Classification Based on the Support Vector Machine for Determining Operational Targets for Controlling Electricity Usage With Conventional Meters: A Case Study of Industrial and Bu... by Galih Arisona, Alief Pascal Taruna, Dwi Irwanto, Arif Bijak Bestari, Wildan Juniawan

“…Various SVM kernels were tested, including Radial Basis Function (RBF), Linear, Polynomial (Poly), and Sigmoid, alongside classifiers such as SVM, Logistic Regression, Decision Tree, and Naïve Bayes. …”
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Exactly Restricting the Phenyl Ring Rotation in Metal‐Organic Framework for Ultra‐Sensitive and Specific Ratiometric Fluorescent Sensing of Sarin by Cong Lyu, Chuanfang Zhao, Meimei Wang, Jiawen Li, Zhenzhen Cai, Xincun Dou, Baiyi Zu

“…Density functional theory (DFT) calculations further verify the recognition of DCP by Eu‐CTTB‐MOF could suppress the rotations of the aromatic rings in CTTB ligand, significantly reducing the nonradiative decay pathways and subsequently enhancing the fluorescent intensity of the CTTB ligand. …”
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HBimmCue: A Versatile Fluorescent Probe for Multi‐Scale Imaging of Lipid Polarity and Membrane Order in Inner Mitochondrial Membrane by Shu Gao, Jing Sun, Yiwei Hou, Xichuan Ge, Ming Shi, Hongxi Zheng, Yan Zhang, Meiqi Li, Baoxiang Gao, Peng Xi

“…Abstract Mitochondrial membrane environmental dynamics are crucial for understanding function, yet high‐resolution observation remains challenging. …”
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Aerosol inhalation of dimeric artesunate phospholipid-conjugated liposomes ameliorates inflammation, fibrosis, and ferroptosis in neonatal mice with hyperoxia-induced lung injury by Rong Guan, Rong Guan, Yu Chen, Qianqian Yu, Qianqian Yu, Bingrui Yu, Shuyu Chen, Siyuan Jia, Huifang Wang, Huaiping Cheng, Zhaofang Tian

“…This research examines the function and fundamental processes of dimeric artesunate phospholipid-conjugated liposomes (Di-ART-GPC) in BPD. …”
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Burdock Fructooligosaccharide Protects Against Diabetic Nephropathy in Mice by Regulating Nrf2 Signaling by Lei Zhu, Mengru Ding, Lina Liu, Pingchuan Yuan, Taili Shao, Chunyan Liu, Chuanhu Xi, Jun Han, Yuyan Zhou, Donglin Zhang, Guodong Wang

“…Additionally, BFO protected against streptozotocin‐induced renal injury, restored podocyte function, increased both mRNA and protein expression of Nrf2, HO‐1, and Bcl‐2, and decreased those of Bax. …”
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Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages by Tiantian Dai, Zhihua Xu, Yadi Li, Mengni Wu, Yue Qiu, ZhuJun Chao, Renhai Jiang, Yan Chen, Linlin Lu

“…In vitro, knockdown of B7-H3 reduced the expression of CCL3/4 on a cell line of monocytes THP-1. …”
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RNA Interference-Mediated Downregulation of sAC Gene Inhibits Sperm Hyperactivation in Male Rats (Rattus norvegicus) by Jing YU, Xiao-qiang JIANG, Shuai ZHOU, Gen-lin WANG

“…The aim of this study is to investigate the function of sAC in hyperactivation in male rats. Four siRNAs of sAC gene were designed and separately transformed into rat sperm using electrotransformation method. …”
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CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20 by Chen Zheng, Hu Hei, Yifei Zhai, Wenbo Gong, Runfang Zhang, Songtao Zhang

“…The proliferation and apoptosis of CD8+ T cells were detected by immunofluorescence and flow cytometry. …”
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Mesenchymal stem cell-derived exosomes ameliorate diabetic kidney disease through NOD2 signaling pathway by Yinghui Wang, Donglin Lu, Shasha Lv, Xiangchun Liu, Gang Liu

