Xin Zhang, Xin Zhang, Yanan Duan, Yanan Duan, Yanan Duan, Xiao Zhang, Xiao Zhang, Miaomiao Li, Miaomiao Li, Ling Li, Renwei Zhang, Renwei Zhang, Shiguo Liu, Shiguo Liu

“…Functional studies revealed that the heterozygous missense mutations c.479G>A/p.S160N and c.404A>T/p.N135I increased mRNA levels, decreased protein expression, and reduced G6PD activity.DiscussionThe incidence of neonatal G6PD deficiency in the Heze area is low, and the most commonly mutated loci were c.1388G>A, c.487G>A, and c.1376G>T. …”
Get full text

Effectiveness of potassium iodide in the treatment of GERD patients in combination with iodine deficiency states by V. B. Boychuk

“…Iodine deficiency was detected by level of iodine in urine, level of TSH, free T4 and free T3. …”
Get full text

Application of in-silico docking for green electrochemical quantification of prucalopride succinate in pharmaceutical, urine, and milk matrices by Ahmed R. Mohamed, Rania A. Sayed, Abdalla Shalaby, Hany Ibrahim

“…The experimental work was backed up by applying molecular docking, whose results were consistent with the practical findings, offering a creative strategy to reduce the experiment’s costs and duration. According to findings, the α-cyclodextrin sensor outperformed the other proposed sensors in terms of Nernstian slope (56.87 mV/decade), linearity range (1 × 10−6 M – 1 × 10−2 M), and detection limit (7.50 × 10−7 M). …”
Get full text

Potential mechanisms of non-coding RNA regulation in Alzheimer’s disease by Yue Sun, Xinping Pang, Xudong Huang, Dinglu Liu, Jingyue Huang, Pengtao Zheng, Yanyu Wei, Chaoyang Pang

“…It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer’s disease, as well as how these non-coding RNAs influence the disease’s progression by regulating gene expression and protein functions. For example, miR-9 targets the UBE4B gene, promoting autophagy-mediated degradation of Tau protein, thereby reducing Tau accumulation and delaying Alzheimer’s disease progression. …”
Get full text

Bayesian optimized deep learning and ensemble classification approach for multiclass plant disease identification by Silpa Padmanabhuni, Pradeepini Gera

“…Abstract Early detection of plant diseases is crucial in smart agriculture to prevent significant crop losses and reduce reliance on chemical pesticides. …”
Get full text

Frailty in Older Adults and Physical Activity by Jorge Luis Abreus Mora, Vivian Bárbara González Curbelo

“…Early interventions, which include exercise and mobilization, help reduce the severity of associated complications and facilitate the functional recovery of this age group. …”
Get full text

Dynamics of retinal changes in early-stage Parkinson’s disease by Ane Murueta-Goyena, Sara Teijeira-Portas, Elisa Blanco Martín, Raquel Vázquez-Picón, Blanca Ruiz Bajo, Jone Bocos, Jorge Sánchez-Molina, Patricia Alves Dias, Ioana Croitoru, Iñaki Rodríguez Agirretxe, Rocío Del Pino, Marian Acera, Beatriz Tijero, Oihane Sáez-Atxukarro, David Romero-Bascones, Juan Carlos Gómez-Esteban, Javier Aritz Urcola, Javier Ruiz Martínez, Iñigo Gabilondo

“…The participants underwent retinal spectral-domain OCT, primary visual function and cognitive examinations. We examined baseline retinal measures and short-term longitudinal differences between groups via linear mixed effects models. …”
Get full text

Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice by Qingzhou Chen, Pengxiao Sun, Jiaxin Zhou, Tantan Long, An Xiao, Zhuoliang Liu, Shihui Xu, Wenjing Lei, Rui Zhang, Jianwei Tian, Miaomiao Zhou, Zheng Hu, Fengxin Zhu, Jing Nie

