Arsenic Trioxide Enhances the Efficacy of PD‐1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway by Xionghui Wang, Simo Cheng, Yannan Xu, Tianxiao Zheng, Changquan Ling, Juan Du

“…ERS activation was confirmed by Western blot detection of Calnexin, PDI, ATF‐4, p‐elF2α, and Caspase‐12. …”
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Targeting PRDX2 to inhibit tumor growth and metastasis in triple-negative breast cancer: the role of FN1 and the PI3K/AKT/SP1 pathway by Jiawei Zhou, Anqi Cheng, Jianqiang Guo, Yafeng Liu, Xuan Li, Maoqian Chen, Dong Hu, Jing Wu

“…Functional experiments demonstrated that in vitro knockdown of PRDX2 suppresses migration, invasion, and epithelial-mesenchymal transition (EMT) in TNBC cells. …”
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Treatment-Related Mechanisms of Tibetan Medicine <i>Terminalia chebula</i> (TC) Aqueous Extract Against Mouse Gastroenteritis Caused by Yak-Origin <i>Salmonella</i> Determined Usin... by Dengyu Li, Kaiqin Zhang, Xiaofeng Xue, Zhanchun Bai, La Yang, Jingjing Qi, Sizhu Suolang

“…The results showed the following: TC can effectively reduce the diarrhea rate; alleviate weight loss caused by <i>Salmonella</i> invasion; reduce the pro-inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α in serum; and increase the concentrations of the anti-inflammatory cytokines IL-4 and IL-10. …”
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NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…However, VASO comes along with another reduction in detection sensitivity. NOise Reduction with DIstribution Corrected (NORDIC) PCA (principal component analysis) is a denoising technique specifically aimed at suppressing thermal noise, which has proven useful for increasing the SNR of high-resolution functional data. …”
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Afucosylated IgG in idiopathic nephrotic syndrome patients with anti-nephrin autoantibodies correlate with disease activity by Sonia Spinelli, Andrea Garbarino, Francesca Lugani, Edoardo La Porta, Noemi Rumeo, Giorgio Piaggio, Alberto Magnasco, Antonella Trivelli, Maria Ludovica Degl’Innocenti, Gino Tripodi, Simona Granata, Francesca Leone, Elena Zocchi, Lorenzo Gallon, Gian Marco Ghiggeri, Enrico Verrina, Gianluigi Zaza, Giovanni Candiano, Maurizio Bruschi

“…Variation in techniques for detecting anti-nephrin Abs and lack of urinary data contribute to uncertainties of results.While reduced IgG fucosylation is known to enhance antibody-dependent cellular cytotoxicity in non-INS autoimmune diseases, its role in modulating anti-nephrin autoantibody function and disease severity in INS remains unexplored. …”
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Influence of Different Synthesis Methods on the Defect Structure, Morphology, and UV-Assisted Ozone Sensing Properties of Zinc Oxide Nanoplates by Pedro P. Ortega, João V. N. Palma, Ana L. Doimo, Laura Líbero, Gabriel F. Yamakawa, Leonnam G. Merízio, Ederson C. Aguiar, Luís F. Silva, Elson Longo

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High temperature induces reproductive dysfunction in male zebrafish via DNA methylation-mediated tssk6 downregulation by Xuan Ma, Rongjian Liu, Zhongchang Ren, Yongmei Qi, Dongqiong Wei, Jiamin Shi, Samra., Cong Yuan, Dejun Huang

“…These findings establish an epigenetic mechanistic link between environmental HT and reproductive function in aquatic organisms.…”
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MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions by Hai-Yu Mo, Ruo-Bing Wang, Meng-Yao Ma, Yi Zhang, Xin-Yu Li, Wang-Rong Wen, Yi Han, Tian Tian

“…In addition, MTHFD2 knockdown reduces the cellular NADPH/NADP+ ratio, colony formation and mitochondrial function, increases cellular ROS and cleaved PARP levels and induces in cell death under hypoxia, a hallmark of solid cancers and a common inducer of oxidative stress. …”
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Mechanism of Modified Tongyou Decoction and Its Separated Formulas Inhibiting Vasculogenic Mimicry in Esophageal Cancer TE-1 Cells via NF-κB/HIF-1α Axis by Qian Wang MS, Yingying Tian MS, Lingyu Kong MD, Zeyi Chen MS, Xin Yan PhD, Chenxi Wu PhD, Huijuan Cao PhD, Fanwu Wu PhD, Yongsen Jia PhD, Prof.