“…To clarify the effect of MSC-Exo on NOD2 signaling pathway in podocytes under high glucose (HG) and DKD, we conduct this study.Methods We co-cultured podocytes and MSCs-Exo under 30 mM HG and injected MSCs-Exo into DKD mice, then we detected the NOD2 signaling pathway by western blot, qRT-PCT, immunofluorescence, transmission electron microscopy and immunohistochemistry both in vitro and in vivo.Results In vitro, HG lead to the apoptosis, increased the ROS level and activated the NOD2 signaling pathway in podocytes, while MSCs-Exo protected podocytes from injury reduced the expression of inflammatory factors including TNF-α, IL-6, IL-1β, and IL-18 and alleviated the inflammatory response, inhibited the activation of NOD2 signaling pathway and the expression of it’s downstream protein p-P65, p-RIP2, prevented apoptosis, increased cell viability in podocytes caused by HG. …”
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Effect of simvastatin on microinflammation in patients with uremia by SU Bo, LI Yi

“…Objective To analyze the effect of simvastatin on microinflammation in patients with uremia.Methods Randomly The selected 76 patients with chronic renal failure in our hospital from January 2015 to January 2017 were divided into the control group and the observation group.The control group was treated with basic treatment and dialysis.The observation group was treated with simvastatin on the basis of the basic treatment program.The serum levels of inflammatory factors,nutritional indexes,blood lipid,renal function and cardiac function indexes were detected.Results Before the treatment,there was no significant difference between the two groups in IL-6,TNF-α,hs-CRP and Alb contents.After treatment,IL-6,TNF-α,hs-CRP and Alb contents were significantly increased in both two groups as compared with those before treatment,but IL-6,hs-CRP and TNF-αlevels were significantly lower,and Alb was significantly higher in the observation group than those in the control group(P<0.05).Before treatment,there was no significant difference in the renal function and blood lipid indexes between two groups.After treatment,the renal function indexes and blood lipid indicators were improved significantly in the two groups as compared with those before treatment.SCr,HDL-C,TG,LDL-C and TC were significantly better in the observation group than those in the control group(P<0.05).Before treatment,there was no significant difference in IVST,LVM and LVMI between two groups(P>0.05).After treatment,IVST,LVM and LVMI indexes in the two groups were decreased,but the decrease was not obvious with the difference being not statistically significant(P >0.05).Conclusions Simvastatin exerts good anti-inflammatory effects,and its combination with basic dialysis for uremia patients could effectively improve the microinflammatory state of patients,improve renal function and blood lipid indexes,and reduce the incidence of adverse reactions.…”
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Antioxidant Peptides from the Fruit Source of the Oil Crop <i>Litsea cubeba</i> Ameliorate FFA-Induced Oxidative Stress Injury: Based on Nrf2/Keap1 Pathway and Molecular Dynamics S... by Li Li, Ying Hu, Yu-Mei Wang, Xiao-Xue Wu, Si-Tong Lin, Hang Li, Ji Zhang, Guo-Rong Fan, Zong-De Wang, Bin Wang, Shang-Xing Chen

“…The intracellular antioxidant protease (CAT, GSH, and SOD) activity levels and lipid peroxidation (MDA) content were measured and intracellular ROS levels were detected. The results showed that after intervention with the antioxidant peptides, the intracellular ROS levels in the NAFLD model cells were significantly reduced, the SOD and CAT activities were increased, the GSH content was elevated, and the MDA content was reduced, which indicated that AQRDAGLL, QEGPFVR, and DVPPPRGPL were able to inhibit the oxidative stress of the cells effectively and to achieve the effect of intervening in NAFLD. …”
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GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Ce... by Jing Ning, Jianqiao Ding, Shu Wang, Youhong Jiang, Daqing Wang, Shenyi Jiang