“…Tubule-specific depleting S100a7a improves renal function and reduces renal injury and inflammation. …”
Get full text

The Possible Inhibition Effect of Lycium barbarum Polysaccharides on Rat Intracerebral Hemorrhage Secondary Neuronal Apoptosis through Intervening Endogenous/Exogenous Pathways of... by Yourui Zou, ShengYu Sun, Usama Ilyas Sharif, Abdul Wasie, Hui Ma

“…An ICH model was established by autologous blood injection and the neurological function in each group was scored at 4, 8, 12, 24, and 48 hours after modeling. …”
Get full text

HYDRODISSECTION FOR PRESERVATION OF NEUROVASCULAR BUNDLE DURING RADICAL PROSTATECTOMY by H. S. Gevorgyan, A. A. Kostin, N. V. Vorobyev, P. V. Shegai

“…The use of this technique may allow the surgeon to provide a more accurate mobilization prostate and selectively controlled intersection vessels heading to the prostate from the neurovascular bundle, reduce intraoperative blood loss,  maintaining continence, erectile function.This literature review is considered by the experience of using nerve-sparing radical prostatectomy using a water-jet dissector, estimated intraoperative parameters using this method.However, we have the lack of extensive research capabilities of this technique when performing nerve-preserving radical prostatectomy, that does not allow to make a comprehensive presentation on the benefits of this technique and its effects on erectile function and quality of urination, further study of this issue in such a difficult category of patients.…”
Get full text

The pulmoprotective effects of pirfenidone against paraquat-induced pulmonary toxicity: a systematic review by Sajjad Sadeghi, Hamid Madanchi, Mohammad Karami, Rezvan Yazdian-Robati, Mohammad Seyedabadi, Hamidreza Mohammadi

“…Results The review identified several studies demonstrated that pirfenidone significantly reduces lung fibrosis and enhances pulmonary function in rat models subjected to paraquat exposure. …”
Get full text

Hsa-miR-146b-3p promotes endothelial cell dysfunction and atherosclerosis development by targeting CREB3L3 to regulate the PI3K/Akt signaling pathway by Shifan ZHOU, Shuming ZHANG, Ningyuan CHEN, Ling HUANG, Chongyang SONG, Shangling PAN, Junhua PENG

“…Finally, the expression levels of target genes were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting. …”
Get full text

Early peripapillary neurovascular injury and its relevant systemic factors in type 2 diabetic patients without retinopathy: An OCTA based study by Haochen Jin, Kaiyue Wang, Changhong Ren, Shan He, Yuan Gao, Xiaofang Liang, Xuxiang Zhang

“…Purpose: To determine the ability of peripapillary neurovascular units (NVU) to detect early changes in the retinal microvasculature and microstructure, and to explore systemic factors linked to the peripapillary NVU injury in type 2 diabetic patients without clinically detectable retinopathy (NDR). …”
Get full text

Multi-Scale Analysis of Knee Joint Acoustic Signals for Cartilage Degeneration Assessment by Anna Machrowska, Robert Karpiński, Marcin Maciejewski, Józef Jonak, Przemysław Krakowski, Arkadiusz Syta

“…EEMD is applied to decompose the signals into intrinsic mode functions (IMFs), which are then analyzed using DFA to quantify the scaling properties and detect irregularities indicative of cartilage damage. …”
Get full text

Assessing the prognostic and therapeutic value of cuproptosis-related genes in colon adenocarcinoma patients by Zhanhui Ye, Yixian Song, Mengqing Zhu, Fuying Zheng, Wenjie Qin, Wenjie Qin, Xue Li, Pei Wang, Zihua Li, Kequan Chen, Aimin Li

“…Using the Weighted Gene Co-expression Network Analysis (WGCNA) method, we identified the gene module most strongly linked to cuproptosis and conducted functional enrichment analysis to explore the roles of genes within this module in COAD tumorigenesis. …”
Get full text