METTL3 mediates m6A methylation modification of ULBP2 and affects the progression of cervical cancer by Hongtao Ren, Yuting Wang, Jiao Yu, Lei An, Xiulong Ma, Jiyuan Pan

“…METTL3 influenced the expression of ULBP2 and impacted the biological function of the CC cells. Silencing ULBP2 reduced the radioresistance of CC in vivo. …”
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Effect of minimally invasive posterior veneer Preparation designs on failure load and mode after fatigue (in-vitro study) by Islam Mohamed Mady, Ahmed Safwat El Kady, Moustafa Nabil Aboushelib, Mohamed Hussein A. Hussein

“…Abstract Background Ceramic veneers are a common option for enhancing dental aesthetics by improving tooth form, shade, and function. Preparation design is considered a critical factor in the success of dental veneers, as it influences the failure load and fatigue survival of posterior minimally invasive ceramic veneer restorations. …”
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The Therapeutic Effect of Traditional LiuJunZi Decoction on Ovalbumin-Induced Asthma in Balb/C Mice by Wenting Xu, Rui Zhao, Bin Yuan

“…The levels of inflammatory factors and immunoglobulins were detected by enzyme-linked immuno sorbent assay (ELISA). …”
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The Impact of Embracing New Antenatal Screening Guidelines on Complications Related to Grand Multiparity in a Jordanian Tertiary Referral Center by Fida Thekrallah, Nadia Muhaidat, Ayman Qatawneh, Kamil Fram, Naser Al-Husban, Fida Asali

“…However, the results of universal screening tests for thyroid function and glucose tolerance were abnormal in only a small number of women. …”
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METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF‐α-stimulated rheumatoid arthritis fibroblast-like synovial cells by Hua Ren, Guohua Wei, Ziwei Kong, Mengyang Zhang, Yuejin Li, Sanjiao Liu, Yifan Guo

“…Herein, we intended to investigate the function of methyltransferase-like 3 (METTL3) and its N6-methyladenosine (m6A) methylation regulation for ras-related C3 botulinum toxin substrate 2 (RAC2) in RA. …”
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Possibilities for managing the left ventricular diastolic dysfunction risk in obese patients by O. V. Gritsenko, G. A. Chumakova, O. V. Gruzdeva, E. A. Subbotin

“…According to echocardiography, LVDD was detected in 20 patients (19,8% after 4,7±0,3 years). …”
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Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway by Xiaoxue Du, Yuzhen Xu, Shijia Chen, Marong Fang

“…The area of infarction reduced in Ki20227 group when compared to the stroke group. …”
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Association analysis of dyslipidemia-related genes in diabetic nephropathy. by Gareth J McKay, David A Savage, Christopher C Patterson, Gareth Lewis, Amy Jayne McKnight, Alexander P Maxwell, Warren 3/UK GoKinD Study Group

“…In a sensitivity analysis, samples from control individuals with reduced renal function (estimated glomerular filtration rate<60 ml/min/1.73 m(2)) were excluded. …”
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HSF1 in macrophages suppressed the progression of asthma via modulating SIRPα/SHP2—Dectin-1/ SYK mediated ROS and inflammatory responses by Xiaojuan Liu, Yingqian Zhang, Huifang Wu, Jingli Zhang, Yingxue Wang, Huifeng Zhang

“…Protein expression in lung tissue and RAW264.7 cells was detected by Western blotting. In in vivo experiments, OVA-induced asthmatic mice exhibited severe airway resistance, collagen deposition, and elevated ROS and pro-inflammatory cytokines.HSF1A treatment improved lung function, reduced fibrosis, and restored redox balance. …”
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Effect of Cistanche deserticola Polysaccharides on the Treatment of Ulcerative Colitis in Mice by Regulating Coke Death Through NLRP3/GSDMD Signaling Pathway by Guangli MA, Qing LI

“…Immunohistochemistry and immunofluorescence results showed that CDPS groups inhibited NLRP3, Caspase-1, and GSDMD-N expression, thereby reducing cell pyroptosis. qPCR analysis confirmed that CDPS groups downregulated mRNA expression of IL-1β, IL-6, TNF-α, NLRP3, Caspase-1 and GSDMD, indicating that CDPS had significant therapeutic effects on DSS-induced ulcerative colitis in mice, with mechanisms potentially related to inhibiting inflammatory response, improving intestinal barrier function, and reducing cell apoptosis and pyroptosis.…”
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SLC25A19 drives colorectal cancer progression by regulating p53 by Jinbo Jiang, Xuemei Li, Jiayong Wang, Shaofei Chen, Lingjuan Chen

