Truncated WT1 Protein Isoform Expression Is Increased in MCF-7 Cells with Long-Term Estrogen Depletion by Saavedra-Alonso Santiago, Zapata-Benavides Pablo, Mendoza-Gamboa Edgar, Chavez-Escamilla Ana Karina, Arellano-Rodríguez Mariela, Rodriguez-Padilla Cristina

“…Initially, the expression of 52-54 kDa protein isoform of WT1 in the breast cancer cell line ER (+) was detected by western blot and was absent in ER (-), and the 36-38 kDa protein isoform of WT1 was detected in all cell lines analyzed. …”
Get full text

Are Wearable ECG Devices Ready for Hospital at Home Application? by Jorge Medina-Avelino, Ricardo Silva-Bustillos, Juan A. Holgado-Terriza

“…The increasing focus on improving care for high-cost patients has highlighted the potential of Hospital at Home (HaH) and remote patient monitoring (RPM) programs to optimize patient outcomes while reducing healthcare costs. This paper examines the role of wearable devices with electrocardiogram (ECG) capabilities for continuous cardiac monitoring, a crucial aspect for the timely detection and management of various cardiac conditions. …”
Get full text

Forecasting Cumulonimbus Clouds: Evaluation of New Operational Convective Index Using Lightning and Precipitation Data by Margarida Belo-Pereira

“…Optimizing the membership functions partially reduces this overestimation. Finally, the added value of <i>IndexCON</i> was illustrated in detail for a thunderstorm episode, using satellite products, lightning and precipitation data.…”
Get full text

Effects of Walnut Protein Peptides on Promotion of White Adipose Tissue Browning and Prevention of Obesity by Yankun FU, Yuzheng CAI, Zhiqiang FENG, Siru CHEN, Tianlin WANG, Lianjun SONG, Tiange LI

“…The morphological changes of inguinal WAT were observed, and the protein expression of key factors involved in WAT browning were detected. Results: WPP treatment decreased the size of lipid droplets, reduced lipid accumulation, and increased mitochondrial quantity in 3T3-L1 adipocytes. …”
Get full text

Immunological landscape of children with Mycoplasma pneumoniae pneumonia in the post-COVID-19 era reveals distinctive severity indicators by Ran Jia, Haiyan Guo, Aizhen Lu, Caiyan Zhang, Yuanyuan Qi, Dingmei Wang, Wen He, Qing Wang, Zimei Cheng, Yajing Gao, Guoping Lu, Libo Wang, Xiaowen Zhai, Jin Xu, Xiaobo Zhang, Yi Wang, Yufeng Zhou

“…The proportion of naïve B cells was reduced, while functional B cells, including memory B cells and plasmablasts, increased in S-MPP. 12 out of 95 clinical laboratory indicators and 3 out of 48 cytokines significantly differed between S-MPP and NS-MPP. …”
Get full text

Spectroscopic photoacoustic denoising framework using hybrid analytical and data-free learning method by Fangzhou Lin, Shang Gao, Yichuan Tang, Xihan Ma, Ryo Murakami, Ziming Zhang, John D. Obayemi, Winston O. Soboyejo, Haichong K. Zhang

“…This technique has been widely applied in areas such as vascular mapping, tumor detection, and therapeutic monitoring. However, PA imaging is highly susceptible to noise, leading to a low signal-to-noise ratio (SNR) and compromised image quality. …”
Get full text

Prevalence of Musculoskeletal Disorders in Patients with Coronary Artery Disease by E. D. Bazdyrev, N. A. Terentyeva, K. E. Krivoshapova, V. L. Masenko, E. A. Wegner, А. N. Kokov, S. A. Pomeshkina, O. L. Barbarash

“…The conducted correlation analysis revealed not only the relationship between the parameters of musculoskeletal function, but also their association with age, duration of AH, CAD, and type 2 DM.Conclusion. …”
Get full text

DDIT4 participates in high glucose-induced fibroblast-like synoviocytes overactivation and cartilage injury by regulating glycolysis by Shuo Qiang, Cheng Cheng, Yonghui Dong, Chao Tang, Jia Zheng, Yunke Liu

“…Functional studies showed that DDIT4 overexpression inhibited the overactivation, migration, and invasion of FLSs, as well as alleviated chondrocyte injury co-cultured with FLSs. …”
Get full text

MiR-103-3p regulates chondrocyte autophagy, apoptosis, and ECM degradation through the PI3K/Akt/mTOR pathway by targeting CPEB3 by Jun Li, Farui Sun, Yuanjin Zhang, Xian Pan, Bo Li, Guofu Zhang, Qian Zhou

“…Chondrocyte proliferation was evaluated using cell counting kit-8. Apoptosis was detected by flow cytometry. The levels of apoptosis-, extracellular matrix (ECM)-, autophagy-, and the PI3K/Akt/mTOR pathway-related proteins in chondrocytes were detected using immunoblotting or immunofluorescence. …”
Get full text