“…ELISA assay showed that HIF-1α protein from supernatant was increased and E-cadherin reduced after hypoxia stimulation. The 4 medications inhibited HIF-1α protein secretion, among which MTD and the AB formula showed stronger function. …”
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Influence of semicircular canal morphology on the VOR and swimming activity in larval amphibians: a comparative study in Xenopus and axolotl by Parthena Schneider-Soupiadis, Parthena Schneider-Soupiadis, Michael Forsthofer, Michael Forsthofer, Michael Forsthofer, Felix Schneider-Soupiadis, Felix Schneider-Soupiadis, Gilles Courtand, Rosario Sanchez-Gonzalez, François M. Lambert, Hans Straka

“…Gaze stabilization and locomotion rely often on an accurate sensory detection of head movements by the vestibular system. …”
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The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…In 2017, the position paper by Hummel et al. on olfactory dysfunction gave the definitions of qualitative and quantitative smell impairments [1]. Hyposmia is a reduced ability to detect odors, anosmia is the complete inability to detect odors, parosmia is a change in the normal perception of odors, such as when the smell of something familiar is distorted, or when something that normally smells pleasant now smells foul. …”

The Role of Mitochondria in Diabetic Kidney Disease and Potential Therapeutic Targets by Masanobu Takasu, Seiji Kishi, Hajime Nagasu, Kengo Kidokoro, Craig R. Brooks, Naoki Kashihara

“…Therapeutic strategies focused on restoring mitochondrial function are promising for slowing the progression of DKD and reduce the adverse effects on renal function. …”
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Research on Visual SLAM Navigation Techniques for Dynamic Environments by Tongjun Wang, Peijun Zhao

“…Synchronous positioning and mapping mainly realize the functions of self-positioning and environment map construction for intelligent navigation technology. …”
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Mechanisms of asiaticoside in keloid treatment: Insights from a single-cell transcriptomic approach combined with network pharmacological analysis by Xiaobo Zhou, Li Lin, Canbin Dong, Jui-Ming Lin, Yiyi Gong, Wenyu Wu, Jia Huang

“…Our study demonstrates asiaticoside alleviates keloid by modulating macrophage function and KF activity through NF-κB and PI3K-Akt signaling. …”
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Human Supernumerary Teeth-Derived Apical Papillary Stem Cells Possess Preferable Characteristics and Efficacy on Hepatic Fibrosis in Mice by Jun Yao, Nan Chen, Xiaojing Wang, Leisheng Zhang, Jiali Huo, Ying Chi, Zongjin Li, Zhongchao Han

“…The efficacy on a mouse hepatic fibrosis model was evaluated by using histologic sections and liver function tests. Herein, we showed that SCAP-Ss exhibited comparable immunophenotype and adipogenic differentiation capacity as DPSCs. …”
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Regulation of cholesterol biosynthesis by CTCF and H3K27 methylation is critical for cell migration by Lukasz Stanislaw Kaczmarczyk, Dagmawit Babele, Nehora Levi, Gowthaman Gunasekaran, Mali Salmon-Divon, Gabi Gerlitz

“…In agreement with the cholesterol change we detected altered membrane dynamics in CTCF pLoF cells as measured by reduced formation of migrasomes, extracellular vesicles formed at the rear side of migrating cells. …”
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Genome and Pathogenicity Analysis of an NADC30-like PRRSV Strain in China’s Xinjiang Province by Honghuan Li, Wei Zhang, Yanjie Qiao, Wenxing Wang, Wenxiang Zhang, Yueli Wang, Jihai Yi, Huan Zhang, Zhongchen Ma, Chuangfu Chen

“…Serum biochemical tests indicated significant impairment of liver and kidney function. PRRSV antibodies began to appear gradually after 10 days post infection. …”
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Targeting Antibodies to Carbon Nanotube Field Effect Transistors by Pyrene Hydrazide Modification of Heavy Chain Carbohydrates by Steingrimur Stefansson, Hena H. Kwon, Saeyoung Nate Ahn

“…In an attempt to minimize the antibody footprint on CNT-FETs, we examined whether pyrene hydrazide modification of antibody carbohydrates could reduce the concentration required to functionalize CNT circuits. …”
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PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2 by Ping-Li Yang, Jia-Shun Wang, Xiao-Mei Cheng, Jing-Cai Chen, Hui Zhu, Xiao-Lan Li, Li Cao, Wei Tang

“…Furthermore, strong E2F2 expression was detected in nonkeratinizing NPC tissues. We further demonstrated that rosiglitazone, a PPAR-γ agonist, reduced E2F2 expression and proliferation in NPC cell lines. …”
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Gray matter microstructure alterations with excess extra-cellular free water contribute to cognitive dysfunction in bipolar disorder: A comparative analysis with white matter patho... by Yasuhito Nagai, Toshimasa Fujimura, Wataru Uchida, Rinako Iseki, Koji Kamagata, Shigeki Aoki, Tadafumi Kato

“…Imaging studies reveal reduced cortical thickness and impaired white matter integrity in BD; however, the biological pathophysiology underlying cognitive dysfunctions remains unclear. …”
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