“…Finally, HLA-A2-restricted GPC3 antigenic peptide-modified DCs were co-cultured with T cells to generate specific CTLs, and the killing effects of different CTLs on LUSC cells were studied. A series of cell function experiments showed that GPC3 overexpression promoted the proliferation, migration, and invasion of LUSC cells, inhibited their apoptosis, increased the number of cells in S phase, and reduced the cells in G2/M phase. …”
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Vincamine induces cytoprotective autophagy via regulation of ampk/mtor signaling pathway in gentamicin-induced hepatotoxicity and nephrotoxicity in rats by Alaa Abouelhamd, Nourhan Elpry Mahmoud Shehata, Sara Mohamed Naguib Abdel-Hafez, Dalia H. Abu-Baih

“….), and GET/VIN (received both VIN and GET) for 7 days. Liver and kidney function tests were performed. Serum total antioxidant capacity (TAC) and tissue malondialdehyde (MDA) were quantified. …”
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Nutrigenomic and Nutritional Analyses Reveal the Effects of Pelleted Feeds on Asian Seabass (Lates calcarifer). by Si Yan Ngoh, Daniel Tan, Xueyan Shen, Purushothaman Kathiresan, Junhui Jiang, Woei Chang Liew, Natascha May Thevasagayam, Hsiao Yuen Kwan, Jolly M Saju, Sridatta R S Prakki, Chin Heng Goh, Hong Ching Wong, Tai Teck Chan, Miklós Mézes, László Orbán

“…Significant enrichment of genes with growth-related function tallied with the morphological data measured. …”
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Compensation of Speckle Noise in 2D Images from Triangulation Laser Profile Sensors Using Local Column Median Vectors with an Application in a Quality Control System by Paweł Rotter, Dawid Knapik, Maciej Klemiato, Maciej Rosół, Grzegorz Putynkowski

“…The main function of triangulation-based laser profile sensors—also referred to as laser profilometers or profilers—is the three-dimensional scanning of moving objects using laser triangulation. …”
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Resveratrol Alleviates Skeletal Muscle Insulin Resistance by Downregulating Long Noncoding RNA by Zhihong Liu, Zhimei Zhang, Guangyao Song, Xing Wang, Hanying Xing, Chao Wang

“…Our study revealed that RSV reduced IR in mouse skeletal muscles via the regulation of NONMMUT044897.2.…”
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Topical Vitamin C Promotes the Recovery of Corneal Alkali Burns in Mice by Min Li, Zufeng Chen, Lin Liu, Xiaoyun Ma, Jun Zou

“…However, the specific mechanism and functional modes are still unclear. The present study sought to assess the mechanisms of Vc function on corneal alkali burns. …”
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Huntingtin-Interacting Protein 1-Related (HIP1R) Regulates Rheumatoid Arthritis Synovial Fibroblast Invasiveness by Teresina Laragione, Carolyn Harris, Percio S. Gulko

“…HIP1R and HIP1 DEG lists had a greater than expected number of similar genes (<i>p</i> = 0.0015), suggesting that, despite the major differences detected, both have partially overlapping functions in RA FLS. …”
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MiR-106b-5p improving the progression of chronic kidney disease by inhibiting the TGF-β/Smad pathway by Qihao Ma, Li Xu, Peng Zhou, Bo Yang, Yong Li, Danan Sun

“…Abstract Background Chronic Kidney Disease (CKD) is a progressive disorder marked by renal impairment and declining kidney function. Aims To investigate the expression of miR-106b-5p in CKD and its regulatory relationship with the TGF-β/Smad pathway. …”
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ANALYSIS OF SURFACE DEFECTS OF ALUMINUM AND ITS ALLOYS WITH A SCANNING KELVIN PROBE by A. K. Tyavlovsky, A. L. Zharin, O. K. Gusev, R. I. Varabei, N. I. Muhurov, G. V. Sharonov, K. U. Pantsialeyeu

“…Surfaces with higher mechanical strength and overall better mechanical properties found to have lower CPD values that correspond to higher electron work function and surface energy. The presence of the second mode in the CPD distribution histogram indicates the significant proportion of defect areas on the sample surface.Analysis of visualized CPD distribution maps using defined criteria allows detecting and characterizing such defects as residual stress areas, areas with reduced microhardness, surface contamination spots, corrosion defects. …”
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