Transcriptomic analysis of melatonin-mediated drought stress response genes in alfalfa during germination period by Xiaoxia Zhang, Wenxuan Zhu, Zirui Liu, Xiangling Ren, Yingao Li, Guomin Li, Jingzhuo Wang, Xiaoyan Zhu, Yinghua Shi, Chengzhang Wang, Defeng Li, Hao Sun

“…Abstract Background Drought stress is a predominant abiotic factor contributing to reduced crop yields globally. Therefore, exploring the molecular mechanism of drought control is of great significance to improve drought resistance and ultimately achieve crop yield increase. …”
Get full text

Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…Neurological assessment, histopathology, and protein factors detection assessed PMP’s effectiveness. Further, 1H NMR based metabolomics and 16S rRNA gene sequencing examined gut microbiota metabolites and profiles, respectively, in order to elucidate the underlying mechanisms from the perspective of the gut-brain axis.ResultsPMP significantly improved the neurologic functions and reduced the cerebral infarction volume in MCAO/R rats. …”
Get full text

Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis by Yushun Wu, Jing Liu, Wenying Yu, Xiaoding Wang, Jian Li, Weiquan Zeng

“…Immune profiling showed reduced resting mast cells (p = 0.003) and monocytes (p = 0.02), with ABCC10 correlating negatively with CD8+ T cells (r = -0.65) and M1 macrophages. …”
Get full text

Assessment of retinal microvascular changes in patients with systemic lupus erythematosus using optical coherence tomography angiography by Ahmed Ibrahim Basiony, Sameh Mohamed Elgouhary, Hadeer Elbasuony Mohamed, Enas Sobhy Zahran

“…Objective The aim of this study is to assess the correlation between renal functional and histologic features with the retinal microvasculature alterations in systemic lupus patients through OCTA analysis. …”
Get full text

SFRP1 suppresses granulosa cell proliferation and migration through inhibiting JNK pathway by Shan Zhou, Liang Xia, Liyuan Han

“…Background: Secreted frizzled-related protein 1 (SFRP1) functions as a Wnt antagonist to repress the proliferation and migration of epithelial ovarian cancer cells. …”
Get full text

Integrated Improved Complete Ensemble Empirical Mode Decomposition and Continuous Wavelet Transform Approach for Enhanced Bearing Fault Diagnosis in Noisy Environments by Mahesh Kumar Janarthanan, Andrews Athisayam, Murali Karthick Krishna Moorthy, Gowtham Sivakumar, Saravanan Poornalingam

“…ICEEMD decomposes complex vibration signals into intrinsic mode functions, effectively filtering out noise and enhancing feature extraction. …”
Get full text

A Medical Hardware-Software System for Remote Monitoring of Heart Diseases by T. M. Magrupov, Z. M. Yuldashev, S. P. Abdihalikov

“…Wireless diagnostics of patients’  functional state is important  for ensuring timely detection and treatment of diseases. …”
Get full text

Shengui Sansheng San alleviates the worsening of blood–brain barrier integrity resulted from delayed tPA administration through VIP/VIPR1 pathway by Jiacheng Hu, Yiyang Li, Xingping Quan, Yan Han, Jinfen Chen, Mengchen Yuan, Ying Chen, Manfei Zhou, Enze Yu, Jiahao Zhou, Dawei Wang, Ruibing Wang, Yonghua Zhao

“…The modified neurological severity score (mNSS) test was conducted to evaluate neurological function. The expressions of VIP, VIPR1, ZO-1, Occludin, Lectin, GFAP, NeuN were detected by immunofluorescence staining or western blotting. …”
Get full text

Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model by Rongwan Sun, Leonie-Kim Zimbalski, Stefanie Schreyer, David Baidoe-Ansah, Aida Harutyunyan, Arnd Heuser, Rachel N. Lippert, Joachim Spranger, Knut Mai, Sebastian Brachs

Get full text

A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects by Haochen Jiang, Xin Fu, Salma Althobaiti, Braeden Pinkerton, Shabnam Arash, Xiaoqing Du, Zhenshan Jia, Fang Yu, Kirk W. Foster, Geoffrey M. Thiele, Troy J. Plumb, Dong Wang

“…A single dose of PEG-Dex treatment (35 ​mg/kg Dex dose equivalent) effectively reduced the proteinuria level, ameliorated FSGS lesions and restored kidney function when compared to the dose equivalent daily Dex treatment and Saline control. …”
Get full text

Predictors of external branch of superior laryngeal nerve paresis and paralysis in patients undergoing thyroidectomy: by videostroboscopy by Manoj Kumar N., Rajiv S.R., T. M. Nagaraj, Sweta S., Ramya K., Pavitra N.

“…Abstract Background Thyroidectomy is one of the most commonly done surgery in otorhinolaryngology; hence, a pre-operative analysis of the recurrent laryngeal nerve and superior laryngeal nerve functions of laryngeal musculature is very important. …”
Get full text