Dietary exposure assessment of perchlorate and chlorate in infant formulas marketed in Shanghai, China by Shenghao Yu, Yonghui Ge, Lujing Zhang, Yiqi Li, Wen Zhang, Chang Liu, Shaojie Peng

“…Perchlorate and chlorate are ubiquitous pollutants that can adversely affect the thyroid function in humans. This study assessed the potential health risks associated with the dietary exposure of infants and young children to perchlorate and chlorate present in infant formulas available in Shanghai. …”
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Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

“…After grouping, each group was treated with different methods such as electroacupuncture for 7 days, and the Zea Longa method was used to evaluate the neurological function again on the 1, 3, 5, and 7 days. After 7 days of intervention, the left cerebral cortex tissue of each group was obtained, hematoxylin-eosin (HE) staining was used to observe the pathological changes of the brain tissue, the expression level of LC3-Ⅱ/LC3-Ⅰ protein was detected by Western blot, and the tissue immunofluorescence technology was applied to detect the expression and colocalization of mitophagy-related protein BNIP3L and SQSTM1 labeled. …”
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DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage by Wenchao Tang, Yue Pan, Can Zhu, Didong Lou, Fang Peng, Qin Shi, Yuanyuan Xiao, Yuanyuan Xiao

“…Subsequently, liver function indicators were detected in mouse serum, while liver tissues were subjected to pathological and transmission electron microscopy observations. …”
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Suaeda salsa Polysaccharide Alleviates Hepatic Injury by Regulating Macrophage Polarization in a Mouse Model of High-fat Diet-induced Non-alcoholic Fatty Liver Disease by Sisi QIN, Changyu QIN, Yongheng WANG, Jiawen NING, Ziyu DONG, Lei WU, Xiaolong MA, Fuyuan CAO, Naijun WU, Xitong ZHANG, Liying HOU, Shuang LI

“…Meanwhile, the transcriptional level of macrophage polarization markers detected by qRT-PCR was consistent with the trend of protein expression level detected by WB. …”
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A comprehensive transcriptome based meta-analysis to unveil the aggression nexus of oral squamous cell carcinoma by Soujanya J. Vastrad, Ganesan Rajalekshmi Saraswathy, Jagadish B. Dasari, Gouri Nair, Ashok Madarakhandi, Dominic Augustine, S.V. Sowmya

“…The analysis identified elevated expression of genes involved in extracellular matrix remodelling and immune response, while the expression of genes related to cellular differentiation and barrier functions was reduced, driving the transition to nodal positivity. …”
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Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment by Barbara M. Crisol, Matheus B. Rocha, Beatriz Franco, Ana Paula Morelli, Carlos K. Katashima, Scylas J.A. Junior, Fernanda S. Carneiro, Renata R. Braga, Rafael S. Brícola, Graciana de Azambuja, Raul Gobato Costa, Andrea M. Esteves, Marcelo A. Mori, Maria C.G. Oliveira, Dennys E. Cintra, José R. Pauli, Filip J. Larsen, Adelino S.R. da Silva, Eduardo R. Ropelle

“…Overtraining syndrome reduced mitochondrial function promoted by exercise training, induced muscle hyperalgesia, reduced muscle fiber size and promoted a similar gene signature of myopathy and atrophy models. …”
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Revealing the location and dynamics of a concealed binding site in the dopamine transporter by Rong Zhu, Walter Sandtner, Thomas Stockner, Alexander Heilinger, Marion Holy, Oliver Kudlacek, Linda Wildling, Kusumika Saha, Anna Sophie Fröhlich, Michael Bindl, Paraskevi Tziortzouda, Anna Haider, Julia Gobl, Saanfor Hubert Suh, Jawad Akbar Khan, Julia Bicher, Nina Kastner, Andreas Ebner, Hermann J. Gruber, Michael Freissmuth, Amy Hauck Newman, Harald H. Sitte, Peter Hinterdorfer

“…Herein, we design force sensors with DAT ligands and measure their interaction forces with wild-type and mutated DATs, from which two distinct populations of unbinding strengths and off-rates are detected. The high-force population is reduced by V152I and S422A mutations, or by substituting Na+ with K+ or NMDG+. …”
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Superelastic and Ultra‐Soft MXene/CNF Aerogel@PDMS‐Based Dual‐Modal Pressure Sensor for Complex Stimuli Monitoring by Ao Wang, Zhenqiu Gao, Shaokuan Wu, Yihan Wei, Bohan Lu, Jia Shi, Lanyue Shen, Yina Liu, Xuhui Sun, Zhen Wen

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Intelligent Recognition Technology for the Segmentation of Traffic Indication Images Concerning Different Pavement Materials by Juanhong Xie, Guojian Shi, Weizhi Zhu

“…In this article, the support traffic indication vector recognition (STIVR) method is proposed to classify the best signal detection to avoid traffic congestion and accidents. …”
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A versatile drug delivery system targeting senescent cells by Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano

