Liraglutide alleviates high-fat diet-induced kidney injury in mice by regulating the CaMKKβ/AMPK pathway by Yingli Xuan, Ting-ting Ding, Xiao-lei Mao, Shiqing Pang, Ruibin He, Li Qin, Jiang zi Yuan

“…Besides, hematoxylin–eosin staining and periodic acid-Schiff staining were used to observe the pathological changes of kidney tissue; immunohistochemistry, western blot, and real-time quantitative PCR to assess the calmodulin-dependent protein kinase kinase beta (CaMKKβ)/AMPK signaling pathway activation.Results Liraglutide significantly reduced serum lipid loading, improved kidney function, and relieved kidney histopathological damage and glycogen deposition in the mouse model of obesity-related kidney disease induced by HFD. …”
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Electron-beam FLASH whole brain irradiation induced a unique changes of intestinal flora by Feifei Gao, Wei Cheng, Yanxi Ma, Boyi Yu, Xinle Lang, Xiaodong Jin, Jianxin Wang, Xianhong Liu, Cuixia Di, Hui Wang, Fei Ye, Ting Zhao, Weiqiang Chen, Qiang Li

“…Results eFLASH irradiation significantly reduced radiation neurotoxicity and had a long-term protective effect on cognitive function and learning and memory ability. …”
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Impact of HbA1c variability and time‐in‐range fluctuations on large and small nerve fiber dysfunction in well‐controlled type 2 diabetes: A prospective cohort observational study... by Yun‐Ru Lai, Wen‐Chan Chiu, Ben‐Chung Cheng, I‐Hsun Yu, Ting‐Yin Lin, Hui‐Ching Chiang, Chun‐En Aurea Kuo, Cheng‐Hsien Lu

“…Large and small nerve functions were assessed using the Toronto Clinical Neuropathy Score (TCNS), nerve conduction studies, quantitative thermal testing, and Sudoscan. …”
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Comprehensive analysis of a novel LYST mutation in a Tunisian patient with Chediak-Higashi syndrome by Yessine Amri, Saoussen Chouchene, Hajer Foddha, Amani Abderahmene, Ikbel Kooli, Adnen Toumi, Kawthar Hadj Khalifa, Rihem Mezrigui, Taieb Messaoud, Mohsen Hassine, Rym Dabboubi

“…The findings were confirmed through Sanger sequencing, and bioinformatic tools were employed to predict the functional consequences of the detected mutations. Results The patient presented with classical symptoms of CHS, including silver hair, hypopigmented skin, recurrent infections, and neurological decline, with an unusually late onset at 18 years. …”
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Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…In vitro experiments, compared with the OGD/R group, the bergenin group reduced the oxidative stress level, mitochondrial dysfunction and ferroptosis of H9C2 cells. …”
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High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling by Hao Liu, Zhenzhan Zhang, Peilin Zhen, Meijuan Zhou

“…Overexpression of VSTM2L in cancer cells treated with CRT was analyzed for the function of cell proliferation and viability, clone formation, DNA damage repair, and apoptosis ability. …”
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The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism by Shengjie Tang, Fang Wu, Xihua Lin, Weiwei Gui, Fenping Zheng, Hong Li

“…The content/morphology of the liver, serum lipid, and liver function was measured. The expression of genes related to lipolysis and synthesis in liver was detected by quantitative real-time PCR (qRT-PCR). …”
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Nonalcoholic fatty liver disease developed after pancreatoduodenectomy for solid pseudopapillary neoplasm in a 10-year-old girl: a case report by Toshio Sawai, Shogo Zuo, Taichi Terai, Satoshi Nishiwada, Kenji Nakagawa, Minako Nagai, Takehiro Akahori, Hiromichi Kanehiro, Masayuki Sho

“…Conclusions Pediatric PD is rare, and residual pancreatic function is usually sufficient, unlike in adult cases. …”
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Effect of FTY720 on Angiotensin Ⅱ-mediated chronic kidney diseases by HAN Qi, LI Ming-mei, YANG Guo-sheng, PENG Qing-ping, WANG Xiao-hui

“…Conclusions FTY720 can alleviate pathological damage of the kidney in rats induced by Ang Ⅱ, which may decrease urinary proteins and improve the renal function by reducing expression of inflammatory factors.…”
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Echocardiographic diagnosis of interarterial AAOCA in children: a framework integrating anatomical landmarks and systolic dysfunction for risk assessment by Rui Hu, Xuming Mo, Shanliang Zhu, Jun Chen, Ying Tang, Yumei Xu

