Tumor Initiation and Progression in People Living on Antiretroviral Therapies by Seun E. Olufemi, Daniel A. Adediran, Temitope Sobodu, Isaac O. Adejumo, Olumide F. Ajani, Elijah K. Oladipo

“…Firstly, while ART restores immune function, it does not fully normalize it. Chronic immune activation and persistent inflammation continue to be prevalent, creating a conducive environment for oncogenesis. …”
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A novel approach to skin disease segmentation using a visual selective state spatial model with integrated spatial constraints by Yu Bai, Hai Zhou, Hongjie Zhu, Shimin Wen, Binbin Hu, Haotian Li, Huazhang Wang, Daji Ergu, Fangyao Liu

“…Automated techniques for skin lesion segmentation assist dermatologists in early detection and ongoing monitoring of various skin diseases, ultimately improving patient outcomes and reducing healthcare costs. …”
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CRISPR/Cas9-Mediated Knockout of <i>BmGDAP2</i> in the Silkworm, <i>Bombyx mori</i>: Extended Lifespan and Altered Gene Expression Impacting Developmental Pathways by Chaojun Yuan, Zichong Zhou, Qifeng Guo, Ying Yang, Yue Sun, Yong Liu, Wenyi Jia, Shuoqi Fan, Jinxin Wu, Xiaoting Hua, Ping Lin, Ping Zhao, Qingyou Xia

“…At present, little is known about the function of <i>GDAP2</i> in insects. In this study, <i>BmGDAP2</i> was detected to be highly expressed in the head, epidermis, midgut, and anterior silk glands of silkworms. …”
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Enhancing visual perception by modulating prestimulus alpha and beta power with tRNS by Jinwen Wei, Huiru Zou, Qianyuan Tang, Ziqing Yao, Gan Huang, Zhen Liang, Li Zhang, Lijie Ren, Xiaodong Cai, Chen Yao, Changsong Zhou, Zhiguo Zhang

“…In a sham-controlled, within-subject design, 29 participants completed a visual detection task combined with electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recordings. …”
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Mechanism study of KCMF1 promoting proliferation and NF-κB signaling transduction in colorectal cancer cells by WU Zhibai, XU Guiqin, ZHANG Li, YANG Zhaojuan, LIU Yun, JIAO Kun, CHEN Zehong, XU Chen, ZUO You, ZHENG Ningqian, YE Zhiqian, LIU Yongzhong

“…Meanwhile, the activity of NF-κB reporter was reduced in tumor cells upon KCMF1 knockdown (P&lt;0.01). …”
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Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses by Lucie Janeckova, Monika Stastna, Dusan Hrckulak, Linda Berkova, Jan Kubovciak, Jakub Onhajzer, Vitezslav Kriz, Stela Dostalikova, Tereza Mullerova, Katerina Vecerkova, Marketa Tenglerova, Stepan Coufal, Klara Kostovcikova, Richard S. Blumberg, Dominik Filipp, Konrad Basler, Tomas Valenta, Michal Kolar, Vladimir Korinek

“…However, the exact function of Tcf4 in specifying the secretory lineage and its contribution to antimicrobial peptide production remain incompletely understood. …”
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A comparative parasitological, histopathological, and proteomic analysis of Schistosoma mansoni infected mice treated with ivermectin and praziquantel by Eman Sayed El-Wakil, Mona Mohamed Tolba, Mona Hasan El-Sayad, Maha Khairy Hassen, Hayat S. Al-Rashidi, Mina A. Almayouf, Wafa Abdullah I. Al-Megrin, Hind Alzaylaee, Esraa Abdelhamid Moneer

“…Molecular and biological function administered from the NCBInr database revealed the presence of glycolytic proteins, structural proteins, and cytosol stress response. …”
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Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression by Simon Gebremeskel, Adam Nelson, Brent Johnston, Brian D Lichty

“…This results from late detection, high rates of metastasis, and resistance to standard chemotherapies. …”
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FCGBP promotes ovarian cancer progression via activation of IL-6/JAK-STAT signaling pathway by Zhiqin Fu, Kelie Chen, Fang Zheng, Wangang Gong, Ding Chao, Chao Lu

