Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…There were some statistically significant positive effects of pramipexole on secondary outcomes (reduction in depressive symptoms at 36 weeks, response and remission rates at trial exit, psychosocial function). Pramipexole was associated with an increased rate of hypomania/manic symptoms, but this appeared to be reduced by coadministration with an antipsychotic. …”
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Suppression of radiation-induced salivary gland dysfunction by IGF-1. by Kirsten H Limesand, Sherif Said, Steven M Anderson

“…Previous studies in a rat model have shown no correlation between induction of apoptosis in the salivary gland and either the immediate or chronic decrease in salivary function following gamma-radiation treatment.<h4>Methodology/principal finding</h4>A significant level of apoptosis can be detected in the salivary glands of FVB mice following gamma-radiation treatment of the head and neck and this apoptosis is suppressed in transgenic mice expressing an activated mutant of Akt (myr-Akt1). …”
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Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress by Tingting Fang, Congcong Ma, Bingyun Yang, Meiyu Zhao, Luning Sun, Ningning Zheng

“…Roxadustat (FG-4592), as an inhibitor of HIF-PHD, reduces HIF-1α degradation and regulates the transcription and function of downstream target genes. …”
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Intervention and regulation effect of Haematococcus pluvialis extract on blood glucose and lipid of diabetic mice by Huang Heru, Wang Shanshan, Ni Xiaofeng, Chen Riping, Zhang Jiali, Chen Yixiang, Shen Shengrong

“…Three dose groups had the lowest blood glucose levels which reduced by 53.6%, 23.9% and 17.9% respectively in 90 min, while the model group reduced by 5.3%. …”
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Rossby Number Regime, Convection Suppression, and Dynamo-generated Magnetism in Inflated Hot Jupiters by Albert Elias-López, Matteo Cantiello, Daniele Viganò, Fabio Del Sordo, Simranpreet Kaur, Clàudia Soriano-Guerrero

“…Consequently, the heat flux and the derived surface magnetic fields can be greatly reduced to or below Jovian values, contrary to what is commonly assumed, thus negatively affecting estimates for coherent radio emission, and possibly explaining the failure in detecting it so far.…”
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Disruption of reproductive and thyroid endocrine systems in zebrafish following early life and whole life cycle exposure to low-dose norgestrel by Shuyan Mai, Weicai Hu, Yan-Qiu Liang, Zhongdian Dong, Chang-Gui Pan, Zhiyun Liu, Runting Ouyang, Yangjie Zeng, Zhong Lin, Liping Hou

“…Norgestrel (NGT), a synthetic progestin, is frequently detected in aquatic environments and known to disrupt fish endocrine systems. …”
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Protective effect of exercise induced metabolite-3 in ischemia-reperfusion injury by Zijie CHENG, Xuejun WANG, Zimu WANG, Juying QIAN

“…Transcriptomic analysis suggested that EIM-3 exerts its protective function potentially by regulating glucose metabolim. …”
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A Self-Adaptive Parameter Optimization Algorithm in a Real-Time Parallel Image Processing System by Ge Li, Xuehe Zhang, Jie Zhao, Hongli Zhang, Jianwei Ye, Weizhe Zhang

“…We use load capacity functions (LC) to estimate the load for each processor and then make continuous self-adaptation towards a balanced status based on the fluctuated LC results; meanwhile, we pick up a proper set of target detection and location parameters according to the results of LC. …”
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Circular RNA circ-Olfm1 induces progression of Alzheimer’s disease by regulating FOXO3a by YANG Hongyan, LIAO Qirong, HOU Mingliang

“…Water maze test was used to evaluate the effect of circ-Olfm1 knockout on cognitive function, and immunofluorescence assay was employed to observe the deposition of amyloid β (Aβ) plaque in the brain. ④ The interaction between circ-Olfm1 and miR-330-5p was verified by double luciferase reporter gene analysis. ⑤ The protein levels of AMPK and FOXO3a were detected by Western blotting. ⑥ Transmission electron microscopy was utilized to observe the mitochondria of the hippocampus. ⑦ The levels of inflammatory factors IL-6, IL-1β and TNF-α were detected by ELISA. …”
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Targeting FCRLA to induce necrosis in lung adenocarcinoma: a novel strategy for prognosis and therapy via MPT-Driven pathways by Xiaoli Sun, Xiaoli Sun, Xiaoli Sun, Xiaoli Sun, Bowen Cai, Shusen Zhang, Xiaowei Cao, Zhen Wang, Zhigang Cai, Zhigang Cai, Zhigang Cai

“…The JC-1 probe indicated that the mitochondrial membrane potential in the FCRLA-knockdown group was significantly reduced, suggesting impaired mitochondrial function.DiscussionRASGRP2, CD79A, and FCRLA have been identified as being associated with MPTDN in LUAD cells. …”
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TRAF2 regulates the progression of pulmonary fibrosis through β-catenin-Snail signaling pathway by Zhijie Wan, Jingwen Gu, Wanli Duan, Yuanyuan Chen, Shuya Song, Jingyu Luo, Xide Zhang, Yanyong Yang, Yanyong Yang, Fu Gao, Fu Gao, Ying Xu