“…Postoperatively, 10/11 cases achieved normal cardiac function. Conclusions Echocardiography provides a clinically actionable protocol for preoperative AAOCA diagnosis by integrating anatomical markers (Acute deviation, parallel course) and functional metrics (LVEF, wall motion). …”
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The effect of TIM1+ Breg cells in liver ischemia-reperfusion injury by Yu Zhang, Cheng Zhang, Beng Yang, Chuanhui Peng, Jie Zhou, Shenli Ren, Zhenhua Hu

“…HE, TEM, and Tunel were used to detect liver tissue injury, changes in the liver ultrastructure and liver cell apoptosis, respectively. …”
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Incretin-based approaches for type 2 diabetes therapy: effects on circulating cytokines and adipocyte’s secretome by Margarita Agareva, Svetlana Michurina, Alina Tomilova, Ekaterina Shestakova, Anastasia Voznesenskaya, Maria Sineokaya, Ekaterina Zubkova, Elizaveta Ratner, Iurii Stafeev, Yelena Parfyonova, Marina Shestakova

“…Conclusions The effect of semaglutide injections directly on adipose tissue can change the function of ADSC, making them more angiogenic and adipogenic. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Although phosphatase and tensin homolog (PTEN) have been recognized as a potential tumor suppressor in all kinds of cancers, its function in RCC remains to be thoroughly elucidated. …”
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Digital Image Speckle Correlation (DISC): Facial Muscle Tracking for Neurological and Psychiatric Disorders by Shi Fu, Pawel Polak, Susan Fiore, Justin N. Passman, Raphael Davis, Lucian M. Manu, Miriam Rafailovich

“…<b>Background/Objectives</b>: Quantitative assessments of facial muscle function and cognitive responses can enhance the clinic evaluations in neuromuscular disorders such as Bell’s palsy and psychiatric conditions including anxiety and depression. …”
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Three cases of atypical Rasmussen's encephalitis with delayed‐onset seizures by Hongru Guo, Pan Gong, Guojing Yu, Chongyang Tang, Guoming Luan, Qingzhu Liu, Lixin Cai, Taoyun Ji

“…Early diagnosis and treatment can reduce unnecessary investigations and improve prognosis. …”
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Anti-inflammatory and barrier repair mechanisms of active components in Daemonorops draco Bl. for UVB-induced skin damage by Xingyi Wu, Ying Zhang, Fan Yi, Zaijun Geng, Miaomiao Guo, Xiao Ling, Jun Li, Li Li

“…XJ-2 primarily protected the internal structure and function of the cells by inhibiting the mass production of ROS and Ca2+ inflow. …”
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Sensitive and precise quantification of insulin-like mRNA expression in Caenorhabditis elegans. by L Ryan Baugh, Nicole Kurhanewicz, Paul W Sternberg

“…We used deletion mutants to demonstrate specificity of the assay, and we used optimized conditions to assay insulin-like gene expression throughout the C. elegans life cycle. We detected expression for nearly all insulin-like genes and find that they are expressed in a variety of distinct patterns suggesting complexity of regulation and specificity of function. …”
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SERS Sensors with Bio-Derived Substrates Under the Way to Agricultural Monitoring of Pesticide Residues by Kseniya V. Serebrennikova, Nadezhda S. Komova, Anatoly V. Zherdev, Boris B. Dzantiev

“…Uncontrolled use of pesticides in agriculture leads to negative consequences for the environment, as well as for human and animal health. Therefore, timely detection of pesticides will allow application of measures to eliminate the excess of maximum residue limits and reduce possible negative consequences in advance. …”
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Treatment with hydrogen-rich water protects against thioacetamide-induced hepatic encephalopathy in rats through stabilizing liver–brain disturbance by Xujiao Wang, Xiao Liu, Peng Zhou, Jianguo Feng, Jing Jia, Bingqing Xie, Ye Chen, Jun Zhou

“…The results showed that hydrogen-rich water can improve the behavioral changes of the HE rats, reduce blood ammonia, reduce liver function damage, alleviate the pathological changes of liver and brain tissue, significantly inhibit the systemic and local oxidative stress and inflammation of the brain tissue of the HE rats, and reduce neuronal apoptosis. …”
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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia. by Hildegard Nikki Hall, Hemant Bengani, Robert B Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A Marsh, Graeme R Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M Mannens, Veronica Van Heyningen, Joe Rainger, Brian P Brooks, David R FitzPatrick

“…Classical aniridia is a congenital and progressive panocular disorder almost exclusively caused by heterozygous loss-of-function variants at the PAX6 locus. We report nine individuals from five families with severe aniridia and/or microphthalmia (with no detectable PAX6 mutation) with ultrarare monoallelic missense variants altering the Arg51 codon of MAB21L1. …”
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