Biosynthesis of silver nanoparticles from plant extracts: a comprehensive review focused on anticancer therapy by Pratibha Pandey, Sorabh Lakhanpal, Ashok Kumar Bishoyi, S. Renuka Jyothi, Swati Mishra, Meenakshi Verma, Ajay Singh, Mir Waqas Alam, Safia Obaidur Rab, Mohd Saeed, Fahad Khan

“…Plants possess intricate phytochemical components including sugars, polyphenols, amino acids, flavonoids, terpenoids, alkaloids, and proteins, which can function as reducing and stabilizing agents. In recent years, the application of plant-derived AgNPs has increased significantly, particularly in cancer treatment. …”
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WSDC-ViT: a novel transformer network for pneumonia image classification based on windows scalable attention and dynamic rectified linear unit convolutional modules by Yu Gu, Haotian Bai, Meng Chen, Lidong Yang, Baohua Zhang, Jing Wang, Xiaoqi Lu, Jianjun Li, Xin Liu, Dahua Yu, Ying Zhao, Siyuan Tang, Qun He

“…This study proposes the WSDC-ViT network to enhance computer-aided pneumonia detection and alleviate the diagnostic workload for radiologists. …”
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Evaluation of immune response to hepatitis B vaccine and its determinants among immunized anti-HBc-negative children in Ethiopia: A community-based cross-sectional study by Adane Adugna, Desalegn Abebaw, Mohammed Jemal

“…Generalized linear models with a Poisson distribution, log link function, and robust standard errors were used for multivariable analysis, with 95 % confidence intervals. …”
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Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway... by Bai Gao, Yuchen Jing, Xi Li, Shuyan Cong

“…The spontaneous HD was alleviated by silencing USP11, as evidenced by improved locomotor activity and spatial memory, attenuated striatal atrophy in R6/1 mice, reduced accumulation of mutant huntingtin protein, and restored mitochondrial function in vitro and in vivo. …”
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hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NF-κB Signaling Pathway by Jian Wang, Binghui Du

“…Materials and Methods: The expression of hsa_circRNA_092488 was evaluated in venous blood samples obtained from DVT patients (n=42) and healthy controls (n=42). Gain- and loss-of-function studies of hsa_circRNA_092488 were carried out. …”
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Extract of <i>Curculigo capitulata</i> Ameliorates Postmenopausal Osteoporosis by Promoting Osteoblast Proliferation and Differentiation by Ying Wang, Xueru Wang, Kaijin Wang, Weiwei Qin, Ning Li

“…The traditional medicinal plant <i>Curculigo capitulata</i> is commonly used to strengthen bones and support kidney function, but its role in treating PMOP is not well understood. …”
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Running and Thinking: Unmasking the Lingering Effects of Sports Concussions Through Complex Dual-Task Testing by Gabriel Lavoie, Mathieu Bolduc, Veronik Sicard, Franco Lepore, Dave Ellemberg

“…Athletes performed a complex rapid decision-making and executive function computerized task while walking continuously and maintaining a predetermined speed on a non-motorized treadmill (6.5 km/h). …”
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Effects of total coumarins from Pileostegia tomentella on exosomal miRNA expression and angiogenesis in colorectal cancer cells by Ying Liu, Dao-hai Cheng, Zheng-ying Su, Ji-hua Lv, Li Wang, Yu-yin Deng, Li Li

“…Co-culture experiments for human umbilical vein endothelial cells (HUVECs) and exosomes were performed to detect the uptake of exosomes in HUVECs and its influence on HUVECs cells migration and lumen formation ability. …”
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Preclinical studies of the falnidamol as a highly potent and specific active ABCB1 transporter inhibitor by Baojie Liu, Yongzheng Lu, Ruihui Lin, Junbao Xu, Zilin Shang, Xinyu Hou, Xulong Shao, Zhifang Pan, Tao Yu, Weiguo Feng

“…Further studies found that falnidamol reduced ABCB1’s efflux function, resulting in enhanced intracellular agent accumulation and thus overcoming MDR. …”
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Anti-Inflammatory Regulatory Role of Signal Transducer and Activator of Transcription 3 Phosphorylation in Regulating Hypersensitivity Responses to Echinococcus granulosus Hydatid... by Li SS, Zhou JR, Wang CS, Wang JL, Li YQ, Kulaixi X, Cao LW, Batesurong B, Ye JR

