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Lipopolysaccharide-binding protein (LBP): a prognostic biomarker for gastric cancer linked to immune infiltration
Published 2025-03-01“…Abstract Background Gastric cancer, characterized by rising global incidence and mortality, faces significant challenges due to the lack of effective early detection methods, delaying timely interventions and underscoring the need for novel biomarkers. …”
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2203
Integrated Multi-Level Investigation of Friend Leukemia Integration 1 Transcription Factor as a Novel Immune-Inflammatory Biomarker in Rheumatoid Arthritis: Bridging Bioinformatics...
Published 2025-03-01“…FLI1 exhibited positive correlations with CRP, ESR, CCP, RF, IL-6, IL-10, IL-8, and TNF-α. The combined detection of FLI1 with CRP, ESR, CCP, and RF demonstrated the highest efficacy in evaluating RA disease activity. …”
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2204
CKD patients comorbid with hypertension are associated with imbalanced gut microbiome
Published 2025-02-01“…Our findings demonstrate that imbalances in gut microorganisms and functions are associated with increased susceptibility to hypertension in CKD patients and could be targeted for improving kidney function in CKD.…”
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2205
Wuling capsule alleviates hyperuricaemia and protects UA- injured HK-2 cells by regulating uric acid transporter proteins
Published 2025-04-01“…Histopathological analysis of liver and kidney tissues were detected by HE staining. The biochemical indices were measured using specific kits. …”
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2206
Computer Vision as a Tool to Support Quality Control and Robotic Handling of Fruit: A Case Study
Published 2024-10-01“…The system can automate the detection and handling of fruits, particularly tomatoes, reducing the reliance on manual labor and minimizing damage during processing. …”
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2207
Striatal infusion of cholesterol promotes dose‐dependent behavioral benefits and exerts disease‐modifying effects in Huntington's disease mice
Published 2020-09-01“…Abstract A variety of pathophysiological mechanisms are implicated in Huntington's disease (HD). Among them, reduced cholesterol biosynthesis has been detected in the HD mouse brain from pre‐symptomatic stages, leading to diminished cholesterol synthesis, particularly in the striatum. …”
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2208
Sleep in Juvenile Idiopathic Arthritis: An Exploratory Investigation of Heart Rate Variability
Published 2025-06-01“…<b>Conclusions:</b> Patients with JIA exhibited sleep disruption and alterations in cardiovascular autonomic functioning during sleep. Reduced HRV across all sleep stages in these patients suggests underlying autonomic nervous dysfunction. …”
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2209
Colonic Aging and Colorectal Cancer: An Unignorable Interplay and Its Translational Implications
Published 2025-07-01“…Key findings synthesized from the literature highlight the critical roles of impaired colonic stem cell function, epithelial barrier disruption (“leaky gut”), persistent low-grade inflammation, and altered microbial communities and their metabolites in promoting CRC initiation and progression. …”
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2210
Long Short-Term Memory-Based Computerized Numerical Control Machining Center Failure Prediction Model
Published 2025-03-01“…The quality of the processed products in CNC machining centers is a critical factor in manufacturing equipment. The anomaly detection and predictive maintenance functions are essential for improving efficiency and reducing time and costs. …”
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2211
Microstructural analysis does not support altered interhemispheric wiring of the human anterior commissure in corpus callosum dysgenesis
Published 2024-01-01“…Consequently, other, presently unknown, compensatory mechanisms are likely involved in supporting this function.…”
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2212
MaPep1 and MbPep1, as plant elicitor peptides in banana, confer resistance to banana blood disease caused by Ralstonia syzygii subsp. celebesensis
Published 2025-07-01“…Peptides play regulatory roles in various plant development and defence processes. They function as molecular messengers that detect threats and trigger defence responses. …”
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2213
Emerging Healthcare Technologies in Gastrointestinal Endoscopy: 75 Years of Evolution
Published 2025-05-01“…Machine learning algorithms assist in real-time polyp detection, classification, and predictive analytics, enhancing diagnostic accuracy while reducing inter-observer variability and human error. …”
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2214
Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats
Published 2024-10-01“…These gene expression changes were accompanied by reduced global histone 3 acetylation in the mPFC, while no significant changes in DNA methylation and no significant changes of histone-acetylation at the promoter regions of the analyzed genes were detected. …”
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2215
Overexpression of KRAS enhanced the stemness of esophageal cancer cells inhibited by overexpression of circ0043898
Published 2025-07-01“…Conclusions Overexpression of circ0043898 reduced CSCs markers and the number of stem cell spheroidization. …”
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2216
Treatment related impairments in arm and shoulder in patients with breast cancer: a systematic review.
Published 2014-01-01“…The following health outcomes were extracted: reduced joint mobility, reduced muscle strength, pain, lymphedema and limitations in daily activities. …”
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2217
Frailty in rheumatoid arthritis: prevalence, fenotype signs and associated factors
Published 2023-10-01“…Frailty syndrome was detected in 40.6%, prefrailty in 55.4% of patients with RA, robust patients were 4.0%. …”
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2218
Heterozygosity in NPC may be associated with neurologic and systemic phenotypes
Published 2025-08-01“…By broadening our understanding of the genetic and phenotypic spectrum of NPC, we can improve detection (which is straightforward in obligate heterozygotes, i.e., parents of NPC patients), reduce long-term health risks, and utilize targeted treatments that address the needs of carriers as well as affected individuals.…”
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2219
Transcriptomic analysis reveals that selenium-enriched Lactobacillus plantarum alleviates high -salinity stress in common carp through lipid metabolism and ferroptosis signalling p...
Published 2025-09-01“…The analyses included histopathology, detection kits, transcriptomics, and quantitative real-time PCR. …”
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2220
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy
Published 2024-11-01“…High age, especially in combination with frailty, has been associated to immune senescence, which is the age-related decline in immune function, thereby possibly hindering ICI effectiveness. …”
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