“…Methods The GEPIA database and immunohistochemical staining were utilized to detect the expression of SLC25A19 in CRC tissues. …”
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l-carnitine protects against bile acid-induced mitochondrial dysfunction and IGF-1 impairment in hepatocyte cultures by Wafa'a Alqabandi, Maira Alsaeid, Gursev Dhaunsi

“…We investigated the effects of glycochenodeoxycholic acid (GCDC) on mitochondrial function and insulin-like growth factor-1 (IGF-1) activity in hepatocytes and also examined if l-carnitine (CRNT) has any protective role. …”
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ROLE OF PULMONARY HYPERTENSION IN THE DEVELOPMENT OF CIRRHOTIC CARDIOMYOPATHY by M. V. Chistyakova, A. V. Govorin, E. V. Radaeva

“…In patients with LC complicated by PH, a strong correlation was found between the diameter-of the portal vein and blood flow velocity in pulmonary artery (r=0.65, p&lt;0.05), between the diameter of the inferior vena cava and right ventricle-rapid filling flow (r=0.93, p&lt;0.05), between the diastolic function of the right ventricle (E/A) and the blood flow velocity in the portal vein (r=0.73;-p&lt;0.05). …”
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Absorber-Free Mode-Locking of a Hybrid Integrated Diode Laser at Sub-GHz Repetition Rate by Anzal Memon, Albert van Rees, Jesse Mak, Youwen Fan, Peter J. M. van der Slot, Hubertus M. J. Bastiaens, Klaus-Jochen Boller

“…To stabilize the repetition rate, hybrid mode-locking is demonstrated by weak RF modulation of the diode current. The RF injection reduces the Lorentzian linewidth component from 8.9 kHz to a detection-limited value of around 300 mHz. …”
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Hypermobile Ehlers-Danlos Syndrome: Cerebrovascular, Autonomic and Neuropathic Features by Peter Novak, MD, PhD, David M. Systrom, MD, Sadie P. Marciano, PA-C, Alexandra Witte, PA-C, Arabella Warren, MD, PhD, Donna Felsenstein, MD, Matthew P. Giannetti, MD, Matthew J. Hamilton, MD, Jennifer Nicoloro-SantaBarbara, PhD, Mariana Castells, MD, Khosro Farhad, MD, David M. Pilgrim, MD, William J. Mullally, MD, Mark C. Fishman, MD, Jeff M. Milunsky, MD, Aubrey Milunsky, MD, Joel Krier, MD

“…Small fiber neuropathy using structural criteria was detected in 64%, and using combined structural and functional criteria in 82%. …”
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CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Background: Colony-stimulating factor 3 (CSF3) is a cytokine that promotes inflammation by stimulating the maturation, proliferation, and trafficking of myeloid progenitor cells. However, the functional importance of CSF3 in colorectal cancer (CRC) remains unclear. …”
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Deconvolution of expression microarray data reveals 131I-induced responses otherwise undetected in thyroid tissue. by Britta Langen, Nils Rudqvist, Johan Spetz, Khalil Helou, Eva Forssell-Aronsson

“…In conclusion, previously reported trends of 131I-induced transcriptional responses in thyroid were reproduced with deconvolved data and usually with a higher detection rate. Deconvolution also resolved an issue with detecting damage and stress responses in enriched data, and may reduce false negatives in other contexts as well. …”
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The Emergence of AI-Driven Virtual Hospitals: Redefining Patient Care Beyond Physical Boundaries by Ifrah Hameed, Hafiz Muhammad Haseeb Khaliq

“…This ensures early detection of healthcare disorders followed by interventions thereby enhancing patient safety. …”
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A Novel SOH Estimation Method for Lithium-Ion Batteries Based on the PSO–GWO–LSSVM Prediction Model with Multi-Dimensional Health Features Extraction by Xu He, Zhengpu Wu, Jinghan Bai, Junchao Zhu, Lu Lv, Lujun Wang

“…The correlation between HFs and SOH is comprehensively evaluated through Pearson and Spearman correlation analyses, followed by Gaussian filtering and outlier detection to enhance feature quality. With strong generalization and robustness, least squares support vector machine (LSSVM) is widely applied to nonlinear computations and function approximation. …”
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Prevalence and Variability of <i>Helicobacter pylori</i> Clarithromycin Resistance Mutations in Pediatric Patients in Poland: A Genotypic Analysis Using the Bosphore Genotyping Kit by Tomasz Bogiel, Anna Szaflarska-Popławska, Agnieszka Krawczyk

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