“…Apoptosis assays revealed that both inhibitors caused varying degrees of cell damage (P < 0.01), potentially leading to late-stage apoptosis.Conclusion: Immunoblotting analyses confirmed that treatment with the two inhibitors reduced STAT3 phosphorylation levels at the S727 and Y705 sites, thereby inhibiting cell degranulation and alleviating immune responses.Keywords: allergic reaction, Echinococcus granulosus hydatid cyst fluid, RBL-2H3 cells, STAT3 phosphorylation…”
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Effects of melatonin on peritoneal fibrosis induced by high glucose peritoneal dialysis in rats by XING Bei-bei, ZHU Qi-jin, QI Xiang-ming, XU Xing-xin, WU Yong-gui

“…Objective To investigate the effects of melatonin（MT） on peritoneal fibrosis induced by high glucose peritoneal dialysis in rats.Methods 38 SD male rats were randomly assigned into 5 groups:control group（n = 6）,peritoneal fibrosis group（n = 8）,peritoneal fibrosis ± MT 5 mg·kg^-1 ·d^-1 administration group（low MT dose group,n = 8）,peritoneal fibrosis ± MT 10 mg·kg^-1·d^-1 administration group（moderate MT dose group,n = 8）,peritoneal fibrosis ± MT 20 mg·kg^-1 ·d^-1 administration group（high MT dose group,n = 8）.The rats were injected intraperitoneal with4.25%peritoneal dialysis fluid at 100 ml·kg^-1 daily to build peritoneal fibrosis model.After 28 days,4 h peritoneal equilibration test（PET） was carried out,measuring amount of ultrafiltration（UF）,and calculating both dialysate-to-plasma ratios（D/P） for creatinine at 4 h and the ratio of glucose at4 h to the dialysate glucose concentration at time zero（D/D0）.Rats were killed,taking the parietal peritoneum HE and Masson staining to observe the morphological changes of the peritoneum.We use immunohistochemical methods to detect the expressions of transforming growth factor β1（TGF-β1）,collagen Ⅰ（Col-Ⅰ） and orsmooth muscle actin（α-SMA）.Results（1） Compared with the control group,UF and D4/D0 were significantly decreased（P<0.05） and D/Purea was markedly increased（P<0.05） in model group;Compared with the model group,UF and D4/D0 were significantly increased（P<0.05） and D/Purea was markedly decreased（P<0.05） in MT groups.（2） In the control group,the peritoneal tissues had smooth surface,the visible flat mesothelial monolayer cells covered loose connective tissues;compared with the control group,the peritonea of the model group were markedly thickened,with rough surface,and mesothelial cells were swelling and lost with collagen deposition.All above mentioned pathological changes reduced markedly in MT groups.（3） Expressions of TGF-β1,Col-1 and α-SMA were significantly increased in model group than the control group（P<0.05）;they were significantly decreased by treatment with MT.Conclusions MT can inhibit peritoneal fibrosis in rats by improving the structure and function of the peritoneum and inhibiting the expressions of the TGF-β1,α-SMA and Col- Ⅰ.…”
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The effect of miR-381 on proliferation and prognosis of breast cancer by altering CCNA2 expression by Ming-Gang Cao, Yan Wang, Zhi-Min Yang, Yang Wang, Mei-Qing Wang, Shuai Zhuo, Yan Yang, Chun-Sheng Liu

“…Background MiR-381 can regulate the expression of cyclin A2 (CCNA2) to inhibit the proliferation and migration of bladder cancer cells, but whether miR-381 has the same function in breast cancer is not well know.Methods The over express or silence miR-381 expressing cell lines were constructed by lentivirus infection to reveal the biological functions of miR-381 in vitro. …”
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Atrial arrhythmias associated with anti-tumor drugs in patients with malignant tumors and type 2 diabetes mellitus by Beibei Zhang, Lei Zhang, Yili Ren, Chenkai Xu