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Porphyromonas gingivalis-induced periodontitis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier by Yiting Jiang, Yiting Jiang, Yiting Jiang, Yiting Jiang, Yiting Jiang, Yiting Jiang, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Lina Xu, Xuri Zhao, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Hui Shen, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Che Qiu, Zhiyan He, Zhiyan He, Zhiyan He, Zhiyan He, Zhiyan He, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song, Zhongchen Song, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou

“…Neuroinflammation was observed by detecting the expression of proinflammatory cytokines and glia activation. …”
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Rapid diagnosis of rheumatoid arthritis and ankylosing spondylitis based on Fourier transform infrared spectroscopy and deep learning by Wei Shuai, Xue Wu, Chen Chen, Enguang Zuo, Xiaomei Chen, Zhengfang Li, Xiaoyi Lv, Lijun Wu, Cheng Chen

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International Proficiency Test Targeting a Large Panel of Botulinum Neurotoxin Sero- and Subtypes in Different Matrices by Christine Rasetti-Escargueil, Michel Robert Popoff, Bettina Kampa, Sylvia Worbs, Maud Marechal, Daniel Guerin, Eléa Paillares, Werner Luginbühl, Emmanuel Lemichez

“…Participants have implemented a wide array of detection methods based on functional, immunological, and mass spectrometric principles. …”
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Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian Origin <i>Klebsiella pneumoniae</i> from Jiangsu, China by Yulu Xue, Fangyu Shi, Bangyue Zhou, Yi Shi, Wenqing Luo, Jing Zhu, Yang Yang, Sujuan Chen, Tao Qin, Daxin Peng, Yinyan Yin

“…Virulence gene analysis revealed striking disparities, with human isolates harboring 10–20 virulence factors (median 15) versus 6–7 (median 6.5) in avian counterparts. Finally, functional pathogenesis assessments demonstrated human-derived strains exhibited stronger epithelial cell adhesion (2-fold higher) and invasion (1.97-fold higher) in Calu-3 cell models and paradoxically showed reduced macrophage phagocytosis (2.85-fold lower at 2 h) for immune escape. …”
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Okra polysaccharide mitigates carrageenan-induced thrombosis in mice by regulating inflammation and oxidative stress by Jinping Ni, Jinping Ni, Xiwen Cao, Xianqing Hu, Xianqing Hu, Shenwen Fu, Shenwen Fu, Shenwen Fu, Meixiu Jiang, Yuqi Ni, Yuqi Ni

“…In addition, OP inhibited inflammation by suppressing the toll-like receptor 4 (TLR4)/nuclear factor κB (NF-κB) pathway and reduced oxidative damage by elevating the level of GSH and antioxidant enzyme in liver and lung tissues. …”
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miRNA‐221 and miRNA‐222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours by Michaela Angelika Ihle, Marcel Trautmann, Helen Kuenstlinger, Sebastian Huss, Carina Heydt, Jana Fassunke, Eva Wardelmann, Sebastian Bauer, Hans-Ulrich Schildhaus, Reinhard Buettner, Sabine Merkelbach-Bruse

“…In gastrointestinal stromal tumours (GISTs) expression of miR‐221 and miR‐222 is reduced compared to control tissue and other sarcomas but the functional effects of this downregulation are not fully understood. …”
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QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis by Yulai Zhou, Yan Gao, Yinghui Peng, Changjing Cai, Ying Han, Yihong Chen, Gongping Deng, Yanhong Ouyang, Hong Shen, Shan Zeng, Yangfeng Du, Zemin Xiao

“…However, no circRNA-based therapies have yet entered clinical development, underscoring the need for comprehensive detection and mechanistic studies of circRNAs in CRC. …”
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Impact of a pharmacist driven antimicrobial stewardship program on inpatient antibiotic consumption in a Chinese Tertiary Hospital: a 5-year retrospective study by Can Qian, Ting Yuan, Fuyong Zhang, Shiyuan Gou, Chunmei Jiang, Xuebing Chen, Ya Huang, Xiaolin Zhao, You Du, Chenglong Li, Yangyun Han, Huaiyu Su

“…IntroductionAntimicrobial Stewardship programs are crucial for reducing overall antibiotic consumption, but in practice, there are often issues with unclear responsibilities and ambiguous tasks. …”
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Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital by Yanye Tu, Hui Gao, Feng Wang, Rongqing Zhao, Shiyong Chen, Yanzi Chang, Hong Li

“…Plasmid analysis identified three distinct plasmids, among which an IncX3-type plasmid carrying bla NDM−5 was confirmed, while the functional characteristics of the remaining two plasmids require further investigation. …”
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Hemp inflorescence meal as a novel feed ingredient in laying hens: Safety assessment, nutritional characterization, and effects on egg quality by Hathairat Saengsuwan, Chaiyapoom Bunchasak, Choawit Rakangthong, Kanokporn Poungpong

“…These findings support HIM as a functional, sustainable feed component in poultry nutrition. …”
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