“…TRAF2 knockdown significantly reduced collagen deposition and myofibroblast activation, thereby alleviating fibrosis. …”
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IL-33 Inhibits Hepatitis B Virus through Its Receptor ST2 in Hydrodynamic HBV Mouse Model by Xiuzhu Gao, Xiumei Chi, Xiaomei Wang, Ruihong Wu, Hongqin Xu, MengRu Zhan, Dong Li, Yanhua Ding, Damo Xu, Junqi Niu

“…The concentrations of HBV DNA, HBsAg, HBeAg, and molecules related to liver function were detected in the collected serum at different time points from model mice. …”
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Arecoline alleviates autism spectrum disorder-like behaviors and cognition disorders in a valproic acid mouse model by activating the AMPK/CREB/BDNF signaling pathway by Chunyan Wen, Zhizhong Xu, Fengling Cao, Qianfa Yuan, Weichao Su, Zhiyuan Huang

“…Western blotting was used to detect changes in protein expression in the frontal cortex after arecoline treatment. …”
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Persistent versus resolved donor-specific antibodies predict 10-year antibody-mediated rejection and kidney transplant outcomes in Thailand by Theerachai Thammathiwat, Suwasin Udomkarnjananun, Thunyatorn Wuttiputhanun, Athiphat Banjongjit, Chayada Wattanaburanon, Gantapong Sainont, Jaranit Kaewkungwal, Salin Wattanatorn, Kriang Tungsanga, Kearkiat Praditpornsilpa, Yingyos Avihingsanon, Natavudh Townamchai

“…For patients with persistent DSA, surveillance biopsies should be considered to facilitate early detection and treatment of rejection, thus preserving kidney allograft function.…”
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Association of Omega-3 Index and Blood Cell Count-Derived Systemic Inflammatory Indexes among Testicular Germ Cell Tumor Survivors by Milica Zeković, Marko Živković, Marija Takić, Sanja Stanković, Nebojša Bojanić, Aleksandar Janičić, Uroš Bumbaširević

“…Background and objectives: Although testicular cancer is considered the paradigm of highly curable malignancy, treatment-induced adverse effects and potential impairment of gonadal function may cause non-negligible long-term health repercussions, including metabolic disturbances and cardiovascular sequelae. …”
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Data-driven machine learning algorithm model for pneumonia prediction and determinant factor stratification among children aged 6–23 months in Ethiopia by Addisalem Workie Demsash, Rediet Abebe, Wubishet Gezimu, Gemeda Wakgari Kitil, Michael Amera Tizazu, Abera Lambebo, Firomsa Bekele, Solomon Seyife Alemu, Mohammedamin Hajure Jarso, Geleta Nenko Dube, Lema Fikadu Wedajo, Sanju Purohit, Mulugeta Hayelom Kalayou

“…Principal component analysis and heatmap function were used for correlation detection between features. …”
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Effects of water stress on berry quality and organic acid synthesis gene expression in Beihong grape by WANG Jiayue, LI Guangzong, LI Juan, SHAN Shouming, LI Xiang

“…[Objective] Water stress refers to the phenomenon in that the normal physiological function of plants is disrupted due to inadequate or excessive soil water. …”
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Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acidA receptors by Anika Fuhr, Robin Roediger, Mariana Simelitidis, Jutta Gamper-Tsigaras, Markus Templin, Michael Kormann, Bernd Antkowiak, Uwe Rudolph, David Köhler, Peter Rosenberger, Kristian-Christos Ngamsri, Franziska M. Konrad

“…The ionotropic GABAA-receptors are known from the central nervous system (CNS) and have recently been detected in the lung. These receptors have been shown to influence inflammatory processes. …”
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Effects of in ovo feeding of vitamin C on embryonic development, hatching process, and chick rectal temperature of broiler embryos by Shan Du, Jianchuan Zhou, Xiang Ao, Xiang Ao, Yufei Zhu, Yufei Zhu

“…In conclusion, our data demonstrated that VC accelerated the hatching process and reduced chicks’ rectal temperature, which may be related to the improvement of liver function and changes in metabolism, as indicated by blood biochemical indicators.…”
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Prosthetic valve thrombosis in a patient secondary to COVID-19: a case report by L. V. Rasputina, D. V. Didenko

“…The patient with a congenital heart defect, a condition after aortic valve replacement, mitral and tricuspid valve annuloplasty (15.03.2022) due to bicuspid aortic valve, combined aortic defect with predominance of stage III-IV regurgitation; stage III secondary arterial hypertension; chronic heart failure IIA, functional class III, stage C, reduced systolic left ventricular function; a two-chamber pacemaker due to complete AV blockade; paroxysmal atrial flutter presented to a cardiologist with worsening shortness of breath and weakness one month after a moderate COVID-19 infection. …”
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