“…Serial 12-lead electrocardiograms (ECGs) were performed pre- and post-chemotherapy cycles to detect new-onset atrial arrhythmias. Multivariate Cox regression identified risk factors, adjusting for age, hypertension, renal function, and cardiac biomarkers (troponin I, NT-proBNP). …”
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Analysis of Gait and Foot Pressure in Patients with Different Severity of Knee Osteoarthritis by LING Xingjin, OU Jianlin, XIE Wenhao, CHEN Zhuoming, OUYANG Hui

“…ObjectiveTo analyze the gait characteristics of patients with different severity of knee osteoarthritis and the differences in the peak pressure points in different subdivisions of the foot to provide a basis for the clinical diagnosis, treatment and rehabilateral of knee osteoarthritis.MethodsA total of 64 patients with bilateral knee osteoarthritis admitted to the Department of Bone and Joint Surgery, Department of Rheumatology and Immunology, Department of Rehabilitation Medicine, and Department of Spine and Trauma Surgery of the First Affiliated Hospital of Jinan University from August 2020 to February 2021 were selected, based on the K-L classification (Kellgren-Lawrence classification) criteria of imaging, and the 50 cases of patients who met the criteria were divided into mild and moderate-severe groups, of which 26 cases of patients with grades I and II were included in the mild group, and 24 cases of patients with grades III and IV were in the moderate-severe group.The gait spatiotemporal parameters and peak plantar pressure points of the two groups were detected using the gait and balance function training assessment system and smart rehabilitation shoes respectively. …”
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Efficacy of Shenkang Injection combined with renin-angiotensin-aldosterone system blockers in diabetic nephropathy: a systematic review and meta-analysis of randomized controlled t... by Xinyue Zhang, Xuyuan Lao, Shengchun Liao, Chaoyang Ye, Chen Wang

“…No publication bias was detected for TER, SCr, BUN, 24h-UTP, TG, and adverse reactions, though UPER and TC showed potential bias.Conclusion SKI combined with RAAS blockers may enhance renal function and metabolic profiles in DN patients. …”
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Hepatoprotective effect of Nobiletin against 5-fluorouracil induce hepatotoxicity by Safa A. Yahya, Nada N. Al-Shawi

“…All groups, seven animals of each group were sacrificed at day fifteenth (15); and, serum was collected to measure inflammatory and anti-inflammatory markers (interlukin-6 and interlukin-10) and liver function tests(ALT, LDH and AST); furthermore, liver tissue samples were collected to measure level of caspase-3, malondialdehyde and reduced form of glutathione, assessment of Hemeoxygenase-1 and NADPH quinone dehydrogenase-1 enzymes. …”
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LncRNA MIAT Upregulates NEGR1 by Competing for miR-150-5p as a Competitive Endogenous RNA in SCIRI Rats by Zheng Wang, Jianguang Liu, Qiuxiang Yang, Mengjie Ma

“…Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL) staining was used to detect apoptosis in the spinal cord tissue of rats in each group. …”
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Periostin Induces Epithelial‐Mesenchymal Transition via p38‐MAPK Pathway in Human Renal Tubular Cells by High Glucose by Xiaoling Xiong, Xing Feng, Yuqing Ding

“…Studies have shown periostin mainly located in the dilated mesangium, tubulointerstitial and fibrotic regions of the diabetic kidney disease, which was negatively correlated with renal function. However, the underlying mechanism remains poorly explored. …”
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Boosting Aeroponic System Development with Plasma and High-Efficiency Tools: AI and IoT—A Review by Waqar Ahmed Qureshi, Jianmin Gao, Osama Elsherbiny, Abdallah Harold Mosha, Mazhar Hussain Tunio, Junaid Ahmed Qureshi

“…A major drawback is the inefficiency of nitrogen fixation, resulting in insufficient nutrient availability and heightened plant stress from uncontrolled misting, which ultimately reduces yield. Many studies have investigated plasma uses in both soil-based and soilless plant cultures; nevertheless, however, its function in aeroponics remains unexplored. …”
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Case Report: Post-operative mitral valve replacement complicating with a large cardiac mass and the role of TEE in Imaging [version 2; peer review: 2 approved] by Deepa Noronha, Chaithra Nayak, Syed Waleem Pasha, Padmanabh Kamath, Narasimha Pai D

“…Henceforth, sonographers must be skilled in the detection and identification of unusual complications to guide redo interventions. …”
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