“…This study aimed to investigate the clinical relevance, functional role, and underlying mechanisms of FCGBP in ovarian cancer progression. …”
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Immunological profiling in type 2 diabetes mellitus and type 2 diabetic kidney disease: insights from single-cell LacNAc sequencing by Mengyun Xiao, Zigan Xu, Xiaohui Zhu, Jing Chen, Ru Wang, Yaxuan Wang, Xiang Gao, Shaodong Luan, Xiaoyan Pu

“…Functional enrichment analysis of overlapping differentially expressed genes (DEGs) and subclusters revealed enrichment in NET formation pathways. …”
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Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…The results of Mendelian randomization analysis further confirm that PTEN is an important therapeutic target for improving cognitive function. Conclusion: Collectively, our preliminary findings indicated that SGD can improve cognitive function of PICI mice. …”
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Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis by Lu Lin, Weijun Yu, Ruhan Yang, Mingzhi Liu, Yuanjie Shi, Shucheng Hu, Guanglong Li, Jiaqi Tang, Yue Shen, Zhurong Cui, Min Jin, Yuting Gu, Eryi Lu

“…UCHL1 was knocked down using shRNA to validate its function and regulation of Yes-associated protein (YAP) activity. …”
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A case of brainstem encephalitis with acute neuropathy associated with prolonged chikungunya viraemia by Tembe Carveth-Johnson, Benjamin McLoughlin, Daniel Rice-Wilson, Fiona Chatterjee, Teresa Cutino-Moguel, Matthew Buckland, Apeksha Shah, David Harrington

“…A 66-year-old man presented to hospital in London, United Kingdom, with back pain and reduced mobility shortly after returning from Chandigarh, India. …”
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Progress in CRISPR Technology for Antiviral Treatments: Genome Editing as a Potential Cure for Chronic Viral Infections by Fatemeh Nouri, Farnaz Alibabaei, Behina Forouzanmehr, Hamed Tahmasebi, Valentyn Oksenych, Majid Eslami

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Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury by Jiang W, Zhang J, Zhang Y, Huang Z

“…Phosphorylated proteins were detected in the AMPK/mTOR signaling pathway.Results: In sepsis and sepsis-AKI, σ-1R levels were reduced, whereas the levels of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) increased. σ-1R promoted the proliferation of LPS-induced HK-2 cells while inhibiting apoptosis. …”
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Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p. by Chen Bian, Tongda Xu, Hong Zhu, Defeng Pan, Yang Liu, Yuanyuan Luo, Pei Wu, Dongye Li

“…The purpose of this study was to determine which miRs and target genes LUT exerted such function through.<h4>Methods</h4>Expression of various miRs in perfused rat hearts was detected using a gene chip. …”
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Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium by Garrett Rhodes, Kristen L. Segars, Yoonjoo K. Lee, Audrey E. K. Hutcheon, Celeste B. Rich, Vickery Trinkaus-Randall

“…Pannexin1 inhibition reduced mobilization of calcium between cells near the leading edge, and MATLAB scripts revealed a reduction in cell-cell communication that was also detected in cultured cells. …”
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Role of ferroptosis in acute cadmium-induced liver injury in mice by YIN Qizi, TANG Yuting, ZHANG Saijun, GUO Siyu, LI Jing, WANG Ziyue, JI Yanli

“…Results The acute Cd exposure reduced liver weight and organ coefficient in mice, and significantly caused liver function and pathological damage. …”
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Erhong Jiangzhi Decoction Inhibits Lipid Accumulation and Alleviates Nonalcoholic Fatty Liver Disease with Nrf2 Restoration Under Obesity by Li F, Xie R, Li T, Ren S

“…ELISA was exploited to detect the expression of lipid accumulation, liver function, inflammation, and oxidative stress related indicators. …”
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Development and Optimization of a Novel Deep Learning Model for Diagnosis of Quince Leaf Diseases by A. Naderi Beni, H. Bagherpour, J. Amiri Parian

“…IntroductionDetection of tree leaf diseases plays a crucial role in the horticultural field. …”
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